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Kidney Tumors in Adult: Epidemiological, Clinical, Histopathological, Therapeutic and Progressive Aspects
Modou Ndiaye,
Abdoulaye Ndiath,
Babacar Sine,
Alioune Sarr,
Ousmane Sow,
Omar Gaye,
Ndiaga Seck Ndour,
Aboubacar Traoré,
Cyrille Zé Ondo,
Amath Thiam,
Ngor Mack Thiam,
El Hadji Malick Diaw,
Ousmane Dabo,
Boubacar Fall,
Babacar Diao,
Papa Ahmed Fall,
Alain Khassim Ndoye
Issue:
Volume 4, Issue 2, December 2020
Pages:
39-44
Received:
6 May 2020
Accepted:
25 May 2020
Published:
8 June 2020
Abstract: Objective: To study the epidemiological, diagnostic and therapeutic profile of kidney tumors in adults over the past five years. Patients and methods: This was a retrospective, descriptive and analytical Study from the 1st of January 2014 to 31st of December 2018. All patients aged 18 years or older hospitalized, followed or operated in the service for a kidney tumor were included in the serie. The parameters studied were: epidemiological, clinical and paraclinical aspects, TNM stage (2017), treatment, histological type, evolution and survival. The calculation of survival rate was done with SPSS IBM statistics 24. Results: sixty-seven patients were included. The average annual incidence was 13. The average age of the patients was 49.6±15.6 years. The sex-ratio was 1.2. Hypertension, smoking and obesity were the main risk factors found. The average size of the tumor was 7.7±4.40 cm. The left kidney location was more frequent. Thirteen patients (20%) had a localized tumor in the kidney, twenty patients (31%) had locally advanced cancer and thirty two patients (49%) had metastasized cancer. Forty-seven patients (70%) had surgical treatment, including five patients with an anti-angiogenic adjuvant therapy. Twelve (17.9%) patients had an anti-angiogenic therapy only. Clear cell carcinoma was the most common histology type. The overall survival (OS) rate for cancer patients at 2 years was 22% for surgical treatment, 8% for medical treatment. Conclusion: this work reveals that adult kidney cancer affects young adult and is discovered at advanced stages without any significant change in the epidemiological and clinical profile of these cancers during the two decades.
Abstract: Objective: To study the epidemiological, diagnostic and therapeutic profile of kidney tumors in adults over the past five years. Patients and methods: This was a retrospective, descriptive and analytical Study from the 1st of January 2014 to 31st of December 2018. All patients aged 18 years or older hospitalized, followed or operated in the service...
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Feminizing Genitoplasty in Congenital Adrenal Hyperplasia: 20-year Experience of Regional Comprehensive Care
Katie Lynn Canalichio,
Jennifer Ahn,
Anne-Marie Elizabeth Amies Oelschlager,
Patricia Yvonne Fechner,
Elizabeth McCauley,
Linda Ramsdell,
Paul Merguerian,
Margarett Shnorhavorian
Issue:
Volume 4, Issue 2, December 2020
Pages:
45-50
Received:
10 June 2020
Accepted:
28 June 2020
Published:
13 July 2020
Abstract: Background: There is need for data on long-term patient outcomes following feminizing genitoplasty (FG) in females with congenital adrenal hyperplasia (CAH). We aim to describe postoperative and longitudinal psychosocial, endocrine, gynecologic, and urologic outcomes. Methods: We performed a retrospective review of past 20 years looking at females with CAH status post FG. Patients without follow-up were excluded. We captured demographic data, intraoperative details, 30-day complication rates, and longitudinal outcomes. Results: Twenty patients met inclusion criteria. Prader scores ranged from 3-5. Median age at surgery was 1.0 year (IQR 0.6, 1.3). Median follow-up was 4.5 years (IQR 0.7, 9.6). Genetic testing was performed in 15/20 and all had causative variants in the CYP21A2 gene. Thirty-day surgical complications occurred in 5/20 patients (Clavien I-IIIb). All patients over 3 years were toilet trained, with only 1 patient requiring surgery for urinary incontinence. In post-pubertal patients, 5/6 had vaginal stenosis at median age 17.8 years (IQR 14.9, 21.1). Four patients received treatment for behavioral/psychiatric diagnoses. No patient had gender dysphoria. Conclusion: FG is safe as demonstrated by our low major complication rate. Our experience highlights the value of multidisciplinary care through adolescence and young adulthood to support long-term medical and psychosocial outcomes in females with CAH.
