Abstract: Appendix has long been thought of as an organ serving no useful purpose in the body. The newer researches prove to the contrary, as with the advent of the newer histological techniques and surgical avenues, it has been found to have very useful functions. The position of the tip of the appendix determines its clinical presentation in case of any disease pertaining to appendix, specially the very common condition of the inflammation of the appendix, clinically termed Appendicitis. Extensive literature review was done and it was observed that location of its tip is subject to ethnic and geographic variations, and therefore, presentation may mimic a disease other than the appendicitis, to the disadvantage of the attending or diagnosing physician. Now it has also been found to be a very important part of gut associated lymphoid tissue (GALT). Reconstructive surgery has found it as an organ that can be restructured and used for the repair and reconstruction of various organs. It is found that there is a lot of room for further studies in the light of new found evidences.Abstract: Appendix has long been thought of as an organ serving no useful purpose in the body. The newer researches prove to the contrary, as with the advent of the newer histological techniques and surgical avenues, it has been found to have very useful functions. The position of the tip of the appendix determines its clinical presentation in case of any di...Show More
Abstract: Background: N-Nitrosodimethylamine (NDMA) is a potent hepatotoxin that induces fibrosis of the liver. Cymbopogon citratus, a plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. Aim of the work: This work is aimed to study the protective effect of Cymbopogon citratus ethanolic leaf extract against hepatic injury and fibrosis induced by repeated intermittent administration of Dimethylnitrosamine (DMN) in rats. Materials and methods: A total of 30 rats divided into 3 groups were used. Group 1 served as control, Group 2 was given intraperitoneal injection with DMA at a concentration of 10mg/kg body weight on three consecutive days of each week over a period of three weeks. Group 3 was given DMA at a concentration of 10mg/kg body weight on three consecutive days of each week over a period of three weeks and 100 mg/kg body weight of Cymbopogon citratus ethanolic aqueous leaf extract 5 hours after administration of DMN. Results: It was found that DMN produces histopathological changes of the liver; including signs of severe hepatic injury. The cytoplasm of most hepatocytes appeared vacuolated with pyknotic and karyolytic nuclei, congested blood vessels and focal necrotic areas with marked increase of the collagen fibers deposition around the blood vessels. Ultrastructural changes showed Pyknotic nuclei, vacuolated cytoplasm and reduction or complete loss of cristae in the mitochondria. These were reversed by simultaneous treatment with Cymbopogon citratus. In conclusion: The results of this present study indicated that aqueous leaf extracts of Cymbopogon citratus has an antihepatotoxic action against DMN induced hepatic oxidative damage in rats which might be ascribed to its antioxidant and free radical scavenging property.Abstract: Background: N-Nitrosodimethylamine (NDMA) is a potent hepatotoxin that induces fibrosis of the liver. Cymbopogon citratus, a plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. Aim of the work: This work is aimed to study the pro...Show More
