Background: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. Covid-19 has spread around Bangladesh and children are also being infected with comparatively fewer symptoms and lower case-fatality rates. Objectives: To assess the clinical profile, disease severity, presence of co-morbidities and outcome of pediatric COVID-19 patients. Methods: This prospective observational study was conducted in the fever clinic and the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU). Data were collected from the confirmed cases by using a structured questionnaire by face to face interview and also over telephone at 1st visit and at 2nd and 8th week of disease course. Collected data were analyzed using appropriate statistical tests. Result: Among 2091 suspected COVID 19 cases attending fever clinic and department of Pediatrics, 462 (22.09%) were real time polymerized chain reaction (RT PCR) COVID 19 positive. Of them 377 (81.60%) responded to the questionnaire and subsequent follow up. Highest numbers of cases were found in June 2020. More than 60% of cases were within the age group of 10 to 18 years and 3.44% were infants. Male: female ratio was 1.04:1. Associated co-morbid conditions were present in 21.48% patients. Fever was the most common (72.67%) clinical feature followed by others. Incidences of severe and critical illness were more in older children. Most of the moderate cases and all of the severe and critical COVID cases were managed in the inpatient department including Pediatric intensive care unit. Among them, 100% required oxygen therapy, 72.41% needed oral or IV steroids, 8.6% and 6.9% needed intravenous immunoglobulin and biological agents (Tocilizumab) respectively. Seventeen patients (4.5%) recovered with some complications. Conclusions: Among suspected cases 22% were RT-PCR positive. Majorities were in the older age group and most of the moderate and all the severe and critical cases also belonged to older age group. Most of the cases (94.42%) recovered without complication and 4.5% recovered with some complications. Mortality was 1.06%.
Published in | American Journal of Pediatrics (Volume 7, Issue 2) |
DOI | 10.11648/j.ajp.20210702.17 |
Page(s) | 72-78 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
COVID 19, RT PCR, Disease Severity, Outcome
[1] | Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015; 1282: 1–23. |
[2] | Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020 Feb 15; 395 (10223): 497-506. |
[3] | Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020 382: 727–33. |
[4] | Zeng LK, Tao XW, Yuan WH, Wang J, Liu X, Liu ZS. First case of neonate infected with novel coronavirus pneumonia in China. Chin. J. Pediatr. 2020 Feb 17; 58: E009. |
[5] | Coronavirus Update (Live): 8,036,812 Cases and 436,471 Deaths from COVID-19 Virus Pandemic – Worldometer. Available from: https://www.worldometers.info/coronavirus/? |
[6] | Bangladesh Coronavirus: 90,619 Cases and 1,209 Deaths – Worldometer. Available from: https://www.worldometers.info/coronavirus/country/bangladesh/. |
[7] | Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. New Engl J of Med. 2020 Apr 30; 382 (18): 1708-20. |
[8] | Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy. 2020 Jul; 75 (7): 1730-41. |
[9] | COVID-19 IAP Guidelines. Indian Academy of Paediatrics. Available from https://iapindia.org/get-latest-guidanceon-COVID-19/. Accessed on 2.05.2020. |
[10] | Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. Jama. 2020 Apr 7; 323 (13): 1239-42. |
[11] | Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 2020; 382 (17): 1663-1665. |
[12] | CDC COVID-19 Response Team. Coronavirus disease 2019 in children—United States, MMWR Morb Mortal Wkly Rep. 2020; 69 (14): 422-426. |
[13] | OPEN Pediatrics. Coronavirus Disease (COVID-19). Accessed May 5, 2020. https://www.openpediatrics.org/group/coronavirus-diseasecovid-19. |
[14] | WHO-China Joint Mission, Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19), (2020) Geneva Accessed March 1, 2020 https://www.who.int/docs/default-source/coronaviruse/who-china-jointmission-on-covid-19-final report.pdf. |
[15] | Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020 Jun 3; 369. |
