Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins

Shazia Rashid; Javed Anver Qureshi; Rukhshan Khurshid; Huma Ashraf; Saima Rasheed; Uzma Faryal

doi:doi:10.11648/j.ijcems.20210705.14

| Peer-Reviewed

Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins

Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, Uzma Faryal

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 7, Issue 5)

Received: 3 August 2021 Accepted: 13 September 2021 Published: 28 October 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 7, Issue 5)
DOI	10.11648/j.ijcems.20210705.14
Page(s)	152-159
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

STEMI, NSTEMI, Resistin, Cardiac Troponin T, Cardiac Troponin I

References

[1]	Harrington DH, Stueben F, Lenahan CM. ST-Elevation Myocardial Infarction and Non-ST-Elevation Myocardial Infarction: Medical and Surgical Interventions. Crit Care NursClin North Am. 2019 Mar; 31 (1): 49-64.
[2]	Rupprecht HJ, Geeren M, Geeren M, Weilemann S, Schuster HP. [Acute coronary syndrome without ST-elevation (NSTE-ACS)]. Herz. 2019 Feb; 44 (1): 10-15.
[3]	Tripathy D, Kant S, Pandey K, Ehtesham NZ. Resistin in metabolism, inflammation, and disease. The FEBS Journal 2020; 287: 3141–3149.
[4]	Pang L, Zhang Y, Yu Y, Zhang S. Resistin promotes the expression of vascular endothelial growth factor in ovary carcinoma cells. Int J Mol Sci. 2013; 14 (5): 9751-9766. doi: 10.3390/ijms14059751.
[5]	Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2012; 165 (3): 622-632. doi: 10.1111/j.1476-5381.2011.01369.x.
[6]	Zhang J., Gao Y., Zheng Y., Liu F., Yang Y., Li X., Ma X., Ma Y., Xie X. Increased serum resistin level is associated with coronary heart disease. Oncotarget. 2017; 8: 50148-50154.
[7]	Fang C, Lei J, Zhou SX, Zhang YL, Yuan GY, Wang JF. Association of higher resistin levels with inflammatory activation and endothelial dysfunction in patients with essential hypertension. Chin Med J (Engl). 2013 Feb; 126 (4): 646-9.
[8]	R. P. Tiwari, A. Jain, Z. Khan et al., “Cardiac troponins I and T: molecular markers for early diagnosis, prognosis, and accurate triaging of patients with acute myocardial infarction,” Molecular Diagnosis & Therapy 2012; 16 (6): 371–381.
[9]	Hajar R. Evolution of Myocardial Infarction and its Biomarkers: A Historical Perspective. Heart Views. 2016; 17 (4): 167-172. doi: 10.4103/1995-705X.201786.
[10]	Wanamaker BL, Seth MM, Sukul D, Dixon SR, Bhatt DL, Madder RD et al. Relationship Between Troponin on Presentation and In-Hospital Mortality in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Am Heart Ass. 2019; 8: e013551.
[11]	Daubert MA, Jeremias A. The utility of troponin measurement to detect myocardial infarction: review of the current findings. Vasc Health Risk Manag. 2010; 6: 691-699. doi: 10.2147/vhrm.s5306.
[12]	Schoffstall B, LaBarbera VA, Brunet NM, et al. Interaction between troponin and myosin enhances contractile activity of myosin in cardiac muscle. DNA Cell Biol. 2011; 30 (9): 653-659. doi: 10.1089/dna.2010.1163.
[13]	Wasyanto T and Febrilia L. Association between Resistin and High Sensitive Troponin I in St Elevation Myocardial Infarction and Systolic Heart Failure. Indonesian J Med 2020; 5 (1).
[14]	Torbjørn O, De Lemos James A, Sabatine Marc S, Christophi Costas A, Murguia RM et al. "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease" New Eng J Med 2009; 361 (26): 2538–2547.
[15]	Buturak A, Değirmencioğlu A, Baryrak F, Kins T, Karakurt H, Demir AR et al. Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study. Anatol J Cardiol. 2016; 16 (12): 940-946 \| DOI: 10.14744/AnatolJCardiol.2016.687.
[16]	Sasso FC, Rinaldi L, Lascar N, Marrone A, Pafundi PC, Adinolfi LE. Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes. J Dia Res 2018; 2018: 8 pages https://doi.org/10.1155/2018/3106056
