Clinicopathological Analysis of 2 Cases of Intracranial Mesenchymal Chondrosarcoma
Liang Juan,
Qian Lu,
Xue Fenglin,
Li Ting,
Zhou Hongping,
Bian Li
Issue:
Volume 10, Issue 6, November 2022
Pages:
124-128
Received:
1 November 2022
Accepted:
23 November 2022
Published:
30 November 2022
DOI:
10.11648/j.ajcem.20221006.11
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Abstract: Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of intracranial MC were retrospectively analyzed, and related literatures were reviewed. Results Both patients were admitted to hospital because of headache and limited vision. Imaging examination showed intracranial and extracerebral lesions (possible meningioma?). Microscopically, the tumor showed bidirectional differentiation and consisted of small round undifferentiated mesenchymal cells with basically the same size and scattered islands of relatively mature hyaline cartilage. Hemangiopericytoma conformation was seen in some areas. Immunophenotype: small round cells CD99 and vimentin (+), Ki-67 proliferation index 15% to 30%, PCK, Syn and NSE (-), chondrocytes S-100 (+), local expression of cartilage matrix collagen II. Conclusion Primary intracranial MC is extremely rare and easy to be misdiagnosed. It needs to be compared with meningiomas, extraosseous Ewing's sarcoma, solitary fibrous tumor/hemangiopericytoma, soft tissue malignant lymphoma, small cell metastatic carcinoma and other types of chondrosarcoma. Phase identification.
Abstract: Objective To analyze the clinical imaging data, pathological manifestations, molecular genetic characteristics and treatment of intracranial mesenchymal chondrosarcoma (MC), and to explore its diagnosis, differential diagnosis basis and clinical treatment plan. Methods The clinicopathological features, imaging data and immunophenotype of 2 cases of...
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Different Neurological Pathologies Found in Humans Can Be Modelled into Mice Brains
Issue:
Volume 10, Issue 6, November 2022
Pages:
129-132
Received:
23 January 2022
Accepted:
10 February 2022
Published:
9 January 2023
Abstract: Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are neurological diseases that affect a considerable population around the world. In this research two articles that implement trials on mice regarding these diseases were analyzed and compared to determine which advancement is most significant to human process. The articles were: Boosting a gut bacterium helps mice fight an ALS-like disease, and a protein helps disease-causing immune cells invade patients’ brains. Gene expression in healthy mice and human brains can provide data to explore the capability of modeling neurological diseases in these rodents. Therefore, if different neurological pathologies found in mice can be modeled into the human brain, both research papers equally contribute to the scientific knowledge. The approach used was a direct compare and contrast method of both papers. In addition, a meta-analysis implementing different criteria to identify trends in different data. After the investigation was carried, it was found that 31% of genes were similar between human and mice brains. This provides a pronounced framework for human diseases to be modeled onto mice; this could open the possibility to discover new treatments and further understand the diseases’ etiologies. Although there is still margin for error. Considering there is a lot still unknown about ALS when compared to MS, it was concluded that both research papers contribute to the scientific community, but not equally. The ALS article provides a new framework for finally understanding and treating this disease. Some factors that influenced the findings were the difficult access to information and the timeframe implemented.
Abstract: Amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are neurological diseases that affect a considerable population around the world. In this research two articles that implement trials on mice regarding these diseases were analyzed and compared to determine which advancement is most significant to human process. The articles were: Boos...
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