Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting

Awoleke Jacob Olumuyiwa; Omoyajowo Adefunke Christianah; Ajayi David Daisi; Awoleke Adeola Olabisi

doi:doi:10.11648/j.jgo.20190701.14

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Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting

Awoleke Jacob Olumuyiwa, Omoyajowo Adefunke Christianah, Ajayi David Daisi, Awoleke Adeola Olabisi

Published in Journal of Gynecology and Obstetrics (Volume 7, Issue 1)

Received: 16 February 2019 Accepted: 22 March 2019 Published: 13 April 2019

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Abstract

Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biologic determinants for active maternal CMV infection in a Nigerian setting. Using a cross-sectional design, ELISA kits were employed to quantify the anti-CMV IgG and IgM antibodies in the sera of consecutive antenatal attendees at the Ekiti State University Teaching Hospital (EKSUTH), Nigeria. Among the respondents, 23 (12.4%) were seropositive for both anti-CMV IgG and IgM antibodies. The regression analysis showed that the likelihood of being seropositive for both anti-CMV IgG and IgM antibodies was predicted by having a child less than 5 years old (adjusted OR: 5.53; 95% CI: 1.08 – 28.30; p = 0.04), while those who were skilled workers were least likely to be seropositive for both antibodies (adjusted OR: 0.06; 95% CI: 0.01 – 0.95; p = 0.04). Also, infection with cytomegalovirus was associated with pre-eclampsia (adjusted OR: 0.03; 95% CI: 0.002 – 0.41; p = 0.01). High prevalence of active maternal CMV infection was noted from the study, and this was associated with pre-eclampsia and caring for children under-5. Educating pregnant non-immune women about CMV and its prevention, coupled with the improvement in socio-economic status of the populace can reduce the burden in low-resource settings.

Published in	Journal of Gynecology and Obstetrics (Volume 7, Issue 1)
DOI	10.11648/j.jgo.20190701.14
Page(s)	25-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Cytomegalovirus, Socio-biologic Predictors, Immunoglobulin M (IgM), Screening, Low-resource Setting

References

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APA Style

Awoleke Jacob Olumuyiwa, Omoyajowo Adefunke Christianah, Ajayi David Daisi, Awoleke Adeola Olabisi. (2019). Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting. Journal of Gynecology and Obstetrics, 7(1), 25-30. https://doi.org/10.11648/j.jgo.20190701.14

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ACS Style

Awoleke Jacob Olumuyiwa; Omoyajowo Adefunke Christianah; Ajayi David Daisi; Awoleke Adeola Olabisi. Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting. J. Gynecol. Obstet. 2019, 7(1), 25-30. doi: 10.11648/j.jgo.20190701.14

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AMA Style

Awoleke Jacob Olumuyiwa, Omoyajowo Adefunke Christianah, Ajayi David Daisi, Awoleke Adeola Olabisi. Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting. J Gynecol Obstet. 2019;7(1):25-30. doi: 10.11648/j.jgo.20190701.14

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@article{10.11648/j.jgo.20190701.14,
  author = {Awoleke Jacob Olumuyiwa and Omoyajowo Adefunke Christianah and Ajayi David Daisi and Awoleke Adeola Olabisi},
  title = {Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {7},
  number = {1},
  pages = {25-30},
  doi = {10.11648/j.jgo.20190701.14},
  url = {https://doi.org/10.11648/j.jgo.20190701.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190701.14},
  abstract = {Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biologic determinants for active maternal CMV infection in a Nigerian setting. Using a cross-sectional design, ELISA kits were employed to quantify the anti-CMV IgG and IgM antibodies in the sera of consecutive antenatal attendees at the Ekiti State University Teaching Hospital (EKSUTH), Nigeria. Among the respondents, 23 (12.4%) were seropositive for both anti-CMV IgG and IgM antibodies. The regression analysis showed that the likelihood of being seropositive for both anti-CMV IgG and IgM antibodies was predicted by having a child less than 5 years old (adjusted OR: 5.53; 95% CI: 1.08 – 28.30; p = 0.04), while those who were skilled workers were least likely to be seropositive for both antibodies (adjusted OR: 0.06; 95% CI: 0.01 – 0.95; p = 0.04). Also, infection with cytomegalovirus was associated with pre-eclampsia (adjusted OR: 0.03; 95% CI: 0.002 – 0.41; p = 0.01). High prevalence of active maternal CMV infection was noted from the study, and this was associated with pre-eclampsia and caring for children under-5. Educating pregnant non-immune women about CMV and its prevention, coupled with the improvement in socio-economic status of the populace can reduce the burden in low-resource settings.},
 year = {2019}
}

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TY  - JOUR
T1  - Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting
AU  - Awoleke Jacob Olumuyiwa
AU  - Omoyajowo Adefunke Christianah
AU  - Ajayi David Daisi
AU  - Awoleke Adeola Olabisi
Y1  - 2019/04/13
PY  - 2019
N1  - https://doi.org/10.11648/j.jgo.20190701.14
DO  - 10.11648/j.jgo.20190701.14
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 25
EP  - 30
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20190701.14
AB  - Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biologic determinants for active maternal CMV infection in a Nigerian setting. Using a cross-sectional design, ELISA kits were employed to quantify the anti-CMV IgG and IgM antibodies in the sera of consecutive antenatal attendees at the Ekiti State University Teaching Hospital (EKSUTH), Nigeria. Among the respondents, 23 (12.4%) were seropositive for both anti-CMV IgG and IgM antibodies. The regression analysis showed that the likelihood of being seropositive for both anti-CMV IgG and IgM antibodies was predicted by having a child less than 5 years old (adjusted OR: 5.53; 95% CI: 1.08 – 28.30; p = 0.04), while those who were skilled workers were least likely to be seropositive for both antibodies (adjusted OR: 0.06; 95% CI: 0.01 – 0.95; p = 0.04). Also, infection with cytomegalovirus was associated with pre-eclampsia (adjusted OR: 0.03; 95% CI: 0.002 – 0.41; p = 0.01). High prevalence of active maternal CMV infection was noted from the study, and this was associated with pre-eclampsia and caring for children under-5. Educating pregnant non-immune women about CMV and its prevention, coupled with the improvement in socio-economic status of the populace can reduce the burden in low-resource settings.
VL  - 7
IS  - 1
ER  -

