A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term

Saima Ali; Shumaila Mubasher; Ambreen Naveed Haq

doi:doi:10.11648/j.jgo.20140206.11

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A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term

Saima Ali, Shumaila Mubasher, Ambreen Naveed Haq

Published in Journal of Gynecology and Obstetrics (Volume 2, Issue 6)

Received: 2 October 2014 Accepted: 9 October 2014 Published: 30 October 2014

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Abstract

Our objective was to compare the efficacy of vaginal misoprostol and tablet PGE2 for induction of labor at term.Methods: In this RCT a total of 140 women at term gestation were given either misoprostol (50 mcg) or prostaglandin E2 (3 mg) for induction of labour. The study was conducted at the Gynae/Obstetrics department, PAEC Hospital Islamabad, in a period of six months. All women requiring induction, having gestational age > 37 weeks, singleton pregnancy with cephalic presentation, bishop score < 6 and reassuring fetal heart rate tracing were included in the study. The study outcome was measurement of efficacy in terms of induction delivery interval, number of vaginal deliveries achieved within 24 hours, mode of delivery, total doses, need for oxytocin and number of successful inductions. Results: The mean age and average gestational age was similar in the two groups of patients. In group A (51.4%) patients required two doses while in group B (32.9%) took two doses. Similarly, (60%) patients required oxytocin in group A compared to (50%) in group B. The mean delivery induction interval was 10.8 hours (650 minutes) in group A compared to 9.01 hours (541 minutes) in group B; and this difference in two means is statistically significant. In group A (18.5%) patients required emergency cesarean section while in group B (27.1%) needed cesarean section. The major indication for emergency cesarean section in group B was fetal distress. Therefore misoprostol can play a very important role in the practice of obstetrics and gynecology in resource depleted countries where other prostaglandins are expensive and storage at low temperature is a problem.

Published in	Journal of Gynecology and Obstetrics (Volume 2, Issue 6)
DOI	10.11648/j.jgo.20140206.11
Page(s)	81-85
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Misoprostol, Prostaglandin E2, Term Pregnancy, Labour Induction

References

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APA Style

Saima Ali, Shumaila Mubasher, Ambreen Naveed Haq. (2014). A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term. Journal of Gynecology and Obstetrics, 2(6), 81-85. https://doi.org/10.11648/j.jgo.20140206.11

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ACS Style

Saima Ali; Shumaila Mubasher; Ambreen Naveed Haq. A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term. J. Gynecol. Obstet. 2014, 2(6), 81-85. doi: 10.11648/j.jgo.20140206.11

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AMA Style

Saima Ali, Shumaila Mubasher, Ambreen Naveed Haq. A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term. J Gynecol Obstet. 2014;2(6):81-85. doi: 10.11648/j.jgo.20140206.11

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@article{10.11648/j.jgo.20140206.11,
  author = {Saima Ali and Shumaila Mubasher and Ambreen Naveed Haq},
  title = {A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {2},
  number = {6},
  pages = {81-85},
  doi = {10.11648/j.jgo.20140206.11},
  url = {https://doi.org/10.11648/j.jgo.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20140206.11},
  abstract = {Our objective was to compare the efficacy of vaginal misoprostol and tablet PGE2 for induction of labor at term.Methods: In this RCT a total of 140 women at term gestation were given either misoprostol (50 mcg) or prostaglandin E2 (3 mg) for induction of labour. The study was conducted at the Gynae/Obstetrics department, PAEC Hospital Islamabad, in a period of six months. All women requiring induction, having gestational age > 37 weeks, singleton pregnancy with cephalic presentation, bishop score < 6 and reassuring fetal heart rate tracing were included in the study. The study outcome was measurement of efficacy in terms of induction delivery interval, number of vaginal deliveries achieved within 24 hours, mode of delivery, total doses, need for oxytocin and number of successful inductions. Results: The mean age and average gestational age was similar in the two groups of patients. In group A (51.4%) patients required two doses while in group B (32.9%) took two doses. Similarly, (60%) patients required oxytocin in group A compared to (50%) in group B. The mean delivery induction interval was 10.8 hours (650 minutes) in group A compared to 9.01 hours (541 minutes) in group B; and this difference in two means is statistically significant. In group A (18.5%) patients required emergency cesarean section while in group B (27.1%) needed cesarean section. The major indication for emergency cesarean section in group B was fetal distress. Therefore misoprostol can play a very important role in the practice of obstetrics and gynecology in resource depleted countries where other prostaglandins are expensive and storage at low temperature is a problem.},
 year = {2014}
}

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TY  - JOUR
T1  - A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term
AU  - Saima Ali
AU  - Shumaila Mubasher
AU  - Ambreen Naveed Haq
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.jgo.20140206.11
DO  - 10.11648/j.jgo.20140206.11
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 81
EP  - 85
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20140206.11
AB  - Our objective was to compare the efficacy of vaginal misoprostol and tablet PGE2 for induction of labor at term.Methods: In this RCT a total of 140 women at term gestation were given either misoprostol (50 mcg) or prostaglandin E2 (3 mg) for induction of labour. The study was conducted at the Gynae/Obstetrics department, PAEC Hospital Islamabad, in a period of six months. All women requiring induction, having gestational age > 37 weeks, singleton pregnancy with cephalic presentation, bishop score < 6 and reassuring fetal heart rate tracing were included in the study. The study outcome was measurement of efficacy in terms of induction delivery interval, number of vaginal deliveries achieved within 24 hours, mode of delivery, total doses, need for oxytocin and number of successful inductions. Results: The mean age and average gestational age was similar in the two groups of patients. In group A (51.4%) patients required two doses while in group B (32.9%) took two doses. Similarly, (60%) patients required oxytocin in group A compared to (50%) in group B. The mean delivery induction interval was 10.8 hours (650 minutes) in group A compared to 9.01 hours (541 minutes) in group B; and this difference in two means is statistically significant. In group A (18.5%) patients required emergency cesarean section while in group B (27.1%) needed cesarean section. The major indication for emergency cesarean section in group B was fetal distress. Therefore misoprostol can play a very important role in the practice of obstetrics and gynecology in resource depleted countries where other prostaglandins are expensive and storage at low temperature is a problem.
VL  - 2
IS  - 6
ER  -

