A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population

Shuo Li; Yu-Ming Xu; Hong Zheng; Edward Randell; Hai-Zheng Wang; Jianxun Cui; Guang Sun; Guangju Zhai; Fei-Yu Han; Ya-Gang Xie

doi:doi:10.11648/j.ijgg.20170501.12

A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population

Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, Jianxun Cui, Guang Sun, Guangju Zhai, Fei-Yu Han, Ya-Gang Xie

Published in International Journal of Genetics and Genomics (Volume 5, Issue 1)

Received: 6 March 2017 Published: 10 March 2017

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Abstract

The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.

Published in	International Journal of Genetics and Genomics (Volume 5, Issue 1)
DOI	10.11648/j.ijgg.20170501.12
Page(s)	14-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

9p21 Locus, Ischemic Stroke, Chinese, Genetic Association Study

References

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APA Style

Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, et al. (2017). A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. International Journal of Genetics and Genomics, 5(1), 14-18. https://doi.org/10.11648/j.ijgg.20170501.12

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ACS Style

Shuo Li; Yu-Ming Xu; Hong Zheng; Edward Randell; Hai-Zheng Wang, et al. A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. Int. J. Genet. Genomics 2017, 5(1), 14-18. doi: 10.11648/j.ijgg.20170501.12

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AMA Style

Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, et al. A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. Int J Genet Genomics. 2017;5(1):14-18. doi: 10.11648/j.ijgg.20170501.12

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@article{10.11648/j.ijgg.20170501.12,
  author = {Shuo Li and Yu-Ming Xu and Hong Zheng and Edward Randell and Hai-Zheng Wang and Jianxun Cui and Guang Sun and Guangju Zhai and Fei-Yu Han and Ya-Gang Xie},
  title = {A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population},
  journal = {International Journal of Genetics and Genomics},
  volume = {5},
  number = {1},
  pages = {14-18},
  doi = {10.11648/j.ijgg.20170501.12},
  url = {https://doi.org/10.11648/j.ijgg.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20170501.12},
  abstract = {The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.},
 year = {2017}
}

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TY  - JOUR
T1  - A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population
AU  - Shuo Li
AU  - Yu-Ming Xu
AU  - Hong Zheng
AU  - Edward Randell
AU  - Hai-Zheng Wang
AU  - Jianxun Cui
AU  - Guang Sun
AU  - Guangju Zhai
AU  - Fei-Yu Han
AU  - Ya-Gang Xie
Y1  - 2017/03/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ijgg.20170501.12
DO  - 10.11648/j.ijgg.20170501.12
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 14
EP  - 18
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20170501.12
AB  - The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.
VL  - 5
IS  - 1
ER  -

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Author Information

Shuo Li

Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada
Yu-Ming Xu

Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, P. R. China
Hong Zheng

Department of Genetics, Faculty of Medicine, Zhengzhou University, Zhengzhou, P. R. China
Edward Randell

Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada
Hai-Zheng Wang

Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, P. R. China
Jianxun Cui

Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada
Guang Sun

Disciplines of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada
Guangju Zhai

Disciplines of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada
Fei-Yu Han

Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada
Ya-Gang Xie

Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

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APA Style

Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, et al. (2017). A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. International Journal of Genetics and Genomics, 5(1), 14-18. https://doi.org/10.11648/j.ijgg.20170501.12

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ACS Style

Shuo Li; Yu-Ming Xu; Hong Zheng; Edward Randell; Hai-Zheng Wang, et al. A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. Int. J. Genet. Genomics 2017, 5(1), 14-18. doi: 10.11648/j.ijgg.20170501.12

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AMA Style

Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, et al. A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. Int J Genet Genomics. 2017;5(1):14-18. doi: 10.11648/j.ijgg.20170501.12

Copy | Download

@article{10.11648/j.ijgg.20170501.12,
  author = {Shuo Li and Yu-Ming Xu and Hong Zheng and Edward Randell and Hai-Zheng Wang and Jianxun Cui and Guang Sun and Guangju Zhai and Fei-Yu Han and Ya-Gang Xie},
  title = {A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population},
  journal = {International Journal of Genetics and Genomics},
  volume = {5},
  number = {1},
  pages = {14-18},
  doi = {10.11648/j.ijgg.20170501.12},
  url = {https://doi.org/10.11648/j.ijgg.20170501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20170501.12},
  abstract = {The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.},
 year = {2017}
}

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TY  - JOUR
T1  - A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population
AU  - Shuo Li
AU  - Yu-Ming Xu
AU  - Hong Zheng
AU  - Edward Randell
AU  - Hai-Zheng Wang
AU  - Jianxun Cui
AU  - Guang Sun
AU  - Guangju Zhai
AU  - Fei-Yu Han
AU  - Ya-Gang Xie
Y1  - 2017/03/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ijgg.20170501.12
DO  - 10.11648/j.ijgg.20170501.12
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 14
EP  - 18
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20170501.12
AB  - The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.
VL  - 5
IS  - 1
ER  -

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