Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan

Sharaf Kasimov; Margus Lember

doi:doi:10.11648/j.ijnfs.20130206.21

| Peer-Reviewed

Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan

Sharaf Kasimov, Margus Lember

Published in International Journal of Nutrition and Food Sciences (Volume 2, Issue 6)

Received: 4 December 2013 Published: 30 December 2013

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objective: To determine the prevalence of adult-type hypolactasia in the Tajik population living in the south of Uzbekistan by genotyping of allelic variants C/T-13910 and identifying their tolerance to milk. Methods: 100 ethnic Tajik adults were examined for C/T-13910 single nucleotide polymorphisms using polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire developed to assess dyspepsia after milk and dairy consumption. Results: A genetic marker of hypolactasia - C/C-13910 genotype was detected in 83% of the adult Tajik population. However, despite the high prevalence of lactose intolerance in the Tajik population, the majority consume between 100-200 ml of milk per day. Conclusion: The Tajik population is characterized by a high prevalence of hypolactasia. Milk consumption is not affected by the determined genotypes since people of Tajik ethnicity consume milk in small quantities.

Published in	International Journal of Nutrition and Food Sciences (Volume 2, Issue 6)
DOI	10.11648/j.ijnfs.20130206.21
Page(s)	332-336
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Hypolactasia, Milk Consumption, Tajik Population

