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Anesthetic Management for Third Molar Surgery in a Patient with Concurrent Nutcracker, SMA, and Median Arcuate Ligament Syndromes

Received: 17 May 2025     Accepted: 3 June 2025     Published: 23 June 2025
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Abstract

Background Concurrent nutcracker syndrome, superior mesenteric artery syndrome, and median arcuate ligament syndrome (the clinical expression of which is referred to celiac artery compression syndrome), is an extremely rare phenomenon. The purpose of this case report is to describe the anesthetic management of a patient who presented with this rare concurrence, for removal of third molar teeth under general anesthesia. The patient additionally had a history of problematic reactions to benzodiazepines, which further complicated his anesthetic management. Case Presentation A 16-year-old male presented for removal of his symptomatic third molar teeth. Comprehensive history and examination was performed, and medical clarification from his physician was obtained. The patient was treated in an outpatient setting with an anesthetic technique that avoided the use of nitrous oxide and any benzodiazepine, and which included oxygen, fentanyl, decadron, propofol, and local anesthesia. Postoperative antibiotics and pain medications were prescribed. Comprehensive post-operative instructions stressed the importance of postural requirements and adequate nutrition. The patient tolerated the procedure well, and experienced an uneventful recovery. Conclusion This case report illustrates the importance of comprehensive preoperative evaluation, including consultation with any treating physicians of record. It also serves to highlight the efficacy of total intravenous anesthesia, without the use of benzodiazepines or nitrous oxide. The importance of postoperative postural and nutritional requirements are critical with respect to the treatment of patients with any concurrence of the syndromes described in this report.

Published in International Journal of Clinical Oral and Maxillofacial Surgery (Volume 11, Issue 1)
DOI 10.11648/j.ijcoms.20251101.16
Page(s) 53-57
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Nutcracker Syndrome, Superior Mesenteric Artery Syndrome, Median Arcuate Ligament Syndrome, Celiac Artery Compression Syndrome, General Anesthesia, Third Molar Surgery

1. Introduction
Nutcracker syndrome (NCS) is an uncommon syndrome that presents with signs and symptoms caused by compression of the left renal vein (LRV), whereas ‘nutcracker phenomenon’ is solely used to refer to the anatomical configuration without clinical symptoms Compression of the LRV within the aortomesenteric window leads to proximal dilatation of the LRV. Although NCS can demonstrate a wide variability of symptoms at presentation, the exact prevalence of NCS is unknown, and as such is potentially underdiagnosed . Specific signs and symptoms of NCS can include hematuria, orthostatic proteinuria, left flank and upper left quadrant abdominal or pelvic pain, dyspareunia, dysmenorrhea, and fatigue .
Superior mesenteric artery (SMA) syndrome is a rare condition defined as compression of the duodenum between the abdominal aorta and the superior mesenteric artery, and can be a rare cause of proximal bowel obstruction, with increased morbidity and mortality associated with its complications, particularly when concern arises for bowel obstruction in the setting of recent weight loss . SMA syndrome presents with vague symptoms of bowel obstruction, including epigastric pain, nausea, vomiting, abdominal distension, weight loss, early satiety, and postprandial epigastric pain . While rare, SMA syndrome can result in significant morbidity and mortality from malnutrition, dehydration, electrolyte abnormalities, gastric pneumatosis and portal venous gas, gastrointestinal hemorrhage, and gastric perforation . Additionally, due to the presence of a short suspensory ligament of Treitz, resulting anatomic abnormalities may include high suspension of the duodenojejunal flexure, intestinal malrotation, and increased lumbar lordosis .
Median arcuate ligament syndrome (MALS) involves the compression of the celiac artery (CA) by the median arcuate ligament, and refers to the underlying anatomic abnormality, while celiac artery compression syndrome (CACS) describes the resulting clinical syndrome characterized by postprandial abdominal pain, weight loss, epigastric pain during exercise, nausea, vomiting, and occasional abdominal bruit, with potential for pseudoaneurysm of the gastroduodenal artery, which can lead to fatal bleeding . Symptomatic MALS, again referred to as CACS, is a rare condition.
It is important to recognize that chronic vascular compression syndromes, such as those described above, can cause epigastric pain which intensifies with forced inhalation and after meals, and there are still controversies about the origin of these painful symptoms .
The three syndromes discussed above, NCS, SMA syndrome, and MALS/CACS, including their underlying anatomic anomalies and most common presenting symptoms, are presented below in Table 1.
Table 1. The anatomic anomalies and most common presenting signs and symptoms of NCS, SMA syndrome, and MALS/CACS.

