Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection

Zhao Jiqiang; Zhao Jiquan; Huo Feng; Wang Shaping; Zheng Yujian

doi:doi:10.11648/j.sd.20210904.17

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Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection

Zhao Jiqiang, Zhao Jiquan, Huo Feng, Wang Shaping, Zheng Yujian

Published in Science Discovery (Volume 9, Issue 4)

Received: 22 April 2021 Accepted: 4 June 2021 Published: 9 June 2021

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Abstract

Objective To discuss the preservation solution (PS) contamination and initial experience of liver transplantation from organ donation by citizens after death and initial experience. Methods The 78 liver transplant recipients were divided into positive group and negative group based on the finding of the culture of PS. The positive group received the sequential therapy of antibiotics with ertapenem and imipenem for one week, and the negative group stopped using imipenem. The situation of PS contamination and infection after liver transplantation and prognosis during the follow-up 3 months of the recipients were analyzed. Results PS culture positive rate was 41.03%, and 33 strains of pathogens were isolated. The most common pathogenic bacteria were gram-negative bacilli (9 strains, 27.27%) and coagulase –negative staphylococci (9 strains, 27.27%). The infection rate after liver transplantation was 31.25% and 13.04%, respectively, in positive group and negative group (χ²=3.837, P=0.048). The most frequent infection sites were lower respiratory tract (5 cases, 31.25%), abdominal cavity (5 cases, 31.25%) and surgical incision (4 cases, 25.00%). There was no significant difference in postoperative infection rate among patients with different CTP, MELD and surgical methods (P>0.05). One case (1.28%) was infected with the same pathogenic bacteria as PS contamination 3 weeks after liver transplantation, and died of multiple organ failure. There was no significantly difference in the acute rejection rate (1,3.13% and 2, 4.35%) and mortality (2,6.25% and 5,10.87%) between the two groups (P>0.05). Conclusion Contamination of the PS is frequent in liver transplantation, and it is the risk factor for postoperative infection of recipients. Early targeted antimicrobial treatment against pathogens cultured from PS play a positive role in reducing the contamination-associated infection rate after liver transplantation.

Published in	Science Discovery (Volume 9, Issue 4)
DOI	10.11648/j.sd.20210904.17
Page(s)	171-177
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Bacterial Contamination, Preservation Solution, Liver, Transplantation, Recipient Infection, Ertapenem

References

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APA Style

Zhao Jiqiang, Zhao Jiquan, Huo Feng, Wang Shaping, Zheng Yujian. (2021). Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection. Science Discovery, 9(4), 171-177. https://doi.org/10.11648/j.sd.20210904.17

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ACS Style

Zhao Jiqiang; Zhao Jiquan; Huo Feng; Wang Shaping; Zheng Yujian. Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection. Sci. Discov. 2021, 9(4), 171-177. doi: 10.11648/j.sd.20210904.17

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AMA Style

Zhao Jiqiang, Zhao Jiquan, Huo Feng, Wang Shaping, Zheng Yujian. Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection. Sci Discov. 2021;9(4):171-177. doi: 10.11648/j.sd.20210904.17

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@article{10.11648/j.sd.20210904.17,
  author = {Zhao Jiqiang and Zhao Jiquan and Huo Feng and Wang Shaping and Zheng Yujian},
  title = {Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection},
  journal = {Science Discovery},
  volume = {9},
  number = {4},
  pages = {171-177},
  doi = {10.11648/j.sd.20210904.17},
  url = {https://doi.org/10.11648/j.sd.20210904.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20210904.17},
  abstract = {Objective To discuss the preservation solution (PS) contamination and initial experience of liver transplantation from organ donation by citizens after death and initial experience. Methods The 78 liver transplant recipients were divided into positive group and negative group based on the finding of the culture of PS. The positive group received the sequential therapy of antibiotics with ertapenem and imipenem for one week, and the negative group stopped using imipenem. The situation of PS contamination and infection after liver transplantation and prognosis during the follow-up 3 months of the recipients were analyzed. Results PS culture positive rate was 41.03%, and 33 strains of pathogens were isolated. The most common pathogenic bacteria were gram-negative bacilli (9 strains, 27.27%) and coagulase –negative staphylococci (9 strains, 27.27%). The infection rate after liver transplantation was 31.25% and 13.04%, respectively, in positive group and negative group (χ2=3.837, P=0.048). The most frequent infection sites were lower respiratory tract (5 cases, 31.25%), abdominal cavity (5 cases, 31.25%) and surgical incision (4 cases, 25.00%). There was no significant difference in postoperative infection rate among patients with different CTP, MELD and surgical methods (P>0.05). One case (1.28%) was infected with the same pathogenic bacteria as PS contamination 3 weeks after liver transplantation, and died of multiple organ failure. There was no significantly difference in the acute rejection rate (1,3.13% and 2, 4.35%) and mortality (2,6.25% and 5,10.87%) between the two groups (P>0.05). Conclusion Contamination of the PS is frequent in liver transplantation, and it is the risk factor for postoperative infection of recipients. Early targeted antimicrobial treatment against pathogens cultured from PS play a positive role in reducing the contamination-associated infection rate after liver transplantation.},
 year = {2021}
}

