Seasonality of Vitamin D Insufficiency in Children of Moscow

Zakharova Irina; Borovik Tatyana; Pludowski Pawel; Tvorogova Tatyana; Solovyeva Ekaterina; Sugyan Narine; Antonenko Natalia; Balashova Nadejda; Kuular Nadejda; Marchenko Vera; Perova Svetlana; Prostakova Valentina; Simakova Natalia; Simonenko Irina; Vasilyeva Svetlana; Mozzhukhina Maria; Koroleva Ekaterina; Rakhteenko Alina; Dmitrieva Yulia; Klimov Leonid; Kuryaninova Victoria

doi:doi:10.11648/j.ajp.20170306.14

Seasonality of Vitamin D Insufficiency in Children of Moscow

Zakharova Irina, Borovik Tatyana, Pludowski Pawel, Tvorogova Tatyana, Solovyeva Ekaterina, Sugyan Narine, Antonenko Natalia, Balashova Nadejda, Kuular Nadejda, Marchenko Vera, Perova Svetlana, Prostakova Valentina, Simakova Natalia, Simonenko Irina, Vasilyeva Svetlana, Mozzhukhina Maria, Koroleva Ekaterina, Rakhteenko Alina, Dmitrieva Yulia, Klimov Leonid, Kuryaninova Victoria

Published in American Journal of Pediatrics (Volume 3, Issue 6)

Received: 11 July 2017 Accepted: 23 October 2017 Published: 30 November 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The article presents the analysis of vitamin D levels in children of various age groups residing in Moscow and assesses the seasonality of vitamin D variations in this population group. In this work, the results of 25 (ОН) D level measurement in 1041 children in the age from 1 month to 18 years collected in the period since 2012 to 2015 have been analyzed. In accordance with the analysis, in spite of the age, the high percentage of vitamin D insufficiency was detected among children in Moscow. The generally accepted optimum level of vitamin D metabolite – calcidiol in blood (>30 ng/ml) was observed only in the small part of the study participants (26%), while the larger part (74%) had the insufficient level of vitamin D of various intensity: 28% - insufficiency (20-29 ng/ml), 33% - deficiency (<20 ng/ml), 13% - severe deficiency (<10 ng/ml). With the age, the insufficiency level was more pronounced. The seasonality analysis showed the significant difference of vitamin D level between summer and winter seasons (p=0.01). The greatest decrease of vitamin D levels was observed in winter (median level of 25(ОН)D 17.0 (11.0; 25.0) ng/ml). In summer months, the relative calcidiol gain was fixed (median – 22.9 (18.0; 33.0) ng/ml) which, however, did not achieve the normal level. Children and, in particular, adolescents residing in Moscow need year-round hypovitaminosis D prophylaxis with cholecalciferol products.

Published in	American Journal of Pediatrics (Volume 3, Issue 6)
DOI	10.11648/j.ajp.20170306.14
Page(s)	83-88
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Vitamin D, Cholecalciferol, Hypovitaminosis D, Vitamin D Deficiency, Seasonal Variations of Vitamin D

