Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma

Brahmacharimayum Arunkumar Sharma; Jayshree Phurailatpam; Gaurav Goswami; Thaodem Tomcha Singh; Laishram Jaichand Singh; Yengkhom Indibor Singh

doi:doi:10.11648/j.ijcocr.20170201.11

Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma

Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, Yengkhom Indibor Singh

Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 1)

Received: 27 December 2016 Accepted: 10 January 2017 Published: 9 February 2017

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Abstract

The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 1)
DOI	10.11648/j.ijcocr.20170201.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

HDR-ILRT, Nasopharyngeal Cancer, BED, Treatment Time

References

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APA Style

Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, et al. (2017). Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. International Journal of Clinical Oncology and Cancer Research, 2(1), 1-6. https://doi.org/10.11648/j.ijcocr.20170201.11

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ACS Style

Brahmacharimayum Arunkumar Sharma; Jayshree Phurailatpam; Gaurav Goswami; Thaodem Tomcha Singh; Laishram Jaichand Singh, et al. Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. Int. J. Clin. Oncol. Cancer Res. 2017, 2(1), 1-6. doi: 10.11648/j.ijcocr.20170201.11

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AMA Style

Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, et al. Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. Int J Clin Oncol Cancer Res. 2017;2(1):1-6. doi: 10.11648/j.ijcocr.20170201.11

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@article{10.11648/j.ijcocr.20170201.11,
  author = {Brahmacharimayum Arunkumar Sharma and Jayshree Phurailatpam and Gaurav Goswami and Thaodem Tomcha Singh and Laishram Jaichand Singh and Yengkhom Indibor Singh},
  title = {Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {2},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.ijcocr.20170201.11},
  url = {https://doi.org/10.11648/j.ijcocr.20170201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170201.11},
  abstract = {The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.},
 year = {2017}
}

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TY  - JOUR
T1  - Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma
AU  - Brahmacharimayum Arunkumar Sharma
AU  - Jayshree Phurailatpam
AU  - Gaurav Goswami
AU  - Thaodem Tomcha Singh
AU  - Laishram Jaichand Singh
AU  - Yengkhom Indibor Singh
Y1  - 2017/02/09
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20170201.11
DO  - 10.11648/j.ijcocr.20170201.11
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20170201.11
AB  - The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.
VL  - 2
IS  - 1
ER  -

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Author Information

Brahmacharimayum Arunkumar Sharma

Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India
Jayshree Phurailatpam

Department of Physiology, Regional Institute of Medical Sciences, Imphal, India
Gaurav Goswami

Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India
Thaodem Tomcha Singh

Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India
Laishram Jaichand Singh

Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India
Yengkhom Indibor Singh

Department of Radiotherapy, Regional Cancer Centre, Regional Institute of Medical Sciences, Imphal, India

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Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, et al. (2017). Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. International Journal of Clinical Oncology and Cancer Research, 2(1), 1-6. https://doi.org/10.11648/j.ijcocr.20170201.11

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ACS Style

Brahmacharimayum Arunkumar Sharma; Jayshree Phurailatpam; Gaurav Goswami; Thaodem Tomcha Singh; Laishram Jaichand Singh, et al. Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. Int. J. Clin. Oncol. Cancer Res. 2017, 2(1), 1-6. doi: 10.11648/j.ijcocr.20170201.11

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AMA Style

Brahmacharimayum Arunkumar Sharma, Jayshree Phurailatpam, Gaurav Goswami, Thaodem Tomcha Singh, Laishram Jaichand Singh, et al. Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma. Int J Clin Oncol Cancer Res. 2017;2(1):1-6. doi: 10.11648/j.ijcocr.20170201.11

Copy | Download

@article{10.11648/j.ijcocr.20170201.11,
  author = {Brahmacharimayum Arunkumar Sharma and Jayshree Phurailatpam and Gaurav Goswami and Thaodem Tomcha Singh and Laishram Jaichand Singh and Yengkhom Indibor Singh},
  title = {Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {2},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.ijcocr.20170201.11},
  url = {https://doi.org/10.11648/j.ijcocr.20170201.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170201.11},
  abstract = {The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.},
 year = {2017}
}

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TY  - JOUR
T1  - Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma
AU  - Brahmacharimayum Arunkumar Sharma
AU  - Jayshree Phurailatpam
AU  - Gaurav Goswami
AU  - Thaodem Tomcha Singh
AU  - Laishram Jaichand Singh
AU  - Yengkhom Indibor Singh
Y1  - 2017/02/09
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20170201.11
DO  - 10.11648/j.ijcocr.20170201.11
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20170201.11
AB  - The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.
VL  - 2
IS  - 1
ER  -

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