A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma

Yayoi Fukuda; Hitomi Nakamura; Keiichi Kumasawa; Tadashi Kimura

doi:doi:10.11648/j.jgo.20190703.17

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A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma

Yayoi Fukuda, Hitomi Nakamura, Keiichi Kumasawa, Tadashi Kimura

Published in Journal of Gynecology and Obstetrics (Volume 7, Issue 3)

Received: 27 March 2019 Accepted: 11 May 2019 Published: 12 June 2019

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Abstract

Granulocyte colony-stimulating factor (G-CSF) is cytokine which belongs to the family of colony-stimulating factors and recombinant human G-CSF has been widely used in clinical practice for treating patients with neutropenia for over 20 years. Recently, it has also seen use in assisted reproductive technology (ART) treatment based on the hypothesis that G-CSF might help the uterine endometrium proliferate and prepare for implantation. However, the risk of this treatment has not been fully assessed yet and there is a potential complication with its usage. It has been reported that G-CSF stimulates cell proliferation in hematopoietic cells and various other cell types, including cancer cells, suggesting that repeated local G-CSF administration into the uterine cavity might raises the risk of contracting uterine endometrial carcinoma. Based on this hypothesis, we assessed the effect of G-CSF on human uterine carcinoma cell proliferation, using cell lines. Our study showed that G-CSF administration produced dose-dependent suppression of proliferation of human uterine endometrial carcinoma cells through a G-CSF receptor-independent mechanism via a part of mitogen-activated protein kinase (MAPK) signaling pathway. While further studies will be needed to confirm G-CSFs efficacy in improving the outcomes of ART treatment, our data at least suggests that repeated G-CSF administration does not increase the risk of uterine endometrial carcinoma and may even lower it.

Published in	Journal of Gynecology and Obstetrics (Volume 7, Issue 3)
DOI	10.11648/j.jgo.20190703.17
Page(s)	92-99
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Granulocyte Colony-stimulating Factor (G-CSF), Uterine Endometrial Carcinoma, Assisted Reproductive Technology (ART) Treatment

References

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APA Style

Yayoi Fukuda, Hitomi Nakamura, Keiichi Kumasawa, Tadashi Kimura. (2019). A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma. Journal of Gynecology and Obstetrics, 7(3), 92-99. https://doi.org/10.11648/j.jgo.20190703.17

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ACS Style

Yayoi Fukuda; Hitomi Nakamura; Keiichi Kumasawa; Tadashi Kimura. A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma. J. Gynecol. Obstet. 2019, 7(3), 92-99. doi: 10.11648/j.jgo.20190703.17

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AMA Style

Yayoi Fukuda, Hitomi Nakamura, Keiichi Kumasawa, Tadashi Kimura. A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma. J Gynecol Obstet. 2019;7(3):92-99. doi: 10.11648/j.jgo.20190703.17

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@article{10.11648/j.jgo.20190703.17,
  author = {Yayoi Fukuda and Hitomi Nakamura and Keiichi Kumasawa and Tadashi Kimura},
  title = {A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {7},
  number = {3},
  pages = {92-99},
  doi = {10.11648/j.jgo.20190703.17},
  url = {https://doi.org/10.11648/j.jgo.20190703.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190703.17},
  abstract = {Granulocyte colony-stimulating factor (G-CSF) is cytokine which belongs to the family of colony-stimulating factors and recombinant human G-CSF has been widely used in clinical practice for treating patients with neutropenia for over 20 years. Recently, it has also seen use in assisted reproductive technology (ART) treatment based on the hypothesis that G-CSF might help the uterine endometrium proliferate and prepare for implantation. However, the risk of this treatment has not been fully assessed yet and there is a potential complication with its usage. It has been reported that G-CSF stimulates cell proliferation in hematopoietic cells and various other cell types, including cancer cells, suggesting that repeated local G-CSF administration into the uterine cavity might raises the risk of contracting uterine endometrial carcinoma. Based on this hypothesis, we assessed the effect of G-CSF on human uterine carcinoma cell proliferation, using cell lines. Our study showed that G-CSF administration produced dose-dependent suppression of proliferation of human uterine endometrial carcinoma cells through a G-CSF receptor-independent mechanism via a part of mitogen-activated protein kinase (MAPK) signaling pathway. While further studies will be needed to confirm G-CSFs efficacy in improving the outcomes of ART treatment, our data at least suggests that repeated G-CSF administration does not increase the risk of uterine endometrial carcinoma and may even lower it.},
 year = {2019}
}

