Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report

Ibrahim Hacibey; Esat Kaba; Sule Ozsoy; Emrah Yuruk; Ahmet Yaser Muslumanoglu

doi:doi:10.11648/j.ijcu.20230702.13

| Peer-Reviewed

Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report

Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu

Published in International Journal of Clinical Urology (Volume 7, Issue 2)

Received: 28 March 2023 Accepted: 2 May 2023 Published: 31 July 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.

Published in	International Journal of Clinical Urology (Volume 7, Issue 2)
DOI	10.11648/j.ijcu.20230702.13
Page(s)	40-43
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Prostate, Lymphoma, Hematuria

References

[1]	Chu PG, Huang Q, Weiss LM. Incidental and concurrent malignant lymphomas discovered at the time of prostatectomy and prostate biopsy: a study of 29 cases. Am J Surg Pathol. 2005; 29 (5): 693-699.
[2]	Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972; 29 (1): 252- 260.
[3]	Bostwick DG, Iczkowski KA, Amin MB, Discigil G, Osborne B. Malignant lymphoma involving the prostate: report of 62 cases. Cancer. 1998; 83 (4): 732-738.
[4]	Sarris A, Dimopoulos M, Pugh W, Cabanillas F. Primary lymphoma of the prostate: good outcome with doxorubicin-based combination chemotherapy. J Urol. 1995; 153 (6): 1852-1854.
[5]	Terris MK, Hausdorff J, Freiha FS. Hematolymphoid malignancies diagnosed at the time of radical prostatectomy. J Urol. 1997; 158 (4): 1457-1459.
[6]	Bostwick DG, Mann RB. Malignant lymphomas involving the prostate. A study of 13 cases. Cancer. 1985; 56 (12): 2932-2938.
[7]	Patel DR, Gomez GA, Henderson ES, Gamarra M. Primary prostatic involvement in non Hodgkin lymphoma. Urology. 1988; 32: 96–8.
[8]	Steuter J, Weisenburger DD, Bociek RG, Bierman P, Vose J, Bast M, Loberiza F, et al. Non-Hodgkin lymphoma of the prostate. Am J Hematol. 2011; 86 (11): 952-954.
[9]	Gorgel SN, Sefik E, Olgunelma V, Sahin E, Balci U, Calli AO. Primary non-Hodgkin follicular lymphoma of the prostate: A case report. Turk J Urol. 2014; 40 (1): 57-58.
[10]	Alongi F, Aniko MD, Ferreri AJ, Rosso A, Cozzarini C, Fallanca F, Berardi G, et al. Consolidation radiotherapy for a rare case of extranodal mucosa-associated lymphoid tissue non-Hodgkin's lymphoma synchronous with prostate adenocarcinoma. Tumori. 2010; 96 (3): 498-502.
[11]	Xu M, Yang Q, Li M, Geng W, Huang W, Chen Y. Prostate involvement by intravascular large B-cell lymphoma: a case report with literature review. Int J Surg Pathol. 2011; 19 (4): 544-547.
[12]	Johnson TR, Barber DB, Teichman JM, Able AC. T-cell lymphocytic lymphoma involving the prostate presenting as elevated PSA in paraplegia: case report. J Spinal Cord Med. 1996; 19 (4): 258-260.
[13]	Taleb A, Ismaili N, Belbaraka R, Bensouda A, Elghissassi I, Elmesbahi O, Droz JP, et al. Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature. Cases J. 2009; 2: 8875.

Cite This Article

Plain Text BibTeX RIS

APA Style

Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu. (2023). Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. International Journal of Clinical Urology, 7(2), 40-43. https://doi.org/10.11648/j.ijcu.20230702.13

Copy | Download

ACS Style

Ibrahim Hacibey; Esat Kaba; Sule Ozsoy; Emrah Yuruk; Ahmet Yaser Muslumanoglu. Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. Int. J. Clin. Urol. 2023, 7(2), 40-43. doi: 10.11648/j.ijcu.20230702.13

Copy | Download

AMA Style

Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu. Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. Int J Clin Urol. 2023;7(2):40-43. doi: 10.11648/j.ijcu.20230702.13

