Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation

Jieshi Wu; Quanming Zhao; Rui Luo; Yankun Li; Facai Xu; Ruisheng Xu

doi:doi:10.11648/j.bs.20220804.14

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Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation

Jieshi Wu, Quanming Zhao, Rui Luo, Yankun Li, Facai Xu, Ruisheng Xu

Published in Biomedical Sciences (Volume 8, Issue 4)

Received: 19 November 2022 Accepted: 2 December 2022 Published: 8 December 2022

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Abstract

Infection is a serious complication after lumbar internal fixation, and it is the focus of current spinal surgery research. Procalcitonin is sensitive and specific biomarker for identifying bacterial infection, but whether it can be used as a detection index for the early diagnosis of infection after lumbar internal fixation requires further research. Objective: To investigate the clinical significance of procalcitonin (PCT) combined with C-reactive protein (CRP) detection in the early diagnosis of infection after lumbar internal fixation. Methods: Patients who underwent lumbar internal fixation in our hospital from August 2019 to December 2021 were retrospectively studied. According to the results of wound secretion culture, they were divided into an infection group and a noninfection group. Venous blood was collected at different time points after the operation to detect and analyse serum PCT and serum CRP. The sensitivity and specificity of combined CRP and PCT for diagnosing surgical site infection were calculated. Results: There was no significant difference in preoperative indicators among all patients, and postoperative PCT and CRP indicators were significantly higher than those before surgery. The sensitivity of PCT combined with CRP to detect early postoperative infection was higher than that of single use. Conclusion: The combined detection of serum PCT and CRP can be used as a diagnostic index for early infection after lumbar internal fixation and has value in clinical application.

Published in	Biomedical Sciences (Volume 8, Issue 4)
DOI	10.11648/j.bs.20220804.14
Page(s)	138-143
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Procalcitonin, C-reactive Protein, Lumbar Internal Fixation, Infection, Early Diagnosis

References

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APA Style

Jieshi Wu, Quanming Zhao, Rui Luo, Yankun Li, Facai Xu, et al. (2022). Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation. Biomedical Sciences, 8(4), 138-143. https://doi.org/10.11648/j.bs.20220804.14

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ACS Style

Jieshi Wu; Quanming Zhao; Rui Luo; Yankun Li; Facai Xu, et al. Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation. Biomed. Sci. 2022, 8(4), 138-143. doi: 10.11648/j.bs.20220804.14

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AMA Style

Jieshi Wu, Quanming Zhao, Rui Luo, Yankun Li, Facai Xu, et al. Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation. Biomed Sci. 2022;8(4):138-143. doi: 10.11648/j.bs.20220804.14

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@article{10.11648/j.bs.20220804.14,
  author = {Jieshi Wu and Quanming Zhao and Rui Luo and Yankun Li and Facai Xu and Ruisheng Xu},
  title = {Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation},
  journal = {Biomedical Sciences},
  volume = {8},
  number = {4},
  pages = {138-143},
  doi = {10.11648/j.bs.20220804.14},
  url = {https://doi.org/10.11648/j.bs.20220804.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20220804.14},
  abstract = {Infection is a serious complication after lumbar internal fixation, and it is the focus of current spinal surgery research. Procalcitonin is sensitive and specific biomarker for identifying bacterial infection, but whether it can be used as a detection index for the early diagnosis of infection after lumbar internal fixation requires further research. Objective: To investigate the clinical significance of procalcitonin (PCT) combined with C-reactive protein (CRP) detection in the early diagnosis of infection after lumbar internal fixation. Methods: Patients who underwent lumbar internal fixation in our hospital from August 2019 to December 2021 were retrospectively studied. According to the results of wound secretion culture, they were divided into an infection group and a noninfection group. Venous blood was collected at different time points after the operation to detect and analyse serum PCT and serum CRP. The sensitivity and specificity of combined CRP and PCT for diagnosing surgical site infection were calculated. Results: There was no significant difference in preoperative indicators among all patients, and postoperative PCT and CRP indicators were significantly higher than those before surgery. The sensitivity of PCT combined with CRP to detect early postoperative infection was higher than that of single use. Conclusion: The combined detection of serum PCT and CRP can be used as a diagnostic index for early infection after lumbar internal fixation and has value in clinical application.},
 year = {2022}
}

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TY  - JOUR
T1  - Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation
AU  - Jieshi Wu
AU  - Quanming Zhao
AU  - Rui Luo
AU  - Yankun Li
AU  - Facai Xu
AU  - Ruisheng Xu
Y1  - 2022/12/08
PY  - 2022
N1  - https://doi.org/10.11648/j.bs.20220804.14
DO  - 10.11648/j.bs.20220804.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 138
EP  - 143
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20220804.14
AB  - Infection is a serious complication after lumbar internal fixation, and it is the focus of current spinal surgery research. Procalcitonin is sensitive and specific biomarker for identifying bacterial infection, but whether it can be used as a detection index for the early diagnosis of infection after lumbar internal fixation requires further research. Objective: To investigate the clinical significance of procalcitonin (PCT) combined with C-reactive protein (CRP) detection in the early diagnosis of infection after lumbar internal fixation. Methods: Patients who underwent lumbar internal fixation in our hospital from August 2019 to December 2021 were retrospectively studied. According to the results of wound secretion culture, they were divided into an infection group and a noninfection group. Venous blood was collected at different time points after the operation to detect and analyse serum PCT and serum CRP. The sensitivity and specificity of combined CRP and PCT for diagnosing surgical site infection were calculated. Results: There was no significant difference in preoperative indicators among all patients, and postoperative PCT and CRP indicators were significantly higher than those before surgery. The sensitivity of PCT combined with CRP to detect early postoperative infection was higher than that of single use. Conclusion: The combined detection of serum PCT and CRP can be used as a diagnostic index for early infection after lumbar internal fixation and has value in clinical application.
VL  - 8
IS  - 4
ER  -