Syndrome

Anatomic Anomaly

Signs and Symptoms

Nutcracker syndrome (NCS)

Compression of the left renal vein (LRV)

Hematuria, orthostatic proteinuria, left flank and upper left quadrant or pelvic pain, dyspareunia, dysmenorrhea, fatigue

Superior mesenteric artery (SMA) syndrome

Compression of the duodenum between the abdominal aorta and superior mesenteric artery

Epigastric pain, nausea, vomiting, abdominal distension, weight loss, early satiety, postprandial epigastric pain

Median arcuate ligament syndrome (MALS)/Celiac artery compression syndrome (CACS)

Compression of the celiac artery by the median arcuate ligament

Postprandial abdominal pain, weight loss, epigastric pain with exercise, nausea, vomiting, weight loss, occasional abdominal bruit

As noted above, these syndromes are reportedly rare, and while case reports suggest that concurrences of these syndrome do occur, such concurrences may have been overlooked due to nonspecific symptoms and potentially conflicting imaging findings . Indeed, as these syndromes often present with incidental findings, and may be asymptomatic, their concurrence can be challenging to diagnose .
2. Case presentation
A sixteen-year-old male presented for examination and consultation regarding removal of his four impacted third molar teeth, #’s 1, 16, 17, 32, due to impaction, intermittent pain, and planned orthodontic treatment. Past medical history was found to be significant for multiple medical disorders related to renal and gastrointestinal tract function, including NCS, SMA syndrome, and MALS. He had undergone multiple surgical procedures, including duodenojejunostomy and excision of the celiac ganglion, both of which, by history, improved his overall symptomatology. His medications were Dexilant, Zofran, and Tylenol. He additionally reported no gastritis or other complications associated with prior use of ibuprofen. He apparently had experienced seizure activity with possible extrapyramidal reactions to previously administered benzodiazepines, including Versed and Ativan. He did complain of intermittent abdominal pain, as well as left hip pain. He utilized a well-balanced diet, and reported normal stools and urinary output. His past medical history was otherwise noncontributory.
Physical examination demonstrated a well-appearing 16 year old, in no apparent distress, interactive and pleasant in manner. Musculoskeletal examination demonstrated normal muscle strength and tone, normal range of motion, no laxity or swelling of joints, and no back or hip tenderness to palpation. Abdominal examination demonstrated no tenderness, masses or bruits.
Head and neck examination was normal, with no tenderness, masses, or lymphadenopathy noted. His cranial nerve function was intact grossly. Intraoral examination demonstrated dentition in a good state of repair, without visibility of his third molar teeth. He demonstrated slight crowding of his dentition, which was otherwise stable. His oral hygiene was good, with no soft tissue lesions. No masses or swelling were present, and his peritonsillar tissues were atrophic, without pharyngeal injection. His airway was classified as Mallampati Class 2. His mandibular range of motion was adequate, with unforced mandibular vertical opening over 35mm, and with good lateral excursive and protrusive function. No temporomandibular joint (TMJ) pain, clicking or popping was observed.
His panoramic radiograph demonstrated impacted third molar teeth #’s 1, 16, 17, 32 (Figure 1).
Figure 1. Panoramic radiograph demonstrating impacted third molar teeth #’s 1, 16, 17, 32.
Medical clarification with the patient’s treating physician of record was obtained, and proposed anesthetic management and postoperative concerns were discussed.
The patient subsequently returned for removal of his third molar teeth under general anesthesia in an outpatient oral and maxillofacial surgery setting. It was decided that nitrous oxide and any benzodiazpenines would not be administered, and as such a total intravenous anesthesia (TIVA) technique, without the use of any inhalation anesthetics, was determined to be the most appropriate option for anesthetic management for this patient. He was administered four liters/minute of oxygen by nasal mask, intravenous was access was obtained, and a 0.9 sodium chloride solution was utilized for infusion. He was then administered 50 micrograms of Fentanyl, 190 milligrams of Propofol, and 4 milligrams of Decadron, supplemented by appropriate local anesthesia, consisting of Lidocaine with epinephrine, Septocaine w/ epinephrine, and Marcaine with epinephrine. The four third molar teeth were removed in standard fashion for complete boney impacted third molar teeth, and the duration of the procedure was forty-eight minutes. He tolerated the procedure well, and was observed and monitored for an appropriate time period. He was discharged shortly thereafter in stable condition, having tolerated the procedure well. He was given appropriate postoperative instructions, which included specific and detailed in structions as to postural and nutritional recommendations, and was prescibed amoxicillin and hydrocodone with acetaminophen. It was advised that the opioid should be utilized conservatively, and should be supplemented with alternating administration of ibuprofen and acetaminophen. The patient experienced an uncomplicated postoperative course, and was doing well at his two-week postoperative evaluation.
