Review Article
Underutilized Medicinal Plant in Ethiopia: The Case of Aloe Species
Issue:
Volume 10, Issue 1, March 2024
Pages:
1-5
Received:
7 February 2024
Accepted:
22 February 2024
Published:
7 March 2024
Abstract: Ethiopian aloe species are known for traditional medicine for both human and livestock as well as for the preparation of various cosmetic products such as soap and lotion. The aloe species contributed great economic and social benefits for many local communities. In recent years, there has been a growing interest in the use of aloe species in the beauty and wellness industry. Many international companies have started to source aloe from Ethiopia, recognizing its high quality and potency. However, there are concerns about the sustainability of aloe harvesting in Ethiopia. Due to the high demand for aloe products, there has been an increase in over-harvesting without replanting and unsustainable practices. This has led to a decline in some aloe species that hastens the need for better management and conservation efforts. Government and non-government groups should pay attention in order to minimize the damage to the aloe species. Traditional medicine practitioners, research institutes, and universities as well as biodiversity conservation institutes should give attention to the valuable aloe species in the country. As the species are declining from time to time, the devotions of the Ministry of Agriculture, Ministry of Labor and Skill, and Biotechnology Institute are essential to ensure the sustainability and proper uses of these valuable plants for future generations.
Abstract: Ethiopian aloe species are known for traditional medicine for both human and livestock as well as for the preparation of various cosmetic products such as soap and lotion. The aloe species contributed great economic and social benefits for many local communities. In recent years, there has been a growing interest in the use of aloe species in the b...
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Review Article
The Role of Mesenchymal Stem Cell Exosomes in the Onset and Progression of Alzheimer's Disease
Issue:
Volume 10, Issue 1, March 2024
Pages:
6-13
Received:
8 February 2024
Accepted:
27 February 2024
Published:
13 March 2024
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease with progressive loss of memory and cognitive function. Because its pathogenesis has not been fully elucidated, there is still a lack of understanding of its pathogenesis and effective treatment. Many studies have shown that Mesenchymal stem cells Exosomes (MSCs-Exo) can promote anti-inflammatory, regulate immune function, enhance amyloid (Aβ) degradation, and promote axon growth of nerve cells. Exosomes can effectively cross the blood-brain barrier, and have better biocompatibility and biosafety than nanomaterials, and more diverse ways to carry drugs. Adipose stem cell exosomes can not only treat AD by their own characteristics, but also regulate AD and other neurological diseases as A drug carrier that can efficiently and freely cross the blood-brain barrier: they can effectively reduce Aβ42 plaques and improve the neuronal microenvironment through microglia. In AD model mice, excessive activation of microglia demonstrated the formation of an inflammatory microenvironment in the brain. The inflammatory microenvironment erodes healthy neurons to a certain extent, forcing them to overactivate inflammatory signaling pathways so that they can't function normally, Adipose stem cell exosomes can effectively clear the expression of inflammatory factors in hypoxia-induced AD neuronal model and promote synaptic repair through microRNA/ phosphatase and tensin homolog (miR-223/PTEN) and phosphatidylinositol kinase (PI3K/Akt) pathways. It can promote the polarization of microglia towards anti-inflammatory phenotype and promote neuronal repair. Adipose stem cell exosomes can also be used to improve memory and cognitive dysfunction by alleviating Tau phosphating or delaying hippocampus volume decay, targeting the core pathological mechanism of AD to achieve therapeutic effects. This article mainly introduces the role of MSC exosomes in the pathogenesis and development of AD.
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease with progressive loss of memory and cognitive function. Because its pathogenesis has not been fully elucidated, there is still a lack of understanding of its pathogenesis and effective treatment. Many studies have shown that Mesenchymal stem cells Exosomes (MSCs-Exo) can promote anti-inflammat...
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