Drug-Induced Liver Diseases in Children and Adolescents

Sergey Postnikov; Nataliya Teplova; Aleksey Ermilin; Anna Gratzhianskaya; Marya Kostyleva

doi:doi:10.11648/j.ajp.20190502.14

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Drug-Induced Liver Diseases in Children and Adolescents

Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva

Published in American Journal of Pediatrics (Volume 5, Issue 2)

Received: 9 March 2019 Accepted: 22 April 2019 Published: 20 May 2019

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Abstract

Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.

Published in	American Journal of Pediatrics (Volume 5, Issue 2)
DOI	10.11648/j.ajp.20190502.14
Page(s)	56-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Drug and Liver Disease, Risk Factors of Hepatotoxicity, Mechanisms and Types of DILD, Hepatoprotectors, Prevention of DILD

References

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APA Style

Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva. (2019). Drug-Induced Liver Diseases in Children and Adolescents. American Journal of Pediatrics, 5(2), 56-63. https://doi.org/10.11648/j.ajp.20190502.14

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ACS Style

Sergey Postnikov; Nataliya Teplova; Aleksey Ermilin; Anna Gratzhianskaya; Marya Kostyleva. Drug-Induced Liver Diseases in Children and Adolescents. Am. J. Pediatr. 2019, 5(2), 56-63. doi: 10.11648/j.ajp.20190502.14

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AMA Style

Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva. Drug-Induced Liver Diseases in Children and Adolescents. Am J Pediatr. 2019;5(2):56-63. doi: 10.11648/j.ajp.20190502.14

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@article{10.11648/j.ajp.20190502.14,
  author = {Sergey Postnikov and Nataliya Teplova and Aleksey Ermilin and Anna Gratzhianskaya and Marya Kostyleva},
  title = {Drug-Induced Liver Diseases in Children and Adolescents},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {2},
  pages = {56-63},
  doi = {10.11648/j.ajp.20190502.14},
  url = {https://doi.org/10.11648/j.ajp.20190502.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190502.14},
  abstract = {Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.},
 year = {2019}
}

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TY  - JOUR
T1  - Drug-Induced Liver Diseases in Children and Adolescents
AU  - Sergey Postnikov
AU  - Nataliya Teplova
AU  - Aleksey Ermilin
AU  - Anna Gratzhianskaya
AU  - Marya Kostyleva
Y1  - 2019/05/20
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190502.14
DO  - 10.11648/j.ajp.20190502.14
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 56
EP  - 63
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190502.14
AB  - Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.
VL  - 5
IS  - 2
ER  -

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Author Information

Sergey Postnikov

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Nataliya Teplova

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Aleksey Ermilin

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Anna Gratzhianskaya

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation
Marya Kostyleva

Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

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Plain Text BibTeX RIS

APA Style

Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva. (2019). Drug-Induced Liver Diseases in Children and Adolescents. American Journal of Pediatrics, 5(2), 56-63. https://doi.org/10.11648/j.ajp.20190502.14

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ACS Style

Sergey Postnikov; Nataliya Teplova; Aleksey Ermilin; Anna Gratzhianskaya; Marya Kostyleva. Drug-Induced Liver Diseases in Children and Adolescents. Am. J. Pediatr. 2019, 5(2), 56-63. doi: 10.11648/j.ajp.20190502.14

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AMA Style

Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva. Drug-Induced Liver Diseases in Children and Adolescents. Am J Pediatr. 2019;5(2):56-63. doi: 10.11648/j.ajp.20190502.14

Copy | Download

@article{10.11648/j.ajp.20190502.14,
  author = {Sergey Postnikov and Nataliya Teplova and Aleksey Ermilin and Anna Gratzhianskaya and Marya Kostyleva},
  title = {Drug-Induced Liver Diseases in Children and Adolescents},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {2},
  pages = {56-63},
  doi = {10.11648/j.ajp.20190502.14},
  url = {https://doi.org/10.11648/j.ajp.20190502.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190502.14},
  abstract = {Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.},
 year = {2019}
}

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TY  - JOUR
T1  - Drug-Induced Liver Diseases in Children and Adolescents
AU  - Sergey Postnikov
AU  - Nataliya Teplova
AU  - Aleksey Ermilin
AU  - Anna Gratzhianskaya
AU  - Marya Kostyleva
Y1  - 2019/05/20
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190502.14
DO  - 10.11648/j.ajp.20190502.14
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 56
EP  - 63
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190502.14
AB  - Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.
VL  - 5
IS  - 2
ER  -

Copy | Download