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Cervical Ectopic Pregnancy, a Case Report and Literature Review

Received: 28 May 2020     Accepted: 15 June 2020     Published: 28 June 2020
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Abstract

Cervical ectopic pregnancies (CEP) are rare, comprising less than 1% of ectopic pregnancies with an incidence of one in 2500 to one in 18000, and 1 to 2.0% of all pregnancies. Due to the rich cervical vascularity and the incompatibility of the cervix to hold an advancing pregnancy, there is a marked increase in the potential of hemorrhage leading to mortality, morbidity, and infertility experienced by the implicated women. There is a divergence of preferences among health care providers for CEP management which ranges from non-surgical methods to hysterectomy. However, a timely diagnosis increases the likelihood of implementing more conservative methods and retaining patients’ fertility. New improvements in high-resolution ultrasonography made earlier diagnosis possible, which lead to the development of many conservative treatment approaches that avoid the need for a hysterectomy and preserve fertility. A high index of suspicion, combined with a detailed review of clinical and radiological findings, is essential to make an accurate diagnosis of cervical pregnancy. Our case presents early diagnosis made of a cervical ectopic pregnancy treated medically with the avoidance of surgical intervention and its associated risks. Early diagnosis is essential as it decreases the risks of future infertility and decreases the risk of fatal complications associated with such pregnancies.

Published in Journal of Gynecology and Obstetrics (Volume 8, Issue 4)
DOI 10.11648/j.jgo.20200804.13
Page(s) 85-90
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Cervical Ectopic Pregnancy, Medical Versus Surgical Treatment, Preservation of Fertility, Radiological Findings in Cervical Ectopic Pregnancy