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Author Information

Awoleke Jacob Olumuyiwa

Department of Obstetrics and Gynaecology, Ekiti State University, Ado-Ekiti, Nigeria
Omoyajowo Adefunke Christianah

Department of Mathematics and Statistics, Bowen University, Osun State, Nigeria
Ajayi David Daisi

Department of Medical Laboratory Science, Ekiti State University Teaching Hospital, Ado – Ekiti, Nigeria
Awoleke Adeola Olabisi

School of Nursing, Ekiti State University Teaching Hospital, Ado – Ekiti, Nigeria

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Awoleke Jacob Olumuyiwa, Omoyajowo Adefunke Christianah, Ajayi David Daisi, Awoleke Adeola Olabisi. (2019). Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting. Journal of Gynecology and Obstetrics, 7(1), 25-30. https://doi.org/10.11648/j.jgo.20190701.14

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ACS Style

Awoleke Jacob Olumuyiwa; Omoyajowo Adefunke Christianah; Ajayi David Daisi; Awoleke Adeola Olabisi. Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting. J. Gynecol. Obstet. 2019, 7(1), 25-30. doi: 10.11648/j.jgo.20190701.14

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AMA Style

Awoleke Jacob Olumuyiwa, Omoyajowo Adefunke Christianah, Ajayi David Daisi, Awoleke Adeola Olabisi. Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting. J Gynecol Obstet. 2019;7(1):25-30. doi: 10.11648/j.jgo.20190701.14

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@article{10.11648/j.jgo.20190701.14,
  author = {Awoleke Jacob Olumuyiwa and Omoyajowo Adefunke Christianah and Ajayi David Daisi and Awoleke Adeola Olabisi},
  title = {Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {7},
  number = {1},
  pages = {25-30},
  doi = {10.11648/j.jgo.20190701.14},
  url = {https://doi.org/10.11648/j.jgo.20190701.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190701.14},
  abstract = {Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biologic determinants for active maternal CMV infection in a Nigerian setting. Using a cross-sectional design, ELISA kits were employed to quantify the anti-CMV IgG and IgM antibodies in the sera of consecutive antenatal attendees at the Ekiti State University Teaching Hospital (EKSUTH), Nigeria. Among the respondents, 23 (12.4%) were seropositive for both anti-CMV IgG and IgM antibodies. The regression analysis showed that the likelihood of being seropositive for both anti-CMV IgG and IgM antibodies was predicted by having a child less than 5 years old (adjusted OR: 5.53; 95% CI: 1.08 – 28.30; p = 0.04), while those who were skilled workers were least likely to be seropositive for both antibodies (adjusted OR: 0.06; 95% CI: 0.01 – 0.95; p = 0.04). Also, infection with cytomegalovirus was associated with pre-eclampsia (adjusted OR: 0.03; 95% CI: 0.002 – 0.41; p = 0.01). High prevalence of active maternal CMV infection was noted from the study, and this was associated with pre-eclampsia and caring for children under-5. Educating pregnant non-immune women about CMV and its prevention, coupled with the improvement in socio-economic status of the populace can reduce the burden in low-resource settings.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting
AU  - Awoleke Jacob Olumuyiwa
AU  - Omoyajowo Adefunke Christianah
AU  - Ajayi David Daisi
AU  - Awoleke Adeola Olabisi
Y1  - 2019/04/13
PY  - 2019
N1  - https://doi.org/10.11648/j.jgo.20190701.14
DO  - 10.11648/j.jgo.20190701.14
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 25
EP  - 30
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20190701.14
AB  - Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biologic determinants for active maternal CMV infection in a Nigerian setting. Using a cross-sectional design, ELISA kits were employed to quantify the anti-CMV IgG and IgM antibodies in the sera of consecutive antenatal attendees at the Ekiti State University Teaching Hospital (EKSUTH), Nigeria. Among the respondents, 23 (12.4%) were seropositive for both anti-CMV IgG and IgM antibodies. The regression analysis showed that the likelihood of being seropositive for both anti-CMV IgG and IgM antibodies was predicted by having a child less than 5 years old (adjusted OR: 5.53; 95% CI: 1.08 – 28.30; p = 0.04), while those who were skilled workers were least likely to be seropositive for both antibodies (adjusted OR: 0.06; 95% CI: 0.01 – 0.95; p = 0.04). Also, infection with cytomegalovirus was associated with pre-eclampsia (adjusted OR: 0.03; 95% CI: 0.002 – 0.41; p = 0.01). High prevalence of active maternal CMV infection was noted from the study, and this was associated with pre-eclampsia and caring for children under-5. Educating pregnant non-immune women about CMV and its prevention, coupled with the improvement in socio-economic status of the populace can reduce the burden in low-resource settings.
VL  - 7
IS  - 1
ER  -

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