3. Discussion
For the patient with concurrent Nutcraker syndrome, Superior mesenteric artery syndrome, and Median arcuate ligament syndrome (Also referred to as Celiac artery compression syndrome), anesthetic and surgical planning presents numerous challenges, which include high risk of aspiration, potential sensitivity to neuromuscular blockers, and avoidance of and careful management of nausea and vomiting. Additionally, when providing anesthesia to a patient with these concurrent problems, key considerations include careful management of intra-abdominal pressure, utilizing an anesthetic approach including a combination of light general anesthesia with careful titration of opioids, close monitoring of vital signs, maintaining adequate intravascular volume to prevent hypotension, while at the same time avoiding excessive fluid administration that could increase abdominal pressure, and prioritizing gentle handling of the abdominal area during surgery.
The decision to utilize total invenous anesthesia (TIVA) with popofol in this case, while not utilizing an inhalation agent, such as sevoflurane, was based upon the fact an inhalation technique for this case may have required medication for postoperatove nausea and vomiting (PONV), which would have been problematic with this patient’s symptomatology . Additionally, it has been demonstrated that TIVA without intubation is an efficient anesthetuc technique for head and neck surgery .
In the case presented above, an additional consideration included the avoidance of nitrous oxide, due to its blood: gas partition coefficient being 34 times greater than that of nitrogen . As such, due to its propensity to diffuse rapidly into closed spaces more rapidly than nitrogen can diffuse out, this can lead to increased gas volume and pressure within closed spaces. As such, nitrous oxide was considered to be contraindicated in this case, due to its potential to affect intra-abdominal pressure. Therefore, only oxygen was utilized as an inhalant agent, which is the standard of practice in anesthetic management, either singly or utilizing a balanced approach. Additionally, as the patient had previously experienced seizure activity, with possible extrapyramindal reactions, to intravenous and orally administered benzodiazepines, no benzodiazepine was administered in this case. As TIVA is widely practiced with adjunctive medications which serve to overcome any disadvantages of each, and provide a balanced technique with additional benefits, it was important to include decadron, due its anti-inflammatory and antiemetic effects . As the primary drawback to the selected technique, the inablity to utilize a benzodiazepine negated the potential benefits of the sedative, anxiolytic, and amnestic properties of this drug class . As Midazolam, which is the dominant benzodiazepine utilized for outpatient procedural sedation in oral and maxillofacial surgery, has sugnificant synergistic effects with bioth bpropofol and opiods, it would have been beneficial to utilize it in this case as an adjunctive agent .
It was also important to pay close attention to posture during and after surgery, which is important with regard to any patient with Nutcracaker syndrome, so as to avoid excessive pressure on the renal vein. Postural considerations are also critically important with respect to proper nutritional support, as a hallmark of medical treatment for patients with these maladies involves a conservative approach with a focus on weight gain and monitoring caloric needs, combined with a focus upon positional changes, including the prone and left lateral decubitus positions, as an aid to tolerating enteral feeding .
As with all surgical procedures in the oral and maxillofacial region, postoperative pain control is of critical importance to the recovery of the patient, in particular during the period of time when the patient is in the recovery suite, or has been discharged to home. As the effects of the anesthetic agents are attenuated, the local anesthetic effect will diminsh as well, and it is at this point that conservative use of a balanced combination of opioids, ibuprofen and acetaminophen be utilized. As opiods can significantly impact gut motility, thereby slowing the movement of food through the digestive tract, careful consideration must be given to the the need for the use of opiods sparingly, if at all, in patients with these maladies during the postopertive period. This must be aproached within the context of adequate and balanced nutritional support. These considerations all serve to underscore the need for thorough evaluation and treatment planning in patients presenting with symptoms of vascular compression disorders .
