Obesity, a case accompanied by increased insulin resistance, is associated with low follicle stimulating hormone, luteinizing hormone, total testosterone and progesterone and estradiol levels. As there is no scientific report on diabetes complications and its effects on type 2 diabetic patients in the province of Meisan (southern of Iraq), the present investigation was done to evaluate the levels of body mass index, insulin resistance and the levels of sex hormones in serum of both men and women type 2 diabetic patients. Data obtained in the present study, show a significant increase in insulin resistance level (4.24 ± 0.57 Vs. 1.36±0.23 and 4.31 ± 0.59 Vs. 1.18 ±0.13, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. Also, the present study show a significant decrease in follicle stimulating hormone level (7.24±1.14 Vs. 12.79 ±0.87 and 38.14 ± 4.44 Vs. 54.16 ± 3.64, P < 0.05), a significant decrease in luteinizing hormone level (5.32 ± 0.74 Vs. 7.54± 1.27 and 30.12 ± 4.20 Vs. 43.33±2.07, P < 0.05), a significant decrease in testosterone level (4.69 ± 0.92 Vs. 8.20 ± 2.2 and 0.57 ± 0.11 Vs. 0.69± 0.21, P < 0.01), a significant decrease in progesterone level (0.25 ±0.03 Vs. 0.42 ± 0.10 and 0.30 ± 0.04 Vs. 0.46± 0.12, P < 0.05) and a significant decrease in estradiol level (25.04 ± 3.35 Vs. 33.80±8.4 and 34.33 ± 4.21 Vs. 41.42±5.64, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. In conclusion, the findings further demonstrated that insulin resistance plays an important role in the pathogenesis of many human diseases, such as diabetes, obesity, and reduction of fertility. Therefore, the associated of obesity and increased insulin resistance is accompanied by low levels of follicle stimulating hormone, luteinizing hormone, testosterone, progesterone and estradiol in both men and women.
Published in | Advances in Biochemistry (Volume 5, Issue 5) |
DOI | 10.11648/j.ab.20170505.11 |
Page(s) | 79-88 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2017. Published by Science Publishing Group |
Insulin Resistance, Obesity, Sex Hormones, Type 2 Diabetes Mellitus
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APA Style
Adnan Jassim Mohammed Al-Fartosy, Ibrahim Majar Mohammed. (2017). Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq. Advances in Biochemistry, 5(5), 79-88. https://doi.org/10.11648/j.ab.20170505.11
ACS Style
Adnan Jassim Mohammed Al-Fartosy; Ibrahim Majar Mohammed. Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq. Adv. Biochem. 2017, 5(5), 79-88. doi: 10.11648/j.ab.20170505.11
AMA Style
Adnan Jassim Mohammed Al-Fartosy, Ibrahim Majar Mohammed. Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq. Adv Biochem. 2017;5(5):79-88. doi: 10.11648/j.ab.20170505.11
@article{10.11648/j.ab.20170505.11, author = {Adnan Jassim Mohammed Al-Fartosy and Ibrahim Majar Mohammed}, title = {Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq}, journal = {Advances in Biochemistry}, volume = {5}, number = {5}, pages = {79-88}, doi = {10.11648/j.ab.20170505.11}, url = {https://doi.org/10.11648/j.ab.20170505.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20170505.11}, abstract = {Obesity, a case accompanied by increased insulin resistance, is associated with low follicle stimulating hormone, luteinizing hormone, total testosterone and progesterone and estradiol levels. As there is no scientific report on diabetes complications and its effects on type 2 diabetic patients in the province of Meisan (southern of Iraq), the present investigation was done to evaluate the levels of body mass index, insulin resistance and the levels of sex hormones in serum of both men and women type 2 diabetic patients. Data obtained in the present study, show a significant increase in insulin resistance level (4.24 ± 0.57 Vs. 1.36±0.23 and 4.31 ± 0.59 Vs. 1.18 ±0.13, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. Also, the present study show a significant decrease in follicle stimulating hormone level (7.24±1.14 Vs. 12.79 ±0.87 and 38.14 ± 4.44 Vs. 54.16 ± 3.64, P < 0.05), a significant decrease in luteinizing hormone level (5.32 ± 0.74 Vs. 7.54± 1.27 and 30.12 ± 4.20 Vs. 43.33±2.07, P < 0.05), a significant decrease in testosterone level (4.69 ± 0.92 Vs. 8.20 ± 2.2 and 0.57 ± 0.11 Vs. 0.69± 0.21, P < 0.01), a significant decrease in progesterone level (0.25 ±0.03 Vs. 0.42 ± 0.10 and 0.30 ± 0.04 Vs. 0.46± 0.12, P < 0.05) and a significant decrease in estradiol level (25.04 ± 3.35 Vs. 33.80±8.4 and 34.33 ± 4.21 Vs. 41.42±5.64, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. In conclusion, the findings further demonstrated that insulin resistance plays an important role in the pathogenesis of many human diseases, such as diabetes, obesity, and reduction of fertility. Therefore, the associated of obesity and increased insulin resistance is accompanied by low levels of follicle stimulating hormone, luteinizing hormone, testosterone, progesterone and estradiol in both men and women.}, year = {2017} }
TY - JOUR T1 - Biochemical Study of the Effects of Insulin Resistance on Sex Hormones in Men and Women Type-2 Diabetic Patients / Meisan-Iraq AU - Adnan Jassim Mohammed Al-Fartosy AU - Ibrahim Majar Mohammed Y1 - 2017/09/12 PY - 2017 N1 - https://doi.org/10.11648/j.ab.20170505.11 DO - 10.11648/j.ab.20170505.11 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 79 EP - 88 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20170505.11 AB - Obesity, a case accompanied by increased insulin resistance, is associated with low follicle stimulating hormone, luteinizing hormone, total testosterone and progesterone and estradiol levels. As there is no scientific report on diabetes complications and its effects on type 2 diabetic patients in the province of Meisan (southern of Iraq), the present investigation was done to evaluate the levels of body mass index, insulin resistance and the levels of sex hormones in serum of both men and women type 2 diabetic patients. Data obtained in the present study, show a significant increase in insulin resistance level (4.24 ± 0.57 Vs. 1.36±0.23 and 4.31 ± 0.59 Vs. 1.18 ±0.13, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. Also, the present study show a significant decrease in follicle stimulating hormone level (7.24±1.14 Vs. 12.79 ±0.87 and 38.14 ± 4.44 Vs. 54.16 ± 3.64, P < 0.05), a significant decrease in luteinizing hormone level (5.32 ± 0.74 Vs. 7.54± 1.27 and 30.12 ± 4.20 Vs. 43.33±2.07, P < 0.05), a significant decrease in testosterone level (4.69 ± 0.92 Vs. 8.20 ± 2.2 and 0.57 ± 0.11 Vs. 0.69± 0.21, P < 0.01), a significant decrease in progesterone level (0.25 ±0.03 Vs. 0.42 ± 0.10 and 0.30 ± 0.04 Vs. 0.46± 0.12, P < 0.05) and a significant decrease in estradiol level (25.04 ± 3.35 Vs. 33.80±8.4 and 34.33 ± 4.21 Vs. 41.42±5.64, P < 0.05) respectively, in men and women type 2 diabetic patients compared to control. In conclusion, the findings further demonstrated that insulin resistance plays an important role in the pathogenesis of many human diseases, such as diabetes, obesity, and reduction of fertility. Therefore, the associated of obesity and increased insulin resistance is accompanied by low levels of follicle stimulating hormone, luteinizing hormone, testosterone, progesterone and estradiol in both men and women. VL - 5 IS - 5 ER -