References

[1]	J.T. Troelsen "Adult-type hypolactasia and regulation of lactase expression". Biochim. Biophys. Acta Vol.1723(1–3): 2005, pp.19–32.
[2]	N. Kretchmer "Expression of lactase during development". Am. J. Hum. Genet. Vol. 45 (4): 1989, pp.487–8.
[3]	Y. Itan, B.L.Jones, CJE Ingram, D.M.Swallow and M.G. Thomas. A worldwide correlation of lactase persistence phenotype and genotypes. BMC Evol Biol. Vol. 9; 2010, pp.10-36.
[4]	D.M. Swallow "Genetics of lactase persistence and lactose intolerance". Annual Review of Genetics Vol.37:2003, pp.197–219.
[5]	T. Sahi "Genetics and epidemiology of adult-type hypolactasia". Scand. J. Gastroenterol. Vol. 202: 1994, pp.7–20.
[6]	C.E. Woteki, E. Weser and E.A. Young "Lactose malabsorption in Mexican-American children". Am. J. Clin. Nutr. Vol. 29 (1): 1976, pp.19–24.
[7]	Y. Itan, A. Powell, M.A Beaumont, J. Burger and M.G. Thomas. "The origins of lactase persistence in Europe". In Tanaka, Mark M. PLoS Comput. Biol. Vol. 5 (8): 2009
[8]	J.Hussin, P. Nadeau, J.F. Lefebvre and D. Labuda. "Haplotype allelic classes for detecting ongoing positive selection". BMC Bioinformatics 11: 65, 2010.
[9]	S. Myles, N. Bouzekri, E. Haverfield, M. Cherkaoui, J.M.Dugoujon and R.Ward "Genetic evidence in support of a shared Eurasian-North African dairying origin". Biomedical and Life Sciences Vol. 117 (1): 2005, pp. 34–42.
[10]	N.S. Enattah, T. G. K. Jensen, M.Nielsen, R. Lewinski, M.Kuokkanen, H.Rasinpera, El- H.Shanti, J.Kee Seo, M.Alifrangis, F.K.Insaf, N. Abdrazak, A. Ahmed, N. Sirajedin , D.Comas, S. Q.m Mehdi, L. Groop, E. M. Vestergaard, F. Imtiaz, M.S. Rashed, B. Meyer, J. Troelsen and L. Peltonen. "Independent Introduction of Two Lactase-Persistence Alleles into Human Populations Reflects Different History of Adaptation to Milk Culture". American Journal of Human Genetics Vol. 82(1):2008, pp.57–72.
[11]	C.Ghudini, A. Sottini, C. Zanotti, F. Serana, M. Marini, L.Caimi and L.Imberti, "Adult-type hypolactasia genotyping in Northern Italy: prevalence of C/T-13910 polymorphism and questions after comparison with existing date". Minevra Gastroenterol Dietol. Vol. 56 (1), 2010, pp.19-23.
[12]	T. Bersaglieri, P.C. Sabeti, N.Patterson, T.Vanderploeg, S.F. Schaffner, J. A. Drake, M.Rhodes, D.E. Reich and J.N. Hirschhorn "Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene". Am J Hum Genet Vol.74 (6): 2004, pp.1111.
[13]	G.Flatz, H.J. Henze, E. Palabiyikoglu, K.Dagalp and T. Turkkan. Distribution of the adult lactase phenotypes in Turkey. Tropical and geographical medicine. Vol.38: 1986. pp. 255-258
[14]	Sh.Kasimov, M.Lember. Adult-Type Hypolactasia in an ethnic Uzbek population. Int.J.Health&Nutrition. Vol. 4(1): 2013, pp. 46-49.
[15]	E. Heyer, L.Brazier, L.Ségurel, T. Hegay, F. Austerlitz, L.Quintana-Murci, M.Georges, P. Pasquet and M Veuille. Lactase persistence in Central Asia: Phenotype, genotype, and evolution. Human Biology. Vol. 83(3): 2011, pp. 379-92.
[16]	Y.G. Wang, Y.S. Yan, J.J. Xu, R.F. Du, S.D. Flatz, W. Kühnau and G. Flatz. Prevalence of primary adult lactose malabsorption in three populations of northern China. Human Genetics; Vol. 67(1): 1984. pp. 103-6.
[17]	NS. Enattah, T. Sahi, E. Savilahti, JD. Terwilliger, L. Peltonen and I. Järvelä. "Identification of a variant associated with adult-type hypolactasia". Nat. Genet. Vol.30 (2): 2002, pp.233–7.
[18]	M Sadre, K. Karbazi. Lactose intolerance in Iran. American Journal of Clinical Nutrition; Vol. 32 (9): 1979, pp.1948-54
[19]	M. Lember, S.Torniainen, M. Kull, R. Kallikorm, P. Saadla, T. Rajasalu, H. Komu and I. Järvelä.. Lactase non-persistence and milk consumption in Estonia. World Journal of Gastroenterology; Vol. 12(45): 2006, pp.7329-7331
[20]	O. Hovde, P. Farup. "A comparison of diagnostic test for lactose malabsorbtion – which one is the best?", BMC Gastroenterol, Vol. 9, 2009, pp.82-88.
[21]	M.Lember, A.Tamm, A.Piirsoo, K.Suurmaa, R.Kermes, R.Kermesand, T.Sahi and M.Isokoski "Lactose malabsorbtion in Khants in western Siberia". Scand. Journal of Gastroenterology: Vol.30, 1995, pp.225-227.
[22]	M.Saberi-Firoozi, F.Khademolhosseini, D.Mehrabani, M.Yousefi, M.Salehi and ST Heidary "Subjective lactose intolerance in apparently healthy adults in southern Iran: Is it related to irritable bowel syndrome?". Indian Journal Medical Sciences, Vol.61 (11), 2007, pp.591-597.
[23]	Adams, Anne and Cox, Anna L. "Questionnaires, in-depth interviews and focus group". Research Methods for Human Computer Interaction. Cambridge, UK:Cambridge University Press, 2008, pp.17-34.
[24]	R.Almon, P.Engfeld, C.Tysk, M.Sjöström and T.K.Nilson, "Prevalence and trends in adult-type hypolactasia in different age cohorts in Central Sweden diagnosed by genotyping for the adult-type hypolactasia-linked LCT-13910C > T mutation". Scand. J. Gastroenterol.., Vol. 42 (2), 2007, pp.165-70.
[25]	JT Trolsen, J.Olsen, J.Møller and H. Sjöström "An upstream polymorphism associated with lactase persistence has increased enhancer activity". Gastroenterology Vol.125, (6): 2003, pp.1686-94.
[26]	M.Lember, A.Tamm, K.Villako. Lactose malabsorption in Estonians and Russian. European Journal of Gastroenterology & Hepatology; Vol. 3: 1991, pp. 479-481.
[27]	R.Mattar, D F. de Campos Mazo and FJ Carrilho. Lactose intolerance: diagnosis, genetic, and clinical factors. Clin Exp Gastroenterol. Vol.5:2012, pp.113–121.
[28]	F. Suarez, DA Savaiano and VD Levitt. "A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance". The New England Journal of Medicine; Vol. 333(1): 1995, pp.1-4.
[29]	Raja A.H.Kuchay, Mumtaz Anvar, Baby R.Thapa, Akhtar Mahmood and Safrun Mahmood. "Correlation of G/A-22018 single-nucleotide polymorphism with lactase activity and its usefulness in improving the diagnosis among North Indian children". Genes Nutr. Vol.8(1): 2013, pp.145-151.
[30]	S.Torniainen, M.Hedelin, V.Autio, H.Rasinperä, KA. Bälter, A.Klint, R.Bellocco, F.Viklund, P.Stattin, T.Ikonen, T.L.J. Tammela, J.Schleutker, H.Grönberg and I. Järvelä. "Lactase persistence, dietary intake of milk, and the risk for prostate cancer in Sweden and Finland". Cancer Epidemiol Biomarkers Prev. Vol. 16(5): 2007, pp. 956-61.
[31]	Y.Yoshida, G. Sasaki, S. Goto, S. Yanagiya and K. Takashina. "Studies on the etiology of milk intolerance in Japanese adults". Gastroenterologia Japonica. Vol. 10 (1): 1975, pp 29-34
[32]	R. Qiao, C.Huang, H.Du, G. Zeng, L. Li and S.Ye. "Milk consumption and lactose intolerance in adults". Biomed Environ Sci. Vol. 24(5): 2011, pp. 512-7.