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Author Information

Saima Ali

Pakistan Atomic Energy Commision Hospital (PAEC), Islamabad, Pakistan
Shumaila Mubasher

Pakistan Atomic Energy Commision Hospital (PAEC), Islamabad, Pakistan
Ambreen Naveed Haq

Pakistan Atomic Energy Commision Hospital (PAEC), Islamabad, Pakistan

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APA Style

Saima Ali, Shumaila Mubasher, Ambreen Naveed Haq. (2014). A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term. Journal of Gynecology and Obstetrics, 2(6), 81-85. https://doi.org/10.11648/j.jgo.20140206.11

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ACS Style

Saima Ali; Shumaila Mubasher; Ambreen Naveed Haq. A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term. J. Gynecol. Obstet. 2014, 2(6), 81-85. doi: 10.11648/j.jgo.20140206.11

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AMA Style

Saima Ali, Shumaila Mubasher, Ambreen Naveed Haq. A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term. J Gynecol Obstet. 2014;2(6):81-85. doi: 10.11648/j.jgo.20140206.11

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@article{10.11648/j.jgo.20140206.11,
  author = {Saima Ali and Shumaila Mubasher and Ambreen Naveed Haq},
  title = {A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {2},
  number = {6},
  pages = {81-85},
  doi = {10.11648/j.jgo.20140206.11},
  url = {https://doi.org/10.11648/j.jgo.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20140206.11},
  abstract = {Our objective was to compare the efficacy of vaginal misoprostol and tablet PGE2 for induction of labor at term.Methods: In this RCT a total of 140 women at term gestation were given either misoprostol (50 mcg) or prostaglandin E2 (3 mg) for induction of labour. The study was conducted at the Gynae/Obstetrics department, PAEC Hospital Islamabad, in a period of six months. All women requiring induction, having gestational age > 37 weeks, singleton pregnancy with cephalic presentation, bishop score < 6 and reassuring fetal heart rate tracing were included in the study. The study outcome was measurement of efficacy in terms of induction delivery interval, number of vaginal deliveries achieved within 24 hours, mode of delivery, total doses, need for oxytocin and number of successful inductions. Results: The mean age and average gestational age was similar in the two groups of patients. In group A (51.4%) patients required two doses while in group B (32.9%) took two doses. Similarly, (60%) patients required oxytocin in group A compared to (50%) in group B. The mean delivery induction interval was 10.8 hours (650 minutes) in group A compared to 9.01 hours (541 minutes) in group B; and this difference in two means is statistically significant. In group A (18.5%) patients required emergency cesarean section while in group B (27.1%) needed cesarean section. The major indication for emergency cesarean section in group B was fetal distress. Therefore misoprostol can play a very important role in the practice of obstetrics and gynecology in resource depleted countries where other prostaglandins are expensive and storage at low temperature is a problem.},
 year = {2014}
}

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TY  - JOUR
T1  - A Comparison of Vaginal Misoprostol and Prostaglandin E2 for Induction of Labour at Term
AU  - Saima Ali
AU  - Shumaila Mubasher
AU  - Ambreen Naveed Haq
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.jgo.20140206.11
DO  - 10.11648/j.jgo.20140206.11
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 81
EP  - 85
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20140206.11
AB  - Our objective was to compare the efficacy of vaginal misoprostol and tablet PGE2 for induction of labor at term.Methods: In this RCT a total of 140 women at term gestation were given either misoprostol (50 mcg) or prostaglandin E2 (3 mg) for induction of labour. The study was conducted at the Gynae/Obstetrics department, PAEC Hospital Islamabad, in a period of six months. All women requiring induction, having gestational age > 37 weeks, singleton pregnancy with cephalic presentation, bishop score < 6 and reassuring fetal heart rate tracing were included in the study. The study outcome was measurement of efficacy in terms of induction delivery interval, number of vaginal deliveries achieved within 24 hours, mode of delivery, total doses, need for oxytocin and number of successful inductions. Results: The mean age and average gestational age was similar in the two groups of patients. In group A (51.4%) patients required two doses while in group B (32.9%) took two doses. Similarly, (60%) patients required oxytocin in group A compared to (50%) in group B. The mean delivery induction interval was 10.8 hours (650 minutes) in group A compared to 9.01 hours (541 minutes) in group B; and this difference in two means is statistically significant. In group A (18.5%) patients required emergency cesarean section while in group B (27.1%) needed cesarean section. The major indication for emergency cesarean section in group B was fetal distress. Therefore misoprostol can play a very important role in the practice of obstetrics and gynecology in resource depleted countries where other prostaglandins are expensive and storage at low temperature is a problem.
VL  - 2
IS  - 6
ER  -

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