4. Conclusion
The extraction of impacted third molar teeth, particularly for those patients who have been diagnosed with complex medical conditions, presents a challenge with respect to diagnosis, treatment planning, medical consultation and clarification, anesthetic management, surgical approach, and provision of appropriate postoperative care. This case highlights the importance of understanding the anatomic variabilities in any given patient, and the need to formulate an individual treatment plan for every patient. The syndromes discussed in this case presentation provide an opportunity to appreciate a rare concurrence of syndromes, and the importance of understanding how these syndromes may affect the provision of oral and maxillofacial surgical care for the patient. It also highlights the importance of the need to adjust anesthetic technique when indicated, which in this case served to promote an enhanced surgical outcome.
Declarations
Informed consent was obtained from the parents of the parent.
Clinical Trial Number
Not applicable.
Funding
The suthors declare that no funds, grants, or other support were received during the preparation of this manuscript.
Conflicts of Interest
The authors declare no conflicts of interest.
References
[1] F. Dieleman, J. F. Hamming, Y. Erben, J. R van der Vorst, “Nutcracker Syndrome: Challenges in Diagnosis and Surgical Treatment,” Annals of Vascular Surgery 94 (2023): 178-185.
[2] N. Van Horne, J. P. Jackson (2023) Superior Mesenteric Artery Syndrome. NCBI Bookshelf, National Library of Health. National Institutes of Health.
[3] H. Kasan, E. Al-Jabbari, N. Shroff, M. Barghash, A. Shestopalav, P. Bhargava, “Coexistence of superior mesenteric artery syndrome ans nutcracker phenomenon,” Radiology Case Reports 17, no. 6 (2022): 1927-1930.
[4] K. K. Jensen, P. Bonde, J. H. Storkholm, S. T. Heerwagen, P. N. Larsen, J. Eiberg, “Spontaneous intestinal bleeding due to pseudoaneurism of the gastroduodenal artery: case report of a rare complication to median arcuate ligament syndrome,” Journal of Surgical Case Reports 12 (2020): 1-3.
[5] I. Pennisi, R. Farina, P. V. Foti, A. Basile, “The Ultrasound Findings in a Rare Case of Nutcracker Syndrome, Wilkie’s Syndrome, and Dunbar Syndrome Combination,” Journal of Medical Ultrasound 31, no. 1 (2022): 55-59.
[6] T. Laskowski, N. Tihonov, M. Richard, D. Katz, A. d’Audriffret, “Concurrent nutcracker syndrome and superior mesenteric artery syndrome requiring duodenojejunal bypass and left renal vein transposition,” Annals of Vascular Surgery – Brief Reports and Innovations 2, no. 3 (2022).
[7] F. Fleti, J. Song, X. J. Wang, “Under Pressure: Concomitant Median Arcuate Ligament Syndrome and Nutcracker Syndrome,” The American Journal of Gastroenterology 118, no. 10 (2023): 2634-2635.
[8] H. O. Simsek, O. Kocaturk, L. Demetoglu, B. Gursoytrak, “Propofol based total intravenous anesthesia versus sevoflurane based inhalation anesthesia: The postoperative characteristics in oral and maxillofacial surgery,” Journal of Cranio-Maxillofacial Surgery 48, no. 9 (2020): 880-884.
[9] K. Nakamura, T. Muto, T. Yoshida, H. Hiramatsu, Y. Watanabe, “Efficacy of total intravenous anesthesia without intubation for laryngeal framework surgery,” Acta Otolaryngology 128, no. 9 (2008): 1037-1042.
[10] R. K. Stoelting, R. D. Miller, Basics of Anesthesia (Churchill Livingstone, 4th edition, 2000). ISBN 0-443-06573-X.
[11] S. J. S. Bajwa, S. Vinayagam, S. Shinde, S. Dalal, J. Vennel, “Recent advances in total intravenous anaesthesia and anaesthetic pharmacology,” Indian Journal of Anaesthesia 67, no. 1 (2023): 56-62.
[12] L. Evered, K. O. Pryor, “Benzodiazepines and postoperatice delirium: should we be as cautious as we are?” British Journal of Anaesthesia 131, no. 4 (2023): 629-631.
[13] J. R. Sneyd, P. L. Gambus, A. E. Rigby-Jones, “Current status of perioperative hypnotics, role of benzodiazepines, and the case for remimazolam: a anarrative review,” British Journal of Anaesthesia 127, no. 1 (2021): 41-55.
[14] S. Diab, F. Hayek, “Combined Superior Mesenteric Artery Syndrome and Nutcracker Syndrome in a Young Patient: A Case Report and Review of the Literature,” American Journal of Case Reports 21 (2020): e922619-1-e922619-5.
[15] M. Boroomand-Saboor, H. Moradi, “Double trouble: A case report of concurrent superior mesenteric artery syndrome ans nucracker syndrome in a previously healthy young adult,” International Journal of Surgery Case Reports 127 (2025).
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  • APA Style