Abstract: Background: There is need for data on long-term patient outcomes following feminizing genitoplasty (FG) in females with congenital adrenal hyperplasia (CAH). We aim to describe postoperative and longitudinal psychosocial, endocrine, gynecologic, and urologic outcomes. Methods: We performed a retrospective review of past 20 years looking at females ...
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Urological Emergency in a University Hospital Setting: Epidemiological, Diagnostic and Therapeutic Aspects
Modou Ndiaye,
Ousmane Sow,
Alioune Sarr,
Abdoulaye Ndiath,
Cyrille Ze Ondo,
Babacar Sine,
Amath Thiam,
Ndeye Aissatou Bagayogo,
Samba Thiapato Faye,
Ndiaga Seck Ndour,
Aboubacar Traore,
Omar Gaye,
Ngor Mack Thiam,
El Hadj Malick Diaw,
Yaya Sow,
Babacar Diao,
Alain Khassim Ndoye
Issue:
Volume 4, Issue 2, December 2020
Pages:
51-54
Received:
15 June 2020
Accepted:
2 July 2020
Published:
13 July 2020
Abstract: Aim: To report the epidemiological and diagnostic aspects and evaluate the management of urological emergency in a university hospital. Patients and method: We conducted a single-center retrospective descriptive study over the period January 2015 to December 2017. We collected medical records of patients with urological emergency referred by the urology care team in our center. Results: Three hundred patients were identified over a period of 36 months. The mean age of the patients was 47.8±22.9 years (2 years - 92 years). The sex-ratio was 10.5. The most common emergency was haematuria (25.6%) and urinary retention (21.6%). Urogenital infections were noted in 19% of patients mostly scrotal cellulitis (10%) and acute pyelonephritis (3.6%). The number of emergency hospitalization was 230 (76.7%). We performed 143 emergency surgical procedures (47.6%). The overall mortality rate was 1%. Conclusion: Urological emergency were dominated in our context by hematuria and urinary retention occurring most often in young adults. However, infectious and lithiasic diseases remain common conditions.
Abstract: Aim: To report the epidemiological and diagnostic aspects and evaluate the management of urological emergency in a university hospital. Patients and method: We conducted a single-center retrospective descriptive study over the period January 2015 to December 2017. We collected medical records of patients with urological emergency referred by the ur...
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Migration of an Intra Uterine Device (IUD) on a Bilharzian Bladder: An Exceptional Fact About a Case
Mamadou Bissiriou Bah,
Koutou Mahoï,
Ibrahima Bah,
Ricardo Lahoumbo Gnammi,
Mamadou II Barry,
Ibrahima Koussi Bah,
Demba Cissé,
Thierno Mamadou Oury Diallo,
Mamadou Diao Bah,
Daouda Kanté,
Abdoulaye Bobo Diallo,
Oumar Raphiou Bah
Issue:
Volume 4, Issue 2, December 2020
Pages:
55-58
Received:
22 June 2020
Accepted:
17 July 2020
Published:
23 July 2020
Abstract: Intra uterine device (IUD) migration is a rare complication of female contraception. The mechanism for this migration is still poorly understood. Its association with a bilharzian bladder is exceptional. Urinary schistosomiasis is an endemic disease in our regions. A real public health problem, it affects poor populations of farmers and fishermen. And also women when they do their household chores in infested water. Through an observation, we analyze the clinical and therapeutic aspects of the intra vesical migration of an IUD on a bilharzian bladder. The diagnosis was made on a 31 years old patient who had an IUD 1 year 3 months ago. She had presented some urinary disorders such as dysuria, micturition burns and intermittent hematuria, evolving for 3 months. A urine pellet had highlighted Schistosoma haematobium eggs. After medical treatment and sterilization of the urine, the symptoms remained. A cystoscopy was performed which found the IUD in the bladder. There followed a surgical exploration by an under umbilical laparotomy for the removal of the IUD. Migration of the IUD into the bladder and bilharzian cystitis are two distincts nosologies afections but similar clinical manifestations. In both cases, a good clinical and paraclinical analysis makes it possible to make their diagnosis and ensure adequate management.
Abstract: Intra uterine device (IUD) migration is a rare complication of female contraception. The mechanism for this migration is still poorly understood. Its association with a bilharzian bladder is exceptional. Urinary schistosomiasis is an endemic disease in our regions. A real public health problem, it affects poor populations of farmers and fishermen. ...