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Author Information

Jieshi Wu

Department of Orthopaedics, Affiliated Hospital of Jiangnan University, Wuxi, China
Quanming Zhao

Department of Orthopaedics, Guizhou Provincial People's Hospital, Guiyang, China
Rui Luo

Department of Orthopaedics, Guizhou Provincial People's Hospital, Guiyang, China
Yankun Li

Department of Orthopaedics, Guizhou Provincial People's Hospital, Guiyang, China
Facai Xu

Department of Orthopaedics, Haidong Second People's Hospital, Haidong, China
Ruisheng Xu

Department of Orthopaedics, Affiliated Hospital of Jiangnan University, Wuxi, China

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Plain Text BibTeX RIS

APA Style

Jieshi Wu, Quanming Zhao, Rui Luo, Yankun Li, Facai Xu, et al. (2022). Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation. Biomedical Sciences, 8(4), 138-143. https://doi.org/10.11648/j.bs.20220804.14

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ACS Style

Jieshi Wu; Quanming Zhao; Rui Luo; Yankun Li; Facai Xu, et al. Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation. Biomed. Sci. 2022, 8(4), 138-143. doi: 10.11648/j.bs.20220804.14

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AMA Style

Jieshi Wu, Quanming Zhao, Rui Luo, Yankun Li, Facai Xu, et al. Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation. Biomed Sci. 2022;8(4):138-143. doi: 10.11648/j.bs.20220804.14

Copy | Download

@article{10.11648/j.bs.20220804.14,
  author = {Jieshi Wu and Quanming Zhao and Rui Luo and Yankun Li and Facai Xu and Ruisheng Xu},
  title = {Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation},
  journal = {Biomedical Sciences},
  volume = {8},
  number = {4},
  pages = {138-143},
  doi = {10.11648/j.bs.20220804.14},
  url = {https://doi.org/10.11648/j.bs.20220804.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20220804.14},
  abstract = {Infection is a serious complication after lumbar internal fixation, and it is the focus of current spinal surgery research. Procalcitonin is sensitive and specific biomarker for identifying bacterial infection, but whether it can be used as a detection index for the early diagnosis of infection after lumbar internal fixation requires further research. Objective: To investigate the clinical significance of procalcitonin (PCT) combined with C-reactive protein (CRP) detection in the early diagnosis of infection after lumbar internal fixation. Methods: Patients who underwent lumbar internal fixation in our hospital from August 2019 to December 2021 were retrospectively studied. According to the results of wound secretion culture, they were divided into an infection group and a noninfection group. Venous blood was collected at different time points after the operation to detect and analyse serum PCT and serum CRP. The sensitivity and specificity of combined CRP and PCT for diagnosing surgical site infection were calculated. Results: There was no significant difference in preoperative indicators among all patients, and postoperative PCT and CRP indicators were significantly higher than those before surgery. The sensitivity of PCT combined with CRP to detect early postoperative infection was higher than that of single use. Conclusion: The combined detection of serum PCT and CRP can be used as a diagnostic index for early infection after lumbar internal fixation and has value in clinical application.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Early Diagnosis of PCT Combined with CRP in Patients with Infection After Lumbar Internal Fixation
AU  - Jieshi Wu
AU  - Quanming Zhao
AU  - Rui Luo
AU  - Yankun Li
AU  - Facai Xu
AU  - Ruisheng Xu
Y1  - 2022/12/08
PY  - 2022
N1  - https://doi.org/10.11648/j.bs.20220804.14
DO  - 10.11648/j.bs.20220804.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 138
EP  - 143
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20220804.14
AB  - Infection is a serious complication after lumbar internal fixation, and it is the focus of current spinal surgery research. Procalcitonin is sensitive and specific biomarker for identifying bacterial infection, but whether it can be used as a detection index for the early diagnosis of infection after lumbar internal fixation requires further research. Objective: To investigate the clinical significance of procalcitonin (PCT) combined with C-reactive protein (CRP) detection in the early diagnosis of infection after lumbar internal fixation. Methods: Patients who underwent lumbar internal fixation in our hospital from August 2019 to December 2021 were retrospectively studied. According to the results of wound secretion culture, they were divided into an infection group and a noninfection group. Venous blood was collected at different time points after the operation to detect and analyse serum PCT and serum CRP. The sensitivity and specificity of combined CRP and PCT for diagnosing surgical site infection were calculated. Results: There was no significant difference in preoperative indicators among all patients, and postoperative PCT and CRP indicators were significantly higher than those before surgery. The sensitivity of PCT combined with CRP to detect early postoperative infection was higher than that of single use. Conclusion: The combined detection of serum PCT and CRP can be used as a diagnostic index for early infection after lumbar internal fixation and has value in clinical application.
VL  - 8
IS  - 4
ER  -

Copy | Download