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Biological Effective Dose and Overall Treatment Time in the High Dose Rate Brachytherapy of Nasopharyngeal Carcinoma
Brahmacharimayum Arunkumar Sharma,
Jayshree Phurailatpam,
Gaurav Goswami,
Thaodem Tomcha Singh,
Laishram Jaichand Singh,
Yengkhom Indibor Singh
Issue:
Volume 2, Issue 1, February 2017
Pages:
1-6
Received:
27 December 2016
Accepted:
10 January 2017
Published:
9 February 2017
DOI:
10.11648/j.ijcocr.20170201.11
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Abstract: The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachytherapy (HDR-BT)boost, following external beam radiation therapy (EBRT) treated in the period from 2009 to 2015. All patients were irradiated by HDR –Intra Luminal Radiotherapy (ILRT) following EBRT using a telecobalt unit and a technique that employed two lateral opposed fields with a dose of 66 ± 4 Gy. The total biological equivalent dose prescribed was 106.50 ± 9 Gy (range 92 - 123 Gy). The probabilities of disease recurrence within a median follow-up of 25 months (range 13 – 72 months) are expected as 0.03, 0.26, 0.58 and 0.90 (p=0.05) for the overall treatment time of 75, 150, 250 and 350 days respectively. It was observed that the local recurrence of disease increases with increased treatment time and it is significant (p=0.05) when the overall treatment time is above 100 days where BED lost becomes more than 0.10 Gy/day. The relative risk of local recurrence of stage III is about 2.59 times higher than that of stage II patients.
Abstract: The aim of this study is to evaluate the decrease of biological effective dose (BED) and its correlation with local control of tumour in the treatment of nasopharyngeal carcinoma (NPC) when the overall treatment time is prolonged. A retrospective study was carried out on 39 NPC with stage II and III treated with fractionated High Dose Rate–Brachyth...
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Effect of Black Tea on Micronuclei (Oral Cancer Biomarker) Among Indian Population
Aniket Adhikari,
Madhusnata De
Issue:
Volume 2, Issue 1, February 2017
Pages:
7-9
Received:
10 December 2016
Accepted:
3 February 2017
Published:
27 February 2017
DOI:
10.11648/j.ijcocr.20170201.12
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Abstract: Introduction Tea is the most widely consumed beverage worldwide and important agricultural product. Being rich in natural antioxidants, tea is used in the management of different types of cancers including oral cavity. Micronuclei (MN) act as a biomarker for oral cancer. These are small, extra nuclear bodies that are formed during mitosis from lagging chromosomes. The micronucleus test is used as a tool for genotoxicity. In this present study subjects were screened from Department of E. N. T. & Oral and Maxillofacial surgery of RKMSP hospital, Kolkata and different areas of Eastern and North Eastern states of India. Exfoliated cell were examined from buccal mucosa for MN. Percentage of MN was low after black tea supplementation. We can concluded that betel quid has an immense role in changing the oral pathology and tea has chemo preventive property.
Abstract: Introduction Tea is the most widely consumed beverage worldwide and important agricultural product. Being rich in natural antioxidants, tea is used in the management of different types of cancers including oral cavity. Micronuclei (MN) act as a biomarker for oral cancer. These are small, extra nuclear bodies that are formed during mitosis from lagg...
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The Role of Morus Nigra Extract and Its Active Compounds as Drug Candidate on Human Colorectal Adenocarcinoma Cell Line HT-29
Ece Çakıroğlu,
Tuğba Uysal,
Gizem Çalıbaşı Koçal,
Fatih Aygenli,
Gülin Baran,
Yasemin Baskın
Issue:
Volume 2, Issue 1, February 2017
Pages:
10-14
Received:
15 January 2017
Accepted:
3 February 2017
Published:
1 March 2017
DOI:
10.11648/j.ijcocr.20170201.13
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Abstract: According to laboratory-based in vitro researches, there are numerous medicinal plants and natural compounds that indicate potential as an anticancer agent. Morus nigra (M.nigra) (black mulberry) and its active components are strong candidates to be anticancer agents. The purpose of the present study was to investigate antiproliferative and antimigratory effects of M.nigra extract, its leptin Morniga G (MorG) and one of its component Chalcone 4 hydrate; and their synergistic effect in combination with cetuximab application on colorectal adenocarcinoma cell line HT-29. The antiproliferative effect was determined by impedance based proliferation assay following exposure to M.nigra extract (10%, 1%, 0.1%), MorG (0.5, 5, 50 µM) and Chalcone 4 hydrate (0.5, 5, 50 µM) for 48 hours. The antimigratory effect of M.nigra extract and its coponents, was investigated by a wound-healing assay for 48 h. According to results, Morus nigra extract and its leptin MorG reduced cell viability. After 48 hours of 200 µg/ml Cetuximab exposure with M.nigra extract and MorG at different concentrations, a significant decrease on the cell viability was detected when compared to Cetuximab application. MorG can be suggested as a potantial conjugate for targeted drug. However, futher studies are required to fully understand its mechanisms of action.
