Risk Factors of Patent Ductus Arteriosus in Preterm

Anak Agung Made Wijaya Kusuma; Eka Gunawijaya; I Gusti Ngurah Sanjaya Putra; Ni Putu Veny Kartika Yantie; I Made Kardana; I Made Gede Dwi Lingga Utama; I Wayan Gustawan

doi:doi:10.11648/j.ajp.20200602.29

Risk Factors of Patent Ductus Arteriosus in Preterm

Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, I Made Gede Dwi Lingga Utama, I Wayan Gustawan

Published in American Journal of Pediatrics (Volume 6, Issue 2)

Received: 14 March 2020 Accepted: 7 April 2020 Published: 29 April 2020

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Abstract

Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P<0.05) as risk factors for PDA including premature rupture of membranes >12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.

Published in	American Journal of Pediatrics (Volume 6, Issue 2)
DOI	10.11648/j.ajp.20200602.29
Page(s)	168-172
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Risk Factor, PDA, Preterm, Thrombocytopenia, Premature Rupture of Membranes

References

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[2]	Clyman RI, Couto J, Murphy, GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012; 36: 123-9.
[3]	Pourarian S, Cheriki S, Sharma D, Bijanzadeh F, Farahbakhsh N. Prevalence and risk factors associated with the patency of ductus arteriosus in premature neonates: A prospective observational study from Iran. J Matern-Fetal Neo M. 2017; 30: 1460-4.
[4]	Echtler K, Stark K, Lorenz M, Kerstan S. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010; 16: 75-82.
[5]	Sallmon H, Weber SC, Huning B, Stein A, Horn PA, Metze BC, et al. Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. Pediatrics. 2012; 130: 623-30.
[6]	Chen YY, Wang HP, Chang JT, Chiou YH, Huang YF, Hsieh KS. Perinatal factors in patent ductus arteriosus in very low-birthweight infants. Pediatr Int. 2014; 56: 72-6.
[7]	Hamrick SE, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics. 2010; 125: 1020-30.
[8]	The ́baud B, Michelakis ED, Wu XC, Moudgil R, Kuzyk M. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation. 2004; 110: 1372-9.
[9]	Antonucci R, Bassareo P, Zaffanello M, Pusceddu M, Fanos V. Patent ductus arteriosus in the preterm infant: new insight into pathogenesis and clinical mana-gement. J Matern-Fetal Neo M. 2010; 23: 34-7.
[10]	Fan F, Zhu S, Chen L, Zou Y, Fan L, Kang J. Role of prostaglandin E2 and its receptors in the process of ductus arteriosus maturation and functional closure in the rabbit. Clin Exp Pharmacol Physiol. 2010; 37: 574-80.
[11]	Yajima I, Colombo S, Puig I, Champeval D, Kumasaka M, Belloir E. A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus. PLoS One. 2013; 8: e 53183.
[12]	Hermes-Desantis ER, Clyman RI. Patent ductus arteriosus: pathophysiology and management. J Perinatol. 2006; 26: 14-8.
[13]	Simbolon D. Faktor risiko sepsis pada bayi baru lahir di RSUD Curup Kabupaten Rejang Lebong. Buletin Penelitian Kesehatan. 2008; 36: 127-34.
[14]	Gonzalez A, Sosenko IR, Chandar J, Hummler H, Claure N, Bancalari E. Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 grams or less. J Pediatr. 1996; 128: 470-8.
[15]	Simon SR, Zogchel L, Bas-Suarez MP, Cavallaro G, Clyman RI, Villamor E. Platelet counts and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. Neonatology. 2015; 108: 143-51.

