The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication

Baxodir Muхamadiev; Shurangiz Kasimova; Nodirabegim Kasimova

doi:doi:10.11648/j.ijbmr.20210901.12

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The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication

Baxodir Muхamadiev, Shurangiz Kasimova, Nodirabegim Kasimova

Published in International Journal of Biomedical Materials Research (Volume 9, Issue 1)

Received: 1 September 2020 Accepted: 10 October 2020 Published: 22 June 2021

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Abstract

The outbreak of SARS requires the search for antiviral compounds to prevent and treat this disease. Currently, there is no specific treatment for coronavirus infection associated with SARS-COVID-19. Among researchers working in this area, there are various approaches to create an effective vaccine against this infection, there is no consensus on this problem. We will assess the antiviral potential of GA, GL, RT against two clinical isolates of coronavirus (M-1 and M-2) from SARS patients admitted to the Bukhara Multifunctional Clinical Center. The chemical structure of these substances interacts with the structures of the virus, changing the various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (which are in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components. Inhibits viruses at concentrations that are non-toxic to normally functioning cells. All these properties of these substances have attracted our attention, and some of them have confirmed their importance. Our results indicate that GA and RT should be used to treat coronavirus infection. RT, in turn, has antiviral, anticancer effects and will also be studied in detail.

Published in	International Journal of Biomedical Materials Research (Volume 9, Issue 1)
DOI	10.11648/j.ijbmr.20210901.12
Page(s)	10-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

SARS Coronavirus, Glycyrrhizic Acid, Glabridin, Resveratrol, Replication, Enzymes

References

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[2]	Mukhamadiyev B. T. et al. «Production of extracts from vegetable raw materials by carbon dioxide» Food science and Technology, V. 14, №1, 2020, 54-64.
[3]	Mukhamadiyev B. T. et al. «Supercritical CO² – extraction resveratrol’s from mulberry leaves». Butlerov communications V. 49, 2017, NI, 119-116.
[4]	Cunate J. et al. «Glycirrhizin, an active component of licorice roots and replication of SARS-associated coronavirus». The LANCET, V. 361, 14, 2003. P. 2045.
[5]	Tioen M. et al. «Extraction of Glycyprhizic acid and Glabridin from Licorice», S. Sut. Mol. Sci, 9, 2008, 571.
[6]	Grance I. M. et al. «Interferon, ribavirin, 6-azauridine and glycyrrhizine: antiviral compounds active against pathogenic flavoviruses». Antiviral Res. 2013, 98, 82.
[7]	Baltina L. et al. «Prospects for the creation of new antivir.al drug based on glycrrhizic acid and its derivatives: a review». Pharmaceutical chemistry I. 43, 2009, 3-12.
[8]	Haraguchi H et al. «Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata», Bioorganic and Medicinal Chemistry, 16 (2008), 109-117.
[9]	Fan YG, Shi ZQ., He BL. Extraction, separation & application fot Glycyrrhizinic acid. Natural Product Research & Development; 1996, 8: 93-99.
[10]	Jatav VS., Singh SK., Sharma AK. Recent Pharmacological trends in Glycyrrhiza glabra. International Journal of Pharmaceutics & Pharmaceutical Frontier Research; 2011, 1: 170-85.
[11]	Lakshmi T., Geetha RV., Glycyrrhiza glabra commonly known as licorice-a therapeutic review. International Journal of Pharmaceutics & Pharmaceutical Sciences, 2011, 3: 20-25.
[12]	Mirmala P., Selvaraj T. Anti-inflammatory & antibacterial activities of Glycyrrhiza glabra. Journal of Agriculture Technology: 2011, 7: 815-23.
[13]	Yazdi A., Sardari S., Sayyah Md. Evaluation of anticonvulsant activity of leaves of Glycyrrhiza glabra grown in Iran as a possible renewable source for anticonvulsant compounds. Iranian journal of Pharmaceutical research. 2011, 6: 18-27.
[14]	Latif M., Iqbal L., Fatima N. evaluation of antioxidant & urease inhibition activity of roots of Glycyrrhiza glabra. Pakistan journal of Pharmaceutical Sciences; 2012, 25: 99-102.
[15]	Nitalikar M., Munde KC, Dhore BV. Studies of antibacterial activities of Glycyrrhiza glabra root extract. International Journal of Pharmaceutics & Pharmaceutical Sciences, 2010, 2: 899-901.

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APA Style

Baxodir Muхamadiev, Shurangiz Kasimova, Nodirabegim Kasimova. (2021). The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication. International Journal of Biomedical Materials Research, 9(1), 10-12. https://doi.org/10.11648/j.ijbmr.20210901.12

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ACS Style

Baxodir Muхamadiev; Shurangiz Kasimova; Nodirabegim Kasimova. The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication. Int. J. Biomed. Mater. Res. 2021, 9(1), 10-12. doi: 10.11648/j.ijbmr.20210901.12

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AMA Style

Baxodir Muхamadiev, Shurangiz Kasimova, Nodirabegim Kasimova. The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication. Int J Biomed Mater Res. 2021;9(1):10-12. doi: 10.11648/j.ijbmr.20210901.12