References

[1]	Gromova O. A., Torshin I. Yu. Vitamin D–change of the paradigm /Edited by E. I. Gusev, I. N. Zakharova–М.:TORUS PRESS, 2015.–464 p.
[2]	Hossein-Nezhad A., Spira A., Holick M. F. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial // PloS One.–2013.–Vol 8, № 3.– p. e58725.
[3]	Munns C. F., Shaw N., Kiely M., Specker B. L., Thacher T. D., Ozono K., Michigami T., Tiosano D., Mughal M. Z., Mäkitie O., Ramos-Abad L., Ward L., DiMeglio L. A., Atapattu N., Cassinelli H., Braegger C., Pettifor J. M., Seth A., Idris H. W., Bhatia V., Fu J., Goldberg G., Sävendahl L., Khadgawat R., Pludowski P., Maddock J., Hyppönen E., Oduwole A., Frew E., Aguiar M., Tulchinsky T., Butler G., Högler W. Global consensus recommendations on prevention and management of nutritional hypovitaminosis D // Hormone Research in Paediatrics.–2016.–Vol. 85, № 2.–P. 83–106.
[4]	Saggese G., Vierucci F., Boot A. M., Czech-Kowalska J., Weber G., Camargo C. A., Mallet E., Fanos M., Shaw N. J., Holick M. F. Vitamin D in childhood and adolescence: an expert position statement // Eur. J. Pediatrics.–2015.–Vol. 174, № 5.–P. 565–576.
[5]	Schlögl M., Holick M. F. Vitamin D and neurocognitive function // Clinical Interventions in Aging.–2014.–Vol. 9.–P. 559–568.
[6]	Hossein-Nezhad A., Holick M. F. Vitamin D for health: a global perspective // Mayo Clinic Proceedings.–Elsevier, 2013.–Vol. 88, № 7.–P. 720–755.
[7]	Gromova O. A., Torshin I. Yu., Zakharova I. N., Spirichev V. B., Limanova О. А., Borovik T. E., Yatsyk G. V. On vitamin D dosing in children and adolescents // Problems of modern pediatrics.–2015.–Volume 14, № 1.–P. 38–47.
[8]	Andersen R., Brot C., Jakobsen J., Mejborn H., Mølgaard C., Skovgaard L. T., Trolle E., Tetens I., Ovesen L. Seasonal changes in vitamin D status among Danish adolescent girls and elderly women: the influence of sun exposure and vitamin D intake // Eur. J. Clin. Nutr.–2013.–Vol. 67, № 3.–P. 270–274.
[9]	Maxwell J. D. Seasonal variation in vitamin D // Proceedings of the Nutrition Society.–1994.–Vol. 53, № 3.–P. 533–543.
[10]	Meier C. Woitge H. W., Witte K., Lemmer B., Seibel M. J. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial // Journal of Bone and Mineral Research.–2004.–Vol. 19, № 8.–P. 1221–1230.
[11]	Rockell J. E., Green T. J., Skeaff C. M., Whiting S. J., Taylor R. W., Williams S. M., Parnell W. R., Scragg R., Wilson N., Schaaf D., Fitzgerald E. D., Wohlers M. W. Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5–14 y // The Journal of Nutrition.–2005. – Vol. 135, № 11.–P. 2602–2608.
[12]	Davies P. S., Bates C. J., Cole T. J., Prentice A., Clarke P. C. Vitamin D: seasonal and regional differences in preschool children in Great Britain // Eur. J. Clin. Nutr.—1999.—Vol. 53, № 3.–Р. 195–198.