References
[1] Barnhart K. T.: Ectopic pregnancy. N Engl J Med 2009; 361: pp. 379-387.
[2] Williams Gynecology By John Schorge, Joseph Schaffer, Lisa Halvorson, Barbara Hoffman, Karen Bradshaw, and F. Cunningham. Journal of Midwifery & Women's Health. 2010; 55 (4): e59-e59.
[3] Leeman L. Cervical Ectopic Pregnancy: Diagnosis With Endovaginal Ultrasound Examination and Successful Treatment With Methotrexate. Archives of Family Medicine. 2000; 9 (1): 72-77.
[4] Cepni I, Ocal P, Erkan S, Erzik B. Conservative treatment of cervical ectopic pregnancy with transvaginal ultrasound-guided aspiration and single-dose methotrexate. Fertility and Sterility. 2004; 81 (4): 1130-1132.
[5] Helmy S, Koch M, Kölbl H, Grohmann-Izay B, Solomayer E, Bader Y. Correlation of the volume of ectopic pregnancy and MTX therapy outcome: a retrospective cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2015; 184: 108-111.
[6] Sorbi F, Sisti G, Pieralli A, et al. Cervicoisthmic choriocarcinoma mimicking cesarean section scar ectopic pregnancy. J Res Med Sci. 2013; 18 (10): 914–917.
[7] Kouliev T, Cervenka K. Emergency Ultrasound in Cervical Ectopic Pregnancy. The Journal of Emergency Medicine. 2010; 38 (1): 55-56.
[8] Chukus A, Tirada N, Restrepo R, Reddy N. Uncommon Implantation Sites of Ectopic Pregnancy: Thinking beyond the Complex Adnexal Mass. RadioGraphics. 2015; 35 (3): 946-959.
[9] Perkins K, Boulet S, Kissin D, Jamieson D. Risk of Ectopic Pregnancy Associated With Assisted Reproductive Technology in the United States, 2001–2011. Obstetrics & Gynecology. 2015; 125 (1): 70-78.
[10] Vitale S. G., Rapisarda A. M. C., Laganà A. S. (2018) Cervical Ectopic Pregnancy: The Role of Hysteroscopy. In: Tinelli A., Alonso Pacheco L., Haimovich S. (eds) Hysteroscopy. Springer, Cham.
[11] Spitzer D, Steiner H, Graf A, Zajc M, Staudach A. Conservative treatment of cervical pregnancy by curettage and local prostaglandin injection. Human Reproduction. 1997; 12 (4): 860-866.
[12] Fylstra DL, Coffey MD. Treatment of cervical pregnancy with cerclage, curettage and balloon tamponade. A report of three cases. J Reprod Med. 2001; 46 (1): 71–74.
[13] Jung S, Byun J, Lee J, Choi B, Hahn S. Characteristic MR findings of cervical pregnancy. Journal of Magnetic Resonance Imaging. 2001; 13 (6): 918-922.
[14] Karande V, Flood J, Heard N, Veeck L, Muasher S. Analysis of ectopic pregnancies resulting from in-vitro fertilization and embryo transfer*. Human Reproduction. 1991; 6 (3): 446-449.
[15] Paalman RJ, McElin TW. Cervical pregnancy. Review of the literature and presentation of cases. Am J Obstet Gynecol. 1959; 77: 1261.
[16] Raskin M. Diabnosis of cervical pregnancy by ultrasound: A case report. American Journal of Obstetrics and Gynecology. 1978; 130 (2): 234-235.
[17] Jurkovic D, Hacket E, Campbell S. Diagnosis and treatment of early cervical pregnancy: a review and a report of two cases treated conservatively. Ultrasound in Obstetrics and Gynecology. 1996; 8 (6): 373-380.
[18] Oyelese Y, Elliott T, Asomani N, Hamm R, Napoli L, Lewis K. Sonography and Magnetic Resonance Imaging in the Diagnosis of Cervico-Isthmic Pregnancy. Journal of Ultrasound in Medicine. 2003; 22 (9): 981-983.
[19] Yao M, Tulandi T. Practical and current management of tubal and nontubal ectopic pregnancies. Current Problems in Obstetrics, Gynecology and Fertility 2000; 23: 94–107.
[20] Osada H, Teramoto S, Kaijima H, Segawa T, Miyauchi O, Nagaishi M et al. A Novel Treatment for Cervical and Cesarean Section Scar Pregnancies by Transvaginal Injection of Absolute Ethanol to Trophoblasts: Efficacy in 19 Cases. Journal of Minimally Invasive Gynecology. 2019; 26 (1): 129-134.
[21] Takeda K, Mackay J, Watts S. Successful Management of Cervical Ectopic Pregnancy with Bilateral Uterine Artery Embolization and Methotrexate. Case Reports in Emergency Medicine. 2018; 1-4.
[22] Timor-Tritsch I, Monteagudo A, Bennett T, Foley C, Ramos J, Kaelin Agten A. A new minimally invasive treatment for cesarean scar pregnancy and cervical pregnancy. American Journal of Obstetrics and Gynecology. 2016; 215 (3): 351. e1-351. e8.
[23] Tanos V, ElAkhras S, Kaya B. Hysteroscopic management of cervical pregnancy: Case series and review of the literature. Journal of Gynecology Obstetrics and Human Reproduction. 2019; 48 (4): 247-253.
[24] Mashiach S. Cervical Shirodkar cerclage may be the treatment modality of choice for cervical pregnancy. Human Reproduction. 2002; 17 (2): 493-496.
[25] Trojano G, Colafiglio G, Saliani N, Lanzillotti G, Cicinelli E. Successful management of a cervical twin pregnancy: neoadjuvant systemic methotrexate and prophylactic high cervical cerclage before curettage. Fertility and Sterility. 2009; 91 (3): 935. e17-935. e19.
[26] Taylor J, Yalcinkaya T, Akar M. Successful conservative management of cervical ectopic pregnancy: a case series. Archives of Gynecology and Obstetrics. 2010; 283 (6): 1215-1217.
[27] Sardo A, Alviggi C, Zizolfi B, Spinelli M, Rosa P, Placido G et al. Cervico-isthmic pregnancy successfully treated with bipolar resection following methotrexate administration: case report and literature review. Reproductive BioMedicine Online. 2013; 26 (1): 99-103.
[28] De Greef I, Berteloot P, Timmerman D, Deprest J, Amant F. Viable cervical pregnancy with levonorgestrel containing intrauterine device, treated successfully with methotrexate and mifepristone. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2005; 120 (2): 233-235.
[29] Jeong E, Kim Y, Ji I, Kim H. Triplet Cervical Pregnancy Treated With Intraamniotic Methotrexate. Obstetrics & Gynecology. 2002; 100 (5, Part 2): 1117-1119.
[30] Song M, Moon M, Kim J, Kim T. Serial Transvaginal Sonographic Findings of Cervical Ectopic Pregnancy Treated With High-Dose Methotrexate. Journal of Ultrasound in Medicine. 2009; 28 (1): 55-61.
[31] Hosni M, Herath R, Rashid M. Diagnostic and Therapeutic Dilemmas of Cervical Ectopic Pregnancy. Obstetrical & Gynecological Survey. 2014; 69 (5): 261-276.
[32] Hung T, Jeng C, Yang Y, Wang K, Lan C. Treatment of cervical pregnancy with methotrexate. International Journal of Gynecology & Obstetrics. 1996; 53 (3): 243-247.
[33] Ushakov F, Elchalal U, Aceman P, Schenker J. Cervical Pregnancy. Obstetrical & Gynecological Survey. 1997; 52 (1): 45-59.
[34] Wolcott HD, Kaunitz AM, Nuss RC, et al. Successful pregnancy after previous conservative treatment of an advanced cervical pregnancy. Obstet Gynecol. 1998; 71: 1023–1025.
Cite This Article
  • APA Style

