Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis

Entela Treska; Alma Koci

doi:doi:10.11648/j.ijsqa.20150101.11

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Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis

Entela Treska, Alma Koci

Published in International Journal of Science and Qualitative Analysis (Volume 1, Issue 1)

Received: 11 May 2015 Accepted: 18 May 2015 Published: 22 May 2015

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Abstract

The aim of the study is the evaluation of serum Alkaline Phosphatase and Gamma-glutamyl Transferase levels in pregnant women as indicators of cholestasis. Cholestasis is defined as a decrease in bile flow due to the obstruction of it through intra/extra hepatic bile ducts. GGT enzyme was previously thought to be helpful in confirming a hepatic source of ALP however, GGT elevations lack the necessary specificity to be a useful confirmatory test for ALP. We analyzed 500 cases of pregnant women from year 2011-2013. Serum enzyme levels (ALP and GGT) were measured respectively using Beckman Synchron LX 20 and Enzymatic method Activity Colorimetric Kit, at the Medical Laboratory “PhD. Stelijan Buzo” in Tirana. According to the laboratory reference values of ALP (100-290 U/L): 50% of the cases resulted normally pregnant women, 50% suffering from liver disease (<100 U/L or >290 U/L); whereas according to values of GGT (8-31 U/L): 75% resulted normally pregnant women, 25% with liver damage (<8 U/L or >31 U/L). Micronutrients deficiency leads to irreversible disorders of development; Nutritional advice would have been more effective either for the mother and the future of her child. There are few reported cases of young mothers, with sufficient income, which limit some foods due to fear of increasing body weight, while forgetting that the lack of appropriate micro-nutrients, directly affects the health of growing babies.

Published in	International Journal of Science and Qualitative Analysis (Volume 1, Issue 1)
DOI	10.11648/j.ijsqa.20150101.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Cholestasis, ALP Assay Protocol, GGT Assay Protocol, Cholestatic Enzymes, Enzymes and Pregnancy

References

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[19]	Tate SS, Meister A "gamma-Glutamyl transpeptidase from kidney".Methods in Enzymology 113: 400–419. doi:10.1016/S0076-6879(85)13053-3.ISBN 978-0-12-182013-8. PMID 2868390, (1985).
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APA Style

Entela Treska, Alma Koci. (2015). Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis. International Journal of Science and Qualitative Analysis, 1(1), 1-5. https://doi.org/10.11648/j.ijsqa.20150101.11

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ACS Style

Entela Treska; Alma Koci. Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis. Int. J. Sci. Qual. Anal. 2015, 1(1), 1-5. doi: 10.11648/j.ijsqa.20150101.11

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AMA Style

Entela Treska, Alma Koci. Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis. Int J Sci Qual Anal. 2015;1(1):1-5. doi: 10.11648/j.ijsqa.20150101.11

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@article{10.11648/j.ijsqa.20150101.11,
  author = {Entela Treska and Alma Koci},
  title = {Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis},
  journal = {International Journal of Science and Qualitative Analysis},
  volume = {1},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijsqa.20150101.11},
  url = {https://doi.org/10.11648/j.ijsqa.20150101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijsqa.20150101.11},
  abstract = {The aim of the study is the evaluation of serum Alkaline Phosphatase and Gamma-glutamyl Transferase levels in pregnant women as indicators of cholestasis. Cholestasis is defined as a decrease in bile flow due to the obstruction of it through intra/extra hepatic bile ducts. GGT enzyme was previously thought to be helpful in confirming a hepatic source of ALP however, GGT elevations lack the necessary specificity to be a useful confirmatory test for ALP. We analyzed 500 cases of pregnant women from year 2011-2013. Serum enzyme levels (ALP and GGT) were measured respectively using Beckman Synchron LX 20 and Enzymatic method Activity Colorimetric Kit, at the Medical Laboratory “PhD. Stelijan Buzo” in Tirana. According to the laboratory reference values of ALP (100-290 U/L): 50% of the cases resulted normally pregnant women, 50% suffering from liver disease (290 U/L); whereas according to values of GGT (8-31 U/L): 75% resulted normally pregnant women, 25% with liver damage (31 U/L). Micronutrients deficiency leads to irreversible disorders of development; Nutritional advice would have been more effective either for the mother and the future of her child. There are few reported cases of young mothers, with sufficient income, which limit some foods due to fear of increasing body weight, while forgetting that the lack of appropriate micro-nutrients, directly affects the health of growing babies.},
 year = {2015}
}

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TY  - JOUR
T1  - Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis
AU  - Entela Treska
AU  - Alma Koci
Y1  - 2015/05/22
PY  - 2015
N1  - https://doi.org/10.11648/j.ijsqa.20150101.11
DO  - 10.11648/j.ijsqa.20150101.11
T2  - International Journal of Science and Qualitative Analysis
JF  - International Journal of Science and Qualitative Analysis
JO  - International Journal of Science and Qualitative Analysis
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2469-8164
UR  - https://doi.org/10.11648/j.ijsqa.20150101.11
AB  - The aim of the study is the evaluation of serum Alkaline Phosphatase and Gamma-glutamyl Transferase levels in pregnant women as indicators of cholestasis. Cholestasis is defined as a decrease in bile flow due to the obstruction of it through intra/extra hepatic bile ducts. GGT enzyme was previously thought to be helpful in confirming a hepatic source of ALP however, GGT elevations lack the necessary specificity to be a useful confirmatory test for ALP. We analyzed 500 cases of pregnant women from year 2011-2013. Serum enzyme levels (ALP and GGT) were measured respectively using Beckman Synchron LX 20 and Enzymatic method Activity Colorimetric Kit, at the Medical Laboratory “PhD. Stelijan Buzo” in Tirana. According to the laboratory reference values of ALP (100-290 U/L): 50% of the cases resulted normally pregnant women, 50% suffering from liver disease (290 U/L); whereas according to values of GGT (8-31 U/L): 75% resulted normally pregnant women, 25% with liver damage (31 U/L). Micronutrients deficiency leads to irreversible disorders of development; Nutritional advice would have been more effective either for the mother and the future of her child. There are few reported cases of young mothers, with sufficient income, which limit some foods due to fear of increasing body weight, while forgetting that the lack of appropriate micro-nutrients, directly affects the health of growing babies.
VL  - 1
IS  - 1
ER  -