Abstract: According to laboratory-based in vitro researches, there are numerous medicinal plants and natural compounds that indicate potential as an anticancer agent. Morus nigra (M.nigra) (black mulberry) and its active components are strong candidates to be anticancer agents. The purpose of the present study was to investigate antiproliferative and antimig...
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Esophageal Carcinoma in El-Gharbia Governorate, Egypt: Clinico-Epidemiologic Study and Treatment Outcome
Ahmed Abdelmabood Zeeneldin,
Magdy Saber,
Ashraf Hamed Hassouna,
Sara Ahmed Farag
Issue:
Volume 2, Issue 1, February 2017
Pages:
15-21
Received:
25 January 2017
Accepted:
10 February 2017
Published:
2 March 2017
DOI:
10.11648/j.ijcocr.20170201.14
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Abstract: Background: Esophageal carcinoma (EC) is rare and little is known about them in Egypt. Gharbia population-based cancer registry (GPBCR) is the first population-based cancer registry in Egypt located in the Tanta Cancer Center (TCC). It has been successfully functioning since January 1999, covering 4.1 million population. We aimed to determine EC characteristics in Egyptian patients. Materials and methods: Retrospective analysis of 70 cases with ECs, who were identified in GPBCR between January 2000 and December 2002; of whom 35 were treated at TCC. Patients’ medical records were reviewed regarding clinic-epidemiologic, treatment, and follow-up data. Results: Median age was 60 years (range, 18-83 years) with male predominance (63%). Dysphagia was the most common presentation (75%). The lower third was the commonest site (55%) followed by the middle third (25%). Squamous cell carcinoma (SCC) was the commonest histology (66%) followed by adenocarcinoma (AC; 24%). Majority of ACs (70%) were located in the lower esophagus while SCC had no site of preference (p=0.04). Less than one third of patients were candidates for radical treatment while the majority of patients received palliative and supportive treatment. Surgery, radiotherapy and chemotherapy were employed in 43%, 20%, and 34% of patients respectively. The median progression-free survival and overall survival were 6 and 7 months, respectively. Site, histology, stage and treatment modality had no significant impact on survival. Conclusions: Esophageal carcinoma in Gharbia Governorate, Egypt is characterized by predominance of male gender, lower third location and squamous histology. Overall and progression free survivals are dismal.
Abstract: Background: Esophageal carcinoma (EC) is rare and little is known about them in Egypt. Gharbia population-based cancer registry (GPBCR) is the first population-based cancer registry in Egypt located in the Tanta Cancer Center (TCC). It has been successfully functioning since January 1999, covering 4.1 million population. We aimed to determine EC ch...
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Job Satisfaction Across Some Selected Demographic Variables Among Hospital Health Workers in South-West Shoa Zone, Oromia Regional State, Ethiopia
Issue:
Volume 2, Issue 1, February 2017
Pages:
22-28
Received:
9 September 2015
Accepted:
4 October 2015
Published:
3 March 2017
DOI:
10.11648/j.ijcocr.20170201.15
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Abstract: The issue of employees’ job satisfaction such as what it is and why it is important has become an important corporate objective which bring with it a great deal of research (Scheid, 2005). Thus, the objective of this study was to examine the level of job satisfaction across demographic factors among hospital health workers at South-West Shoa Zone, Oromia Regional State. To come up with the result, this cross-sectional survey was conducted on 220 healthcare workers who were selected based on systematic random sampling technique. Spector’s self-administered Job Satisfaction Scale was used to collect data. In order to get the result, descriptive statistics such as mean and standard deviation; and inferential statistics including independent sample t-test, one way ANOVA followed by Bonferroni post-hoc analysis was computed. Regarding gender differences, the study have revealed female health workers had high job satisfaction than males, which was also statistically significant, t (219) =3.039, p= .001. Statistically significant differences on job satisfaction were also found for age group, F (2, 218) = 3.287, p = 0.039; level of education, F (2, 218) = 3.936, p = .021. Based on service year, no statistically significant difference were obtained among three groups of health workers, F (2, 218) = .391, p = .677. The study findings could provide decision makers with valuable insights in identifying factors to focus on improving job satisfaction.
Abstract: The issue of employees’ job satisfaction such as what it is and why it is important has become an important corporate objective which bring with it a great deal of research (Scheid, 2005). Thus, the objective of this study was to examine the level of job satisfaction across demographic factors among hospital health workers at South-West Shoa Zone, ...
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