Dengue fever is a self-limiting, systemic viral illness that has a wide range of clinical manifestations. Last year dengue was severe in children with much mortality. This study was aimed to see the clinical profile of dengue and to find out the risk factors for developing severity. This cross sectional study was conducted over four months (June-September, 2018) in Department of Pediatrics of United Hospital Limited. All admitted dengue cases were analyzed. The predictors of developing severity were assessed by comparing variables between classical and severe dengue fever groups. A total of 106 children with Dengue fever were admitted. Mean age was 5.8±3 years with male predominance (60%). Common presentations include fever (100%), flushed appearance (72%), rash (43%), vomiting (39%), abdominal pain (36%), shock (28%) and respiratory distress (23%). In risk factor analysis, overweight (OR: 8.275, CI: 1.378-49.706) and massive serositis (OR: 17.86, CI: 4.733-67.399) were found statistically significant predictors of severe dengue. The overall mortality was 3%. So, overweight children and those patients who develop massive serositis are at increased risk of having severe dengue. Early identification of these features can help physicians to manage these cases judiciously.
Published in | American Journal of Pediatrics (Volume 5, Issue 4) |
DOI | 10.11648/j.ajp.20190504.19 |
Page(s) | 219-223 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Dengue in Children, Dengue Severity, Risk Factors of Dengue
[1] | National Guideline for clinical management of Dengue syndrome. 4th edition, 2018. |
[2] | WHO fact sheets- Dengue and severe dengue. April 2019. |
[3] | Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et.al. The global distribution and burden of dengue. Nature; 496: 504-507. |
[4] | Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012; 6: 1760. |
[5] | Alam S, Sadat S, Swapan Z, Ahmed A, Karim N, Paul HK, ZamanS. Clinical Profile of Dengue Fever in Children. Bangladesh J Child Health. 2009; 33 (2): 55-58. |
[6] | Dengue fever and dengue haemorrhagic fever. World Health Organization. 2009. |
[7] | Prevention and control of dengue and dengue hemorrhagic fever: comprehensive guidelines. World Health Organisation. 1999. |
[8] | CDC 2007. Center for Disease Control, CDC Health Center. Georgia, USA. |
[9] | Kalayanarooj S, Nimmannitiya S. Is dengue severity related to nutritional status? Southeast Asian J Trop Med. Public Health. 2005; 36: 378-84. |
[10] | Chuansumrit A, Puripokal C, Butthep P, WongtirapornW, Sasanakul W, Tangnararatchakit K, et al. Laboratory predictors of dengue shock syndrome during the febrile stage. Southeast Asian J Trop Med Public Health. 2010; 41: 326-32. |
[11] | Sutaryo. Dengue. Yogyakarta: MedicaFakultasKedokteran UGM; 2004. |
[12] | Tantracheewathorn T, Tantracheewathorn S. Risk factors of Dengue shock syndrome in children. J Med Assoc Thai. 2007; 90: 272-7. |
[13] | Islam TQ. Changing Epidemiological and Clinical pattern of Dengue inBangladesh 2018. J MEDICINE 2019; 20: 1-3. |
[14] | Rodhain F, Rosen L. Mosquito vectors and dengue virusvector relationships. In: Gubler DJ, Kuno G, editors. Dengueand Dengue Hemorrhagic Fever. New York: CAB. International; 1997; 45-60. |
[15] | Gubler DJ. The changing epidemiology of yellow fever anddengue, 1900 to 2003: Full circle? Comp ImmunolMicrobiolInfect Dis 2004; 27: 319-30. |
[16] | CDC BMI for age growth chart. Centers for Disease Control and Prevention. Factsheet 2018. |
[17] | Sarker A, Tara PHDAR d, Chatterjee S. Molecular typing of dengue virus circulating in Kolkata India in 2010. Journal of tropical medicine. 2012; 13. |
[18] | Ahmed FU, Mahmood BC, Sharma JD, Hoque SM, Zaman R, Hasan MS. Dengur and Dengue Haemorrhagic fever in Children during the 2000 outbreak in Chittagong, Bangladesh. Dengue Bulletin 2001; 25: 33-39. |
[19] | Mobarak MR, Islam R, Bhuiya AKM, Akand N, Begum F. Evaluation of Dengue Fever in a tertiary care children hospital of Bangladesh. Northern International Medical College Journal.2017; 9 (1): 274-277. |
[20] | Gupta E, Dar L, Kapoor G, Broor S the changing epidemiology of dengue in Delhi, India. Virology Journal. 2006; 5 (3): 1. |
[21] | Chakravarti a, Kumaria R. Eco-epidemiologycal analysis of dengue infection during an outbreak of dengue fever, India. Virology journal.2005; 14 (2): 1. |
[22] | Rahman M, Rahman K, Siddque AK, Shoma S, Kamal AH, Ali KS, et al. FirstOutbreak of Dengue Hemorrhagic Fever, Bangladesh. Emerg Infect Dis2002; 8: 738-40. |