[16] | Novel Coronavirus (COVID-19) Guidelines. Disease Control Division, Directorate General of Health Services, Ministry of Health and Family Welfare, Government of the People’s Republic of Bangladesh. Available from https://www.mohfw.gov.bd. Accessed on 2.05.2020. |
[17] | Wang D, Ju XL, Xie F, Lu Y, Li FY, Huang HH, et al. Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China. Zhonghuaerkezazhi. 2020: 269-74. |
[18] | Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr. 2020 Mar 19: 1-9. |
[19] | Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020 Jun 1; 145 (6). |
[20] | Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults. PediatrPulmonol. 2020 May; 55 (5): 1169-74. |
[21] | Li W, Cui H, Li K, Fang Y, Li S. Chest computed tomography in children with COVID-19 respiratory infection. PediatrRadiol. 2020 Mar 11: 1-4. |
[22] | https://iedcr.gov.bd/website/, date: 20 June, 2020. |
[23] | COVID 19 management synopsis, Bangabandhu Sheikh Mujib Medical University, year of publication 2020. |
[24] | Pauline V, Diem LV, Arnaud G, Manuel S, Laurent K, Frederique J. Clinical features of covid-19, The wide array of symptoms has implications for the testing strategy. BMJ. 2020; 369. |
[25] | Anwar S, Shamsad IA, Morshed AA, Farzana F. Clinical Profile of Child COVID-19 Patients of Bangladesh. AJP. 2021; 7 (1): 5-8. |
[26] | Ghosh UK, Sultana A, Ghosh NK, Akram A, Ahmed E, Rana IH, et al. Clinico-demographic Profile of Coronavirus Infection among Bangladeshi Children: A Tertiary Care Hospital Study. Bangladesh J Infect Dis. 2020 Nov 8: S16-21. |
[27] | Guo CX, He L, Yin JY, Meng XG, Tan W, Yang GP, et al. Epidemiological and clinical features of pediatric COVID-19. BMC Medicine. 2020 Dec; 18 (1): 1-7. |
[28] | Nallasamy K, Angurana SK, Jayashree M, Mathew JL, Bansal A, Singh MP, et al. Clinical Profile, Hospital Course and Outcome of Children with COVID-19. Indian J Pediatr. 2021 Feb 13: 1-6. |
[29] | TirunehTiyare F. Clinical Profile of Covid-19 in Children, Review of Existing Literatures. Pediatric Health Med Ther. 2020; 11: 385-392 https://doi.org/10.2147/PHMT.S266063. |
[30] | Graff K, Smith C, Silveira L, Jung S, Curran-Hays S, Jarjour J, et al. Risk Factors for Severe COVID-19 in Children. Pediatr Infect Dis J. 2021 Apr 1; 40 (4): e137-45. |
[31] | Tsankov BK, Allaire JM, Irvine MA, Lopez AA, Sauvé LJ, Vallance BA, et al. Severe COVID-19 infection and pediatric comorbidities: a systematic review and meta-analysis. Int J Infect Dis. 2021; 103: 246-256. |
[32] | Health Department-Reported Cases of Multisystem Inflammatory Syndrome in Children (MIS-C) in the United States, https://www.cdc.gov/mis-c/cases/index.html, retrieved on 25 March 2021. |
[33] | https://www.who.int/health-topics/coronavirus#tab=tab_2. |
APA Style
Mujammel Haque, Kamrul Laila, Mohammad Hafiz Al-Mamun, Sutopa Halder Supti, Shahana Akhter Rahman. (2021). Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University. American Journal of Pediatrics, 7(2), 72-78. https://doi.org/10.11648/j.ajp.20210702.17
ACS Style
Mujammel Haque; Kamrul Laila; Mohammad Hafiz Al-Mamun; Sutopa Halder Supti; Shahana Akhter Rahman. Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University. Am. J. Pediatr. 2021, 7(2), 72-78. doi: 10.11648/j.ajp.20210702.17
AMA Style
Mujammel Haque, Kamrul Laila, Mohammad Hafiz Al-Mamun, Sutopa Halder Supti, Shahana Akhter Rahman. Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University. Am J Pediatr. 2021;7(2):72-78. doi: 10.11648/j.ajp.20210702.17
@article{10.11648/j.ajp.20210702.17, author = {Mujammel Haque and Kamrul Laila and Mohammad Hafiz Al-Mamun and Sutopa Halder Supti and Shahana Akhter Rahman}, title = {Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University}, journal = {American Journal of Pediatrics}, volume = {7}, number = {2}, pages = {72-78}, doi = {10.11648/j.ajp.20210702.17}, url = {https://doi.org/10.11648/j.ajp.20210702.17}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20210702.17}, abstract = {Background: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. Covid-19 has spread around Bangladesh and children are also being infected with comparatively fewer symptoms and lower case-fatality rates. Objectives: To assess the clinical profile, disease severity, presence of co-morbidities and outcome of pediatric COVID-19 patients. Methods: This prospective