Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet

Teresa Palmisciano Bedê; Vânia Mattoso; Ana Cláudia Pascoal; Eduardo de Salvo Castro; Carlos Alberto Soares da Costa; Gilson Teles Boaventura; Vilma Blondet de Azeredo

doi:doi:10.11648/j.ijnfs.20160503.13

Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet

Teresa Palmisciano Bedê, Vânia Mattoso, Ana Cláudia Pascoal, Eduardo de Salvo Castro, Carlos Alberto Soares da Costa, Gilson Teles Boaventura, Vilma Blondet de Azeredo

Published in International Journal of Nutrition and Food Sciences (Volume 5, Issue 3)

Received: 21 March 2016 Accepted: 31 March 2016 Published: 16 April 2016

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Abstract

High-fat diet contributes to reduction of bone mineral density and development of cardiovascular diseases. High-fat diet promotes the release substrate for formation of atheromatous plaques as well as increase production of cytokines and prostaglandins, interfering negatively in the concentration of osteoprotegerin - responsible for inhibiting the osteoclastogenesis. The interest by functional foods and their effects on diseases prevention is growing. This study evaluated the effect of whole grape juice consumption and red wine in the osteoprotegerin level and blood pressure in rats fed fat diet. They were used 40 rats Wistar Albino, adult, divided in groups: control - balanced diet; hiperlipydic – high-fat diet; wine - red wine + high-fat diet; juice - grape juice + high-fat diet. Water and ration were offered ad libitum and grape juice and red wine daily, during 60 days. Blood pressure was measured by a tail plestimograph and interleukin 6 (IL-6) and osteoprotegerin by ELISA. Results are expressed as mean and standard deviation. For comparison it was used ANOVA and Tukey as post-test, considering p<0.05. Systolic blood pressure (mmHg) was lower in grape juice group than hiperlipydic and red wine groups and similar to control group. IL-6 level (pg/mL) was lower in grape juice group than wine group, but it was similar to control and hiperlipydic groups. Hiperlipydic and wine groups showed lower osteoprotegerin level (pg/mL) than control and juice groups. Daily consumption of grape juice seems minimize the effects of high-fat diet in cardiovascular diseases risk and bone demineralization, by maintaining adequate concentration of osteoprotegerin and the systolic blood pressure in animals.

Published in	International Journal of Nutrition and Food Sciences (Volume 5, Issue 3)
DOI	10.11648/j.ijnfs.20160503.13
Page(s)	170-174
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Polyphenols, Grape Juice, Red Wine, High - Fat Diet, Blood Pressure, Interleucin 6, Osteoprotegerin, Wistar Rats

References

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Teresa Palmisciano Bedê, Vânia Mattoso, Ana Cláudia Pascoal, Eduardo de Salvo Castro, Carlos Alberto Soares da Costa, et al. (2016). Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet. International Journal of Nutrition and Food Sciences, 5(3), 170-174. https://doi.org/10.11648/j.ijnfs.20160503.13

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ACS Style

Teresa Palmisciano Bedê; Vânia Mattoso; Ana Cláudia Pascoal; Eduardo de Salvo Castro; Carlos Alberto Soares da Costa, et al. Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet. Int. J. Nutr. Food Sci. 2016, 5(3), 170-174. doi: 10.11648/j.ijnfs.20160503.13

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Teresa Palmisciano Bedê, Vânia Mattoso, Ana Cláudia Pascoal, Eduardo de Salvo Castro, Carlos Alberto Soares da Costa, et al. Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet. Int J Nutr Food Sci. 2016;5(3):170-174. doi: 10.11648/j.ijnfs.20160503.13

