Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants

Sanat Kumar Barua; Jagadish Chandra Das; Mohammad Maruf-UL-Quader; Zabeen Chowdhury; Salina Haque; Muhammad Jabed Bin Amin Chowdhury; Aparup Kanti Das; Dhiman Chowdhury

doi:doi:10.11648/j.ajp.20230904.13

Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants

Sanat Kumar Barua, Jagadish Chandra Das, Mohammad Maruf-UL-Quader, Zabeen Chowdhury, Salina Haque, Muhammad Jabed Bin Amin Chowdhury, Aparup Kanti Das, Dhiman Chowdhury

Published in American Journal of Pediatrics (Volume 9, Issue 4)

Received: 11 September 2023 Accepted: 28 September 2023 Published: 14 October 2023

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Abstract

Human milk oligosaccharides (HMOs) constitute a significant and intriguing component of human milk, ranking as the third most abundant solid constituent following lactose and lipids. Meanwhile, gut microbiota encompasses an array of microorganisms, spanning bacteria, archaea, fungi, and viruses, residing within the digestive tract. The intricate interplay among human milk oligosaccharides (HMOs), gut microbiota, and the immune system holds substantial implications for the initial developmental stages of newborns. This comprehensive review aimed to delve into the multifaceted role of HMOs in molding gut microbiota and their profound contribution to the maturation of the immune system in neonates. By conducting a meticulous systematic review of pertinent literature, this study explored the intricate interrelationships among HMOs, gut microbiota, and the immune system in newborn infants. The review analyzed a substantial corpus of recently published original research articles and comprehensive review papers. Google Scholar, PubMed, and SCOPUS served as robust and dependable sources for data acquisition. Besides these, some other reliable sources were also used. Through this article, readers will acquire a lucid comprehension of HMOs' pivotal role in shaping gut microbiota dynamics and fostering immune system maturation in neonates. The insights garnered from these interactions hold the promise of steering interventions geared toward optimizing neonatal health outcomes. Nonetheless, further research is imperative to unveil specific underlying mechanisms and potential therapeutic avenues.

Published in	American Journal of Pediatrics (Volume 9, Issue 4)
DOI	10.11648/j.ajp.20230904.13
Page(s)	204-209
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Human Milk, Oligosaccharides, HMOs, Neonatal Immunity, Gut Microbiota, Digestive Tract

References

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APA Style

Sanat Kumar Barua, Jagadish Chandra Das, Mohammad Maruf-UL-Quader, Zabeen Chowdhury, Salina Haque, et al. (2023). Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants. American Journal of Pediatrics, 9(4), 204-209. https://doi.org/10.11648/j.ajp.20230904.13

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ACS Style

Sanat Kumar Barua; Jagadish Chandra Das; Mohammad Maruf-UL-Quader; Zabeen Chowdhury; Salina Haque, et al. Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants. Am. J. Pediatr. 2023, 9(4), 204-209. doi: 10.11648/j.ajp.20230904.13

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AMA Style

Sanat Kumar Barua, Jagadish Chandra Das, Mohammad Maruf-UL-Quader, Zabeen Chowdhury, Salina Haque, et al. Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants. Am J Pediatr. 2023;9(4):204-209. doi: 10.11648/j.ajp.20230904.13

