Abstract: Background: Medication related problem is defined as: ‘an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Drug related problems are of a major concern in health care because of increased cost, morbidity and mortality. cardiovascular diseases are a group of disorders of the heart and blood vessels. Objective: To discover characterization of medication related problems and contributing factors among cardiovascular patients in the medical ward of Mettu Karl Referral Hospital. Methods: A facility based prospective observational study design was carried from April 07 /2021 to June 09/2021. Data was collected through employing check list and semi-structured questioner. Data was entered and descriptive statistical analysis was done using statistical packages for social sciences 25.0 version statistical software. Both bi-variable and multivariable analysis performed to determine the association between outcome and predictors variables. A p-value of less than 0.05 was considered significant. Results: The overall rate of medication related problems among cardiovascular patients in medical ward was 53 (58.2%). The patient’s age group was in line of 36-59 years 49 (53.8%). Unnecessary drug therapy 15 (28.3%) were the mostly identified type of drug therapy problem followed by dosage too high 11 (20.8%). ACEIs 229 (17.1%) was commonly prescribed medication and potassium sparing 19 (2.2%) was least prescribed drugs. Age ≥ 60 years (AOR: 2.76; 95%CI: 1.342-3.945; P=0.004), rural area residents (AOR: 2.76; 95%CI: 1.014-2.758; P=0.003), length of hospital stay >7 days (AO R: 4.75; 95%CI: 2.986-11.723; P=0.007), number of medication >5 (AOR: 3.632-17.893; 95%CI: 2.986-11.723; P=0.001) were associated factor significantly causes medication related problems. Conclusion and Recommendation: The prevalence of medication related problems amid cardiovascular patients in medical ward was high. Less than half of patients were found to have co-morbidities and were had have social substance users. Hospitals and ministry of Health should have to establish pharmaceutical care services for better patient care.Abstract: Background: Medication related problem is defined as: ‘an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Drug related problems are of a major concern in health care because of increased cost, morbidity and mortality. cardiovascular diseases are a group of disorders of the heart and...Show More
Abstract: Objectives: In a brief summary we present the basic aspects of the of the hemoglobinopathies in the population of the South-East Rodopi within the Bulgarian territory and we report the preliminary results for the identification of β-thalassemia carriers by measuring the expression of the HbA fractions. Design and methods: Separation and measurement of the Hb fractions in blood samples collected among the multi-ethnic Bulgarian population using different methods. Results: By using a cut of 3.2% HbA2 we have found 9.77% carriers of point mutations defects among a group of 532 patients of different ethnic origin. All patients’ carriers have also increased HbF. Most frequent point mutation is IVS I nt 110 (G>A). Discussion: All methods summarized in this paper provide identification at practically high sensitivity and specificity. However, all methods should be followed by routine parent's analysis to confirm the provisional results. Taking into consideration the specific conditions of each patient and the HbA expression, we believe carriers of β-thalassemia can be preselected with a reasonable degree of sensitivity and be confirmed by parent analysis. It is important to consider this uneven distribution of the mutations in the hemoglobin being increased in our region as opposed to the overall carriers in the territory of Bulgaria and Europe.Abstract: Objectives: In a brief summary we present the basic aspects of the of the hemoglobinopathies in the population of the South-East Rodopi within the Bulgarian territory and we report the preliminary results for the identification of β-thalassemia carriers by measuring the expression of the HbA fractions. Design and methods: Separation and measurement...Show More