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Serious Complications Following Lithotripsy - An Iatrogenic Injury Need to Be Care for
Issue:
Volume 4, Issue 2, December 2020
Pages:
59-63
Received:
16 June 2020
Accepted:
15 July 2020
Published:
4 August 2020
Abstract: Between November 2007 and July 2019, four cases with serious complications after ESWL were transfer to our emergency department, the First Hospital of Lanzhou University, a western Hospital of China. Because urosepsis, hypovolemic shock or acute renal function failure, three of these patients died within 14.5 hours (14.5 hours, 48 minutes, and 58 minutes, respectively, mean 5.4 h) after they were admitted. The ESWL missions for these three patients were 4, 7 and 5, with a time interval of 2, 4 and 4 weeks accordingly. An exploratory laparotomy had to perform on the last patient and a ruptured left kidney was confirmed accompany with pyogenic infection during the operation. She died at the seventh day after been admitted. So iatrogenic injury caused by over-treatment and without systemic follow up may be the main cause of these death cases. Clinical data were summarized and literature was reviewed. We found, although ESWL is a simple, safe and effective procedure for the management of urolithiasis, unnecessary hurt will occur when it was used inappropriately. So indispensable attention must be pay on its possible side effects, especially for over-treatment. Well-trained ESWL physicians may be necessary for ESWL profession, which may reduce the incidence rate of severe complications in the ESWL treatment effectively.
Abstract: Between November 2007 and July 2019, four cases with serious complications after ESWL were transfer to our emergency department, the First Hospital of Lanzhou University, a western Hospital of China. Because urosepsis, hypovolemic shock or acute renal function failure, three of these patients died within 14.5 hours (14.5 hours, 48 minutes, and 58 m...
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Chronic Testicular Pain: A Review of Aetiology and Management
Romy Mondschein,
Paul Manohar,
Scott Donnellan,
Devanayagam Manohar
Issue:
Volume 4, Issue 2, December 2020
Pages:
64-67
Received:
11 August 2020
Accepted:
24 August 2020
Published:
16 September 2020
Abstract: Chronic testicular pain affects a growing number of men worldwide. The approach to diagnosis and treatment is variable, resulting in treatment delays of reversible causes that may increase the probability of progression to chronic pain. A large proportion of men have no reversible cause identified and delayed recognition and management of this issue can cause significant morbidity. In this article, an approach to diagnosis and a review of treatment modalities available to manage chronic testicular pain is presented. Randomised control trials and current protocols for management were reviewed, in addition to case series and single-centre experiences of specialists with an interest in managing this condition. It is evident that chronic testicular pain should be managed with a multidisciplinary approach, to address the complex psychosocial elements often co-presenting with chronic pain. Various treatment options are available including medical therapy, non-invasive physiotherapy techniques and invasive surgical techniques. There is good evidence emerging for microsurgical techniques and nerve blocks. More research is required to determine the most effective duration and repetition of treatments. Chronic scrotal pain is physiologically related to other chronic pain syndromes and more research is required to determine the mechanisms behind this and potentially target chronic pain at a cellular level. In summary, chronic testicular pain affects a large number of men and further investigation into aetiology is important to direct treatment. A range of interventions are available -it is recommended that conservative treatments are trialed first in a multidisciplinary setting.
Abstract: Chronic testicular pain affects a growing number of men worldwide. The approach to diagnosis and treatment is variable, resulting in treatment delays of reversible causes that may increase the probability of progression to chronic pain. A large proportion of men have no reversible cause identified and delayed recognition and management of this issu...
