Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of <i>Oroxylum indicum</i>

Md. Mamun-Or-Rashid; Md. Shah Amran; Md. Aslam Hossain

doi:doi:10.11648/j.ijpp.20170101.14

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Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum

Md. Mamun-Or-Rashid, Md. Shah Amran, Md. Aslam Hossain

Published in International Journal of Photochemistry and Photobiology (Volume 1, Issue 1)

Received: 4 January 2017 Accepted: 17 January 2017 Published: 2 March 2017

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Abstract

Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea [1]. In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree [2]. Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine [3]. The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. [4] The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.

Published in	International Journal of Photochemistry and Photobiology (Volume 1, Issue 1)
DOI	10.11648/j.ijpp.20170101.14
Page(s)	21-26
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Oroxylum indicum, Antidiarrheal Activity, Methanolic Extract

References

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Md. Mamun-Or-Rashid, Md. Shah Amran, Md. Aslam Hossain. (2017). Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum. International Journal of Photochemistry and Photobiology, 1(1), 21-26. https://doi.org/10.11648/j.ijpp.20170101.14

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ACS Style

Md. Mamun-Or-Rashid; Md. Shah Amran; Md. Aslam Hossain. Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum. Int. J. Photochem. Photobiol. 2017, 1(1), 21-26. doi: 10.11648/j.ijpp.20170101.14

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AMA Style

Md. Mamun-Or-Rashid, Md. Shah Amran, Md. Aslam Hossain. Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum. Int J Photochem Photobiol. 2017;1(1):21-26. doi: 10.11648/j.ijpp.20170101.14

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@article{10.11648/j.ijpp.20170101.14,
  author = {Md. Mamun-Or-Rashid and Md. Shah Amran and Md. Aslam Hossain},
  title = {Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum},
  journal = {International Journal of Photochemistry and Photobiology},
  volume = {1},
  number = {1},
  pages = {21-26},
  doi = {10.11648/j.ijpp.20170101.14},
  url = {https://doi.org/10.11648/j.ijpp.20170101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpp.20170101.14},
  abstract = {Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea [1]. In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree [2]. Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine [3]. The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. [4] The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.},
 year = {2017}
}

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TY  - JOUR
T1  - Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum
AU  - Md. Mamun-Or-Rashid
AU  - Md. Shah Amran
AU  - Md. Aslam Hossain
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DO  - 10.11648/j.ijpp.20170101.14
T2  - International Journal of Photochemistry and Photobiology
JF  - International Journal of Photochemistry and Photobiology
JO  - International Journal of Photochemistry and Photobiology
SP  - 21
EP  - 26
PB  - Science Publishing Group
SN  - 2640-429X
UR  - https://doi.org/10.11648/j.ijpp.20170101.14
AB  - Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea [1]. In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree [2]. Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine [3]. The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. [4] The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.
VL  - 1
IS  - 1
ER  -

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Author Information

Md. Mamun-Or-Rashid

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh
Md. Shah Amran

mamunpdu@gmail.com
Md. Aslam Hossain

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

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Md. Mamun-Or-Rashid, Md. Shah Amran, Md. Aslam Hossain. (2017). Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum. International Journal of Photochemistry and Photobiology, 1(1), 21-26. https://doi.org/10.11648/j.ijpp.20170101.14

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ACS Style

Md. Mamun-Or-Rashid; Md. Shah Amran; Md. Aslam Hossain. Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum. Int. J. Photochem. Photobiol. 2017, 1(1), 21-26. doi: 10.11648/j.ijpp.20170101.14

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AMA Style

Md. Mamun-Or-Rashid, Md. Shah Amran, Md. Aslam Hossain. Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum. Int J Photochem Photobiol. 2017;1(1):21-26. doi: 10.11648/j.ijpp.20170101.14

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@article{10.11648/j.ijpp.20170101.14,
  author = {Md. Mamun-Or-Rashid and Md. Shah Amran and Md. Aslam Hossain},
  title = {Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum},
  journal = {International Journal of Photochemistry and Photobiology},
  volume = {1},
  number = {1},
  pages = {21-26},
  doi = {10.11648/j.ijpp.20170101.14},
  url = {https://doi.org/10.11648/j.ijpp.20170101.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpp.20170101.14},
  abstract = {Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea [1]. In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree [2]. Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine [3]. The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. [4] The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.},
 year = {2017}
}

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TY  - JOUR
T1  - Evaluation of Anti-diarrheal Activity of Crude Extracts and Different Fractions of Stem Bark and Fruits of Oroxylum indicum
AU  - Md. Mamun-Or-Rashid
AU  - Md. Shah Amran
AU  - Md. Aslam Hossain
Y1  - 2017/03/02
PY  - 2017
N1  - https://doi.org/10.11648/j.ijpp.20170101.14
DO  - 10.11648/j.ijpp.20170101.14
T2  - International Journal of Photochemistry and Photobiology
JF  - International Journal of Photochemistry and Photobiology
JO  - International Journal of Photochemistry and Photobiology
SP  - 21
EP  - 26
PB  - Science Publishing Group
SN  - 2640-429X
UR  - https://doi.org/10.11648/j.ijpp.20170101.14
AB  - Abnormal passage of liquid or unformed stool at an increased frequency is termed as diarrhea: Infectious agents, certain medications, plant and animal toxins, gastrointestinal disorders, and substances that enhance gastrointestinal tract secretions are may be the triggers of diarrhea [1]. In recent times, medicinal plants occupy a considerable position for being the paramount sources of drug discovery irrespective of its categorized groups- herb, shrub or tree [2]. Oroxylum indicum (Linn.) Vent is widely used in Ayurvedic system of medicine [3]. The crude methanolic extract of Oroxylum indicum bark and fruits with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, antihelmentic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. [4] The antidiarrheal activity of methanolic bark and fruits extract and its different fractions of Oroxylum indicum (Ethyl acetate fraction, Dichloromethane fraction, Hexane fraction, Carbon tetrachloride fraction) (400mg/kg) cause reduction of diarrheal feces by 46.5%, 32.6%, 45.3%, 33.7%, 51.2%, respectively compared to standard Loperamide (82.6%). This reveals that methanol extracts of bark and fruits of Oroxylum indicum showed significant antidiarrheal activity.
VL  - 1
IS  - 1
ER  -

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