Specific IgE for Aero and Food Allergens in Adult Chronic Urticaria Patients Without Other Allergic Diseases
Osama Mohamed Abdel Latif
Issue:
Volume 6, Issue 2, June 2018
Pages:
25-29
Received:
18 May 2018
Accepted:
31 May 2018
Published:
13 June 2018
Abstract: Chronic Urticaria (CU) is a diseases characterized by occurrence of spontaneous wheels observed by the patient for more than 6 weeks duration. The prevalence of CU varies from 0.5-5% in adult population. This is a disease of complex etiologies with more areas to be explored by researches. The aim of the study was to detect the Prevalence of allergen sensitizations among adult chronic urticaria patients without other allergic diseases. This study is a cross-sectional case control study. 70 patients with CU without evident cause and 50 healthy control individuals were included in the study. Patients with any other allergic diseases (such as Asthma, allergic Rhinitis, Allergic Conjunctivitis, Drug Allergy, atopic Dermatitis, Anaphylaxis….), patients with other chronic or systemic Diseases (such as Cardiac, respiratory, renal, hepatic, hematological, thyroid or other skin Diseases, etc….) and smokers were excluded from the study. Each patient and control individual was subjected to full medical history, complete medical examination and routine lab test. Determination of allergen-specific IgE (for 20 separate food and 20 aeroallergens) in serum for the patients was done by using EUROLINE Atopy Screen. Each of the patients and control groups were comparable according to age and gender. There was a significant difference between the CU patients and the control group as regard the prevalence of any allergen sensitization (65.7% for CU patients and 18% in control group) p<0.05. There was also a significant difference between the sensitized individual in each group as regard the number of allergens per each individual; for sensitized CU patients the mean was 3 allergens and interquartile range was (2-4), for the sensitized control individuals the mean was 2 and interquartile range was (1-2) with p= 0.014. The mostly frequent allergens were found in the CU sensitized patients was the house dust mite allergens (34.8% of the sensitized CU patients were sensitized to one or more of the two types of mites; dermatophagoides pteronyssinus and or dermatophagoides farinae). The study concluded that; a great prevalence of CU patients proved to be sensitized to common allergens which open the door to start a trials to examine the value of environmental control, food avoidance and specific allergen immunotherapy in this group of patients.
Abstract: Chronic Urticaria (CU) is a diseases characterized by occurrence of spontaneous wheels observed by the patient for more than 6 weeks duration. The prevalence of CU varies from 0.5-5% in adult population. This is a disease of complex etiologies with more areas to be explored by researches. The aim of the study was to detect the Prevalence of allerge...
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Incidence of Positive Anti-Ro/SSA and Anti-La/SSB Antibodies Among Infants with Prolonged Skin Lesions and Its Relation to Autoimmune Disease in the Mother
Mona Sayed Aly Hassan Makhlouf,
Suzan Fahim Ghobashy,
Hanan Farouk Mohamed,
Ikram Idris Alyan,
Fawzy Aly Abualfadl
Issue:
Volume 6, Issue 2, June 2018
Pages:
30-42
Received:
1 June 2018
Accepted:
26 June 2018
Published:
18 July 2018
Abstract: Many literatures reported that neonatal lupus erythematosus and its associated abnormalities mainly, cutaneous lupus lesions, congenital heart block (CHB), hematologic cytopenias, hepatobiliary disease and cardiomyopathy are associated with anti-Ro/SSA and anti-La/SSB antibodies. With skin findings occur in nearly 95% of NLE infants, others reported that 100% of NLE infants with CHB were positive for anti Ro/SSA antibodies and 90.2% of infants with skin NLE were positive for anti Ro/SSA. And long-term follow-up of children with neonatal lupus and their unaffected siblings revealed that 12.24% of NLE children identified definite rheumatic/autoimmune diseases after more than 8 years. Aim of the study: The aim of this study was to determine the incidence of positive anti-Ro/SSA and anti-La/SSB antibodies in infants with recurrent prolonged skin lesions and their mothers to determine asymptomatic mothers at risk to develop autoimmune disease. Subjects and methods: a total of 90 infants with recurrent prolonged skin lesions below the age of 6 months and their mothers attending pediatric screening and follow up clinic at Al Galaa Teaching Hospital in Cairo, Egypt were investigated for positivity of anti Ro/SSA and anti La/SSB antibodies using enzyme linked immunoassay (ELISA). Results: Incidence rate of positive anti Ro/SSA alone and anti La/SSB alone antibodies in infants were 34.4% and 23.3% respectively, and positive both anti Ro/SSA and anti La/SSB antibodies was 21.1%, while in their mothers, positive both anti Ro/SSA and anti La/SSB antibodies was 36.7%. Among the 33 cases with positive antibodies female: male ratio was 2.3:1, and rheumatologic and autoimmune diseases was positive in 14 (42.4%) mothers, while, 19 (57.6%) were asymptomatic mothers, anemia, lymphocytosis, neutropenia with relative lymphocytosis, eosinophilia and thrombocytopenia were found in 6.1%, 9.1%, 3.0%, 9.1% and 12.1% respectively. Liver transaminases were elevated in 4 (12.1%). Positive anti Ro/SSA and anti La/SSB antibodies were statistically significantly correlated with infant age, body weight, body length and head circumference, female sex, infants mothers’ rheumatologic and autoimmune diseases, distribution of skin lesions, positive history of steroid containing cream use, and thrombocytopenia. However, both antibodies showed no statistically significant correlation with infant feeding, rate of recurrent skin lesions, anemia, lymphocytosis, neutropenia with relative lymphocytosis, eosinophilia, positive CRP, and elevated ESR. Conclusion: our infant cases with prolonged skin lesions with positive anti Ro/SSA and anti La/SSB antibodies with their mothers’ especially asymptomatic ones should be investigated and followed up properly for development of NLE and autoimmune diseases.
Abstract: Many literatures reported that neonatal lupus erythematosus and its associated abnormalities mainly, cutaneous lupus lesions, congenital heart block (CHB), hematologic cytopenias, hepatobiliary disease and cardiomyopathy are associated with anti-Ro/SSA and anti-La/SSB antibodies. With skin findings occur in nearly 95% of NLE infants, others reporte...
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