PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation

Yasutomi Kamei; Yukino Hatazawa; Ryoji Yoshimura; Shinji Miura

doi:doi:10.11648/j.bs.20150101.12

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PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation

Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura

Published in Biomedical Sciences (Volume 1, Issue 1)

Received: 9 June 2015 Accepted: 19 June 2015 Published: 23 June 2015

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Abstract

PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.

Published in	Biomedical Sciences (Volume 1, Issue 1)
DOI	10.11648/j.bs.20150101.12
Page(s)	6-9
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Nuclear Receptor, Coactivator, Skeletal Muscle, Metabolism

References

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[12]	J, Lin, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R and Spiegelman BM. "Transcriptional Co-Activator PGC-1 Alpha Drives the Formation of Slow-Twitch Muscle Fibres." Nature. 2002, 418:797-801.
[13]	S, Miura, Kai Y, Ono M and Ezaki O. "Overexpression of Peroxisome Proliferator-Activated Receptor Gamma Co-activator-1alpha Down-Regulates GLUT4 mRNA in Skeletal Muscles." J Biol Chem. 2003, 278:31385-90.
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APA Style

Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura. (2015). PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomedical Sciences, 1(1), 6-9. https://doi.org/10.11648/j.bs.20150101.12

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ACS Style

Yasutomi Kamei; Yukino Hatazawa; Ryoji Yoshimura; Shinji Miura. PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomed. Sci. 2015, 1(1), 6-9. doi: 10.11648/j.bs.20150101.12

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AMA Style

Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura. PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomed Sci. 2015;1(1):6-9. doi: 10.11648/j.bs.20150101.12

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@article{10.11648/j.bs.20150101.12,
  author = {Yasutomi Kamei and Yukino Hatazawa and Ryoji Yoshimura and Shinji Miura},
  title = {PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation},
  journal = {Biomedical Sciences},
  volume = {1},
  number = {1},
  pages = {6-9},
  doi = {10.11648/j.bs.20150101.12},
  url = {https://doi.org/10.11648/j.bs.20150101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20150101.12},
  abstract = {PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.},
 year = {2015}
}

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TY  - JOUR
T1  - PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation
AU  - Yasutomi Kamei
AU  - Yukino Hatazawa
AU  - Ryoji Yoshimura
AU  - Shinji Miura
Y1  - 2015/06/23
PY  - 2015
N1  - https://doi.org/10.11648/j.bs.20150101.12
DO  - 10.11648/j.bs.20150101.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 6
EP  - 9
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20150101.12
AB  - PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.
VL  - 1
IS  - 1
ER  -

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Author Information

Yasutomi Kamei

Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Yukino Hatazawa

Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Ryoji Yoshimura

Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Shinji Miura

Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan

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Plain Text BibTeX RIS

APA Style

Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura. (2015). PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomedical Sciences, 1(1), 6-9. https://doi.org/10.11648/j.bs.20150101.12

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ACS Style

Yasutomi Kamei; Yukino Hatazawa; Ryoji Yoshimura; Shinji Miura. PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomed. Sci. 2015, 1(1), 6-9. doi: 10.11648/j.bs.20150101.12

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AMA Style

Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura. PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomed Sci. 2015;1(1):6-9. doi: 10.11648/j.bs.20150101.12

Copy | Download

@article{10.11648/j.bs.20150101.12,
  author = {Yasutomi Kamei and Yukino Hatazawa and Ryoji Yoshimura and Shinji Miura},
  title = {PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation},
  journal = {Biomedical Sciences},
  volume = {1},
  number = {1},
  pages = {6-9},
  doi = {10.11648/j.bs.20150101.12},
  url = {https://doi.org/10.11648/j.bs.20150101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20150101.12},
  abstract = {PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation
AU  - Yasutomi Kamei
AU  - Yukino Hatazawa
AU  - Ryoji Yoshimura
AU  - Shinji Miura
Y1  - 2015/06/23
PY  - 2015
N1  - https://doi.org/10.11648/j.bs.20150101.12
DO  - 10.11648/j.bs.20150101.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 6
EP  - 9
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20150101.12
AB  - PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.
VL  - 1
IS  - 1
ER  -

Copy | Download