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Effect of Co-Administration of Vitamin E Isoforms d-α-Tocopherol and d-δ-Tocotrienol Rich Fraction on the Healing of Skin Wounds in Diabetic Rats
Bijo Elsy,
Aijaz Ahmed Khan,
Veena Maheshwari
Issue:
Volume 3, Issue 5, September 2017
Pages:
52-62
Received:
19 January 2017
Accepted:
15 February 2017
Published:
31 October 2017
Abstract: Normal wound healing involves sequence of events which is believed to be altered in diabetes due to hyperglycemia, infection and oxidative stress. The latter may be reduced by antioxidants which neutralize the chain formation of free radicals. Vitamin E is a well-known antioxidant and has saturated tocopherols and unsaturated tocotrienols. The most active form being the α-tocopherol. The present study was designed to explore the combined effect of d-α-tocopherol and d-δ-tocotrienol rich fraction (d-δ-TRF) on wound healing process in both healthy and alloxan-induced diabetic rats. Diabetes was induced with alloxan (100 mg/kg S. C). Twenty four albino rats were divided into four groups; healthy control, diabetic control, healthy treated and diabetic treated. Treated groups received 100 mg/kg of d-α-tocopherol and d-δ-TRF each orally and daily for 3 weeks. Under general anesthesia, full-thickness excisional skin wounds were created on the dorsal surface of thoracic region. Macroscopic and microscopic features of wound healing stages were recorded at weekly intervals and biochemical parameters were estimated at the end of 3 weeks. It was observed that as compared to control in the treated group there was early reappearance of epidermal and dermal components, reduced serum creatinine level, increased serum antioxidant status and total protein content and controlled glycemic status. It is concluded that oral co-administration of d-α-tocopherol and d-δ-TRF promotes skin wound healing in both healthy and diabetic rats through its antioxidant potency, therefore suggested that vitamin E isoforms hold promising future in the effective management of wounds in both otherwise healthy and diabetics.
Abstract: Normal wound healing involves sequence of events which is believed to be altered in diabetes due to hyperglycemia, infection and oxidative stress. The latter may be reduced by antioxidants which neutralize the chain formation of free radicals. Vitamin E is a well-known antioxidant and has saturated tocopherols and unsaturated tocotrienols. The most...
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Kaposi Sarcoma: Clinical Indices and Diagnosis
Chukwunonso Livinus Udeh,
Pramod Singh Khatri
Issue:
Volume 3, Issue 5, September 2017
Pages:
63-69
Received:
27 February 2017
Accepted:
12 April 2017
Published:
31 October 2017
Abstract: Any type of cancer that originate from the connective tissues are termed Sarcomas. The name Kaposi in relation to Kaposi sarcoma was derived from a Hungarian Dermatologist, Dr. Moritz Kaposi who is the first to describe this kind of tumor. KS is caused by a Herpes virus called HHV-8 or KSHV which is transmitted through unprotected sexual intercourse (higher in MSM), sharing of used needles, blood transfusion and organ transplant. There are five (5) epidemiological types of KS; Classic, Transplant, African, AIDS-related and Non-epidemic gay related. KS is the commonest symptom of an advanced HIV infected patient and its proliferation is faster due to the weakened immune system. Awareness about this sarcoma is poor. This disease is generally diagnosed as brown, red or purple patches/plagues/nodules on the skin, mucosal cavity of the GIT, Lungs and the oral cavity. There are also immunohistochemical staining endothelial markers that are used to differentiate KS from other types of sarcomas. CD31 is best used as an endothelial marker for lesions from HIV+ patients. Some other common markers include CD4, LNA-1, BCL-2 and VEGFR-3. Other symptoms of KS are shortness of breath, internal bleeding Anemia and Fatigue. Highly Active Antiretroviral Therapy (HAART) is believed to be the most efficient treatment for AIDS-related KS. Other soothing treatments available are chemotherapy, topical ointments, cryotherapy, photodynamic therapy, laser therapy and a times excisional surgery. There are active clinical trials towards treatment of KS. Some of which are done by combining different doses of HAART regimen with other therapeutic agents. One of the CTs been conducted by the National Cancer Institute in the U.S is the Phase II/ Phase I study using Pomalidomide in treating HIV and Non-HIV patients with Kaposi Sarcoma.
Abstract: Any type of cancer that originate from the connective tissues are termed Sarcomas. The name Kaposi in relation to Kaposi sarcoma was derived from a Hungarian Dermatologist, Dr. Moritz Kaposi who is the first to describe this kind of tumor. KS is caused by a Herpes virus called HHV-8 or KSHV which is transmitted through unprotected sexual intercours...
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Hypopigmentation After Local Corticosteroid Injection for De Quervain Tenosynovitis
Issue:
Volume 3, Issue 5, September 2017
Pages:
70-72
Received:
20 March 2017
Accepted:
13 April 2017
Published:
31 October 2017
Abstract: The clinical presentation hypopigmentation is a rare complication after intralesional injection of triamcinolone acetonide. A 32-year-old female, yellow race, visited our dermatology department for a hypopigmented patch in right dorsum of her right thumb. The lesion developed after injection of an intralesional corticosteroid. The patient was diagnosed with hypopigmentation secondary to the triamcinolone injection. Three months after injection, her hypopigmentation showed improvement upon physical examination. Hypopigmentation is a very rare side effect of intralesional triamcinolone injection, which may be associated with gender. The mechanism is unknown, need for further study.
Abstract: The clinical presentation hypopigmentation is a rare complication after intralesional injection of triamcinolone acetonide. A 32-year-old female, yellow race, visited our dermatology department for a hypopigmented patch in right dorsum of her right thumb. The lesion developed after injection of an intralesional corticosteroid. The patient was diagn...
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Arcana of the Magus of Lunar Magnetism in the Life of a Native
Issue:
Volume 3, Issue 5, September 2017
Pages:
73-77
Received:
31 March 2017
Accepted:
5 May 2017
Published:
31 October 2017
Abstract: Lunar Magnetism which seem to greatly influence the various stages of a native such as female menstrual cycle, ovulation, fertilisation, formation of zygote, development into embryo, foetus, childbirth and all stages of life of the native to the point of termination of mundane existence corroborates with Vedic Astrology and Seymour’s findings of the resemblance between Gauquelin's four-pronged pattern for Venus, Mars, Jupiter, Saturn, and the Moon and the pattern for the monthly average of the lunar daily magnetic variationis discussed in this paper.
Abstract: Lunar Magnetism which seem to greatly influence the various stages of a native such as female menstrual cycle, ovulation, fertilisation, formation of zygote, development into embryo, foetus, childbirth and all stages of life of the native to the point of termination of mundane existence corroborates with Vedic Astrology and Seymour’s findings of th...
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