observational study was conducted in the fever clinic and the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU). Data were collected from the confirmed cases by using a structured questionnaire by face to face interview and also over telephone at 1st visit and at 2nd and 8th week of disease course. Collected data were analyzed using appropriate statistical tests. Result: Among 2091 suspected COVID 19 cases attending fever clinic and department of Pediatrics, 462 (22.09%) were real time polymerized chain reaction (RT PCR) COVID 19 positive. Of them 377 (81.60%) responded to the questionnaire and subsequent follow up. Highest numbers of cases were found in June 2020. More than 60% of cases were within the age group of 10 to 18 years and 3.44% were infants. Male: female ratio was 1.04:1. Associated co-morbid conditions were present in 21.48% patients. Fever was the most common (72.67%) clinical feature followed by others. Incidences of severe and critical illness were more in older children. Most of the moderate cases and all of the severe and critical COVID cases were managed in the inpatient department including Pediatric intensive care unit. Among them, 100% required oxygen therapy, 72.41% needed oral or IV steroids, 8.6% and 6.9% needed intravenous immunoglobulin and biological agents (Tocilizumab) respectively. Seventeen patients (4.5%) recovered with some complications. Conclusions: Among suspected cases 22% were RT-PCR positive. Majorities were in the older age group and most of the moderate and all the severe and critical cases also belonged to older age group. Most of the cases (94.42%) recovered without complication and 4.5% recovered with some complications. Mortality was 1.06%.}, year = {2021} }
TY - JOUR T1 - Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University AU - Mujammel Haque AU - Kamrul Laila AU - Mohammad Hafiz Al-Mamun AU - Sutopa Halder Supti AU - Shahana Akhter Rahman Y1 - 2021/05/08 PY - 2021 N1 - https://doi.org/10.11648/j.ajp.20210702.17 DO - 10.11648/j.ajp.20210702.17 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 72 EP - 78 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20210702.17 AB - Background: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. Covid-19 has spread around Bangladesh and children are also being infected with comparatively fewer symptoms and lower case-fatality rates. Objectives: To assess the clinical profile, disease severity, presence of co-morbidities and outcome of pediatric COVID-19 patients. Methods: This prospective observational study was conducted in the fever clinic and the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU). Data were collected from the confirmed cases by using a structured questionnaire by face to face interview and also over telephone at 1st visit and at 2nd and 8th week of disease course. Collected data were analyzed using appropriate statistical tests. Result: Among 2091 suspected COVID 19 cases attending fever clinic and department of Pediatrics, 462 (22.09%) were real time polymerized chain reaction (RT PCR) COVID 19 positive. Of them 377 (81.60%) responded to the questionnaire and subsequent follow up. Highest numbers of cases were found in June 2020. More than 60% of cases were within the age group of 10 to 18 years and 3.44% were infants. Male: female ratio was 1.04:1. Associated co-morbid conditions were present in 21.48% patients. Fever was the most common (72.67%) clinical feature followed by others. Incidences of severe and critical illness were more in older children. Most of the moderate cases and all of the severe and critical COVID cases were managed in the inpatient department including Pediatric intensive care unit. Among them, 100% required oxygen therapy, 72.41% needed oral or IV steroids, 8.6% and 6.9% needed intravenous immunoglobulin and biological agents (Tocilizumab) respectively. Seventeen patients (4.5%) recovered with some complications. Conclusions: Among suspected cases 22% were RT-PCR positive. Majorities were in the older age group and most of the moderate and all the severe and critical cases also belonged to older age group. Most of the cases (94.42%) recovered without complication and 4.5% recovered with some complications. Mortality was 1.06%. VL - 7 IS - 2 ER -