Cite This Article

Plain Text BibTeX RIS

APA Style

Sharaf Kasimov, Margus Lember. (2013). Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan. International Journal of Nutrition and Food Sciences, 2(6), 332-336. https://doi.org/10.11648/j.ijnfs.20130206.21

Copy | Download

ACS Style

Sharaf Kasimov; Margus Lember. Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan. Int. J. Nutr. Food Sci. 2013, 2(6), 332-336. doi: 10.11648/j.ijnfs.20130206.21

Copy | Download

AMA Style

Sharaf Kasimov, Margus Lember. Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan. Int J Nutr Food Sci. 2013;2(6):332-336. doi: 10.11648/j.ijnfs.20130206.21

Copy | Download

@article{10.11648/j.ijnfs.20130206.21,
  author = {Sharaf Kasimov and Margus Lember},
  title = {Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {2},
  number = {6},
  pages = {332-336},
  doi = {10.11648/j.ijnfs.20130206.21},
  url = {https://doi.org/10.11648/j.ijnfs.20130206.21},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20130206.21},
  abstract = {Objective: To determine the prevalence of adult-type hypolactasia in the Tajik population living in the south of Uzbekistan by genotyping of allelic variants C/T-13910 and identifying their tolerance to milk. Methods: 100 ethnic Tajik adults were examined for C/T-13910 single nucleotide polymorphisms using polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire developed to assess dyspepsia after milk and dairy consumption. Results: A genetic marker of hypolactasia - C/C-13910 genotype was detected in 83% of the adult Tajik population. However, despite the high prevalence of lactose intolerance in the Tajik population, the majority consume between 100-200 ml of milk per day. Conclusion: The Tajik population is characterized by a high prevalence of hypolactasia. Milk consumption is not affected by the determined genotypes since people of Tajik ethnicity consume milk in small quantities.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan
AU  - Sharaf Kasimov
AU  - Margus Lember
Y1  - 2013/12/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ijnfs.20130206.21
DO  - 10.11648/j.ijnfs.20130206.21
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 332
EP  - 336
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20130206.21
AB  - Objective: To determine the prevalence of adult-type hypolactasia in the Tajik population living in the south of Uzbekistan by genotyping of allelic variants C/T-13910 and identifying their tolerance to milk. Methods: 100 ethnic Tajik adults were examined for C/T-13910 single nucleotide polymorphisms using polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire developed to assess dyspepsia after milk and dairy consumption. Results: A genetic marker of hypolactasia - C/C-13910 genotype was detected in 83% of the adult Tajik population. However, despite the high prevalence of lactose intolerance in the Tajik population, the majority consume between 100-200 ml of milk per day. Conclusion: The Tajik population is characterized by a high prevalence of hypolactasia. Milk consumption is not affected by the determined genotypes since people of Tajik ethnicity consume milk in small quantities.
VL  - 2
IS  - 6
ER  -