[13]	Gordon C. M., DePeter K. C., Feldman H. A., Grace E., Emans S. J. Prevalence of vitamin D deficiency among healthy adolescents // Arch. Pediatr. Adolesc. Med.–2004.–Vol. 158, № 6.–Р. 531–537.
[14]	Holick M. F. Evidence-based D-bate on health benefits of vitamin D revisited // Dermato-endocrinology.–2012.–Vol. 4, № 2.–P. 183–190.
[15]	Priemel M., von Domarus C., Klatte T. O., Kessler S., Schlie J., Meier S., Proksch N., Pastor F., Netter C., Streichert T., Püschel K., Amling M. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients // Journal of Bone and Mineral Research.–2010.–Vol. 25, № 2.–P. 305–312.
[16]	Zakharova I. N.,Vasilyeva S. V., Dmitrieva Yu. A., Mozzhukhina M. V., Evseeva E. A. Correction of vitamin D insufficiency // Effective pharmacotherapy.–2014.–№. 3.–P. 38–45.
[17]	Wacker M., Holick M. F. Vitamin D–effects on skeletal and extraskeletal health and the need for supplementation // Nutrients.–2013. –Vol. 5, № 1.–P. 111–148.
[18]	Holick M. F., Binkley N. C., Bischoff-Ferrari H. A., Gordon C. M., Hanley D. A., Heaney R. P., Murad M. H., Weaver C. M. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline // J. Clin. Endocrinol. Metabolism. –2011.–Vol. 96, № 7.–P. 1911–1930.
[19]	Zakharova I. N., Maltsev S. B., Borovik T. E., Yatsyk G. V., Malyavskaya S. I., Vakhlova I. V., Shumatova T. A., Romantsova E. V., Romanyuk F. P., Klimov L. Ya., Pirozhkova N. I., Kolesnikova S. M., Kuryaninova V. A., Vasilyeva S. V., Mozzhukhina M. V., Evseva E. A. The results of multicenter study “Rodnichok” to examine vitamin D insufficiency in younger children in Russia // Pediatrics. G. N. Speransky journal.–2015.–Volume 94, № 1.–P. 62–67.
[20]	Kodentsova V. M., Gromova О. А., Makarova S. G. Micronutrients in nutrition of children and use of vitamin-mineral complexes // Pediatric pharmacology.–2015.–Volume 12, № 5.–P. 537–542.
[21]	Gromova О. А., Torshin I. Yu. Vitamins and minerals between Scylla and Haribda. Edited by E. I. Gusev, V. G. Spirichev. М.: MCNMO, 2013.–693 p.
[22]	Thacher T. D., Clarke B. L. Vitamin D insufficiency // Mayo Clin. Proc.–2011.–Vol. 86, № 1l.–P. 50–60.
[23]	Saygitov R. T. Differentiated (“seasonal”) approach in prophylactic of vitamin D3 insufficiency in children // Problems of modern pediatrics.–2009.–Volume 8, № 5.–P.70–79.
[24]	Pludowski P., Grant W. B., Bhattoa H. P., Bayer M., Povoroznyuk V., Rudenka E., Ramanau H., Varbiro S., Rudenka A., Karczmarewicz E., Lorenc R., Czech-Kowalska J., Konstantynowicz J. Vitamin D status in Central Europe // International Journal of Endocrinology.–2014.–Т. 2014.
[25]	Kodentsova V. M., Vrzhesinskaya О. А. Fortified food products in nutrition of children: history, problems and prospectives // Problems of pediatric dietology.–2012.–Volume 10, № 5.–P. 32–44.