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Prospective Randomized Study of Fixed Laser Setting Verses Variable Laser Settings for a Better Stone Free Rate
Chandra Mohan Vaddi,
Siddalinga Swamy Panchekante Matha,
Ramakrishna Paidakula,
Soundarya Ganesan,
Manas Babu,
Hemnath Anandan
Issue:
Volume 4, Issue 2, December 2020
Pages:
68-72
Received:
10 September 2020
Accepted:
25 September 2020
Published:
7 October 2020
Abstract: OBJECTIVE: To assess the outcome of variable laser settings verses fixed setting on the stone free rate and complications. MATERIAL AND METHOD: We conducted a prospective, single-blind randomized controlled study. Solitary renal non lower pole stones 10 to 20 cm were included. A total of 113 Patients were randomly divided in to two groups. In group A, fixed laser setting was used at 1.0J energy and 12Hz frequency during the entire procedure. In Group B, variable laser settings were used; initial fine fragmentation was performed @ 1.0J X 12Hz. Once the residual stone reduced enough to wobble, the energy was reduced to 0.8 J and 8Hz. Settings were further reduced to 0.5J and 5Hz as required to complete the fragmentation process with minimal migration. RESULT: Group A had 58 patients and Group B 55 patients for analysis of perioperative variables. Stone free rate (<2mm) is in favor of systematic stone dusting with variable frequency (95.8% vs 83.6%, p=0.05). Post-operative fever and pain were not statistically significant between the groups (fever 10.3% vs 9.1%, p=1.00) (pain mean VAS 1/10 in group A vs 2/10 in group B). CONCLUSION: The solitary hard stones of 10 to 20 mm can be treated with more than 95% SFR using variable laser settings producing fine dust, without increase in significant postoperative complications or hospital stay.
Abstract: OBJECTIVE: To assess the outcome of variable laser settings verses fixed setting on the stone free rate and complications. MATERIAL AND METHOD: We conducted a prospective, single-blind randomized controlled study. Solitary renal non lower pole stones 10 to 20 cm were included. A total of 113 Patients were randomly divided in to two groups. In group...
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Sutureless Laparoscopic Inguinal Hernia Repair in Children − Don’t Risk Injury with Sutures
William Kagetsu Bukowski,
Timothy Paul Bukowski
Issue:
Volume 4, Issue 2, December 2020
Pages:
73-76
Received:
22 September 2020
Accepted:
6 October 2020
Published:
13 October 2020
Abstract: Introduction: There have been multiple descriptions for the laparoscopic repair of inguinal hernia in children. Except for one, they all involve a suture ligation of the internal ring. Our concern is that suture ligation of the internal ring can injure the vas deferens, gonadal vessels, or cause unnecessary bleeding. We report the results of our laparoscopic inguinal hernia repairs, where we incise the peritoneum of the internal ring, and dissect the tunica vaginalis for 1 cm. We do not suture ligate the internal ring. This includes patients who underwent laparoscopic evaluation and treatment for intraabdominal testicles, and thus have 6 month laparoscopic follow-up of those patients having a staged orchiopexy. Study design: We reviewed the charts from 2005 to 2016 of all patients with CPT codes 54692 (laparoscopic orchiopexy) and 49650 (laparoscopic inguinal hernia). During laparoscopy for the nonpalpable testicle, we proceeded to either a one stage or 2 stage orchiopexy. When we observed inguinal hernia opening on the contralateral side of the undescended testicle, we repaired it by incising around the internal ring, and carefully excising the tunica vaginalis from the internal ring for a distance of 1 cm, leaving the internal oblique muscle to heal together, and peritoneum to resurface the area, without using sutures. (This is the same as is done for the laparoscopic orchiopexy side). In those patients with a staged orchiopexy, and we reevaluated the hernia sight for closure. Results: We reviewed charts of 87 patients with ages ranging from 3 months to 10 years. Eighteen of these had bilateral laparoscopic orchiopexy, 38 had left, and 24 had right. We performed 21 bilateral laparoscopic hernia repairs, 27 had left only, and 18 had right only. Of those patients with hernias, 11 hernias were found on the side opposite an undescended testis. In 4 patients we had the opportunity to perform a second stage orchiopexy six months later and observed the inguinal ring had closed. Follow up was at least 6 months for all patients, and no clinical hernias resulted. Conclusion: Laparoscopic inguinal hernia repair in children can be successfully and safely performed by excising the hernia sac (patent processus vaginalis) from the inguinal canal, and does not require suture ligation of the internal ring.
Abstract: Introduction: There have been multiple descriptions for the laparoscopic repair of inguinal hernia in children. Except for one, they all involve a suture ligation of the internal ring. Our concern is that suture ligation of the internal ring can injure the vas deferens, gonadal vessels, or cause unnecessary bleeding. We report the results of our la...
