The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using pearson test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m2. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children.
| Published in | American Journal of Pediatrics (Volume 6, Issue 1) |
| DOI | 10.11648/j.ajp.20200601.14 |
| Page(s) | 27-30 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Interleukin-6, Hepcidin, Obese, Children
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APA Style
Ni Komang Diah Saputri, I Gusti Lanang Sidiartha, I Made Gede Dwi Lingga Utama. (2020). Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children. American Journal of Pediatrics, 6(1), 27-30. https://doi.org/10.11648/j.ajp.20200601.14
ACS Style
Ni Komang Diah Saputri; I Gusti Lanang Sidiartha; I Made Gede Dwi Lingga Utama. Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children. Am. J. Pediatr. 2020, 6(1), 27-30. doi: 10.11648/j.ajp.20200601.14
AMA Style
Ni Komang Diah Saputri, I Gusti Lanang Sidiartha, I Made Gede Dwi Lingga Utama. Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children. Am J Pediatr. 2020;6(1):27-30. doi: 10.11648/j.ajp.20200601.14
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Download@article{10.11648/j.ajp.20200601.14,
author = {Ni Komang Diah Saputri and I Gusti Lanang Sidiartha and I Made Gede Dwi Lingga Utama},
title = {Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children},
journal = {American Journal of Pediatrics},
volume = {6},
number = {1},
pages = {27-30},
doi = {10.11648/j.ajp.20200601.14},
url = {https://doi.org/10.11648/j.ajp.20200601.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200601.14},
abstract = {The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using pearson test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m2. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children.},
year = {2020}
}
TY - JOUR T1 - Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children AU - Ni Komang Diah Saputri AU - I Gusti Lanang Sidiartha AU - I Made Gede Dwi Lingga Utama Y1 - 2020/02/18 PY - 2020 N1 - https://doi.org/10.11648/j.ajp.20200601.14 DO - 10.11648/j.ajp.20200601.14 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 27 EP - 30 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20200601.14 AB - The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using pearson test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m2. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children. VL - 6 IS - 1 ER -
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