Cite This Article

Plain Text BibTeX RIS

APA Style

Zakharova Irina, Borovik Tatyana, Pludowski Pawel, Tvorogova Tatyana, Solovyeva Ekaterina, et al. (2017). Seasonality of Vitamin D Insufficiency in Children of Moscow. American Journal of Pediatrics, 3(6), 83-88. https://doi.org/10.11648/j.ajp.20170306.14

Copy | Download

ACS Style

Zakharova Irina; Borovik Tatyana; Pludowski Pawel; Tvorogova Tatyana; Solovyeva Ekaterina, et al. Seasonality of Vitamin D Insufficiency in Children of Moscow. Am. J. Pediatr. 2017, 3(6), 83-88. doi: 10.11648/j.ajp.20170306.14

Copy | Download

AMA Style

Zakharova Irina, Borovik Tatyana, Pludowski Pawel, Tvorogova Tatyana, Solovyeva Ekaterina, et al. Seasonality of Vitamin D Insufficiency in Children of Moscow. Am J Pediatr. 2017;3(6):83-88. doi: 10.11648/j.ajp.20170306.14

Copy | Download

@article{10.11648/j.ajp.20170306.14,
  author = {Zakharova Irina and Borovik Tatyana and Pludowski Pawel and Tvorogova Tatyana and Solovyeva Ekaterina and Sugyan Narine and Antonenko Natalia and Balashova Nadejda and Kuular Nadejda and Marchenko Vera and Perova Svetlana and Prostakova Valentina and Simakova Natalia and Simonenko Irina and Vasilyeva Svetlana and Mozzhukhina Maria and Koroleva Ekaterina and Rakhteenko Alina and Dmitrieva Yulia and Klimov Leonid and Kuryaninova Victoria},
  title = {Seasonality of Vitamin D Insufficiency in Children of Moscow},
  journal = {American Journal of Pediatrics},
  volume = {3},
  number = {6},
  pages = {83-88},
  doi = {10.11648/j.ajp.20170306.14},
  url = {https://doi.org/10.11648/j.ajp.20170306.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20170306.14},
  abstract = {The article presents the analysis of vitamin D levels in children of various age groups residing in Moscow and assesses the seasonality of vitamin D variations in this population group. In this work, the results of 25 (ОН) D level measurement in 1041 children in the age from 1 month to 18 years collected in the period since 2012 to 2015 have been analyzed. In accordance with the analysis, in spite of the age, the high percentage of vitamin D insufficiency was detected among children in Moscow. The generally accepted optimum level of vitamin D metabolite – calcidiol in blood (>30 ng/ml) was observed only in the small part of the study participants (26%), while the larger part (74%) had the insufficient level of vitamin D of various intensity: 28% - insufficiency (20-29 ng/ml), 33% - deficiency (<20 ng/ml), 13% - severe deficiency (<10 ng/ml). With the age, the insufficiency level was more pronounced. The seasonality analysis showed the significant difference of vitamin D level between summer and winter seasons (p=0.01). The greatest decrease of vitamin D levels was observed in winter (median level of 25(ОН)D 17.0 (11.0; 25.0) ng/ml). In summer months, the relative calcidiol gain was fixed (median – 22.9 (18.0; 33.0) ng/ml) which, however, did not achieve the normal level. Children and, in particular, adolescents residing in Moscow need year-round hypovitaminosis D prophylaxis with cholecalciferol products.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Seasonality of Vitamin D Insufficiency in Children of Moscow
AU  - Zakharova Irina
AU  - Borovik Tatyana
AU  - Pludowski Pawel
AU  - Tvorogova Tatyana
AU  - Solovyeva Ekaterina
AU  - Sugyan Narine
AU  - Antonenko Natalia
AU  - Balashova Nadejda
AU  - Kuular Nadejda
AU  - Marchenko Vera
AU  - Perova Svetlana
AU  - Prostakova Valentina
AU  - Simakova Natalia
AU  - Simonenko Irina
AU  - Vasilyeva Svetlana
AU  - Mozzhukhina Maria
AU  - Koroleva Ekaterina
AU  - Rakhteenko Alina
AU  - Dmitrieva Yulia
AU  - Klimov Leonid
AU  - Kuryaninova Victoria
Y1  - 2017/11/30
PY  - 2017
N1  - https://doi.org/10.11648/j.ajp.20170306.14
DO  - 10.11648/j.ajp.20170306.14
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 83
EP  - 88
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20170306.14
AB  - The article presents the analysis of vitamin D levels in children of various age groups residing in Moscow and assesses the seasonality of vitamin D variations in this population group. In this work, the results of 25 (ОН) D level measurement in 1041 children in the age from 1 month to 18 years collected in the period since 2012 to 2015 have been analyzed. In accordance with the analysis, in spite of the age, the high percentage of vitamin D insufficiency was detected among children in Moscow. The generally accepted optimum level of vitamin D metabolite – calcidiol in blood (>30 ng/ml) was observed only in the small part of the study participants (26%), while the larger part (74%) had the insufficient level of vitamin D of various intensity: 28% - insufficiency (20-29 ng/ml), 33% - deficiency (<20 ng/ml), 13% - severe deficiency (<10 ng/ml). With the age, the insufficiency level was more pronounced. The seasonality analysis showed the significant difference of vitamin D level between summer and winter seasons (p=0.01). The greatest decrease of vitamin D levels was observed in winter (median level of 25(ОН)D 17.0 (11.0; 25.0) ng/ml). In summer months, the relative calcidiol gain was fixed (median – 22.9 (18.0; 33.0) ng/ml) which, however, did not achieve the normal level. Children and, in particular, adolescents residing in Moscow need year-round hypovitaminosis D prophylaxis with cholecalciferol products.
VL  - 3
IS  - 6
ER  -

