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Pathological and Clinical Characteristics of Triple Negative Breast Cancer and Disease Relapse
Duaa Knaj,
Michael Georgeos
Issue:
Volume 5, Issue 4, December 2020
Pages:
78-81
Received:
29 August 2020
Accepted:
14 September 2020
Published:
19 November 2020
Abstract: Background: Breast cancer is the most common cancer and an important cause of death in women. It has psychological and social repercussions in patients. Objective: We aimed to assess triple negative breast cancer characteristics, patterns and time of disease relapse. Patients and methods: We reviewed the clinical files and pathology reports of 100 patients who had primary triple-negative breast cancer between 2013 -2017 at the oncology center, Tishreen University Hospital in Lattakia, Syria. We collected the information about (age at diagnosis, histological subtype of tumor, histological grade, tumor size, tumor stage, lymph node status), which was taken at the time of diagnosis. We used SPSS in this research, and Chi-square test was used to compare variables. Results: We found that most of patients (85%) were 40 years of age and older when diagnosed with breast cancer. The most common histological subtype was invasive ductal carcinoma IDC (84%). Regarding the size of the primary tumor, the majority (72%) were T2. According to lymph node status at diagnosis, 41 patients (41%) were N0, (33%) of total were N1. We found grade 2 in 52%, followed by grade3 (41%). For the tumor clinical stage, it was according to AJCC 7th edition, stage II (63%) and stage III in (30%). We found that 32 patients had a recurrence (32%) while (68%) had no recurrence during the follow-up period. As for the development of recurrence, (40.6%) had visceral recurrence; the most pattern was hepatic (61.5%) then pulmonary (38.5%). Recurrence occurred in (22 of 32) patients during the first 2 years (68.7%). We found a significant association between lymph node status and recurrence in patients with TNBC (P=0.004) Conclusion: T and N were important predictive factors for relapse in patients with triple-negative breast cancer, which tends to recur often during the first two years of diagnosis with distant metastases as well as localized recurrence.
Abstract: Background: Breast cancer is the most common cancer and an important cause of death in women. It has psychological and social repercussions in patients. Objective: We aimed to assess triple negative breast cancer characteristics, patterns and time of disease relapse. Patients and methods: We reviewed the clinical files and pathology reports of 100 ...
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Cervical Neoplasia: Papillomavirus Infection and Resistance to Anti Tumor Immunity
Mwenze Didier,
Kyabu Véronique,
Bokambandja Fabrice,
Kasamba Eric,
Mukalay Abdon,
Kalenga Prosper,
Lebwaze Bienvenu
Issue:
Volume 5, Issue 4, December 2020
Pages:
82-92
Received:
15 October 2020
Accepted:
28 October 2020
Published:
23 November 2020
Abstract: This study aim to identify the expression of resistance to antitumor immunity on cellular and tissue alterations predictive of Human Papillomavirus infection as well as to establish the relationship between this resistance and the grades of Intraepithelial neoplasms of the cervix in patients from Lubumbashi and Kinshasa in the Democratic Republic of Congo. This is a study on cervical biopsies whose diagnosis of intraepithelial neoplasia was confirmed by a routine histopathological examination in two pathology laboratories in the Democratic Republic of Congo, or the laboratory of Lubumbashi and the LEBOMA laboratory of Kinshasa. The paraffin blocks were selected during a period from March 2017 to March 2020 at the laboratory of Lubumbashi and at the LEBOMA laboratory in Kinshasa. Laboratory manipulations were carried out at the molecular pathology unit of the LEBOMA Pathological Anatomy and Cytology Cabinet in Kinshasa. Papillomavirus infection was retained by the presence of predictive cellular and tissue alterations. The expression of PD-L1 signifies resistance to anti-tumor immunity. The following results were observed; A total of 50 cases of intraepithelial neoplasia were recorded in a set of 107 patients with cervical lesions, i.e. a frequency of 46.7%. The cytological and histological alterations predictive of papillomavirus infection were observed in the following proportions: For cytological changes; koilocytosis was present in 92%, bi-nucleation was observed in 24% and dyskeratosis was identified in 46%, ie 46, 12 and 23 cases, respectively, out of 50 cases of cervical neoplasia recorded. The proportions of histological alterations are presented as follows: 62% of papillomatosis, 86% of acanthosis, 54% of basal hyperplasia and 34% of intraepithelial capillaries, i.e. 31, 43, 27 and 17 cases out of respectively. The 50 cases of intraepithelial neoplasia of the cervix recorded. PD-L1 expression was observed in 16 cases out of all intraepithelial neoplasia, ie 32% of cases. PD-L1 is mainly expressed in high-grade intraepithelial neoplasias, i.e. 81.25% 95% CI=54.35-95.95 and those involving bi-nucleation (OR=26.66 95% CI=4, 63-153.57, Fisher exact, p<0.01), the intraepithelial capillaries or 37.5%; 95% CI=15.20-64.57. It emerges from this study the expression of PD-L1 is not uniform over all the cyto-histological alterations predictive of human papillomavirus infection during neoplasias. intraepithelial of the cervix, but it is much more expressed in high-grade intraepithelial neoplasias and in those comprising the predictive alterations of Papillomavirus infection like the bi-nucleation and the intraepithelial capillary.