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TY - JOUR
T1 - Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection
AU - Zhao Jiqiang
AU - Zhao Jiquan
AU - Huo Feng
AU - Wang Shaping
AU - Zheng Yujian
Y1 - 2021/06/09
PY - 2021
N1 - https://doi.org/10.11648/j.sd.20210904.17
DO - 10.11648/j.sd.20210904.17
T2 - Science Discovery
JF - Science Discovery
JO - Science Discovery
SP - 171
EP - 177
PB - Science Publishing Group
SN - 2331-0650
UR - https://doi.org/10.11648/j.sd.20210904.17
AB - Objective To discuss the preservation solution (PS) contamination and initial experience of liver transplantation from organ donation by citizens after death and initial experience. Methods The 78 liver transplant recipients were divided into positive group and negative group based on the finding of the culture of PS. The positive group received the sequential therapy of antibiotics with ertapenem and imipenem for one week, and the negative group stopped using imipenem. The situation of PS contamination and infection after liver transplantation and prognosis during the follow-up 3 months of the recipients were analyzed. Results PS culture positive rate was 41.03%, and 33 strains of pathogens were isolated. The most common pathogenic bacteria were gram-negative bacilli (9 strains, 27.27%) and coagulase –negative staphylococci (9 strains, 27.27%). The infection rate after liver transplantation was 31.25% and 13.04%, respectively, in positive group and negative group (χ2=3.837, P=0.048). The most frequent infection sites were lower respiratory tract (5 cases, 31.25%), abdominal cavity (5 cases, 31.25%) and surgical incision (4 cases, 25.00%). There was no significant difference in postoperative infection rate among patients with different CTP, MELD and surgical methods (P>0.05). One case (1.28%) was infected with the same pathogenic bacteria as PS contamination 3 weeks after liver transplantation, and died of multiple organ failure. There was no significantly difference in the acute rejection rate (1,3.13% and 2, 4.35%) and mortality (2,6.25% and 5,10.87%) between the two groups (P>0.05). Conclusion Contamination of the PS is frequent in liver transplantation, and it is the risk factor for postoperative infection of recipients. Early targeted antimicrobial treatment against pathogens cultured from PS play a positive role in reducing the contamination-associated infection rate after liver transplantation.
VL - 9
IS - 4
ER -

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Author Information

Zhao Jiqiang

Department of Organ Transplantation, The 3rd Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Zhao Jiquan

The Urinary Surgery, The Eighth Affiliated Hospital, SunYat-Sen University, Shenzhen, China
Huo Feng

Department of Hepatobiliary Surgery, The liver Transplantation Center, Guangzhou General Hospital of Guangzhou Military of PLA, Guangzhou, China
Wang Shaping

Department of Hepatobiliary Surgery, The liver Transplantation Center, Guangzhou General Hospital of Guangzhou Military of PLA, Guangzhou, China
Zheng Yujian

Department of Hepatobiliary Surgery, The liver Transplantation Center, Guangzhou General Hospital of Guangzhou Military of PLA, Guangzhou, China

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APA Style

Zhao Jiqiang, Zhao Jiquan, Huo Feng, Wang Shaping, Zheng Yujian. (2021). Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection. Science Discovery, 9(4), 171-177. https://doi.org/10.11648/j.sd.20210904.17

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ACS Style

Zhao Jiqiang; Zhao Jiquan; Huo Feng; Wang Shaping; Zheng Yujian. Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection. Sci. Discov. 2021, 9(4), 171-177. doi: 10.11648/j.sd.20210904.17

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AMA Style

Zhao Jiqiang, Zhao Jiquan, Huo Feng, Wang Shaping, Zheng Yujian. Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection. Sci Discov. 2021;9(4):171-177. doi: 10.11648/j.sd.20210904.17

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@article{10.11648/j.sd.20210904.17,
  author = {Zhao Jiqiang and Zhao Jiquan and Huo Feng and Wang Shaping and Zheng Yujian},
  title = {Preliminary Analysis of Contamination in Liver Preservation Solution and Prophylaxis for Post-transplant Infection},
  journal = {Science Discovery},
  volume = {9},
  number = {4},
  pages = {171-177},
  doi = {10.11648/j.sd.20210904.17},
  url = {https://doi.org/10.11648/j.sd.20210904.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20210904.17},
  abstract = {Objective To discuss the preservation solution (PS) contamination and initial experience of liver transplantation from organ donation by citizens after death and initial experience. Methods The 78 liver transplant recipients were divided into positive group and negative group based on the finding of the culture of PS. The positive group received the sequential therapy of antibiotics with ertapenem and imipenem for one week, and the negative group stopped using imipenem. The situation of PS contamination and infection after liver transplantation and prognosis during the follow-up 3 months of the recipients were analyzed. Results PS culture positive rate was 41.03%, and 33 strains of pathogens were isolated. The most common pathogenic bacteria were gram-negative bacilli (9 strains, 27.27%) and coagulase –negative staphylococci (9 strains, 27.27%). The infection rate after liver transplantation was 31.25% and 13.04%, respectively, in positive group and negative group (χ2=3.837, P=0.048). The most frequent infection sites were lower respiratory tract (5 cases, 31.25%), abdominal cavity (5 cases, 31.25%) and surgical incision (4 cases, 25.00%). There was no significant difference in postoperative infection rate among patients with different CTP, MELD and surgical methods (P>0.05). One case (1.28%) was infected with the same pathogenic bacteria as PS contamination 3 weeks after liver transplantation, and died of multiple organ failure. There was no significantly difference in the acute rejection rate (1,3.13% and 2, 4.35%) and mortality (2,6.25% and 5,10.87%) between the two groups (P>0.05). Conclusion Contamination of the PS is frequent in liver transplantation, and it is the risk factor for postoperative infection of recipients. Early targeted antimicrobial treatment against pathogens cultured from PS play a positive role in reducing the contamination-associated infection rate after liver transplantation.},
 year = {2021}
}

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