Xanthogranuloma is a benign disorder that is considered to be a very rare event when it happens in the female reproductive organs. It can mimic adnexal tumors clinically and radiologically. The vulva, the vagina, the cervix or the endometrium can be involved. It is a process during which the tissues are infiltrated by lipid-laden histiocytes mixed with lymphocytes, plasma cells and polymorphonuclear leucocytes. In this article, we are reporting a rare case of an adult xanthogranulomatous inflammation of the uterine cervix with a detailed clinical, pathologic, radiologic and follow up data. A 46-year-old lady presented with vaginal bleeding, dysmenorrhea and pelvic heaviness. She underwent a diagnostic dilation and curetting at a peripheral hospital due to increased endometrial thickness on ultrasound. Then, she was misdiagnosed with a diffused large B cell lymphoma (Non-Hodgkin Lymphoma) and was treated with two cycles of chemotherapy. At our department, abdominopelvic ultrasound and CT scan showed a 10 x 9.4 cm round cervical mass associated with hydronephrosis. A cervical biopsy was also taken turned back with a pseudotumoral xanthogranulomatous cervicitis. Consequently, a hysterectomy with bilateral salpingo oophorectomy was decided and performed taking into consideration the possibility of a coexistent associated malignancy of the reproductive organs. In contrast with juvenile xanthogranuloma, we could not have expected from our case of adult xanthogranuloma to regress. Finally, more studies and reported cases are needed in order to assess the adequate management and utility of radiotherapy/chemotherapy in such cases of Xanthogranulomatous inflammation of the female genital tract.
| Published in | Journal of Gynecology and Obstetrics (Volume 7, Issue 5) |
| DOI | 10.11648/j.jgo.20190705.11 |
| Page(s) | 125-129 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Cervical Adult Xanthogranuloma, Pseudotumoral Xanthogranulomatous Cervicitis, Associated Malignancy, Female Genital Tract
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APA Style
Georges Wehbe, Jessie Darido, Mohammad Khaled Ramadan, Rabih Chahine, Ahmad Estaitieh, et al. (2019). Benign Reactive Xanthogranuloma of the Cervix, a Rare Tumor of the Female Genital Tract in a Case Report. Journal of Gynecology and Obstetrics, 7(5), 125-129. https://doi.org/10.11648/j.jgo.20190705.11
ACS Style
Georges Wehbe; Jessie Darido; Mohammad Khaled Ramadan; Rabih Chahine; Ahmad Estaitieh, et al. Benign Reactive Xanthogranuloma of the Cervix, a Rare Tumor of the Female Genital Tract in a Case Report. J. Gynecol. Obstet. 2019, 7(5), 125-129. doi: 10.11648/j.jgo.20190705.11
AMA Style
Georges Wehbe, Jessie Darido, Mohammad Khaled Ramadan, Rabih Chahine, Ahmad Estaitieh, et al. Benign Reactive Xanthogranuloma of the Cervix, a Rare Tumor of the Female Genital Tract in a Case Report. J Gynecol Obstet. 2019;7(5):125-129. doi: 10.11648/j.jgo.20190705.11
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Download@article{10.11648/j.jgo.20190705.11,
author = {Georges Wehbe and Jessie Darido and Mohammad Khaled Ramadan and Rabih Chahine and Ahmad Estaitieh and Ahmad Lakis and Omar Sheikh and Khaled Habib and Saad El Daou and Nicolas Haddad},
title = {Benign Reactive Xanthogranuloma of the Cervix, a Rare Tumor of the Female Genital Tract in a Case Report},
journal = {Journal of Gynecology and Obstetrics},
volume = {7},
number = {5},
pages = {125-129},
doi = {10.11648/j.jgo.20190705.11},
url = {https://doi.org/10.11648/j.jgo.20190705.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190705.11},