Copy | Download

Author Information

Zakharova Irina

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Borovik Tatyana

Department of Nutrition Children, FSAI ?National Scientific and Practical Center of Children’s Health? of the Ministry of Health, Moscow, Russia Federation
Pludowski Pawel

Department of Biochemistry and of Experimental Medicine, The Children’s Memorial Health Institute, Warsaw, Poland
Tvorogova Tatyana

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Solovyeva Ekaterina

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Sugyan Narine

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Antonenko Natalia

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Balashova Nadejda

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Kuular Nadejda

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Marchenko Vera

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Perova Svetlana

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Prostakova Valentina

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Simakova Natalia

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Simonenko Irina

Department of Pediatric, FSBI “Pediatric Medical Center” of the Presidential Administration of the Russian Federation, Moscow, Russia Federation
Vasilyeva Svetlana

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Mozzhukhina Maria

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Koroleva Ekaterina

Department of Pediatric, Clinic of Group of Companies “Mother and a Child”, Moscow, Russia Federation
Rakhteenko Alina

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Dmitrieva Yulia

Department of Pediatric, FSBEI HPT “Russian Medical Academy of Postgraduate Continuing Education” of the Ministry of Health, Moscow, Russia Federation
Klimov Leonid

Department of Pediatric, FSBEI HE “Stavropol State Medical University” of the Ministry of Health, Stavropol, Russia Federation
Kuryaninova Victoria

Department of Pediatric, FSBEI HE “Stavropol State Medical University” of the Ministry of Health, Stavropol, Russia Federation

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Zakharova Irina, Borovik Tatyana, Pludowski Pawel, Tvorogova Tatyana, Solovyeva Ekaterina, et al. (2017). Seasonality of Vitamin D Insufficiency in Children of Moscow. American Journal of Pediatrics, 3(6), 83-88. https://doi.org/10.11648/j.ajp.20170306.14

Copy | Download

ACS Style

Zakharova Irina; Borovik Tatyana; Pludowski Pawel; Tvorogova Tatyana; Solovyeva Ekaterina, et al. Seasonality of Vitamin D Insufficiency in Children of Moscow. Am. J. Pediatr. 2017, 3(6), 83-88. doi: 10.11648/j.ajp.20170306.14

Copy | Download

AMA Style

Zakharova Irina, Borovik Tatyana, Pludowski Pawel, Tvorogova Tatyana, Solovyeva Ekaterina, et al. Seasonality of Vitamin D Insufficiency in Children of Moscow. Am J Pediatr. 2017;3(6):83-88. doi: 10.11648/j.ajp.20170306.14