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@article{10.11648/j.ajp.20230904.13,
  author = {Sanat Kumar Barua and Jagadish Chandra Das and Mohammad Maruf-UL-Quader and Zabeen Chowdhury and Salina Haque and Muhammad Jabed Bin Amin Chowdhury and Aparup Kanti Das and Dhiman Chowdhury},
  title = {Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {4},
  pages = {204-209},
  doi = {10.11648/j.ajp.20230904.13},
  url = {https://doi.org/10.11648/j.ajp.20230904.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230904.13},
  abstract = {Human milk oligosaccharides (HMOs) constitute a significant and intriguing component of human milk, ranking as the third most abundant solid constituent following lactose and lipids. Meanwhile, gut microbiota encompasses an array of microorganisms, spanning bacteria, archaea, fungi, and viruses, residing within the digestive tract. The intricate interplay among human milk oligosaccharides (HMOs), gut microbiota, and the immune system holds substantial implications for the initial developmental stages of newborns. This comprehensive review aimed to delve into the multifaceted role of HMOs in molding gut microbiota and their profound contribution to the maturation of the immune system in neonates. By conducting a meticulous systematic review of pertinent literature, this study explored the intricate interrelationships among HMOs, gut microbiota, and the immune system in newborn infants. The review analyzed a substantial corpus of recently published original research articles and comprehensive review papers. Google Scholar, PubMed, and SCOPUS served as robust and dependable sources for data acquisition. Besides these, some other reliable sources were also used. Through this article, readers will acquire a lucid comprehension of HMOs' pivotal role in shaping gut microbiota dynamics and fostering immune system maturation in neonates. The insights garnered from these interactions hold the promise of steering interventions geared toward optimizing neonatal health outcomes. Nonetheless, further research is imperative to unveil specific underlying mechanisms and potential therapeutic avenues.},
 year = {2023}
}

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TY  - JOUR
T1  - Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants
AU  - Sanat Kumar Barua
AU  - Jagadish Chandra Das
AU  - Mohammad Maruf-UL-Quader
AU  - Zabeen Chowdhury
AU  - Salina Haque
AU  - Muhammad Jabed Bin Amin Chowdhury
AU  - Aparup Kanti Das
AU  - Dhiman Chowdhury
Y1  - 2023/10/14
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230904.13
DO  - 10.11648/j.ajp.20230904.13
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 204
EP  - 209
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230904.13
AB  - Human milk oligosaccharides (HMOs) constitute a significant and intriguing component of human milk, ranking as the third most abundant solid constituent following lactose and lipids. Meanwhile, gut microbiota encompasses an array of microorganisms, spanning bacteria, archaea, fungi, and viruses, residing within the digestive tract. The intricate interplay among human milk oligosaccharides (HMOs), gut microbiota, and the immune system holds substantial implications for the initial developmental stages of newborns. This comprehensive review aimed to delve into the multifaceted role of HMOs in molding gut microbiota and their profound contribution to the maturation of the immune system in neonates. By conducting a meticulous systematic review of pertinent literature, this study explored the intricate interrelationships among HMOs, gut microbiota, and the immune system in newborn infants. The review analyzed a substantial corpus of recently published original research articles and comprehensive review papers. Google Scholar, PubMed, and SCOPUS served as robust and dependable sources for data acquisition. Besides these, some other reliable sources were also used. Through this article, readers will acquire a lucid comprehension of HMOs' pivotal role in shaping gut microbiota dynamics and fostering immune system maturation in neonates. The insights garnered from these interactions hold the promise of steering interventions geared toward optimizing neonatal health outcomes. Nonetheless, further research is imperative to unveil specific underlying mechanisms and potential therapeutic avenues.
VL  - 9
IS  - 4
ER  -

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Author Information

Sanat Kumar Barua

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Jagadish Chandra Das

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Mohammad Maruf-UL-Quader

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Zabeen Chowdhury

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Salina Haque

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Muhammad Jabed Bin Amin Chowdhury

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Aparup Kanti Das

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh
Dhiman Chowdhury

Department of Paediatrics, Chittagong Medical College, Chittagong, Bangladesh

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APA Style

Sanat Kumar Barua, Jagadish Chandra Das, Mohammad Maruf-UL-Quader, Zabeen Chowdhury, Salina Haque, et al. (2023). Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants. American Journal of Pediatrics, 9(4), 204-209. https://doi.org/10.11648/j.ajp.20230904.13

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ACS Style

Sanat Kumar Barua; Jagadish Chandra Das; Mohammad Maruf-UL-Quader; Zabeen Chowdhury; Salina Haque, et al. Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants. Am. J. Pediatr. 2023, 9(4), 204-209. doi: 10.11648/j.ajp.20230904.13

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AMA Style

Sanat Kumar Barua, Jagadish Chandra Das, Mohammad Maruf-UL-Quader, Zabeen Chowdhury, Salina Haque, et al. Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants. Am J Pediatr. 2023;9(4):204-209. doi: 10.11648/j.ajp.20230904.13

