Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug

Jiunn-An Pan; Hsuan-Liang Liu; Ko-Shao Chen

doi:doi:10.11648/j.ijbmr.20190701.13

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Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug

Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen

Published in International Journal of Biomedical Materials Research (Volume 7, Issue 1)

Received: 16 January 2019 Accepted: 20 February 2019 Published: 6 March 2019

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Abstract

Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.

Published in	International Journal of Biomedical Materials Research (Volume 7, Issue 1)
DOI	10.11648/j.ijbmr.20190701.13
Page(s)	16-23
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

TPU, Acetic Acid Plasma, EDC/NHS Grafting, Hybrid Hydrogel

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APA Style

Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen. (2019). Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. International Journal of Biomedical Materials Research, 7(1), 16-23. https://doi.org/10.11648/j.ijbmr.20190701.13

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ACS Style

Jiunn-An Pan; Hsuan-Liang Liu; Ko-Shao Chen. Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. Int. J. Biomed. Mater. Res. 2019, 7(1), 16-23. doi: 10.11648/j.ijbmr.20190701.13

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AMA Style

Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen. Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. Int J Biomed Mater Res. 2019;7(1):16-23. doi: 10.11648/j.ijbmr.20190701.13

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@article{10.11648/j.ijbmr.20190701.13,
  author = {Jiunn-An Pan and Hsuan-Liang Liu and Ko-Shao Chen},
  title = {Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug},
  journal = {International Journal of Biomedical Materials Research},
  volume = {7},
  number = {1},
  pages = {16-23},
  doi = {10.11648/j.ijbmr.20190701.13},
  url = {https://doi.org/10.11648/j.ijbmr.20190701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20190701.13},
  abstract = {Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.},
 year = {2019}
}

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TY  - JOUR
T1  - Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug
AU  - Jiunn-An Pan
AU  - Hsuan-Liang Liu
AU  - Ko-Shao Chen
Y1  - 2019/03/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ijbmr.20190701.13
DO  - 10.11648/j.ijbmr.20190701.13
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 16
EP  - 23
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20190701.13
AB  - Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.
VL  - 7
IS  - 1
ER  -

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Author Information

Jiunn-An Pan

Graduate Institution Engineering Technology-Doctoral, National Taipei University of Technology, Taipei, Taiwan
Hsuan-Liang Liu

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
Ko-Shao Chen

Department of Materials Engineering, Tatung University, Taipei, Taiwan

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APA Style

Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen. (2019). Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. International Journal of Biomedical Materials Research, 7(1), 16-23. https://doi.org/10.11648/j.ijbmr.20190701.13

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ACS Style

Jiunn-An Pan; Hsuan-Liang Liu; Ko-Shao Chen. Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. Int. J. Biomed. Mater. Res. 2019, 7(1), 16-23. doi: 10.11648/j.ijbmr.20190701.13

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AMA Style

Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen. Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. Int J Biomed Mater Res. 2019;7(1):16-23. doi: 10.11648/j.ijbmr.20190701.13

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@article{10.11648/j.ijbmr.20190701.13,
  author = {Jiunn-An Pan and Hsuan-Liang Liu and Ko-Shao Chen},
  title = {Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug},
  journal = {International Journal of Biomedical Materials Research},
  volume = {7},
  number = {1},
  pages = {16-23},
  doi = {10.11648/j.ijbmr.20190701.13},
  url = {https://doi.org/10.11648/j.ijbmr.20190701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20190701.13},
  abstract = {Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug
AU  - Jiunn-An Pan
AU  - Hsuan-Liang Liu
AU  - Ko-Shao Chen
Y1  - 2019/03/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ijbmr.20190701.13
DO  - 10.11648/j.ijbmr.20190701.13
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 16
EP  - 23
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20190701.13
AB  - Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.
VL  - 7
IS  - 1
ER  -

Copy | Download