Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells

Maliha Ghaffar; Sara Khodahemmati; Jintao Li; Muhammad Shahzad; Minglian Wang; Yangjunqi Wang; Yi Zeng

doi:doi:10.11648/j.ijbecs.20180401.15

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Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells

Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, Yangjunqi Wang, Yi Zeng

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 4, Issue 1)

Received: 7 March 2018 Accepted: 24 March 2018 Published: 12 April 2018

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Abstract

The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.

Published in	International Journal of Biomedical Engineering and Clinical Science (Volume 4, Issue 1)
DOI	10.11648/j.ijbecs.20180401.15
Page(s)	25-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

CASC9, Esophageal Cancer, Cell Migration, Invasion, Long Noncoding RNA

References

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APA Style

Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, et al. (2018). Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. International Journal of Biomedical Engineering and Clinical Science, 4(1), 25-29. https://doi.org/10.11648/j.ijbecs.20180401.15

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ACS Style

Maliha Ghaffar; Sara Khodahemmati; Jintao Li; Muhammad Shahzad; Minglian Wang, et al. Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. Int. J. Biomed. Eng. Clin. Sci. 2018, 4(1), 25-29. doi: 10.11648/j.ijbecs.20180401.15

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AMA Style

Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, et al. Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. Int J Biomed Eng Clin Sci. 2018;4(1):25-29. doi: 10.11648/j.ijbecs.20180401.15

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@article{10.11648/j.ijbecs.20180401.15,
  author = {Maliha Ghaffar and Sara Khodahemmati and Jintao Li and Muhammad Shahzad and Minglian Wang and Yangjunqi Wang and Yi Zeng},
  title = {Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {4},
  number = {1},
  pages = {25-29},
  doi = {10.11648/j.ijbecs.20180401.15},
  url = {https://doi.org/10.11648/j.ijbecs.20180401.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20180401.15},
  abstract = {The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.},
 year = {2018}
}

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TY  - JOUR
T1  - Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells
AU  - Maliha Ghaffar
AU  - Sara Khodahemmati
AU  - Jintao Li
AU  - Muhammad Shahzad
AU  - Minglian Wang
AU  - Yangjunqi Wang
AU  - Yi Zeng
Y1  - 2018/04/12
PY  - 2018
N1  - https://doi.org/10.11648/j.ijbecs.20180401.15
DO  - 10.11648/j.ijbecs.20180401.15
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 25
EP  - 29
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20180401.15
AB  - The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.
VL  - 4
IS  - 1
ER  -

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Author Information

Maliha Ghaffar

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China
Sara Khodahemmati

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China
Jintao Li

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China
Muhammad Shahzad

School of Economics and Management, North China Electric Power University, Beijing, China
Minglian Wang

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China
Yangjunqi Wang

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China
Yi Zeng

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science and Bio-Engineering, Beijing University of Technology, Beijing, China

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Plain Text BibTeX RIS

APA Style

Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, et al. (2018). Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. International Journal of Biomedical Engineering and Clinical Science, 4(1), 25-29. https://doi.org/10.11648/j.ijbecs.20180401.15

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ACS Style

Maliha Ghaffar; Sara Khodahemmati; Jintao Li; Muhammad Shahzad; Minglian Wang, et al. Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. Int. J. Biomed. Eng. Clin. Sci. 2018, 4(1), 25-29. doi: 10.11648/j.ijbecs.20180401.15

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AMA Style

Maliha Ghaffar, Sara Khodahemmati, Jintao Li, Muhammad Shahzad, Minglian Wang, et al. Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells. Int J Biomed Eng Clin Sci. 2018;4(1):25-29. doi: 10.11648/j.ijbecs.20180401.15

Copy | Download

@article{10.11648/j.ijbecs.20180401.15,
  author = {Maliha Ghaffar and Sara Khodahemmati and Jintao Li and Muhammad Shahzad and Minglian Wang and Yangjunqi Wang and Yi Zeng},
  title = {Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {4},
  number = {1},
  pages = {25-29},
  doi = {10.11648/j.ijbecs.20180401.15},
  url = {https://doi.org/10.11648/j.ijbecs.20180401.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20180401.15},
  abstract = {The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.},
 year = {2018}
}

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TY  - JOUR
T1  - Down-Regulation of Long Non-Coding RNA CASC9 Suppresses the Migration and Invasion of Esophageal Cancer Cells
AU  - Maliha Ghaffar
AU  - Sara Khodahemmati
AU  - Jintao Li
AU  - Muhammad Shahzad
AU  - Minglian Wang
AU  - Yangjunqi Wang
AU  - Yi Zeng
Y1  - 2018/04/12
PY  - 2018
N1  - https://doi.org/10.11648/j.ijbecs.20180401.15
DO  - 10.11648/j.ijbecs.20180401.15
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 25
EP  - 29
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20180401.15
AB  - The objective of the study was to investigate the role of CASC9 in esophageal cancer cells migration and invasion. Expression of long noncoding RNA (lncRNA) CASC9 was found high in esophageal cancer cells by qRT-PCR. The CASC9 knockdown effects on cell migration and invasion were analyzed in vitro. Expression of lncRNA CASC9 was found markedly high in KYSE-450 cell line as compared to other esophageal cancer cell lines. After the knockdown of CASC9, migration and invasion were significantly decreased as compared to negative control. Increased expression of CASC9 before knockdown and decreased expression after knockdown in esophageal cancer cells, showed that CASC9 may act as a biomarker for esophageal cancer and may help to understand the mechanisms of this lethal disease.
VL  - 4
IS  - 1
ER  -

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