[23] | Zulkipli MS, Dahlui M, Jamil NS, Peramalah D, CheeWai HV, Bulgiba A. The association between obesity and dengue severity among pediatric patients: A systematic review and meta- analysis. PlOSNegi Trop Dis. 2018. https://doi.org/10.1371/journal.pntd.0006263 |
[24] | Juffrie M, Meer GM, Haasnoot K, Sutaryo, Veerman AJ, Thijs LG. Inflammatory mediators in dengue virus infection in children: Interleuki -6 and its relation to C-reactive protein and secretory phospholipase A2. Am J Trop Med Hyg. 2001; 65: 70-75. |
APA Style
Sharmin Afroze, Salim Shakur, Abrar Wahab, Salomee Shakur. (2019). Clinical Profile of Dengue and Predictors of Its Severity Among Children. American Journal of Pediatrics, 5(4), 219-223. https://doi.org/10.11648/j.ajp.20190504.19
ACS Style
Sharmin Afroze; Salim Shakur; Abrar Wahab; Salomee Shakur. Clinical Profile of Dengue and Predictors of Its Severity Among Children. Am. J. Pediatr. 2019, 5(4), 219-223. doi: 10.11648/j.ajp.20190504.19
AMA Style
Sharmin Afroze, Salim Shakur, Abrar Wahab, Salomee Shakur. Clinical Profile of Dengue and Predictors of Its Severity Among Children. Am J Pediatr. 2019;5(4):219-223. doi: 10.11648/j.ajp.20190504.19
@article{10.11648/j.ajp.20190504.19, author = {Sharmin Afroze and Salim Shakur and Abrar Wahab and Salomee Shakur}, title = {Clinical Profile of Dengue and Predictors of Its Severity Among Children}, journal = {American Journal of Pediatrics}, volume = {5}, number = {4}, pages = {219-223}, doi = {10.11648/j.ajp.20190504.19}, url = {https://doi.org/10.11648/j.ajp.20190504.19}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.19}, abstract = {Dengue fever is a self-limiting, systemic viral illness that has a wide range of clinical manifestations. Last year dengue was severe in children with much mortality. This study was aimed to see the clinical profile of dengue and to find out the risk factors for developing severity. This cross sectional study was conducted over four months (June-September, 2018) in Department of Pediatrics of United Hospital Limited. All admitted dengue cases were analyzed. The predictors of developing severity were assessed by comparing variables between classical and severe dengue fever groups. A total of 106 children with Dengue fever were admitted. Mean age was 5.8±3 years with male predominance (60%). Common presentations include fever (100%), flushed appearance (72%), rash (43%), vomiting (39%), abdominal pain (36%), shock (28%) and respiratory distress (23%). In risk factor analysis, overweight (OR: 8.275, CI: 1.378-49.706) and massive serositis (OR: 17.86, CI: 4.733-67.399) were found statistically significant predictors of severe dengue. The overall mortality was 3%. So, overweight children and those patients who develop massive serositis are at increased risk of having severe dengue. Early identification of these features can help physicians to manage these cases judiciously.}, year = {2019} }
TY - JOUR T1 - Clinical Profile of Dengue and Predictors of Its Severity Among Children AU - Sharmin Afroze AU - Salim Shakur AU - Abrar Wahab AU - Salomee Shakur Y1 - 2019/10/23 PY - 2019 N1 - https://doi.org/10.11648/j.ajp.20190504.19 DO - 10.11648/j.ajp.20190504.19 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 219 EP - 223 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20190504.19 AB - Dengue fever is a self-limiting, systemic viral illness that has a wide range of clinical manifestations. Last year dengue was severe in children with much mortality. This study was aimed to see the clinical profile of dengue and to find out the risk factors for developing severity. This cross sectional study was conducted over four months (June-September, 2018) in Department of Pediatrics of United Hospital Limited. All admitted dengue cases were analyzed. The predictors of developing severity were assessed by comparing variables between classical and severe dengue fever groups. A total of 106 children with Dengue fever were admitted. Mean age was 5.8±3 years with male predominance (60%). Common presentations include fever (100%), flushed appearance (72%), rash (43%), vomiting (39%), abdominal pain (36%), shock (28%) and respiratory distress (23%). In risk factor analysis, overweight (OR: 8.275, CI: 1.378-49.706) and massive serositis (OR: 17.86, CI: 4.733-67.399) were found statistically significant predictors of severe dengue. The overall mortality was 3%. So, overweight children and those patients who develop massive serositis are at increased risk of having severe dengue. Early identification of these features can help physicians to manage these cases judiciously. VL - 5 IS - 4 ER -