Copy | Download

@article{10.11648/j.ijcu.20230702.13,
  author = {Ibrahim Hacibey and Esat Kaba and Sule Ozsoy and Emrah Yuruk and Ahmet Yaser Muslumanoglu},
  title = {Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report},
  journal = {International Journal of Clinical Urology},
  volume = {7},
  number = {2},
  pages = {40-43},
  doi = {10.11648/j.ijcu.20230702.13},
  url = {https://doi.org/10.11648/j.ijcu.20230702.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20230702.13},
  abstract = {Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report
AU  - Ibrahim Hacibey
AU  - Esat Kaba
AU  - Sule Ozsoy
AU  - Emrah Yuruk
AU  - Ahmet Yaser Muslumanoglu
Y1  - 2023/07/31
PY  - 2023
N1  - https://doi.org/10.11648/j.ijcu.20230702.13
DO  - 10.11648/j.ijcu.20230702.13
T2  - International Journal of Clinical Urology
JF  - International Journal of Clinical Urology
JO  - International Journal of Clinical Urology
SP  - 40
EP  - 43
PB  - Science Publishing Group
SN  - 2640-1355
UR  - https://doi.org/10.11648/j.ijcu.20230702.13
AB  - Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.
VL  - 7
IS  - 2
ER  -

Copy | Download

Author Information

Ibrahim Hacibey

Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey
Esat Kaba

Department of Radiology, University of Recep Tayyip Erdoğan, Rize, Turkey
Sule Ozsoy

Department of Pathology, Bagcilar Training and Research Hospital, Istanbul, Turkey
Emrah Yuruk

Department of Urology, BHT Clinic Istanbul TEMA Hospital, Istanbul, Turkey
Ahmet Yaser Muslumanoglu

Department of Urology, Bagcilar Training and Research Hospital, Istanbul, Turkey

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu. (2023). Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. International Journal of Clinical Urology, 7(2), 40-43. https://doi.org/10.11648/j.ijcu.20230702.13

Copy | Download

ACS Style

Ibrahim Hacibey; Esat Kaba; Sule Ozsoy; Emrah Yuruk; Ahmet Yaser Muslumanoglu. Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. Int. J. Clin. Urol. 2023, 7(2), 40-43. doi: 10.11648/j.ijcu.20230702.13

Copy | Download

AMA Style

Ibrahim Hacibey, Esat Kaba, Sule Ozsoy, Emrah Yuruk, Ahmet Yaser Muslumanoglu. Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report. Int J Clin Urol. 2023;7(2):40-43. doi: 10.11648/j.ijcu.20230702.13

Copy | Download

@article{10.11648/j.ijcu.20230702.13,
  author = {Ibrahim Hacibey and Esat Kaba and Sule Ozsoy and Emrah Yuruk and Ahmet Yaser Muslumanoglu},
  title = {Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report},
  journal = {International Journal of Clinical Urology},
  volume = {7},
  number = {2},
  pages = {40-43},
  doi = {10.11648/j.ijcu.20230702.13},
  url = {https://doi.org/10.11648/j.ijcu.20230702.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcu.20230702.13},
  abstract = {Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Chronic Lymphocytic Lymphoma / Leukemia Infiltration of Prostate Gland Presenting with Hematuria: A Case Report
AU  - Ibrahim Hacibey
AU  - Esat Kaba
AU  - Sule Ozsoy
AU  - Emrah Yuruk
AU  - Ahmet Yaser Muslumanoglu
Y1  - 2023/07/31
PY  - 2023
N1  - https://doi.org/10.11648/j.ijcu.20230702.13
DO  - 10.11648/j.ijcu.20230702.13
T2  - International Journal of Clinical Urology
JF  - International Journal of Clinical Urology
JO  - International Journal of Clinical Urology
SP  - 40
EP  - 43
PB  - Science Publishing Group
SN  - 2640-1355
UR  - https://doi.org/10.11648/j.ijcu.20230702.13
AB  - Objectives: Primary prostatic malignant lymphoma is an exceedingly rare malignancy, accounting for only 0.09% of all prostate neoplasms and 0.1% of all non-Hodgkin's lymphomas. In this report, we present a case of a 70-year-old male patient who presented with sudden-onset hematuria and was ultimately diagnosed with primary lymphoma of the prostate. Methods: The patient presented to a urology outpatient clinic with a 2-week history of gross hematuria but no lower urinary tract symptoms. Digital rectal examination revealed a firm and enlarged prostate, and serum PSA levels were elevated. Ultrasound evaluation, multiparametric prostate magnetic resonance imaging (mp-MRI), and cystoscopy were performed, revealing only a grossly enlarged prostatic median lobe. A systematic transrectal ultrasound (TRUS)-guided prostate biopsy was then performed and confirmed the diagnosis of primary lymphoma of the prostate. Results & Conclusion: This case highlights the importance of considering primary lymphoma of the prostate in patients presenting with macroscopic hematuria and an enlarged prostate, even if mp-MRI does not reveal any other abnormalities. Early diagnosis is crucial in such cases, as it allows for prompt initiation of treatment and may improve clinical outcomes. Given the rarity of this malignancy, clinicians must remain vigilant for its possible presentation and include it in the differential diagnosis when appropriate.
VL  - 7
IS  - 2
ER  -

Copy | Download