Copy | Download

@article{10.11648/j.ajp.20230904.13,
  author = {Sanat Kumar Barua and Jagadish Chandra Das and Mohammad Maruf-UL-Quader and Zabeen Chowdhury and Salina Haque and Muhammad Jabed Bin Amin Chowdhury and Aparup Kanti Das and Dhiman Chowdhury},
  title = {Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants},
  journal = {American Journal of Pediatrics},
  volume = {9},
  number = {4},
  pages = {204-209},
  doi = {10.11648/j.ajp.20230904.13},
  url = {https://doi.org/10.11648/j.ajp.20230904.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20230904.13},
  abstract = {Human milk oligosaccharides (HMOs) constitute a significant and intriguing component of human milk, ranking as the third most abundant solid constituent following lactose and lipids. Meanwhile, gut microbiota encompasses an array of microorganisms, spanning bacteria, archaea, fungi, and viruses, residing within the digestive tract. The intricate interplay among human milk oligosaccharides (HMOs), gut microbiota, and the immune system holds substantial implications for the initial developmental stages of newborns. This comprehensive review aimed to delve into the multifaceted role of HMOs in molding gut microbiota and their profound contribution to the maturation of the immune system in neonates. By conducting a meticulous systematic review of pertinent literature, this study explored the intricate interrelationships among HMOs, gut microbiota, and the immune system in newborn infants. The review analyzed a substantial corpus of recently published original research articles and comprehensive review papers. Google Scholar, PubMed, and SCOPUS served as robust and dependable sources for data acquisition. Besides these, some other reliable sources were also used. Through this article, readers will acquire a lucid comprehension of HMOs' pivotal role in shaping gut microbiota dynamics and fostering immune system maturation in neonates. The insights garnered from these interactions hold the promise of steering interventions geared toward optimizing neonatal health outcomes. Nonetheless, further research is imperative to unveil specific underlying mechanisms and potential therapeutic avenues.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Human Milk Oligosaccharides and Development of Gut Microbiota with Immune System in Newborn Infants
AU  - Sanat Kumar Barua
AU  - Jagadish Chandra Das
AU  - Mohammad Maruf-UL-Quader
AU  - Zabeen Chowdhury
AU  - Salina Haque
AU  - Muhammad Jabed Bin Amin Chowdhury
AU  - Aparup Kanti Das
AU  - Dhiman Chowdhury
Y1  - 2023/10/14
PY  - 2023
N1  - https://doi.org/10.11648/j.ajp.20230904.13
DO  - 10.11648/j.ajp.20230904.13
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 204
EP  - 209
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20230904.13
AB  - Human milk oligosaccharides (HMOs) constitute a significant and intriguing component of human milk, ranking as the third most abundant solid constituent following lactose and lipids. Meanwhile, gut microbiota encompasses an array of microorganisms, spanning bacteria, archaea, fungi, and viruses, residing within the digestive tract. The intricate interplay among human milk oligosaccharides (HMOs), gut microbiota, and the immune system holds substantial implications for the initial developmental stages of newborns. This comprehensive review aimed to delve into the multifaceted role of HMOs in molding gut microbiota and their profound contribution to the maturation of the immune system in neonates. By conducting a meticulous systematic review of pertinent literature, this study explored the intricate interrelationships among HMOs, gut microbiota, and the immune system in newborn infants. The review analyzed a substantial corpus of recently published original research articles and comprehensive review papers. Google Scholar, PubMed, and SCOPUS served as robust and dependable sources for data acquisition. Besides these, some other reliable sources were also used. Through this article, readers will acquire a lucid comprehension of HMOs' pivotal role in shaping gut microbiota dynamics and fostering immune system maturation in neonates. The insights garnered from these interactions hold the promise of steering interventions geared toward optimizing neonatal health outcomes. Nonetheless, further research is imperative to unveil specific underlying mechanisms and potential therapeutic avenues.
VL  - 9
IS  - 4
ER  -

Copy | Download