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APA Style

Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, et al. (2020). Risk Factors of Patent Ductus Arteriosus in Preterm. American Journal of Pediatrics, 6(2), 168-172. https://doi.org/10.11648/j.ajp.20200602.29

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ACS Style

Anak Agung Made Wijaya Kusuma; Eka Gunawijaya; I Gusti Ngurah Sanjaya Putra; Ni Putu Veny Kartika Yantie; I Made Kardana, et al. Risk Factors of Patent Ductus Arteriosus in Preterm. Am. J. Pediatr. 2020, 6(2), 168-172. doi: 10.11648/j.ajp.20200602.29

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AMA Style

Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, et al. Risk Factors of Patent Ductus Arteriosus in Preterm. Am J Pediatr. 2020;6(2):168-172. doi: 10.11648/j.ajp.20200602.29

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@article{10.11648/j.ajp.20200602.29,
  author = {Anak Agung Made Wijaya Kusuma and Eka Gunawijaya and I Gusti Ngurah Sanjaya Putra and Ni Putu Veny Kartika Yantie and I Made Kardana and I Made Gede Dwi Lingga Utama and I Wayan Gustawan},
  title = {Risk Factors of Patent Ductus Arteriosus in Preterm},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {2},
  pages = {168-172},
  doi = {10.11648/j.ajp.20200602.29},
  url = {https://doi.org/10.11648/j.ajp.20200602.29},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200602.29},
  abstract = {Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.},
 year = {2020}
}

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TY  - JOUR
T1  - Risk Factors of Patent Ductus Arteriosus in Preterm
AU  - Anak Agung Made Wijaya Kusuma
AU  - Eka Gunawijaya
AU  - I Gusti Ngurah Sanjaya Putra
AU  - Ni Putu Veny Kartika Yantie
AU  - I Made Kardana
AU  - I Made Gede Dwi Lingga Utama
AU  - I Wayan Gustawan
Y1  - 2020/04/29
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200602.29
DO  - 10.11648/j.ajp.20200602.29
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 168
EP  - 172
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200602.29
AB  - Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.
VL  - 6
IS  - 2
ER  -

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Author Information

Anak Agung Made Wijaya Kusuma

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia
Eka Gunawijaya

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia
I Gusti Ngurah Sanjaya Putra

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia
Ni Putu Veny Kartika Yantie

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia
I Made Kardana

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia
I Made Gede Dwi Lingga Utama

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia
I Wayan Gustawan

Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

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APA Style

Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, et al. (2020). Risk Factors of Patent Ductus Arteriosus in Preterm. American Journal of Pediatrics, 6(2), 168-172. https://doi.org/10.11648/j.ajp.20200602.29

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ACS Style

Anak Agung Made Wijaya Kusuma; Eka Gunawijaya; I Gusti Ngurah Sanjaya Putra; Ni Putu Veny Kartika Yantie; I Made Kardana, et al. Risk Factors of Patent Ductus Arteriosus in Preterm. Am. J. Pediatr. 2020, 6(2), 168-172. doi: 10.11648/j.ajp.20200602.29

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AMA Style

Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, et al. Risk Factors of Patent Ductus Arteriosus in Preterm. Am J Pediatr. 2020;6(2):168-172. doi: 10.11648/j.ajp.20200602.29

Copy | Download

@article{10.11648/j.ajp.20200602.29,
  author = {Anak Agung Made Wijaya Kusuma and Eka Gunawijaya and I Gusti Ngurah Sanjaya Putra and Ni Putu Veny Kartika Yantie and I Made Kardana and I Made Gede Dwi Lingga Utama and I Wayan Gustawan},
  title = {Risk Factors of Patent Ductus Arteriosus in Preterm},
  journal = {American Journal of Pediatrics},
  volume = {6},
  number = {2},
  pages = {168-172},
  doi = {10.11648/j.ajp.20200602.29},
  url = {https://doi.org/10.11648/j.ajp.20200602.29},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200602.29},
  abstract = {Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.},
 year = {2020}
}

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TY  - JOUR
T1  - Risk Factors of Patent Ductus Arteriosus in Preterm
AU  - Anak Agung Made Wijaya Kusuma
AU  - Eka Gunawijaya
AU  - I Gusti Ngurah Sanjaya Putra
AU  - Ni Putu Veny Kartika Yantie
AU  - I Made Kardana
AU  - I Made Gede Dwi Lingga Utama
AU  - I Wayan Gustawan
Y1  - 2020/04/29
PY  - 2020
N1  - https://doi.org/10.11648/j.ajp.20200602.29
DO  - 10.11648/j.ajp.20200602.29
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 168
EP  - 172
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20200602.29
AB  - Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.
VL  - 6
IS  - 2
ER  -

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