    Traub, D. J., Traub, M. A. (2025). Anesthetic Management for Third Molar Surgery in a Patient with Concurrent Nutcracker, SMA, and Median Arcuate Ligament Syndromes. International Journal of Clinical Oral and Maxillofacial Surgery, 11(1), 53-57. https://doi.org/10.11648/j.ijcoms.20251101.16

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    ACS Style

    Traub, D. J.; Traub, M. A. Anesthetic Management for Third Molar Surgery in a Patient with Concurrent Nutcracker, SMA, and Median Arcuate Ligament Syndromes. Int. J. Clin. Oral Maxillofac. Surg. 2025, 11(1), 53-57. doi: 10.11648/j.ijcoms.20251101.16

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    AMA Style

    Traub DJ, Traub MA. Anesthetic Management for Third Molar Surgery in a Patient with Concurrent Nutcracker, SMA, and Median Arcuate Ligament Syndromes. Int J Clin Oral Maxillofac Surg. 2025;11(1):53-57. doi: 10.11648/j.ijcoms.20251101.16

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  • @article{10.11648/j.ijcoms.20251101.16,
      author = {Daniel Joseph Traub and Michael Aaron Traub},
      title = {Anesthetic Management for Third Molar Surgery in a Patient with Concurrent Nutcracker, SMA, and Median Arcuate Ligament Syndromes
    },
      journal = {International Journal of Clinical Oral and Maxillofacial Surgery},
      volume = {11},
      number = {1},
      pages = {53-57},
      doi = {10.11648/j.ijcoms.20251101.16},
      url = {https://doi.org/10.11648/j.ijcoms.20251101.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcoms.20251101.16},
      abstract = {Background Concurrent nutcracker syndrome, superior mesenteric artery syndrome, and median arcuate ligament syndrome (the clinical expression of which is referred to celiac artery compression syndrome), is an extremely rare phenomenon. The purpose of this case report is to describe the anesthetic management of a patient who presented with this rare concurrence, for removal of third molar teeth under general anesthesia. The patient additionally had a history of problematic reactions to benzodiazepines, which further complicated his anesthetic management. Case Presentation A 16-year-old male presented for removal of his symptomatic third molar teeth. Comprehensive history and examination was performed, and medical clarification from his physician was obtained. The patient was treated in an outpatient setting with an anesthetic technique that avoided the use of nitrous oxide and any benzodiazepine, and which included oxygen, fentanyl, decadron, propofol, and local anesthesia. Postoperative antibiotics and pain medications were prescribed. Comprehensive post-operative instructions stressed the importance of postural requirements and adequate nutrition. The patient tolerated the procedure well, and experienced an uneventful recovery. Conclusion This case report illustrates the importance of comprehensive preoperative evaluation, including consultation with any treating physicians of record. It also serves to highlight the efficacy of total intravenous anesthesia, without the use of benzodiazepines or nitrous oxide. The importance of postoperative postural and nutritional requirements are critical with respect to the treatment of patients with any concurrence of the syndromes described in this report.
    },
     year = {2025}
    }
    

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    T1  - Anesthetic Management for Third Molar Surgery in a Patient with Concurrent Nutcracker, SMA, and Median Arcuate Ligament Syndromes
    
    AU  - Daniel Joseph Traub
    AU  - Michael Aaron Traub
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    AB  - Background Concurrent nutcracker syndrome, superior mesenteric artery syndrome, and median arcuate ligament syndrome (the clinical expression of which is referred to celiac artery compression syndrome), is an extremely rare phenomenon. The purpose of this case report is to describe the anesthetic management of a patient who presented with this rare concurrence, for removal of third molar teeth under general anesthesia. The patient additionally had a history of problematic reactions to benzodiazepines, which further complicated his anesthetic management. Case Presentation A 16-year-old male presented for removal of his symptomatic third molar teeth. Comprehensive history and examination was performed, and medical clarification from his physician was obtained. The patient was treated in an outpatient setting with an anesthetic technique that avoided the use of nitrous oxide and any benzodiazepine, and which included oxygen, fentanyl, decadron, propofol, and local anesthesia. Postoperative antibiotics and pain medications were prescribed. Comprehensive post-operative instructions stressed the importance of postural requirements and adequate nutrition. The patient tolerated the procedure well, and experienced an uneventful recovery. Conclusion This case report illustrates the importance of comprehensive preoperative evaluation, including consultation with any treating physicians of record. It also serves to highlight the efficacy of total intravenous anesthesia, without the use of benzodiazepines or nitrous oxide. The importance of postoperative postural and nutritional requirements are critical with respect to the treatment of patients with any concurrence of the syndromes described in this report.
    
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