Clinical pharmacokinetics was born as a necessity to obtain a better understanding and correlation between the administration of an active ingredient that is administered to a patient and the therapeutic effect obtained in him or her. This discipline, a subspecialty of medicine, aims to learn how a pharmacologic agent behaves in the body in order to thus establish therapeutic schemes, dose, interval and routes of administration, and also to describe drug interactions, antagonistic and synergistic behaviors, adverse reactions and side effects.

Bee able to prescribe active ingredients in safe, effective and optimal way in patients in pathological States must be the goal of every physician. This prescription should be an analytical decision taking into account age, sex, concomitant diseases, as well as the implementation of Pharmacokinetic principles in the treatment of the patient.

Currently we should focus and deepen in the pharmacokinetics of the active principles such as bioavailability, bioequivalence, absorption rate, excretion rate, route of elimination, as well as integrate such as t_1/2 which is pharmacokinetic parameters, Vd for the calculation of a pharmacological dose.

These should be the parameters that need to be analyzed for the creation of therapeutic schemes and individual therapeutic schemes, which I call them TSI, in pharmacologic principles with a narrow therapeutic window (Range). An average dose of an active ingredient does not always provide adequate levels because the concentration in serum depends on factors such as volume of distribution and elimination of the drug speed.These should be the parameters that need to be analyzed for the creation of therapeutic schemes and individual therapeutic schemes, which I call them TSI, in pharmacologic principles with a narrow therapeutic window (Range). An average dose of an active ingredient does not always provide adequate levels because the concentration in serum depends on factors such as volume of distribution and elimination of the drug speed.

Reason why plasma monitoring allows us to make the appropriate adjustments of dosage and avoid the empirical use of pharmacologic agents, thus bringing as a result of using this parameters the decrease of adverse and side effects in patients. Training in the area of medicine and chemistry has allow us to unite these two Sciences and understand the physiopathologic and chemical and biological aspect in human beings, which is the basis on what clinical pharmacokinetics was founded.

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