Abstract: HIV-AIDS remains a major public health issue in Kenya with a prevalence of 5.3% and contributing to 29% of annual mortality. Despite marked improvement in the provision for care and treatment, a search for improvement of the current care and treatment programs may lead to better health outcomes. Various factors influence the prognosis of HIV disease. However, minimal research has been conducted to determine information gathered on enrollment influence HIV-AIDS prognosis. Early identification of how information can inform disease prognosis may aid in improving management strategies and increase quality of life of the HIV infected patients. This research aimed at determining how collected information influence times to HAART eligibility and factors influencing this duration. A retrospective cohort study was carried out in Bondo Sub County Hospital Comprehensive Care Centre. Primary data was collected from patient treatment files, in the period beginning 1st January 2013 to 31st December 2014 in data collection forms entered in Microsoft Excel, cleaned and transferred to Stata ver 13 for survival analysis. In the study period 2015 patients were enrolled and 164 (female=93, male =71) satisfied the inclusion criteria. The medium survival time was 65 days. The WHO stage of enrollment (p = 0.0000) and age of enrollment (p = 0.006) were found to be the major determinants of the time to HAART eligibility. The WHO stages of enrollment and age of enrollment were strongly associated with HIV prognosis and this could be attributed to level of immune status which is affected by both this factors. Age of enrollment and WHO stage of enrollment were the main variables captured in MOH 257 that inform on HIV-HAART naïve disease progression to HAART eligibility. This study needs to be done in a prospective study incorporating time dependent covariates so as to give a clear picture of the other covariates not picked in this study.Abstract: HIV-AIDS remains a major public health issue in Kenya with a prevalence of 5.3% and contributing to 29% of annual mortality. Despite marked improvement in the provision for care and treatment, a search for improvement of the current care and treatment programs may lead to better health outcomes. Various factors influence the prognosis of HIV diseas...Show More
Abstract: Despite the remarkable achievement in prevention and control so far attained, HIV incidence is increasing in some countries and regions, Sub-Saharan Africa accounting for 68% global HIV prevalence with women and young people disproportionately affected. As of 2014 in Nigeria, the HIV prevalence rate among adults ages 15-49 was 3.17 percent. However, the HIV epidemic in Nigeria is complex and varies widely by region. To compare HIV viral load in liquid and dried plasma on filter paper (whatman 903). A study among HIV patients was carried out in Aids Prevention Initiative (APIN) Centre, Jos University Teaching Hospital, Plateau State, Nigeria to compare viral load in dried plasma spot (DPS) against the liquid plasma (LP) which is the gold standard. 84 adult HIV infected subjects were recruited for this survey with each completed a questionnaire and donated blood for the viral load assay using CobasAmpliprep/TaQmananalyser between September to November 2014. Out of the 84 HIV infected adults, 31% (26/84) of the subjects were males while the remaining 69% (58/84) were females. On the other hand, 32 of the patients were treatment experienced, and 52 were treatment naïve. The sensitivities and specificities of dried plasma spots at ambient and refrigeration temperatures were 91.3% and 100% respectively (P < 0.05). Viral load was effectively detected in DPS within the log range of 3.0 to > 6.0.There was a strong positive correlation in this current study between the viral load in LP and DPS as well as LP and DPS-REFR with values of 0.978 and 0.992 respectively as well as mean loss in viral log copies of 0.261 and 0.196. In general, the result of DPS was highly comparable with that of LP, which suggests that DPS could be used as a valuable alternative in resource constrains settings. This range is useful in providing clinical guidance regarding drug regimen switch in individuals on antiretroviral therapy (ART).Abstract: Despite the remarkable achievement in prevention and control so far attained, HIV incidence is increasing in some countries and regions, Sub-Saharan Africa accounting for 68% global HIV prevalence with women and young people disproportionately affected. As of 2014 in Nigeria, the HIV prevalence rate among adults ages 15-49 was 3.17 percent. However...Show More