Abstract: This study aim to identify the expression of resistance to antitumor immunity on cellular and tissue alterations predictive of Human Papillomavirus infection as well as to establish the relationship between this resistance and the grades of Intraepithelial neoplasms of the cervix in patients from Lubumbashi and Kinshasa in the Democratic Republic o...
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Mate Analysis of Comprehensive Treatmentstrategy for Advanced Rectal Cancer
Huaikun Ni,
Ruolei Huang,
Lianming Liao,
Wenjuan Zhou
Issue:
Volume 5, Issue 4, December 2020
Pages:
93-104
Received:
3 November 2020
Accepted:
26 November 2020
Published:
4 December 2020
Abstract: AIM: Objective to evaluate the clinical value of therapeutic lateral lymph node dissection in advanced rectal cancer after neoadjuvant radio-chemotherapy in patients with peritoneal retroperitoneum under MR suggesting perivascular iliac lymph node enlargement (lymph node diameter > 8mm). Methods: Because of this study is a retrospective study, the propensity to evaluate matching group is adopted to one group to Fujian Medical University Union Hospital, Fujian province hospital from January 2009 to June 2014 treated 103 cases of rectum MR images after neoadjuvant chemoradiation weeks iliac blood vessels have the progress of the lymph node enlargement period under peritoneal fold return rectal cancer line TME + therapeutic cases of lateral lymph node cleaning; In the group 2, 192 cases with the same tumor site, stage, type, gender and age as group 1 or similar were matched for the same period by propensity assessment, while the group 2 received TME only. The incidence of pelvic autonomic nerve injury after surgery, the 3-year local recurrence rate of pelvic cavity, and the 5-year tumor-free survival rate were compared between the two groups, so as to explore the clinical value of therapeutic periiliac dissection for advanced rectal cancer under peritoneal reflux. Results: The local recurrence rate of pelvic cavity in group 1 and group 2 was 2.91% (3/103) and 9.90% (19/192), respectively, 3 years after operation (P<0.05). Postoperative dysuria in group 1 and group 2 was 14.56% (15/103) and 5.21% (10/192), respectively, with significant difference (P<0.05). Postoperative sexual dysfunction in group 1 and group 2 was 12.50% (7/56) and 2.15% (2/93), respectively, with significant difference (P<0.05). The 5-year survival rates of group 1 and group 2 were 54.37% (56/103) and 51.56% (99/192), respectively, with no significant difference (P›0.05). The liver metastasis rates of group 1 and group 2 were 26.21% (27/103) and 29.17% (56/192), respectively. Lung metastasis rates in group 1 and group 2 were 19.41% (20/103) and 19.27% (37/192), respectively. Conclusion: After neoadjuvant chemoradiotherapy for advanced rectal cancer, selective lymphatic dissection along the iliac vessels guided by rectal magnetic resonance can reduce the local pelvic recurrence of patients for 3 years, but increase the probability of pelvic autonomic nerve injury, and periiliac lymph node dissection will not increase the 5-year survival rate of patients.
Abstract: AIM: Objective to evaluate the clinical value of therapeutic lateral lymph node dissection in advanced rectal cancer after neoadjuvant radio-chemotherapy in patients with peritoneal retroperitoneum under MR suggesting perivascular iliac lymph node enlargement (lymph node diameter > 8mm). Methods: Because of this study is a retrospective study, the ...
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