Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine

Ekpe EL; Utomi Mercy Nkemjika

doi:doi:10.11648/j.cajph.20170304.11

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Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine

Ekpe EL, Utomi Mercy Nkemjika

Published in Central African Journal of Public Health (Volume 3, Issue 4)

Received: 5 June 2017 Accepted: 5 July 2017 Published: 16 August 2017

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Abstract

Aquagenic pruritus is a common dermatological problem with prevalence as high as 26.5% in some locations of the world. Pruritus is the major symptom manifesting as prick-like, burning or biting sensation after contact with water. Histamine from mast cells has been the main culprit responsible for the itching associated with this problem and some patients are relieved by anti-histamines when given. However, anti-histamines do not relieve symptoms of aquagenic pruritus when given to some other groups of patients; implying that other risk factors or chemical mediators outside histamine may be responsible for this problem. Recently, other associated risk factors have been enumerated from various scientific researches to be responsible for this health problem. This article reviews these other risk factors that are linked up to the pathophysiology of aquagenic pruritus and the possible pharmacological intervention adopted by various authors and researchers globally.

Published in	Central African Journal of Public Health (Volume 3, Issue 4)
DOI	10.11648/j.cajph.20170304.11
Page(s)	40-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Aquagenic, Pruritus, Dermatological, Antihistamine, Histamine, Water

References

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APA Style

Ekpe EL, Utomi Mercy Nkemjika. (2017). Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine. Central African Journal of Public Health, 3(4), 40-43. https://doi.org/10.11648/j.cajph.20170304.11

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ACS Style

Ekpe EL; Utomi Mercy Nkemjika. Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine. Cent. Afr. J. Public Health 2017, 3(4), 40-43. doi: 10.11648/j.cajph.20170304.11

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AMA Style

Ekpe EL, Utomi Mercy Nkemjika. Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine. Cent Afr J Public Health. 2017;3(4):40-43. doi: 10.11648/j.cajph.20170304.11

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@article{10.11648/j.cajph.20170304.11,
  author = {Ekpe EL and Utomi Mercy Nkemjika},
  title = {Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine},
  journal = {Central African Journal of Public Health},
  volume = {3},
  number = {4},
  pages = {40-43},
  doi = {10.11648/j.cajph.20170304.11},
  url = {https://doi.org/10.11648/j.cajph.20170304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20170304.11},
  abstract = {Aquagenic pruritus is a common dermatological problem with prevalence as high as 26.5% in some locations of the world. Pruritus is the major symptom manifesting as prick-like, burning or biting sensation after contact with water. Histamine from mast cells has been the main culprit responsible for the itching associated with this problem and some patients are relieved by anti-histamines when given. However, anti-histamines do not relieve symptoms of aquagenic pruritus when given to some other groups of patients; implying that other risk factors or chemical mediators outside histamine may be responsible for this problem. Recently, other associated risk factors have been enumerated from various scientific researches to be responsible for this health problem. This article reviews these other risk factors that are linked up to the pathophysiology of aquagenic pruritus and the possible pharmacological intervention adopted by various authors and researchers globally.},
 year = {2017}
}

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TY  - JOUR
T1  - Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine
AU  - Ekpe EL
AU  - Utomi Mercy Nkemjika
Y1  - 2017/08/16
PY  - 2017
N1  - https://doi.org/10.11648/j.cajph.20170304.11
DO  - 10.11648/j.cajph.20170304.11
T2  - Central African Journal of Public Health
JF  - Central African Journal of Public Health
JO  - Central African Journal of Public Health
SP  - 40
EP  - 43
PB  - Science Publishing Group
SN  - 2575-5781
UR  - https://doi.org/10.11648/j.cajph.20170304.11
AB  - Aquagenic pruritus is a common dermatological problem with prevalence as high as 26.5% in some locations of the world. Pruritus is the major symptom manifesting as prick-like, burning or biting sensation after contact with water. Histamine from mast cells has been the main culprit responsible for the itching associated with this problem and some patients are relieved by anti-histamines when given. However, anti-histamines do not relieve symptoms of aquagenic pruritus when given to some other groups of patients; implying that other risk factors or chemical mediators outside histamine may be responsible for this problem. Recently, other associated risk factors have been enumerated from various scientific researches to be responsible for this health problem. This article reviews these other risk factors that are linked up to the pathophysiology of aquagenic pruritus and the possible pharmacological intervention adopted by various authors and researchers globally.
VL  - 3
IS  - 4
ER  -