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TY  - JOUR
T1  - A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma
AU  - Yayoi Fukuda
AU  - Hitomi Nakamura
AU  - Keiichi Kumasawa
AU  - Tadashi Kimura
Y1  - 2019/06/12
PY  - 2019
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DO  - 10.11648/j.jgo.20190703.17
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 92
EP  - 99
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20190703.17
AB  - Granulocyte colony-stimulating factor (G-CSF) is cytokine which belongs to the family of colony-stimulating factors and recombinant human G-CSF has been widely used in clinical practice for treating patients with neutropenia for over 20 years. Recently, it has also seen use in assisted reproductive technology (ART) treatment based on the hypothesis that G-CSF might help the uterine endometrium proliferate and prepare for implantation. However, the risk of this treatment has not been fully assessed yet and there is a potential complication with its usage. It has been reported that G-CSF stimulates cell proliferation in hematopoietic cells and various other cell types, including cancer cells, suggesting that repeated local G-CSF administration into the uterine cavity might raises the risk of contracting uterine endometrial carcinoma. Based on this hypothesis, we assessed the effect of G-CSF on human uterine carcinoma cell proliferation, using cell lines. Our study showed that G-CSF administration produced dose-dependent suppression of proliferation of human uterine endometrial carcinoma cells through a G-CSF receptor-independent mechanism via a part of mitogen-activated protein kinase (MAPK) signaling pathway. While further studies will be needed to confirm G-CSFs efficacy in improving the outcomes of ART treatment, our data at least suggests that repeated G-CSF administration does not increase the risk of uterine endometrial carcinoma and may even lower it.
VL  - 7
IS  - 3
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Author Information

Yayoi Fukuda

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Hitomi Nakamura

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Keiichi Kumasawa

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
Tadashi Kimura

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan

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APA Style

Yayoi Fukuda, Hitomi Nakamura, Keiichi Kumasawa, Tadashi Kimura. (2019). A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma. Journal of Gynecology and Obstetrics, 7(3), 92-99. https://doi.org/10.11648/j.jgo.20190703.17

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ACS Style

Yayoi Fukuda; Hitomi Nakamura; Keiichi Kumasawa; Tadashi Kimura. A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma. J. Gynecol. Obstet. 2019, 7(3), 92-99. doi: 10.11648/j.jgo.20190703.17

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AMA Style

Yayoi Fukuda, Hitomi Nakamura, Keiichi Kumasawa, Tadashi Kimura. A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma. J Gynecol Obstet. 2019;7(3):92-99. doi: 10.11648/j.jgo.20190703.17

Copy | Download

@article{10.11648/j.jgo.20190703.17,
  author = {Yayoi Fukuda and Hitomi Nakamura and Keiichi Kumasawa and Tadashi Kimura},
  title = {A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {7},
  number = {3},
  pages = {92-99},
  doi = {10.11648/j.jgo.20190703.17},
  url = {https://doi.org/10.11648/j.jgo.20190703.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190703.17},
  abstract = {Granulocyte colony-stimulating factor (G-CSF) is cytokine which belongs to the family of colony-stimulating factors and recombinant human G-CSF has been widely used in clinical practice for treating patients with neutropenia for over 20 years. Recently, it has also seen use in assisted reproductive technology (ART) treatment based on the hypothesis that G-CSF might help the uterine endometrium proliferate and prepare for implantation. However, the risk of this treatment has not been fully assessed yet and there is a potential complication with its usage. It has been reported that G-CSF stimulates cell proliferation in hematopoietic cells and various other cell types, including cancer cells, suggesting that repeated local G-CSF administration into the uterine cavity might raises the risk of contracting uterine endometrial carcinoma. Based on this hypothesis, we assessed the effect of G-CSF on human uterine carcinoma cell proliferation, using cell lines. Our study showed that G-CSF administration produced dose-dependent suppression of proliferation of human uterine endometrial carcinoma cells through a G-CSF receptor-independent mechanism via a part of mitogen-activated protein kinase (MAPK) signaling pathway. While further studies will be needed to confirm G-CSFs efficacy in improving the outcomes of ART treatment, our data at least suggests that repeated G-CSF administration does not increase the risk of uterine endometrial carcinoma and may even lower it.},
 year = {2019}
}

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TY  - JOUR
T1  - A New Function of Granulocyte Colony-stimulating Factor (G-CSF): Suppression of Cell Proliferation in Uterine Endometrial Carcinoma
AU  - Yayoi Fukuda
AU  - Hitomi Nakamura
AU  - Keiichi Kumasawa
AU  - Tadashi Kimura
Y1  - 2019/06/12
PY  - 2019
N1  - https://doi.org/10.11648/j.jgo.20190703.17
DO  - 10.11648/j.jgo.20190703.17
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 92
EP  - 99
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20190703.17
AB  - Granulocyte colony-stimulating factor (G-CSF) is cytokine which belongs to the family of colony-stimulating factors and recombinant human G-CSF has been widely used in clinical practice for treating patients with neutropenia for over 20 years. Recently, it has also seen use in assisted reproductive technology (ART) treatment based on the hypothesis that G-CSF might help the uterine endometrium proliferate and prepare for implantation. However, the risk of this treatment has not been fully assessed yet and there is a potential complication with its usage. It has been reported that G-CSF stimulates cell proliferation in hematopoietic cells and various other cell types, including cancer cells, suggesting that repeated local G-CSF administration into the uterine cavity might raises the risk of contracting uterine endometrial carcinoma. Based on this hypothesis, we assessed the effect of G-CSF on human uterine carcinoma cell proliferation, using cell lines. Our study showed that G-CSF administration produced dose-dependent suppression of proliferation of human uterine endometrial carcinoma cells through a G-CSF receptor-independent mechanism via a part of mitogen-activated protein kinase (MAPK) signaling pathway. While further studies will be needed to confirm G-CSFs efficacy in improving the outcomes of ART treatment, our data at least suggests that repeated G-CSF administration does not increase the risk of uterine endometrial carcinoma and may even lower it.
VL  - 7
IS  - 3
ER  -

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