This conference paper aims at demonstration of complexity or multiplicity of RNA-binding protein (RBP) and its related RNA. The data in the manuscript are based upon the third Annual Meeting of the RNA study group, held at the Tokyo office of the Kyoto University on May 23 in 2019. The purpose of the meeting is to present recent progress of the study group and have discussion regarding RNA and related molecules, especially focusing on RBP in this year. We had fourteen sessions and documented ten of them in the manuscript. There were exciting and fruitful debates. Actual presentations are shown as follows. Specific RBP Sfpq and Qk are involved in neuronal development in mouse system. Also in mouse, liquid- and solid-like RNA granule formation plays pivotal roles in neuronal functions. Biochemical experiments demonstrate that affinity profiles categorize RNA-Binding proteins into distinctive groups. This presents basis for biological divergence of RBPs. In the context of pathology, RNA aptamers against prion and Alzheimer’s diseases may present therapeutic outcome. Computational analysis is another utility for approaching riddle of RBPs. The study of X-chromosome inactivation is pioneering field of long noncoding RNAs. Redundant triplex interactions between lncRNA and LINE-1s are supposed to be crucial in X-chromosome inactivation. Myogenesis-related lncRNA, Myoparr promotes skeletal muscle atrophy caused by denervation through the regulation of GDF5/BMP14 expression. In neurodegenerative disorders functional loss of TLS/FUS induces onset of frontotemporal lobar degeneration. Conformational change of TLS is induced with binding of various nucleic acid molecules. TLS is also involved in phase separation into aggregation to pathogen generation of neurodegenerative diseases. The meeting has been successfully prorogued. We utilize the data to boost the activity of the field of RNA and RBP. The achievements of the meeting have confirmed pivotal roles of RBPs in living cells. It should be in complexity. We will be able to analyze intricate phenomena of RBP biological actions and contribute to uncover the veiled rules in divergent biological programs.
| Published in | Biomedical Sciences (Volume 5, Issue 1) |
| DOI | 10.11648/j.bs.20190501.12 |
| Page(s) | 7-13 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
RNA-Binding Protein, Long Noncoding RNA, Amyotrophic Lateral Sclerosis, TLS FUS, X Chromosome Inactivation, Phase Separation, Neuron, Computer Simulation
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APA Style
Riki Kurokawa, Akihide Takeuchi, Nobuyuki Shiina, Masato Katahira, Takefumi Yamashita, et al. (2019). Versatility of RNA-Binding Proteins in Living Cells. Biomedical Sciences, 5(1), 7-13. https://doi.org/10.11648/j.bs.20190501.12
ACS Style
Riki Kurokawa; Akihide Takeuchi; Nobuyuki Shiina; Masato Katahira; Takefumi Yamashita, et al. Versatility of RNA-Binding Proteins in Living Cells. Biomed. Sci. 2019, 5(1), 7-13. doi: 10.11648/j.bs.20190501.12
AMA Style
Riki Kurokawa, Akihide Takeuchi, Nobuyuki Shiina, Masato Katahira, Takefumi Yamashita, et al. Versatility of RNA-Binding Proteins in Living Cells. Biomed Sci. 2019;5(1):7-13. doi: 10.11648/j.bs.20190501.12
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Download@article{10.11648/j.bs.20190501.12,
author = {Riki Kurokawa and Akihide Takeuchi and Nobuyuki Shiina and Masato Katahira and Takefumi Yamashita and Yoko Matsuno and Keisuke Hitachi and Shinsuke Ishigaki and Nesreen Haamad and Ryoma Yoneda and Naomi Ueda and Kei Iida and Motoyasu Hosokawa and Masatoshi Hagiwara and Mamiko Iida and Tsukasa Mashima and Yudai Yamaoki and Masatomo So and Takashi Nagata and Gen Sobue and Keiko Kondo and Hiroki Watanabe and Takayuki Uchihashi},
title = {Versatility of RNA-Binding Proteins in Living Cells},
journal = {Biomedical Sciences},
volume = {5},
number = {1},
pages = {7-13},
doi = {10.11648/j.bs.20190501.12},
url = {https://doi.org/10.11648/j.bs.20190501.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20190501.12},
