HIV infected patients have an increased incidence of venous thromboembolism and an important risk factor is antithrombin deficiency. Currently it is estimated that 10% of HIV/AIDS patients who developed venous thromboembolism had antithrombin deficiency with functional antithrombin levels less than 70%. The purpose of this study is to measure functional antithrombin levels in HIV patients prior to development of venous thromboembolic disorder. One hundred and twenty HIV positive and one hundred and twenty-six HIV negative apparently healthy blood donors were studied. Socio-demographic, medical history and clinical characteristics were obtained from the patients. Blood was analyzed for CD4+ lymphocytes count, full blood count and functional antithrombin levels. We also investigated the relationship between functional levels of antithrombin, CD4 + lymphocytes count and some haematological parameters. The functional antithrombin levels were significantly reduced in the people living with HIV/AIDS (72.6%) when compared with the controls (93.7%). There was no correlation between CD4 + lymphocytes count (by proxy the stage of the disease) and functional antithrombin levels in HIV positive patients (r = 0.02, p = 0.9). Patients with HIV infection have a mild deficiency of functional antithrombin that may lead to hypercoagulability.
| Published in | Central African Journal of Public Health (Volume 5, Issue 5) |
| DOI | 10.11648/j.cajph.20190505.13 |
| Page(s) | 198-202 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2019. Published by Science Publishing Group |
Functional, Antithrombin, HIV
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APA Style
Olutogun Tolulase Aderayo, Fasola Foluke Atinuke, Olufemi-Aworinde Kehinde Joyce, Aken’ova Yetunde Adebisi. (2019). Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria. Central African Journal of Public Health, 5(5), 198-202. https://doi.org/10.11648/j.cajph.20190505.13
ACS Style
Olutogun Tolulase Aderayo; Fasola Foluke Atinuke; Olufemi-Aworinde Kehinde Joyce; Aken’ova Yetunde Adebisi. Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria. Cent. Afr. J. Public Health 2019, 5(5), 198-202. doi: 10.11648/j.cajph.20190505.13
AMA Style
Olutogun Tolulase Aderayo, Fasola Foluke Atinuke, Olufemi-Aworinde Kehinde Joyce, Aken’ova Yetunde Adebisi. Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria. Cent Afr J Public Health. 2019;5(5):198-202. doi: 10.11648/j.cajph.20190505.13
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Download@article{10.11648/j.cajph.20190505.13,
author = {Olutogun Tolulase Aderayo and Fasola Foluke Atinuke and Olufemi-Aworinde Kehinde Joyce and Aken’ova Yetunde Adebisi},
title = {Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria},
journal = {Central African Journal of Public Health},
volume = {5},
number = {5},
pages = {198-202},
doi = {10.11648/j.cajph.20190505.13},
url = {https://doi.org/10.11648/j.cajph.20190505.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20190505.13},
abstract = {HIV infected patients have an increased incidence of venous thromboembolism and an important risk factor is antithrombin deficiency. Currently it is estimated that 10% of HIV/AIDS patients who developed venous thromboembolism had antithrombin deficiency with functional antithrombin levels less than 70%. The purpose of this study is to measure functional antithrombin levels in HIV patients prior to development of venous thromboembolic disorder. One hundred and twenty HIV positive and one hundred and twenty-six HIV negative apparently healthy blood donors were studied. Socio-demographic, medical history and clinical characteristics were obtained from the patients. Blood was analyzed for CD4+ lymphocytes count, full blood count and functional antithrombin levels. We also investigated the relationship between functional levels of antithrombin, CD4 + lymphocytes count and some haematological parameters. The functional antithrombin levels were significantly reduced in the people living with HIV/AIDS (72.6%) when compared with the controls (93.7%). There was no correlation between CD4 + lymphocytes count (by proxy the stage of the disease) and functional antithrombin levels in HIV positive patients (r = 0.02, p = 0.9). Patients with HIV infection have a mild deficiency of functional antithrombin that may lead to hypercoagulability.},
year = {2019}
}
TY - JOUR T1 - Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria AU - Olutogun Tolulase Aderayo AU - Fasola Foluke Atinuke AU - Olufemi-Aworinde Kehinde Joyce AU - Aken’ova Yetunde Adebisi Y1 - 2019/08/26 PY - 2019 N1 - https://doi.org/10.11648/j.cajph.20190505.13 DO - 10.11648/j.cajph.20190505.13 T2 - Central African Journal of Public Health JF - Central African Journal of Public Health JO - Central African Journal of Public Health SP - 198 EP - 202 PB - Science Publishing Group SN - 2575-5781 UR - https://doi.org/10.11648/j.cajph.20190505.13 AB - HIV infected patients have an increased incidence of venous thromboembolism and an important risk factor is antithrombin deficiency. Currently it is estimated that 10% of HIV/AIDS patients who developed venous thromboembolism had antithrombin deficiency with functional antithrombin levels less than 70%. The purpose of this study is to measure functional antithrombin levels in HIV patients prior to development of venous thromboembolic disorder. One hundred and twenty HIV positive and one hundred and twenty-six HIV negative apparently healthy blood donors were studied. Socio-demographic, medical history and clinical characteristics were obtained from the patients. Blood was analyzed for CD4+ lymphocytes count, full blood count and functional antithrombin levels. We also investigated the relationship between functional levels of antithrombin, CD4 + lymphocytes count and some haematological parameters. The functional antithrombin levels were significantly reduced in the people living with HIV/AIDS (72.6%) when compared with the controls (93.7%). There was no correlation between CD4 + lymphocytes count (by proxy the stage of the disease) and functional antithrombin levels in HIV positive patients (r = 0.02, p = 0.9). Patients with HIV infection have a mild deficiency of functional antithrombin that may lead to hypercoagulability. VL - 5 IS - 5 ER -
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