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Author Information

Entela Treska

University Hospital of Obstetrics and Gynaecology “Queen Geraldine”, Tirana, Albania
Alma Koci

Clinical and Biochemical Laboratory, Health Centre nr 2, Tirana, Albania

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Plain Text BibTeX RIS

APA Style

Entela Treska, Alma Koci. (2015). Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis. International Journal of Science and Qualitative Analysis, 1(1), 1-5. https://doi.org/10.11648/j.ijsqa.20150101.11

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ACS Style

Entela Treska; Alma Koci. Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis. Int. J. Sci. Qual. Anal. 2015, 1(1), 1-5. doi: 10.11648/j.ijsqa.20150101.11

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AMA Style

Entela Treska, Alma Koci. Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis. Int J Sci Qual Anal. 2015;1(1):1-5. doi: 10.11648/j.ijsqa.20150101.11

Copy | Download

@article{10.11648/j.ijsqa.20150101.11,
  author = {Entela Treska and Alma Koci},
  title = {Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis},
  journal = {International Journal of Science and Qualitative Analysis},
  volume = {1},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijsqa.20150101.11},
  url = {https://doi.org/10.11648/j.ijsqa.20150101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijsqa.20150101.11},
  abstract = {The aim of the study is the evaluation of serum Alkaline Phosphatase and Gamma-glutamyl Transferase levels in pregnant women as indicators of cholestasis. Cholestasis is defined as a decrease in bile flow due to the obstruction of it through intra/extra hepatic bile ducts. GGT enzyme was previously thought to be helpful in confirming a hepatic source of ALP however, GGT elevations lack the necessary specificity to be a useful confirmatory test for ALP. We analyzed 500 cases of pregnant women from year 2011-2013. Serum enzyme levels (ALP and GGT) were measured respectively using Beckman Synchron LX 20 and Enzymatic method Activity Colorimetric Kit, at the Medical Laboratory “PhD. Stelijan Buzo” in Tirana. According to the laboratory reference values of ALP (100-290 U/L): 50% of the cases resulted normally pregnant women, 50% suffering from liver disease (290 U/L); whereas according to values of GGT (8-31 U/L): 75% resulted normally pregnant women, 25% with liver damage (31 U/L). Micronutrients deficiency leads to irreversible disorders of development; Nutritional advice would have been more effective either for the mother and the future of her child. There are few reported cases of young mothers, with sufficient income, which limit some foods due to fear of increasing body weight, while forgetting that the lack of appropriate micro-nutrients, directly affects the health of growing babies.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Cholestasis Detection Enzyme Tests, in Pregnant Women with Different Hospitalization Diagnosis
AU  - Entela Treska
AU  - Alma Koci
Y1  - 2015/05/22
PY  - 2015
N1  - https://doi.org/10.11648/j.ijsqa.20150101.11
DO  - 10.11648/j.ijsqa.20150101.11
T2  - International Journal of Science and Qualitative Analysis
JF  - International Journal of Science and Qualitative Analysis
JO  - International Journal of Science and Qualitative Analysis
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2469-8164
UR  - https://doi.org/10.11648/j.ijsqa.20150101.11
AB  - The aim of the study is the evaluation of serum Alkaline Phosphatase and Gamma-glutamyl Transferase levels in pregnant women as indicators of cholestasis. Cholestasis is defined as a decrease in bile flow due to the obstruction of it through intra/extra hepatic bile ducts. GGT enzyme was previously thought to be helpful in confirming a hepatic source of ALP however, GGT elevations lack the necessary specificity to be a useful confirmatory test for ALP. We analyzed 500 cases of pregnant women from year 2011-2013. Serum enzyme levels (ALP and GGT) were measured respectively using Beckman Synchron LX 20 and Enzymatic method Activity Colorimetric Kit, at the Medical Laboratory “PhD. Stelijan Buzo” in Tirana. According to the laboratory reference values of ALP (100-290 U/L): 50% of the cases resulted normally pregnant women, 50% suffering from liver disease (290 U/L); whereas according to values of GGT (8-31 U/L): 75% resulted normally pregnant women, 25% with liver damage (31 U/L). Micronutrients deficiency leads to irreversible disorders of development; Nutritional advice would have been more effective either for the mother and the future of her child. There are few reported cases of young mothers, with sufficient income, which limit some foods due to fear of increasing body weight, while forgetting that the lack of appropriate micro-nutrients, directly affects the health of growing babies.
VL  - 1
IS  - 1
ER  -

Copy | Download