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@article{10.11648/j.ijnfs.20160503.13,
  author = {Teresa Palmisciano Bedê and Vânia Mattoso and Ana Cláudia Pascoal and Eduardo de Salvo Castro and Carlos Alberto Soares da Costa and Gilson Teles Boaventura and Vilma Blondet de Azeredo},
  title = {Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {5},
  number = {3},
  pages = {170-174},
  doi = {10.11648/j.ijnfs.20160503.13},
  url = {https://doi.org/10.11648/j.ijnfs.20160503.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20160503.13},
  abstract = {High-fat diet contributes to reduction of bone mineral density and development of cardiovascular diseases. High-fat diet promotes the release substrate for formation of atheromatous plaques as well as increase production of cytokines and prostaglandins, interfering negatively in the concentration of osteoprotegerin - responsible for inhibiting the osteoclastogenesis. The interest by functional foods and their effects on diseases prevention is growing. This study evaluated the effect of whole grape juice consumption and red wine in the osteoprotegerin level and blood pressure in rats fed fat diet. They were used 40 rats Wistar Albino, adult, divided in groups: control - balanced diet; hiperlipydic – high-fat diet; wine - red wine + high-fat diet; juice - grape juice + high-fat diet. Water and ration were offered ad libitum and grape juice and red wine daily, during 60 days. Blood pressure was measured by a tail plestimograph and interleukin 6 (IL-6) and osteoprotegerin by ELISA. Results are expressed as mean and standard deviation. For comparison it was used ANOVA and Tukey as post-test, considering p<0.05. Systolic blood pressure (mmHg) was lower in grape juice group than hiperlipydic and red wine groups and similar to control group. IL-6 level (pg/mL) was lower in grape juice group than wine group, but it was similar to control and hiperlipydic groups. Hiperlipydic and wine groups showed lower osteoprotegerin level (pg/mL) than control and juice groups. Daily consumption of grape juice seems minimize the effects of high-fat diet in cardiovascular diseases risk and bone demineralization, by maintaining adequate concentration of osteoprotegerin and the systolic blood pressure in animals.},
 year = {2016}
}

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TY - JOUR
T1 - Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet
AU - Teresa Palmisciano Bedê
AU - Vânia Mattoso
AU - Ana Cláudia Pascoal
AU - Eduardo de Salvo Castro
AU - Carlos Alberto Soares da Costa
AU - Gilson Teles Boaventura
AU - Vilma Blondet de Azeredo
Y1 - 2016/04/16
PY - 2016
N1 - https://doi.org/10.11648/j.ijnfs.20160503.13
DO - 10.11648/j.ijnfs.20160503.13
T2 - International Journal of Nutrition and Food Sciences
JF - International Journal of Nutrition and Food Sciences
JO - International Journal of Nutrition and Food Sciences
SP - 170
EP - 174
PB - Science Publishing Group
SN - 2327-2716
UR - https://doi.org/10.11648/j.ijnfs.20160503.13
AB - High-fat diet contributes to reduction of bone mineral density and development of cardiovascular diseases. High-fat diet promotes the release substrate for formation of atheromatous plaques as well as increase production of cytokines and prostaglandins, interfering negatively in the concentration of osteoprotegerin - responsible for inhibiting the osteoclastogenesis. The interest by functional foods and their effects on diseases prevention is growing. This study evaluated the effect of whole grape juice consumption and red wine in the osteoprotegerin level and blood pressure in rats fed fat diet. They were used 40 rats Wistar Albino, adult, divided in groups: control - balanced diet; hiperlipydic – high-fat diet; wine - red wine + high-fat diet; juice - grape juice + high-fat diet. Water and ration were offered ad libitum and grape juice and red wine daily, during 60 days. Blood pressure was measured by a tail plestimograph and interleukin 6 (IL-6) and osteoprotegerin by ELISA. Results are expressed as mean and standard deviation. For comparison it was used ANOVA and Tukey as post-test, considering p<0.05. Systolic blood pressure (mmHg) was lower in grape juice group than hiperlipydic and red wine groups and similar to control group. IL-6 level (pg/mL) was lower in grape juice group than wine group, but it was similar to control and hiperlipydic groups. Hiperlipydic and wine groups showed lower osteoprotegerin level (pg/mL) than control and juice groups. Daily consumption of grape juice seems minimize the effects of high-fat diet in cardiovascular diseases risk and bone demineralization, by maintaining adequate concentration of osteoprotegerin and the systolic blood pressure in animals.
VL - 5
IS - 3
ER -