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@article{10.11648/j.ijbmr.20210901.12,
  author = {Baxodir Muхamadiev and Shurangiz Kasimova and Nodirabegim Kasimova},
  title = {The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication},
  journal = {International Journal of Biomedical Materials Research},
  volume = {9},
  number = {1},
  pages = {10-12},
  doi = {10.11648/j.ijbmr.20210901.12},
  url = {https://doi.org/10.11648/j.ijbmr.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20210901.12},
  abstract = {The outbreak of SARS requires the search for antiviral compounds to prevent and treat this disease. Currently, there is no specific treatment for coronavirus infection associated with SARS-COVID-19. Among researchers working in this area, there are various approaches to create an effective vaccine against this infection, there is no consensus on this problem. We will assess the antiviral potential of GA, GL, RT against two clinical isolates of coronavirus (M-1 and M-2) from SARS patients admitted to the Bukhara Multifunctional Clinical Center. The chemical structure of these substances interacts with the structures of the virus, changing the various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (which are in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components. Inhibits viruses at concentrations that are non-toxic to normally functioning cells. All these properties of these substances have attracted our attention, and some of them have confirmed their importance. Our results indicate that GA and RT should be used to treat coronavirus infection. RT, in turn, has antiviral, anticancer effects and will also be studied in detail.},
 year = {2021}
}

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TY  - JOUR
T1  - The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication
AU  - Baxodir Muхamadiev
AU  - Shurangiz Kasimova
AU  - Nodirabegim Kasimova
Y1  - 2021/06/22
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbmr.20210901.12
DO  - 10.11648/j.ijbmr.20210901.12
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
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AB  - The outbreak of SARS requires the search for antiviral compounds to prevent and treat this disease. Currently, there is no specific treatment for coronavirus infection associated with SARS-COVID-19. Among researchers working in this area, there are various approaches to create an effective vaccine against this infection, there is no consensus on this problem. We will assess the antiviral potential of GA, GL, RT against two clinical isolates of coronavirus (M-1 and M-2) from SARS patients admitted to the Bukhara Multifunctional Clinical Center. The chemical structure of these substances interacts with the structures of the virus, changing the various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (which are in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components. Inhibits viruses at concentrations that are non-toxic to normally functioning cells. All these properties of these substances have attracted our attention, and some of them have confirmed their importance. Our results indicate that GA and RT should be used to treat coronavirus infection. RT, in turn, has antiviral, anticancer effects and will also be studied in detail.
VL  - 9
IS  - 1
ER  -

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Author Information

Baxodir Muхamadiev

Department of Chemistry, Bukhara Engineering and Technology Institute, Bukhara, Uzbekistan
Shurangiz Kasimova

Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan
Nodirabegim Kasimova

Bukhara State Medical Institute Named After Abu Ali ibn Sino, Bukhara, Uzbekistan

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APA Style

Baxodir Muхamadiev, Shurangiz Kasimova, Nodirabegim Kasimova. (2021). The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication. International Journal of Biomedical Materials Research, 9(1), 10-12. https://doi.org/10.11648/j.ijbmr.20210901.12

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ACS Style

Baxodir Muхamadiev; Shurangiz Kasimova; Nodirabegim Kasimova. The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication. Int. J. Biomed. Mater. Res. 2021, 9(1), 10-12. doi: 10.11648/j.ijbmr.20210901.12

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AMA Style

Baxodir Muхamadiev, Shurangiz Kasimova, Nodirabegim Kasimova. The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication. Int J Biomed Mater Res. 2021;9(1):10-12. doi: 10.11648/j.ijbmr.20210901.12

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@article{10.11648/j.ijbmr.20210901.12,
  author = {Baxodir Muхamadiev and Shurangiz Kasimova and Nodirabegim Kasimova},
  title = {The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication},
  journal = {International Journal of Biomedical Materials Research},
  volume = {9},
  number = {1},
  pages = {10-12},
  doi = {10.11648/j.ijbmr.20210901.12},
  url = {https://doi.org/10.11648/j.ijbmr.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20210901.12},
  abstract = {The outbreak of SARS requires the search for antiviral compounds to prevent and treat this disease. Currently, there is no specific treatment for coronavirus infection associated with SARS-COVID-19. Among researchers working in this area, there are various approaches to create an effective vaccine against this infection, there is no consensus on this problem. We will assess the antiviral potential of GA, GL, RT against two clinical isolates of coronavirus (M-1 and M-2) from SARS patients admitted to the Bukhara Multifunctional Clinical Center. The chemical structure of these substances interacts with the structures of the virus, changing the various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (which are in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components. Inhibits viruses at concentrations that are non-toxic to normally functioning cells. All these properties of these substances have attracted our attention, and some of them have confirmed their importance. Our results indicate that GA and RT should be used to treat coronavirus infection. RT, in turn, has antiviral, anticancer effects and will also be studied in detail.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication
AU  - Baxodir Muхamadiev
AU  - Shurangiz Kasimova
AU  - Nodirabegim Kasimova
Y1  - 2021/06/22
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbmr.20210901.12
DO  - 10.11648/j.ijbmr.20210901.12
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 10
EP  - 12
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20210901.12
AB  - The outbreak of SARS requires the search for antiviral compounds to prevent and treat this disease. Currently, there is no specific treatment for coronavirus infection associated with SARS-COVID-19. Among researchers working in this area, there are various approaches to create an effective vaccine against this infection, there is no consensus on this problem. We will assess the antiviral potential of GA, GL, RT against two clinical isolates of coronavirus (M-1 and M-2) from SARS patients admitted to the Bukhara Multifunctional Clinical Center. The chemical structure of these substances interacts with the structures of the virus, changing the various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (which are in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components. Inhibits viruses at concentrations that are non-toxic to normally functioning cells. All these properties of these substances have attracted our attention, and some of them have confirmed their importance. Our results indicate that GA and RT should be used to treat coronavirus infection. RT, in turn, has antiviral, anticancer effects and will also be studied in detail.
VL  - 9
IS  - 1
ER  -

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