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Repair of Consecutive Cases of Hypospadias at 37 Military Hospital
Ben Adusei,
Sunny Duodo Mante,
Joshua Amegbor,
Paul Kodjo Yegbe
Issue:
Volume 4, Issue 2, December 2020
Pages:
77-80
Received:
24 September 2020
Accepted:
14 October 2020
Published:
30 October 2020
Abstract: The outcome of hypospadias repair usually will depend on the skills of the surgeon, the case load and the type of repair done. We report our results from 37 Military hospital in Accra, Ghana. Hypospadias is one of the commonest urologic congenital anomalies. It is associated with three anatomical anomalies: 1. an abnormal ventral opening of the urethral meatus; 2. Ventral curvature (chordae) of the penis; 3. A hooded foreskin. Method: This was a retrospective study of patients who had hypospadias repair between the periods of 2010 to 2017 at the 37 Military hospital. Data of patients who had hypospadias repair at the urology unit was collected. A total of 51 patients were studied out of a total of 1467 surgeries done within that period. Data on patient age, type of hypospadias, type of repair, complications were recorded. Repair was done for patients older than 6 months. Types of repair for urethral construction included; Glans Approximation procedure, (GAP); meatal advancement and glanuloplasty incorporated, (MAGPI); tubularized incised plate urethroplasty, (TIPU); Mustarde´; buccal mucosal tube tunnelled urethroplasty. For the correction of the chordae, a dermal graft was the main procedure of choice. Results: The commonest age of presentation and repair is before the age 5 years, 54.9% (28/51). The commonest types of hypospadias at presentation is coronal. The commonest complication is urethrocutaneous fistula. Conclusion: The commonest type of hypospadias is the coronal type with almost 55% of patient presenting before the age of 5 years. The commonest type of hypospadias is the coronal type (29.4%). Urethrocutaneous fistula is the commonest complication in hypospadias surgery. The use of dermal graft for the correction of severe chordae is a reliable alternative.
Abstract: The outcome of hypospadias repair usually will depend on the skills of the surgeon, the case load and the type of repair done. We report our results from 37 Military hospital in Accra, Ghana. Hypospadias is one of the commonest urologic congenital anomalies. It is associated with three anatomical anomalies: 1. an abnormal ventral opening of the ure...
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Cancer of the Penis: Clinical Features and Therapeutic Modalities in Senegalese Hospitals
Amath Thiam,
Alioune Sarr,
Ousmane Sow,
Ndeye Aïssatou Bagayogo,
Modou Ndiaye,
Babacar Sine,
Cyrille Ze Ondo,
Abdoulaye Ndiath,
El Hadji Malick Diaw,
Yaya Sow,
Babacar Diao,
Alain Khassim Ndoye
Issue:
Volume 4, Issue 2, December 2020
Pages:
81-84
Received:
14 October 2020
Accepted:
23 October 2020
Published:
4 November 2020
Abstract: Background: Penile cancer is a rare malignancy in Senegal. This rarity is probably related to the fact that circumcision, which has a protective effect, is a common practice in childhood. Some of the known risk factors include uncircumcised status, chronic inflammatory conditions, and a history of condyloma acuminata, smoking, and possibly human papillomavirus exposure. It is a pathology in adults with a maximum incidence after the age of 50. In our practice penile cancer is most often diagnosed at an advanced stage or only a radical and mutilating treatment may be proposed. Aims: To describe the clinical and therapeutic features of penis cancer in Senegal. Patients and methods: we carried out a retrospective, descriptive, bicentric study, collecting the records of patients with penis cancer in the Urology-Andrology department of the Aristide Le Dantec University hospital and the military hospital of Ouakam between January 2010 and December 2019. Results: fourteen cases of penile cancer were diagnosed. The mean age was 53.2 years with extremes of 29 and 84 years, the average consultation time was 21 months. All patients were circumcised in childhood. The tumor was limited to the glans in 2 cases and involved the entire penis in 5 cases. Six patients had bilateral inguinal adenopathies. The histological type was squamous cell carcinoma in all cases with a predominance of grade 2 (8 cases). Patients were classified as cT3 (7 cases), cT2 (5 cases), cT4 (1 case) and cT1 (1 case). Treatment consisted of partial amputation of the penis (5 cases), emasculation and perineal urethrostomy (4 cases) total amputation and perineal urethrostomy (2 cases). Three patients had refused total penis amputation. The average length of follow-up was 26 months (4 and 72 months), 3 lymph nodes recurrences and 2 local recurrences were observed. Two patients died among the operated patients. Conclusion: Cancer of the penis is rare in Senegal. The delay in diagnosis explains the frequency of advanced forms which can only be treated by radical surgery.
Abstract: Background: Penile cancer is a rare malignancy in Senegal. This rarity is probably related to the fact that circumcision, which has a protective effect, is a common practice in childhood. Some of the known risk factors include uncircumcised status, chronic inflammatory conditions, and a history of condyloma acuminata, smoking, and possibly human pa...
