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Research Article
Analysis of Influencing Factors for Chronic Neck Pain with Cognitive Impairment
Ying Su*
Issue:
Volume 13, Issue 2, December 2025
Pages:
63-69
Received:
24 June 2025
Accepted:
7 July 2025
Published:
28 July 2025
Abstract: Background: Cervical spondylosis is a common chronic degenerative musculoskeletal disorder. It is based on the degeneration of the cervical intervertebral discs and secondary pathological changes, affecting the surrounding soft tissues, nerve roots, vertebral arteries, sympathetic nerves, and spinal cord. This condition gives rise to a series of clinical symptoms and signs. Pain represents one of the most crucial manifestations. Notably, when pain symptoms endure for over three months, this may give rise to chronic neck pain (CNP). The progression of this chronic neck pain may increase the risk of cognitive impairment (CI). However, to date, predictive markers for chronic neck pain with cognitive impairment (CNP-CI) remain lacking. Previous investigations have demonstrated that routine blood parameters possess predictive utility for Alzheimer's disease. However, the association between these parameters and chronic neck pain with CNP - CI remains elusive. This study was designed to explore the correlations among routine blood indices and to provide evidence regarding the differences between two groups of patients with chronic neck pain, namely those with and without cognitive impairment. Additionally, this study aims to lay the groundwork for longitudinal experimental investigations into effective intervention strategies for patients with chronic neck pain who develop cognitive impairment. Methods: This cross-sectional study was conducted in West China Hospital, Sichuan University. Montreal Cognitive Assessment (MoCA) was conducted to divide patients into the CNP-CI or CNP-nCI group. Statistical analysis was performed to examine the differences between chronic neck pain patients with cognitive impairment and those without cognitive impairment. All statistical tests were conducted at a significant level of α=0.05 for two-sided testing. Results: The prevalence of chronic neck pain with cognitive impairment in this study demonstrates age-related disparities, with a higher prevalence observed among older individuals (P=0.007). A statistically significant difference in serum calcium was observed between individuals with chronic neck pain and cognitive impairment (P=0.046). Conclusion: The age and serum calcium may serve as influential factors in the development of chronic neck pain with cognitive impairment. This finding can aid healthcare professionals in implementing early intervention and treatment for individuals experiencing this condition.
Abstract: Background: Cervical spondylosis is a common chronic degenerative musculoskeletal disorder. It is based on the degeneration of the cervical intervertebral discs and secondary pathological changes, affecting the surrounding soft tissues, nerve roots, vertebral arteries, sympathetic nerves, and spinal cord. This condition gives rise to a series of cl...
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Research Article
Comparative Evaluation of the Effects of Ephedrine and Phenylephrine on Neonatal Umbilical Cord Blood Gases
Issue:
Volume 13, Issue 2, December 2025
Pages:
70-75
Received:
5 June 2025
Accepted:
23 June 2025
Published:
4 August 2025
Abstract: Background: Ephedrine has commonly been regarded as the vasopressor of choice for treatment of hypotension in obstetrics, but there are concerns it causes neonatal acidosis.While some authors have recommended phenylephrine because it has not been associated with neonatal acidosis, others have found no difference between the two. Objective: To compare umbilical cord blood gases in neonates of parturients who received ephedrine and phenylephrine for prevention of maternal hypotension following subarachnoid block for caesarean section. Methods: Sixty-two neonates whose mothers received either ephedrine (group E) or phenylephrine (group P) during elective caesarean section were randomized in this double blind study into two groups each of 31.Umbilical arterial blood sample was collected and analysed immediately following delivery using an ABGmachine. Results: The mean umbilical artery pH was 7.30±0.05 and 7.31±0.02 for groups E and P respectively (p value=0.097). The mean PaCO2 (mmHg) was 44.44±4.01 and 46±3.95 for groups E and P respectively (p value=0.208). while the mean PaO2 (mmHg) was 25.85±3.14 and 27.40±1.76 for groups E and P respectively (p value=0.075). The mean HCO3-(mmHg) between the groups were 22.53±1.76 and 22.18±1.21 for groups E and P respectively (p value=0.205). Also, the mean base excess in groups E and P were -3.72±0.90 and -3.05±1.1 respectively (p value=0.054). There was no difference in the Apgar scores and maternal haemodynamic parameters in both groups. Conclusion:There was no difference in the umbilical cord gases and Apgar scores of neonates whose mothers received either ephedrine or phenylephrine.
Abstract: Background: Ephedrine has commonly been regarded as the vasopressor of choice for treatment of hypotension in obstetrics, but there are concerns it causes neonatal acidosis.While some authors have recommended phenylephrine because it has not been associated with neonatal acidosis, others have found no difference between the two. Objective: To compa...
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Research Article
Research Advances in the Biological Functions of RBM3
Long Feiyu*
Issue:
Volume 13, Issue 2, December 2025
Pages:
76-81
Received:
21 July 2025
Accepted:
31 July 2025
Published:
13 August 2025
DOI:
10.11648/j.ijacm.20251302.13
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Abstract: In clinical research, "hypothermia therapy" (at 32-34°C) has been proven to be an effective method for alleviating neurological deficits in neonatal hypoxic-ischemic encephalopathy and adult acute brain injury. Even deeper levels of hypothermia have been used in heart and transplant surgeries. However, "hypothermia therapy" in clinical settings cannot avoid many life-threatening side effects. Its effects go far beyond what was initially observed under hypothermic conditions. RNA-binding motif protein 3 (RBM3), a critical cold shock protein, has revealed significance extending far beyond its initial discovery in hypothermia. Induced by diverse stressors-notably mild hypothermia-RBM3 orchestrates complex post-transcriptional processes, modulating mRNA stability, translation, alternative splicing, and phase separation. It further regulates multiple cellular physiological processes, including neuroprotection, tumorigenesis, anti-apoptosis, and cell cycle progression. This review outlines RBM3’s structure and distribution in humans and synthesizes recent advances in understanding its multifaceted biological functions.
Abstract: In clinical research, "hypothermia therapy" (at 32-34°C) has been proven to be an effective method for alleviating neurological deficits in neonatal hypoxic-ischemic encephalopathy and adult acute brain injury. Even deeper levels of hypothermia have been used in heart and transplant surgeries. However, "hypothermia therapy" in clinical settings can...
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