    Daisy Massoud, Rawad Halimeh Rawad Halimeh, Rita Sleiman, Amine Geahchan, Ali Abdallah, et al. (2020). Cervical Ectopic Pregnancy, a Case Report and Literature Review. Journal of Gynecology and Obstetrics, 8(4), 85-90. https://doi.org/10.11648/j.jgo.20200804.13

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    ACS Style

    Daisy Massoud; Rawad Halimeh Rawad Halimeh; Rita Sleiman; Amine Geahchan; Ali Abdallah, et al. Cervical Ectopic Pregnancy, a Case Report and Literature Review. J. Gynecol. Obstet. 2020, 8(4), 85-90. doi: 10.11648/j.jgo.20200804.13

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    AMA Style

    Daisy Massoud, Rawad Halimeh Rawad Halimeh, Rita Sleiman, Amine Geahchan, Ali Abdallah, et al. Cervical Ectopic Pregnancy, a Case Report and Literature Review. J Gynecol Obstet. 2020;8(4):85-90. doi: 10.11648/j.jgo.20200804.13

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  • @article{10.11648/j.jgo.20200804.13,
      author = {Daisy Massoud and Rawad Halimeh Rawad Halimeh and Rita Sleiman and Amine Geahchan and Ali Abdallah and Joe Feghali and Bahige Arida},
      title = {Cervical Ectopic Pregnancy, a Case Report and Literature Review},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {8},
      number = {4},
      pages = {85-90},
      doi = {10.11648/j.jgo.20200804.13},
      url = {https://doi.org/10.11648/j.jgo.20200804.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20200804.13},
      abstract = {Cervical ectopic pregnancies (CEP) are rare, comprising less than 1% of ectopic pregnancies with an incidence of one in 2500 to one in 18000, and 1 to 2.0% of all pregnancies. Due to the rich cervical vascularity and the incompatibility of the cervix to hold an advancing pregnancy, there is a marked increase in the potential of hemorrhage leading to mortality, morbidity, and infertility experienced by the implicated women. There is a divergence of preferences among health care providers for CEP management which ranges from non-surgical methods to hysterectomy. However, a timely diagnosis increases the likelihood of implementing more conservative methods and retaining patients’ fertility. New improvements in high-resolution ultrasonography made earlier diagnosis possible, which lead to the development of many conservative treatment approaches that avoid the need for a hysterectomy and preserve fertility. A high index of suspicion, combined with a detailed review of clinical and radiological findings, is essential to make an accurate diagnosis of cervical pregnancy. Our case presents early diagnosis made of a cervical ectopic pregnancy treated medically with the avoidance of surgical intervention and its associated risks. Early diagnosis is essential as it decreases the risks of future infertility and decreases the risk of fatal complications associated with such pregnancies.},
     year = {2020}
    }
    

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    AU  - Daisy Massoud
    AU  - Rawad Halimeh Rawad Halimeh
    AU  - Rita Sleiman
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    AB  - Cervical ectopic pregnancies (CEP) are rare, comprising less than 1% of ectopic pregnancies with an incidence of one in 2500 to one in 18000, and 1 to 2.0% of all pregnancies. Due to the rich cervical vascularity and the incompatibility of the cervix to hold an advancing pregnancy, there is a marked increase in the potential of hemorrhage leading to mortality, morbidity, and infertility experienced by the implicated women. There is a divergence of preferences among health care providers for CEP management which ranges from non-surgical methods to hysterectomy. However, a timely diagnosis increases the likelihood of implementing more conservative methods and retaining patients’ fertility. New improvements in high-resolution ultrasonography made earlier diagnosis possible, which lead to the development of many conservative treatment approaches that avoid the need for a hysterectomy and preserve fertility. A high index of suspicion, combined with a detailed review of clinical and radiological findings, is essential to make an accurate diagnosis of cervical pregnancy. Our case presents early diagnosis made of a cervical ectopic pregnancy treated medically with the avoidance of surgical intervention and its associated risks. Early diagnosis is essential as it decreases the risks of future infertility and decreases the risk of fatal complications associated with such pregnancies.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Department of Obstetrics and Gynecology, Saint George Hospital University Medical Center, Beirut, Lebanon

  • Department of Obstetrics and Gynecology, Saint George Hospital University Medical Center, Beirut, Lebanon

  • Department of Obstetrics and Gynecology, Saint George Hospital University Medical Center, Beirut, Lebanon

  • Faculty of Medicine, University of Balamand, Beirut, Lebanon

  • Faculty of Medicine, University of Balamand, Beirut, Lebanon

  • Department of Obstetrics and Gynecology, Saint George Hospital University Medical Center, Beirut, Lebanon

  • Department of Obstetrics and Gynecology, Saint George Hospital University Medical Center, Beirut, Lebanon

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