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Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting
Frantz Guy Epoupa Ngalle,
Kelly Donfack,
Edouard Herve Moby Mpah,
Sylvain Raoul Simeni Njonnou,
Charlotte Tchente Nguefack
Issue:
Volume 4, Issue 2, December 2020
Pages:
85-91
Received:
17 October 2020
Accepted:
2 November 2020
Published:
11 November 2020
Abstract: Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data on the subject in Cameron are scarce and nonexistent in the city of Douala. This motivated the realization of this study in two centers in the city of Douala. The objective was to describe the epidemiological profile of male infertility. Methods: We conducted a cross-sectional study among patients who consulted for infertility in two hospital centers in Douala from January 2014 to October 2019. A consecutive sample of all eligible cases was considered for this study. Data were analyzed using Statistical Package for Social Sciences (SPSS Inc, Chicago, Illinois, USA) V. 20.0 and EPI-INFO V. 3.5 software. Analyzed variables included sociodemographic data (age, marital status, educational level, profession, region, alcohol, smoking habit and mean infertility duration) and other causes of infertility (obesity, history of testes infection, STI, testes traumatism, varicocele or varicocele surgery, herniorrhaphy, genetic or malformative disease). Results: We included 137 patients' records. The frequency of male infertility for patients consulting in urology was 5.6%. Their average age was 35.4±7.4 years. The average number of sexual intercourses per week was 2.7±0.97. Those patients were mainly from an intellectual profession (40.2%), married (71.5%) with a higher education level (67.2%). Almost 60% of the studied population had alcohol consumption. Primary infertility accounted for 65.7% of the study population and the average duration of infertility was 5.9±5.3 years. The main factors for infertility were respectively history of sexually transmitted infections (STI) in 59 (43.1%) and childhood mumps in 42 (32.7%) cases. Furthermore, herniorrhaphy (16.1%) and varicocelectomy (10.9%) were the most representative surgical background. Conclusion: Male infertility is not uncommon in urological consultation with primary infertility been more frequent. Risk factors of infertility in our setting included a history of STI, mumps, and surgery.
Abstract: Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data...
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Report of a Case of Primary Signet-ring Cell Carcinoma of the Bladder and Review of the Literature
Baiyun Gao,
Guo Chen,
Yutong Li,
Bin Pan
Issue:
Volume 4, Issue 2, December 2020
Pages:
92-95
Received:
4 December 2020
Accepted:
14 December 2020
Published:
22 December 2020
Abstract: Primary signet-ring cell carcinoma of the bladder is a relatively rare tumor that progresses rapidly and has an extremely poor prognosis. We report a case of primary signet-ring cell carcinoma of the bladder. The patient underwent transurethral holmium laser lithotripsy for bladder calculi in another hospital, and a bladder tumor was found intraoperatively. Bladder tumor biopsy revealed infiltrating high-grade urothelial carcinoma with adenoid differentiation and invasion to the muscular layer. Gastrointestinal endoscopy ruled out other possible sources of tumor, and the patient was admitted to our hospital for treatment in October 2018. Cystoscopy revealed a large round mass in the trigone and right bladder wall, without probing the pedicle of the mass. After radical cystectomy, postoperative pathology showed signet-ring cell carcinoma, which infiltrated the full-thickness of the bladder wall, and cancer emboli were found in vasculature. The prostate gland and bilateral seminal vesicle were involved. After surgery, the patient did not receive any follow-up treatment due to personal factors. The Computed Tomography (CT) review at the 3rd month showed no tumor recurrence or metastasis, and the CEA review at the 6th month was 6790.2 ng/ml, considering that tumor metastasis had occurred. The patient was followed up for 9 months after surgery, and the postoperative survival time was more than 8 months. The prognosis of primary signet-ring cell carcinoma of the bladder is poor and most patients are in advanced stage at the time of diagnosis. Chemotherapy and radiotherapy have poor effect on it. Usually only total cystectomy may bring some hope to patients. Thus, early diagnosis and treatment are crucial.
Abstract: Primary signet-ring cell carcinoma of the bladder is a relatively rare tumor that progresses rapidly and has an extremely poor prognosis. We report a case of primary signet-ring cell carcinoma of the bladder. The patient underwent transurethral holmium laser lithotripsy for bladder calculi in another hospital, and a bladder tumor was found intraope...
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