[17]	Nilgun I, Ismail B, Caglar S, Fatma NT, Mehmet E, Serkan Y et al. Effect of age and gender difference on high sensitive troponin T measurement in the diagnosis of myocardial infarction. J Lab Med 2019; 43 (1): 35-40 doi.org/10.1515/labmed-2018-0326.
[18]	Patange A, Immadisetty S, Vora H, et al. Lipid levels in acute coronary syndromes admitted in medical intensive care unit in a tertiary care hospital. J. Evolution Med. Dent. Sci. 2020; 9 (08): 520-523, DOI: 10.14260/jemds/2020/117.
[19]	Lichtman JH, Leifheit EC, Safdar B, Bao H, Krumholz HM, Lorenze NP et al. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction. Circulation. 2018; 137: 781–790. DOI: 10.1161/CIRCULATIONAHA.117.031650.
[20]	Junior Á, Feldman A, Carvalho AC, Sousa AC, Mansur Ade P, Bozza AE et al. Guideline of the Brazilian Society of Cardiology on Acute Myocardial Infarction Treatment with ST Segment Elevation]. Arq Bras Cardiol. 2015 Aug; 105 (2 Suppl 1): 1-105. Portuguese. doi: 10.5935/abc.20150107.
[21]	Adam AM, Nasir SAR, Merchant AZ, Rizvi AH, Rehan A, Shaikh ATet al. Efficacy of serum blood urea nitrogen, creatinine and electrolytes in the diagnosis and mortality risk assessment of patients with acute coronary syndrome. Indian Heart J. 2018; 70 (3): 353-359. doi: 10.1016/j.ihj.2017.09.009.
[22]	Adefurin A, Darghosian L, Okafor C, et al. Alpha A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction. Int J Cardiol. 2016; 215: 482-486. doi: 10.1016/j.ijcard.2016.04.079.
[23]	Karetnikova V, Gruzdeva O, Uchasova E et al. Glucose levels as a prognostic marker in patients with ST-segment elevation myocardial infarction: a case–control study. BMC Endocr Disord 2016; 16: 31 doi.org/10.1186/s12902-016-0108-8.
[24]	Li M, Chen G, Feng Y and He X. Stress Induced Hyperglycemia in the Context of Acute Coronary Syndrome: Definitions, Interventions, and Underlying Mechanisms. Front. Cardiovasc. Med 2021; 8: 676-892. doi: 10.3389/fcvm.2021.676892.
[25]	Korah TE, Ibrahim HH, Badr EA, El Shafie MK. Serum resistin in acute myocardial infarction patients with and without diabetes mellitus. Postgrad Med J. 2011 Jul; 87 (1029): 463-7. doi: 10.1136/pgmj.2010.113571.
[26]	Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK, Scherer PE. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia. 2014 Jun; 57 (6): 1209-18. doi: 10.1007/s00125-014-3210-3.
[27]	Park HK, Kwak MK, Kim HJ, Ahima RS: Linking resistin, inflammation, and cardiometabolic diseases. The Korean Journal of Internal Medicine 2017, 32 (2): 239- 247.
[28]	Hsieh, HJ., Liu, CA., Huang, B. et al. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications. J Biomed Sci 2014; 21: 3. https://doi.org/10.1186/1423-0127-21-3
[29]	Samsamshariat SZA, Sakhaei F, Salehizadeh L, Keshvari M, Asgary S. Relationship between resistin, endothelin-1, and flow-mediated dilation in patient with and without metabolic syndrome. Adv Biomed Res 2019; 8: 16.
[30]	Erer HB, Sayar N, Guvenc TS, Aksaray S, Yilmaz H, Altay S, Turer A, Oz TK, Karadeniz FO, Oz D, Ekmekci A, Zencirci AE, Eren M. Prognostic value of serum resistin levels in patients with acute myocardial infarction. Kardiol Pol. 2014; 72 (2): 181-6. doi: 10.5603/KP.a2013.0086.
[31]	Acquarone E, Monacelli F, Borghi R, Nencioni A, Odetti P. Resistin: A reappraisal, Mech of Ageing and Develo 2019; 178: 46-63 https://doi.org/10.1016/j.mad.2019.01.004.
[32]	Niaz S, Latif J, Hussain S. Serum resistin: A possible link between inflammation, hypertension and coronary artery disease. Pak J Med Sci 2019; 35 (3).
[33]	Laurikka A, Vuolteenaho K, Toikkanen V, Rinne T, TiinaLeppänen, MattiTarkka et al. Adipocytokine resistin correlates with oxidative stress and myocardial injury in patients undergoing cardiac surgery, Eur J of Cardio-Thor Sur 2014; 46 (4): 729–736, https://doi.org/10.1093/ejcts/ezt634.