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Author Information

Teresa Palmisciano Bedê

Department of Nutrition and Dietetics, Federal Fluminense University, Niteroi, Brazil
Vânia Mattoso
Ana Cláudia Pascoal

Department of Nutrition and Dietetics, Federal Fluminense University, Niteroi, Brazil
Eduardo de Salvo Castro

Department of Nutrition and Dietetics, Federal Fluminense University, Niteroi, Brazil
Carlos Alberto Soares da Costa

Department of Nutrition and Dietetics, Federal Fluminense University, Niteroi, Brazil
Gilson Teles Boaventura

Department of Nutrition and Dietetics, Federal Fluminense University, Niteroi, Brazil
Vilma Blondet de Azeredo

Department of Nutrition and Dietetics, Federal Fluminense University, Niteroi, Brazil

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APA Style

Teresa Palmisciano Bedê, Vânia Mattoso, Ana Cláudia Pascoal, Eduardo de Salvo Castro, Carlos Alberto Soares da Costa, et al. (2016). Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet. International Journal of Nutrition and Food Sciences, 5(3), 170-174. https://doi.org/10.11648/j.ijnfs.20160503.13

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Teresa Palmisciano Bedê; Vânia Mattoso; Ana Cláudia Pascoal; Eduardo de Salvo Castro; Carlos Alberto Soares da Costa, et al. Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet. Int. J. Nutr. Food Sci. 2016, 5(3), 170-174. doi: 10.11648/j.ijnfs.20160503.13

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AMA Style

Teresa Palmisciano Bedê, Vânia Mattoso, Ana Cláudia Pascoal, Eduardo de Salvo Castro, Carlos Alberto Soares da Costa, et al. Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet. Int J Nutr Food Sci. 2016;5(3):170-174. doi: 10.11648/j.ijnfs.20160503.13

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@article{10.11648/j.ijnfs.20160503.13,
  author = {Teresa Palmisciano Bedê and Vânia Mattoso and Ana Cláudia Pascoal and Eduardo de Salvo Castro and Carlos Alberto Soares da Costa and Gilson Teles Boaventura and Vilma Blondet de Azeredo},
  title = {Effect of Grape Juice Consumption and Red Wine in the Osteoprotegerin Level and Systolic Blood Pressure in Rats Wistar Fed High - Fat Diet},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {5},
  number = {3},
  pages = {170-174},
  doi = {10.11648/j.ijnfs.20160503.13},
  url = {https://doi.org/10.11648/j.ijnfs.20160503.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20160503.13},
  abstract = {High-fat diet contributes to reduction of bone mineral density and development of cardiovascular diseases. High-fat diet promotes the release substrate for formation of atheromatous plaques as well as increase production of cytokines and prostaglandins, interfering negatively in the concentration of osteoprotegerin - responsible for inhibiting the osteoclastogenesis. The interest by functional foods and their effects on diseases prevention is growing. This study evaluated the effect of whole grape juice consumption and red wine in the osteoprotegerin level and blood pressure in rats fed fat diet. They were used 40 rats Wistar Albino, adult, divided in groups: control - balanced diet; hiperlipydic – high-fat diet; wine - red wine + high-fat diet; juice - grape juice + high-fat diet. Water and ration were offered ad libitum and grape juice and red wine daily, during 60 days. Blood pressure was measured by a tail plestimograph and interleukin 6 (IL-6) and osteoprotegerin by ELISA. Results are expressed as mean and standard deviation. For comparison it was used ANOVA and Tukey as post-test, considering p<0.05. Systolic blood pressure (mmHg) was lower in grape juice group than hiperlipydic and red wine groups and similar to control group. IL-6 level (pg/mL) was lower in grape juice group than wine group, but it was similar to control and hiperlipydic groups. Hiperlipydic and wine groups showed lower osteoprotegerin level (pg/mL) than control and juice groups. Daily consumption of grape juice seems minimize the effects of high-fat diet in cardiovascular diseases risk and bone demineralization, by maintaining adequate concentration of osteoprotegerin and the systolic blood pressure in animals.},
 year = {2016}
}

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