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Melatonin and Myoinositol: A Foreword Step Toward IVF Success, a Prospective Clinical Trial
Atyaf Hasan,
Al-Quraan Elena,
Al-Quraan Ghassan,
Tayseer Rimawi,
Said Nasrallah
Issue:
Volume 7, Issue 1, January 2019
Pages:
1-7
Received:
2 December 2018
Accepted:
25 January 2019
Published:
19 February 2019
Abstract: Many subfertile couples, who failed to conceive naturally, seek help by means of artificial reproduction techniques such as in vitro fertilization (IVF) to achieve pregnancy. It is clear that oocyte and embryo quality depression are widely considered to be the main challenge of IVF in assisted reproduction. The aim of the study was to assess the effect and the role of melatonin combined with myoinositol on oocyte quality and to investigate its correlation with pregnancy outcome. A total of 315 patient, aged between 30-40, in a 12 month study period from Jan. 2017 to Dec. 2017, with history of one or multiple unsuccessful IVF cycles due to poor oocyte quality were included in this study. The study group (group 1, n=166) was treated with melatonin combined with myoinositol (Seidivid plus, SEIDLAB) for 3 months prior to a new IVF cycle and the control group (group 2, n =149) just received a standard IVF cycle without melatonin and myoinositol. IVF outcomes were compared between the two groups. Primary endpoint was the number of morphologically mature oocytes retrieved (MII oocytes). Secondary endpoints were fertilization rate per number of mature oocytes, embryo quality and pregnancy rate. After treatment, the number of mature oocytes, the fertilization rate, the number of top-quality embryos transferred and pregnancy rate were statistically higher compared to the previous IVF cycle, while there was no difference in the number of retrieved oocyte. The mean number of oocytes retrieved differ between the two groups being (11.56) in group 1 and (10.9) in control one (1920 vs. 1629) and the percentage of mature oocytes was significantly higher in melatonin-treated group (77.03% vs. 69.1%). Concurrently, the mean number of immature oocytes (germinal vesicles) was reduced (22.9% vs. 39.9%). Furthermore, the melatonin –myoinositol treated group showed an increase in fertilization rate (80.2% vs. 77.7%) and the mean number of grade one embryos resulted was also higher (60.05% vs. 49.5%). Clinical pregnancy rate was in tendency higher in the group treated with melatonin and myoinositol (48.3% vs. 40.8%), In the current study It was concluded that Melatonin and myoinositol treatment is likely to become a significant option for improving oocyte and embryo quality in women who cannot become pregnant because of poor oocyte quality.
Abstract: Many subfertile couples, who failed to conceive naturally, seek help by means of artificial reproduction techniques such as in vitro fertilization (IVF) to achieve pregnancy. It is clear that oocyte and embryo quality depression are widely considered to be the main challenge of IVF in assisted reproduction. The aim of the study was to assess the ef...
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Conservative Surgery in the Management of Adenomyosis
Masato Nishida,
Hiroya Itagaki,
Yasuo Otsubo,
Yuko Arai
Issue:
Volume 7, Issue 1, January 2019
Pages:
8-16
Received:
29 December 2018
Accepted:
11 February 2019
Published:
28 February 2019
Abstract: Since 2002, we have performed adenomyomectomy for 1780 women with uterine adenomyosis. We classified adenomyosis in these patients as focal (n=1313), diffuse (n=450) or cystic (n=17) type according to the distribution of the focuses seen in magnetic resonance imaging (MRI) findings. Three different surgical methods for focal, diffuse and cystic adenomyosis are utilized at our institution. The adenomyosis lesion is excised using a loop electrode of a high-frequency cutter in all methods. The median resected lesion weight of focal, diffuse and cystic adenomyosis were 94 g (1-1156 g), 150 g (10-1595 g), and 16 g (3-45 g), respectively. The mean visual analogue score for dysmenorrhea decreased from 9.1 to 1.0 and heavy menstrual bleeding was improved in all cases. Following the procedure, 370 pregnancies occurred in 294 patients, of which 153 (41.9%) were the result of natural conception. Pregnancy rate of the patients younger than 40 years were 35.1% in focal type, 25.4% in diffuse type and 88.9% in cystic type. Among those patients, we experienced 5 cases of uterine rupture. Of 1462 patients who underwent surgery more than 2 years prior to the time of writing, recurrence occurred in 150 (10.3%). Our findings indicate that conservative surgery for uterine adenomyosis using a high-frequency resection device is effective for both focal and diffuse type.