Cite This Article

Plain Text BibTeX RIS

APA Style

Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, et al. (2021). Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. International Journal of Clinical and Experimental Medical Sciences, 7(5), 152-159. https://doi.org/10.11648/j.ijcems.20210705.14

Copy | Download

ACS Style

Shazia Rashid; Javed Anver Qureshi; Rukhshan Khurshid; Huma Ashraf; Saima Rasheed, et al. Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. Int. J. Clin. Exp. Med. Sci. 2021, 7(5), 152-159. doi: 10.11648/j.ijcems.20210705.14

Copy | Download

AMA Style

Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, et al. Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. Int J Clin Exp Med Sci. 2021;7(5):152-159. doi: 10.11648/j.ijcems.20210705.14

Copy | Download

@article{10.11648/j.ijcems.20210705.14,
  author = {Shazia Rashid and Javed Anver Qureshi and Rukhshan Khurshid and Huma Ashraf and Saima Rasheed and Uzma Faryal},
  title = {Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {7},
  number = {5},
  pages = {152-159},
  doi = {10.11648/j.ijcems.20210705.14},
  url = {https://doi.org/10.11648/j.ijcems.20210705.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20210705.14},
  abstract = {Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins
AU  - Shazia Rashid
AU  - Javed Anver Qureshi
AU  - Rukhshan Khurshid
AU  - Huma Ashraf
AU  - Saima Rasheed
AU  - Uzma Faryal
Y1  - 2021/10/28
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcems.20210705.14
DO  - 10.11648/j.ijcems.20210705.14
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 152
EP  - 159
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20210705.14
AB  - Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.
VL  - 7
IS  - 5
ER  -

Copy | Download

Author Information

Shazia Rashid

Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan
Javed Anver Qureshi

Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan
Rukhshan Khurshid

Department of Biochemistry, Shalamar Medical and Dental College, Lahore, Pakistan
Huma Ashraf

Department of Biochemistry, CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan
Saima Rasheed

Department of Biochemistry, Niazi Medical and Dental College, Sargodha, Pakistan
Uzma Faryal

Department of Biochemistry, Women Medical College, Abbottabad, Pakistan

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, et al. (2021). Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. International Journal of Clinical and Experimental Medical Sciences, 7(5), 152-159. https://doi.org/10.11648/j.ijcems.20210705.14

Copy | Download

ACS Style

Shazia Rashid; Javed Anver Qureshi; Rukhshan Khurshid; Huma Ashraf; Saima Rasheed, et al. Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. Int. J. Clin. Exp. Med. Sci. 2021, 7(5), 152-159. doi: 10.11648/j.ijcems.20210705.14

Copy | Download

AMA Style

Shazia Rashid, Javed Anver Qureshi, Rukhshan Khurshid, Huma Ashraf, Saima Rasheed, et al. Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins. Int J Clin Exp Med Sci. 2021;7(5):152-159. doi: 10.11648/j.ijcems.20210705.14

Copy | Download

@article{10.11648/j.ijcems.20210705.14,
  author = {Shazia Rashid and Javed Anver Qureshi and Rukhshan Khurshid and Huma Ashraf and Saima Rasheed and Uzma Faryal},
  title = {Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {7},
  number = {5},
  pages = {152-159},
  doi = {10.11648/j.ijcems.20210705.14},
  url = {https://doi.org/10.11648/j.ijcems.20210705.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20210705.14},
  abstract = {Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Role of Resistin with Endothelium Dysfunction in STEMI and NSTEMI Patients and Its Correlation with Cardiac Markers Troponins
AU  - Shazia Rashid
AU  - Javed Anver Qureshi
AU  - Rukhshan Khurshid
AU  - Huma Ashraf
AU  - Saima Rasheed
AU  - Uzma Faryal
Y1  - 2021/10/28
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcems.20210705.14
DO  - 10.11648/j.ijcems.20210705.14
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 152
EP  - 159
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20210705.14
AB  - Acute coronary syndrome (ACS) is the leading cause of mortality worldwide comprised with ST-segment elevation myocardial infarction (STEMI) and non ST segment elevation myocardial infarction (NSTEMI). A cross sectional study for a period from March 2015 to June 2016 was designed to find out the role of resistin in endothelium dysfunction in STEMI and NSTEMI patients and its correlation with cardiac markers troponins. 100 consented patients with diagnosed STEMI and NSTEMI with age range 40 to 70 years were included in the study. 50 age matched healthy subjects were taken as controls. Base line blood tests fasting blood sugar, blood urea, serum creatinine, serum total cholesterol and serum triglyceride were estimated by auto analyzer using standard kits. Special tests including serum resistin, cardiac troponin T and cardiac troponin I were estimated by the technique of ELISA. Results were analyzed by SPSS 20 and found that the base line parameters except serum creatinine were significantly raised in patients as compare to controls. Level of resistin and cardiac biomarkers cardiac troponin T (cTnT) and cardiac troponin I (cTnI) were significantly raised in STEMI patients as compared to NSTEMI patients. A significant positive correlation of resistin with cardiac troponin T and I was observed in STEMI patients only. It is therefore concluded that increased level of resistin along with cardiac markers may be presented as a predictor of injury of myocardium and in turn indicate the severity of AMI in STEMI patients.
VL  - 7
IS  - 5
ER  -

Copy | Download