Copy | Download

Author Information

Sharaf Kasimov

Department of Continuing Medical Education for General Practitioners of the Tashkent Institute of Postgraduate Medical Education, Uzbekistan
Margus Lember

Department of Internal Medicine, University of Tartu and University Hospital, Tartu, Estonia

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Sharaf Kasimov, Margus Lember. (2013). Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan. International Journal of Nutrition and Food Sciences, 2(6), 332-336. https://doi.org/10.11648/j.ijnfs.20130206.21

Copy | Download

ACS Style

Sharaf Kasimov; Margus Lember. Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan. Int. J. Nutr. Food Sci. 2013, 2(6), 332-336. doi: 10.11648/j.ijnfs.20130206.21

Copy | Download

AMA Style

Sharaf Kasimov, Margus Lember. Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan. Int J Nutr Food Sci. 2013;2(6):332-336. doi: 10.11648/j.ijnfs.20130206.21

Copy | Download

@article{10.11648/j.ijnfs.20130206.21,
  author = {Sharaf Kasimov and Margus Lember},
  title = {Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {2},
  number = {6},
  pages = {332-336},
  doi = {10.11648/j.ijnfs.20130206.21},
  url = {https://doi.org/10.11648/j.ijnfs.20130206.21},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20130206.21},
  abstract = {Objective: To determine the prevalence of adult-type hypolactasia in the Tajik population living in the south of Uzbekistan by genotyping of allelic variants C/T-13910 and identifying their tolerance to milk. Methods: 100 ethnic Tajik adults were examined for C/T-13910 single nucleotide polymorphisms using polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire developed to assess dyspepsia after milk and dairy consumption. Results: A genetic marker of hypolactasia - C/C-13910 genotype was detected in 83% of the adult Tajik population. However, despite the high prevalence of lactose intolerance in the Tajik population, the majority consume between 100-200 ml of milk per day. Conclusion: The Tajik population is characterized by a high prevalence of hypolactasia. Milk consumption is not affected by the determined genotypes since people of Tajik ethnicity consume milk in small quantities.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan
AU  - Sharaf Kasimov
AU  - Margus Lember
Y1  - 2013/12/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ijnfs.20130206.21
DO  - 10.11648/j.ijnfs.20130206.21
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 332
EP  - 336
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20130206.21
AB  - Objective: To determine the prevalence of adult-type hypolactasia in the Tajik population living in the south of Uzbekistan by genotyping of allelic variants C/T-13910 and identifying their tolerance to milk. Methods: 100 ethnic Tajik adults were examined for C/T-13910 single nucleotide polymorphisms using polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire developed to assess dyspepsia after milk and dairy consumption. Results: A genetic marker of hypolactasia - C/C-13910 genotype was detected in 83% of the adult Tajik population. However, despite the high prevalence of lactose intolerance in the Tajik population, the majority consume between 100-200 ml of milk per day. Conclusion: The Tajik population is characterized by a high prevalence of hypolactasia. Milk consumption is not affected by the determined genotypes since people of Tajik ethnicity consume milk in small quantities.
VL  - 2
IS  - 6
ER  -

Copy | Download