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Author Information

Ekpe EL

Department of Chemical Pathology, Faculty of Medicine, College of Medical Sciences University of Calabar, Calabar, Nigeria
Utomi Mercy Nkemjika

Department of Medicine & Surgery, Faculty of Medicine, College of Medical Sciences University of Calabar, Calabar, Nigeria

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Plain Text BibTeX RIS

APA Style

Ekpe EL, Utomi Mercy Nkemjika. (2017). Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine. Central African Journal of Public Health, 3(4), 40-43. https://doi.org/10.11648/j.cajph.20170304.11

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ACS Style

Ekpe EL; Utomi Mercy Nkemjika. Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine. Cent. Afr. J. Public Health 2017, 3(4), 40-43. doi: 10.11648/j.cajph.20170304.11

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AMA Style

Ekpe EL, Utomi Mercy Nkemjika. Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine. Cent Afr J Public Health. 2017;3(4):40-43. doi: 10.11648/j.cajph.20170304.11

Copy | Download

@article{10.11648/j.cajph.20170304.11,
  author = {Ekpe EL and Utomi Mercy Nkemjika},
  title = {Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine},
  journal = {Central African Journal of Public Health},
  volume = {3},
  number = {4},
  pages = {40-43},
  doi = {10.11648/j.cajph.20170304.11},
  url = {https://doi.org/10.11648/j.cajph.20170304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20170304.11},
  abstract = {Aquagenic pruritus is a common dermatological problem with prevalence as high as 26.5% in some locations of the world. Pruritus is the major symptom manifesting as prick-like, burning or biting sensation after contact with water. Histamine from mast cells has been the main culprit responsible for the itching associated with this problem and some patients are relieved by anti-histamines when given. However, anti-histamines do not relieve symptoms of aquagenic pruritus when given to some other groups of patients; implying that other risk factors or chemical mediators outside histamine may be responsible for this problem. Recently, other associated risk factors have been enumerated from various scientific researches to be responsible for this health problem. This article reviews these other risk factors that are linked up to the pathophysiology of aquagenic pruritus and the possible pharmacological intervention adopted by various authors and researchers globally.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Aquagenic Pruritus: A Review of the Pathophysiology – Beyound Histamine
AU  - Ekpe EL
AU  - Utomi Mercy Nkemjika
Y1  - 2017/08/16
PY  - 2017
N1  - https://doi.org/10.11648/j.cajph.20170304.11
DO  - 10.11648/j.cajph.20170304.11
T2  - Central African Journal of Public Health
JF  - Central African Journal of Public Health
JO  - Central African Journal of Public Health
SP  - 40
EP  - 43
PB  - Science Publishing Group
SN  - 2575-5781
UR  - https://doi.org/10.11648/j.cajph.20170304.11
AB  - Aquagenic pruritus is a common dermatological problem with prevalence as high as 26.5% in some locations of the world. Pruritus is the major symptom manifesting as prick-like, burning or biting sensation after contact with water. Histamine from mast cells has been the main culprit responsible for the itching associated with this problem and some patients are relieved by anti-histamines when given. However, anti-histamines do not relieve symptoms of aquagenic pruritus when given to some other groups of patients; implying that other risk factors or chemical mediators outside histamine may be responsible for this problem. Recently, other associated risk factors have been enumerated from various scientific researches to be responsible for this health problem. This article reviews these other risk factors that are linked up to the pathophysiology of aquagenic pruritus and the possible pharmacological intervention adopted by various authors and researchers globally.
VL  - 3
IS  - 4
ER  -

Copy | Download