Antihyperglycaemic and Antihyperlipidemic Activities of <i>Pleiogynium timorense</i> Seeds and Identification of Bioactive Compounds

Ataa Said; Elsayed Ali Abuotabl; Gehan Fawzy Abdel Raoof; Khaled Younes Mohamed

doi:doi:10.11648/j.ijbecs.20180402.11

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Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds

Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 4, Issue 2)

Received: 8 March 2018 Accepted: 24 March 2018 Published: 12 April 2018

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Abstract

The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the ﬁrst study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.

Published in	International Journal of Biomedical Engineering and Clinical Science (Volume 4, Issue 2)
DOI	10.11648/j.ijbecs.20180402.11
Page(s)	30-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Antihyperglycaemic, Bioactive Compounds, Phenolic, Pleiogynium timorense, Seeds

References

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APA Style

Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed. (2018). Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. International Journal of Biomedical Engineering and Clinical Science, 4(2), 30-35. https://doi.org/10.11648/j.ijbecs.20180402.11

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ACS Style

Ataa Said; Elsayed Ali Abuotabl; Gehan Fawzy Abdel Raoof; Khaled Younes Mohamed. Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. Int. J. Biomed. Eng. Clin. Sci. 2018, 4(2), 30-35. doi: 10.11648/j.ijbecs.20180402.11

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AMA Style

Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed. Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. Int J Biomed Eng Clin Sci. 2018;4(2):30-35. doi: 10.11648/j.ijbecs.20180402.11

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@article{10.11648/j.ijbecs.20180402.11,
  author = {Ataa Said and Elsayed Ali Abuotabl and Gehan Fawzy Abdel Raoof and Khaled Younes Mohamed},
  title = {Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {4},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.ijbecs.20180402.11},
  url = {https://doi.org/10.11648/j.ijbecs.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20180402.11},
  abstract = {The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the ﬁrst study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.},
 year = {2018}
}

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TY  - JOUR
T1  - Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds
AU  - Ataa Said
AU  - Elsayed Ali Abuotabl
AU  - Gehan Fawzy Abdel Raoof
AU  - Khaled Younes Mohamed
Y1  - 2018/04/12
PY  - 2018
N1  - https://doi.org/10.11648/j.ijbecs.20180402.11
DO  - 10.11648/j.ijbecs.20180402.11
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20180402.11
AB  - The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the ﬁrst study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.
VL  - 4
IS  - 2
ER  -

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Author Information

Ataa Said

Pharmacognosy Department, National Research Centre, Giza, Egypt
Elsayed Ali Abuotabl

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Gehan Fawzy Abdel Raoof

Pharmacognosy Department, National Research Centre, Giza, Egypt
Khaled Younes Mohamed

Internal Medicine Department, Medical Division, National Research Centre, Giza, Egypt

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Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed. (2018). Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. International Journal of Biomedical Engineering and Clinical Science, 4(2), 30-35. https://doi.org/10.11648/j.ijbecs.20180402.11

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ACS Style

Ataa Said; Elsayed Ali Abuotabl; Gehan Fawzy Abdel Raoof; Khaled Younes Mohamed. Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. Int. J. Biomed. Eng. Clin. Sci. 2018, 4(2), 30-35. doi: 10.11648/j.ijbecs.20180402.11

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AMA Style

Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed. Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. Int J Biomed Eng Clin Sci. 2018;4(2):30-35. doi: 10.11648/j.ijbecs.20180402.11

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@article{10.11648/j.ijbecs.20180402.11,
  author = {Ataa Said and Elsayed Ali Abuotabl and Gehan Fawzy Abdel Raoof and Khaled Younes Mohamed},
  title = {Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {4},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.ijbecs.20180402.11},
  url = {https://doi.org/10.11648/j.ijbecs.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20180402.11},
  abstract = {The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the ﬁrst study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.},
 year = {2018}
}

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TY  - JOUR
T1  - Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds
AU  - Ataa Said
AU  - Elsayed Ali Abuotabl
AU  - Gehan Fawzy Abdel Raoof
AU  - Khaled Younes Mohamed
Y1  - 2018/04/12
PY  - 2018
N1  - https://doi.org/10.11648/j.ijbecs.20180402.11
DO  - 10.11648/j.ijbecs.20180402.11
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20180402.11
AB  - The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the ﬁrst study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.
VL  - 4
IS  - 2
ER  -

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