Copy | Download

@article{10.11648/j.ajp.20170306.14,
  author = {Zakharova Irina and Borovik Tatyana and Pludowski Pawel and Tvorogova Tatyana and Solovyeva Ekaterina and Sugyan Narine and Antonenko Natalia and Balashova Nadejda and Kuular Nadejda and Marchenko Vera and Perova Svetlana and Prostakova Valentina and Simakova Natalia and Simonenko Irina and Vasilyeva Svetlana and Mozzhukhina Maria and Koroleva Ekaterina and Rakhteenko Alina and Dmitrieva Yulia and Klimov Leonid and Kuryaninova Victoria},
  title = {Seasonality of Vitamin D Insufficiency in Children of Moscow},
  journal = {American Journal of Pediatrics},
  volume = {3},
  number = {6},
  pages = {83-88},
  doi = {10.11648/j.ajp.20170306.14},
  url = {https://doi.org/10.11648/j.ajp.20170306.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20170306.14},
  abstract = {The article presents the analysis of vitamin D levels in children of various age groups residing in Moscow and assesses the seasonality of vitamin D variations in this population group. In this work, the results of 25 (ОН) D level measurement in 1041 children in the age from 1 month to 18 years collected in the period since 2012 to 2015 have been analyzed. In accordance with the analysis, in spite of the age, the high percentage of vitamin D insufficiency was detected among children in Moscow. The generally accepted optimum level of vitamin D metabolite – calcidiol in blood (>30 ng/ml) was observed only in the small part of the study participants (26%), while the larger part (74%) had the insufficient level of vitamin D of various intensity: 28% - insufficiency (20-29 ng/ml), 33% - deficiency (<20 ng/ml), 13% - severe deficiency (<10 ng/ml). With the age, the insufficiency level was more pronounced. The seasonality analysis showed the significant difference of vitamin D level between summer and winter seasons (p=0.01). The greatest decrease of vitamin D levels was observed in winter (median level of 25(ОН)D 17.0 (11.0; 25.0) ng/ml). In summer months, the relative calcidiol gain was fixed (median – 22.9 (18.0; 33.0) ng/ml) which, however, did not achieve the normal level. Children and, in particular, adolescents residing in Moscow need year-round hypovitaminosis D prophylaxis with cholecalciferol products.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Seasonality of Vitamin D Insufficiency in Children of Moscow
AU  - Zakharova Irina
AU  - Borovik Tatyana
AU  - Pludowski Pawel
AU  - Tvorogova Tatyana
AU  - Solovyeva Ekaterina
AU  - Sugyan Narine
AU  - Antonenko Natalia
AU  - Balashova Nadejda
AU  - Kuular Nadejda
AU  - Marchenko Vera
AU  - Perova Svetlana
AU  - Prostakova Valentina
AU  - Simakova Natalia
AU  - Simonenko Irina
AU  - Vasilyeva Svetlana
AU  - Mozzhukhina Maria
AU  - Koroleva Ekaterina
AU  - Rakhteenko Alina
AU  - Dmitrieva Yulia
AU  - Klimov Leonid
AU  - Kuryaninova Victoria
Y1  - 2017/11/30
PY  - 2017
N1  - https://doi.org/10.11648/j.ajp.20170306.14
DO  - 10.11648/j.ajp.20170306.14
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 83
EP  - 88
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20170306.14
AB  - The article presents the analysis of vitamin D levels in children of various age groups residing in Moscow and assesses the seasonality of vitamin D variations in this population group. In this work, the results of 25 (ОН) D level measurement in 1041 children in the age from 1 month to 18 years collected in the period since 2012 to 2015 have been analyzed. In accordance with the analysis, in spite of the age, the high percentage of vitamin D insufficiency was detected among children in Moscow. The generally accepted optimum level of vitamin D metabolite – calcidiol in blood (>30 ng/ml) was observed only in the small part of the study participants (26%), while the larger part (74%) had the insufficient level of vitamin D of various intensity: 28% - insufficiency (20-29 ng/ml), 33% - deficiency (<20 ng/ml), 13% - severe deficiency (<10 ng/ml). With the age, the insufficiency level was more pronounced. The seasonality analysis showed the significant difference of vitamin D level between summer and winter seasons (p=0.01). The greatest decrease of vitamin D levels was observed in winter (median level of 25(ОН)D 17.0 (11.0; 25.0) ng/ml). In summer months, the relative calcidiol gain was fixed (median – 22.9 (18.0; 33.0) ng/ml) which, however, did not achieve the normal level. Children and, in particular, adolescents residing in Moscow need year-round hypovitaminosis D prophylaxis with cholecalciferol products.
VL  - 3
IS  - 6
ER  -

Copy | Download