abstract = {This conference paper aims at demonstration of complexity or multiplicity of RNA-binding protein (RBP) and its related RNA. The data in the manuscript are based upon the third Annual Meeting of the RNA study group, held at the Tokyo office of the Kyoto University on May 23 in 2019. The purpose of the meeting is to present recent progress of the study group and have discussion regarding RNA and related molecules, especially focusing on RBP in this year. We had fourteen sessions and documented ten of them in the manuscript. There were exciting and fruitful debates. Actual presentations are shown as follows. Specific RBP Sfpq and Qk are involved in neuronal development in mouse system. Also in mouse, liquid- and solid-like RNA granule formation plays pivotal roles in neuronal functions. Biochemical experiments demonstrate that affinity profiles categorize RNA-Binding proteins into distinctive groups. This presents basis for biological divergence of RBPs. In the context of pathology, RNA aptamers against prion and Alzheimer’s diseases may present therapeutic outcome. Computational analysis is another utility for approaching riddle of RBPs. The study of X-chromosome inactivation is pioneering field of long noncoding RNAs. Redundant triplex interactions between lncRNA and LINE-1s are supposed to be crucial in X-chromosome inactivation. Myogenesis-related lncRNA, Myoparr promotes skeletal muscle atrophy caused by denervation through the regulation of GDF5/BMP14 expression. In neurodegenerative disorders functional loss of TLS/FUS induces onset of frontotemporal lobar degeneration. Conformational change of TLS is induced with binding of various nucleic acid molecules. TLS is also involved in phase separation into aggregation to pathogen generation of neurodegenerative diseases. The meeting has been successfully prorogued. We utilize the data to boost the activity of the field of RNA and RBP. The achievements of the meeting have confirmed pivotal roles of RBPs in living cells. It should be in complexity. We will be able to analyze intricate phenomena of RBP biological actions and contribute to uncover the veiled rules in divergent biological programs.},
year = {2019}
}
TY - JOUR T1 - Versatility of RNA-Binding Proteins in Living Cells AU - Riki Kurokawa AU - Akihide Takeuchi AU - Nobuyuki Shiina AU - Masato Katahira AU - Takefumi Yamashita AU - Yoko Matsuno AU - Keisuke Hitachi AU - Shinsuke Ishigaki AU - Nesreen Haamad AU - Ryoma Yoneda AU - Naomi Ueda AU - Kei Iida AU - Motoyasu Hosokawa AU - Masatoshi Hagiwara AU - Mamiko Iida AU - Tsukasa Mashima AU - Yudai Yamaoki AU - Masatomo So AU - Takashi Nagata AU - Gen Sobue AU - Keiko Kondo AU - Hiroki Watanabe AU - Takayuki Uchihashi Y1 - 2019/08/29 PY - 2019 N1 - https://doi.org/10.11648/j.bs.20190501.12 DO - 10.11648/j.bs.20190501.12 T2 - Biomedical Sciences JF - Biomedical Sciences JO - Biomedical Sciences SP - 7 EP - 13 PB - Science Publishing Group SN - 2575-3932 UR - https://doi.org/10.11648/j.bs.20190501.12 AB - This conference paper aims at demonstration of complexity or multiplicity of RNA-binding protein (RBP) and its related RNA. The data in the manuscript are based upon the third Annual Meeting of the RNA study group, held at the Tokyo office of the Kyoto University on May 23 in 2019. The purpose of the meeting is to present recent progress of the study group and have discussion regarding RNA and related molecules, especially focusing on RBP in this year. We had fourteen sessions and documented ten of them in the manuscript. There were exciting and fruitful debates. Actual presentations are shown as follows. Specific RBP Sfpq and Qk are involved in neuronal development in mouse system. Also in mouse, liquid- and solid-like RNA granule formation plays pivotal roles in neuronal functions. Biochemical experiments demonstrate that affinity profiles categorize RNA-Binding proteins into distinctive groups. This presents basis for biological divergence of RBPs. In the context of pathology, RNA aptamers against prion and Alzheimer’s diseases may present therapeutic outcome. Computational analysis is another utility for approaching riddle of RBPs. The study of X-chromosome inactivation is pioneering field of long noncoding RNAs. Redundant triplex interactions between lncRNA and LINE-1s are supposed to be crucial in X-chromosome inactivation. Myogenesis-related lncRNA, Myoparr promotes skeletal muscle atrophy caused by denervation through the regulation of GDF5/BMP14 expression. In neurodegenerative disorders functional loss of TLS/FUS induces onset of frontotemporal lobar degeneration. Conformational change of TLS is induced with binding of various nucleic acid molecules. TLS is also involved in phase separation into aggregation to pathogen generation of neurodegenerative diseases. The meeting has been successfully prorogued. We utilize the data to boost the activity of the field of RNA and RBP. The achievements of the meeting have confirmed pivotal roles of RBPs in living cells. It should be in complexity. We will be able to analyze intricate phenomena of RBP biological actions and contribute to uncover the veiled rules in divergent biological programs. VL - 5 IS - 1 ER -
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