Abstract: Since 2002, we have performed adenomyomectomy for 1780 women with uterine adenomyosis. We classified adenomyosis in these patients as focal (n=1313), diffuse (n=450) or cystic (n=17) type according to the distribution of the focuses seen in magnetic resonance imaging (MRI) findings. Three different surgical methods for focal, diffuse and cystic ad...
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Dysmenorrhea Characteristics and Self-Care Method used among Female Nursing Students at King Abdulaziz University
Fawziya Alghamdi,
Ahlam Al-Zahrani,
Hawa Alabdulaziz
Issue:
Volume 7, Issue 1, January 2019
Pages:
17-24
Received:
6 December 2018
Accepted:
18 March 2019
Published:
8 April 2019
Abstract: Background: Dysmenorrhoea is a common gynaecological problem that affects women and has a detrimental impact on their lives. However, women seldom seek medical advice and prefer self-care methods to manage their dysmenorrhoea. Identifying the self-care methods used to manage the pain and the source of information related to self-care methods used among dysmenorrhoeal nursing students would assist health care providers in devising an intervention to improve students' health. Methods: A cross-sectional study was conducted from 1st of March up to the end of April in 2018 to identify the characteristics of dysmenorrhoea and the self-care methods used among female nursing students at King Abdulaziz University in Jeddah. Data were collected from 194 participants using self-administered questionnaires. Results: More than half of respondents (60%) complained of moderate menstrual pain followed by severe pain (22%). The majority of respondents (73.7%) experienced cramping pain in the lower abdomen (89.7%), beginning with menstrual flow (50.1%) and lasting one to two days (64.8%). Nausea (52.1%), dizziness (47.9%) and headaches (45.9%) were the most prominent dysmenorrhoea symptoms. The most common method used to relieve dysmenorrhoea was rest (86.6%) followed by a warm compress (67.0%). Ibuprofen was the most common medication used to manage dysmenorrhoea (22.2%), while the most common herb used was cinnamon (39.2%). Family was the main source of information on the methods used for 80.9% of the respondents. Conclusions: The nursing students used various methods to relieve their menstrual pain, including pharmacological and non-pharmacological methods; most students used a combination of both. Safe self-care methods use should be a priority in dysmenorrhoeal nursing student’s education.
Abstract: Background: Dysmenorrhoea is a common gynaecological problem that affects women and has a detrimental impact on their lives. However, women seldom seek medical advice and prefer self-care methods to manage their dysmenorrhoea. Identifying the self-care methods used to manage the pain and the source of information related to self-care methods used a...
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Socio-biologic Predictors of Active Cytomegalovirus Infection Among Pregnant Women in a Low-resource Setting
Awoleke Jacob Olumuyiwa,
Omoyajowo Adefunke Christianah,
Ajayi David Daisi,
Awoleke Adeola Olabisi
Issue:
Volume 7, Issue 1, January 2019
Pages:
25-30
Received:
16 February 2019
Accepted:
22 March 2019
Published:
13 April 2019
Abstract: Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biologic determinants for active maternal CMV infection in a Nigerian setting. Using a cross-sectional design, ELISA kits were employed to quantify the anti-CMV IgG and IgM antibodies in the sera of consecutive antenatal attendees at the Ekiti State University Teaching Hospital (EKSUTH), Nigeria. Among the respondents, 23 (12.4%) were seropositive for both anti-CMV IgG and IgM antibodies. The regression analysis showed that the likelihood of being seropositive for both anti-CMV IgG and IgM antibodies was predicted by having a child less than 5 years old (adjusted OR: 5.53; 95% CI: 1.08 – 28.30; p = 0.04), while those who were skilled workers were least likely to be seropositive for both antibodies (adjusted OR: 0.06; 95% CI: 0.01 – 0.95; p = 0.04). Also, infection with cytomegalovirus was associated with pre-eclampsia (adjusted OR: 0.03; 95% CI: 0.002 – 0.41; p = 0.01). High prevalence of active maternal CMV infection was noted from the study, and this was associated with pre-eclampsia and caring for children under-5. Educating pregnant non-immune women about CMV and its prevention, coupled with the improvement in socio-economic status of the populace can reduce the burden in low-resource settings.
Abstract: Active maternal cytomegalovirus (CMV) infection is the bedrock of congenital CMV with its debilitating sequelae. Information on socio-biologic predictors of active maternal infection in southwest Nigeria is lacking. However, modifying locality-specific risk factors could reduce the burden of CMV. The aim of the study is to identify the socio-biolog...
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