abstract = {Xanthogranuloma is a benign disorder that is considered to be a very rare event when it happens in the female reproductive organs. It can mimic adnexal tumors clinically and radiologically. The vulva, the vagina, the cervix or the endometrium can be involved. It is a process during which the tissues are infiltrated by lipid-laden histiocytes mixed with lymphocytes, plasma cells and polymorphonuclear leucocytes. In this article, we are reporting a rare case of an adult xanthogranulomatous inflammation of the uterine cervix with a detailed clinical, pathologic, radiologic and follow up data. A 46-year-old lady presented with vaginal bleeding, dysmenorrhea and pelvic heaviness. She underwent a diagnostic dilation and curetting at a peripheral hospital due to increased endometrial thickness on ultrasound. Then, she was misdiagnosed with a diffused large B cell lymphoma (Non-Hodgkin Lymphoma) and was treated with two cycles of chemotherapy. At our department, abdominopelvic ultrasound and CT scan showed a 10 x 9.4 cm round cervical mass associated with hydronephrosis. A cervical biopsy was also taken turned back with a pseudotumoral xanthogranulomatous cervicitis. Consequently, a hysterectomy with bilateral salpingo oophorectomy was decided and performed taking into consideration the possibility of a coexistent associated malignancy of the reproductive organs. In contrast with juvenile xanthogranuloma, we could not have expected from our case of adult xanthogranuloma to regress. Finally, more studies and reported cases are needed in order to assess the adequate management and utility of radiotherapy/chemotherapy in such cases of Xanthogranulomatous inflammation of the female genital tract.},
year = {2019}
}
TY - JOUR T1 - Benign Reactive Xanthogranuloma of the Cervix, a Rare Tumor of the Female Genital Tract in a Case Report AU - Georges Wehbe AU - Jessie Darido AU - Mohammad Khaled Ramadan AU - Rabih Chahine AU - Ahmad Estaitieh AU - Ahmad Lakis AU - Omar Sheikh AU - Khaled Habib AU - Saad El Daou AU - Nicolas Haddad Y1 - 2019/09/02 PY - 2019 N1 - https://doi.org/10.11648/j.jgo.20190705.11 DO - 10.11648/j.jgo.20190705.11 T2 - Journal of Gynecology and Obstetrics JF - Journal of Gynecology and Obstetrics JO - Journal of Gynecology and Obstetrics SP - 125 EP - 129 PB - Science Publishing Group SN - 2376-7820 UR - https://doi.org/10.11648/j.jgo.20190705.11 AB - Xanthogranuloma is a benign disorder that is considered to be a very rare event when it happens in the female reproductive organs. It can mimic adnexal tumors clinically and radiologically. The vulva, the vagina, the cervix or the endometrium can be involved. It is a process during which the tissues are infiltrated by lipid-laden histiocytes mixed with lymphocytes, plasma cells and polymorphonuclear leucocytes. In this article, we are reporting a rare case of an adult xanthogranulomatous inflammation of the uterine cervix with a detailed clinical, pathologic, radiologic and follow up data. A 46-year-old lady presented with vaginal bleeding, dysmenorrhea and pelvic heaviness. She underwent a diagnostic dilation and curetting at a peripheral hospital due to increased endometrial thickness on ultrasound. Then, she was misdiagnosed with a diffused large B cell lymphoma (Non-Hodgkin Lymphoma) and was treated with two cycles of chemotherapy. At our department, abdominopelvic ultrasound and CT scan showed a 10 x 9.4 cm round cervical mass associated with hydronephrosis. A cervical biopsy was also taken turned back with a pseudotumoral xanthogranulomatous cervicitis. Consequently, a hysterectomy with bilateral salpingo oophorectomy was decided and performed taking into consideration the possibility of a coexistent associated malignancy of the reproductive organs. In contrast with juvenile xanthogranuloma, we could not have expected from our case of adult xanthogranuloma to regress. Finally, more studies and reported cases are needed in order to assess the adequate management and utility of radiotherapy/chemotherapy in such cases of Xanthogranulomatous inflammation of the female genital tract. VL - 7 IS - 5 ER -
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