A Review on Liquisolid: A Novel Technique for Enhancement of Solubility and Bioavailability of Poorly Water-Insoluble Drugs
Andrew Chekwube Ezegbe,
Grace Amarachi Ezegbe,
Josephat Ikechukwu Ogbonna,
Sabinus Ifeanyi Ofoefule
Issue:
Volume 4, Issue 2, June 2023
Pages:
17-24
Received:
6 June 2023
Accepted:
25 June 2023
Published:
6 July 2023
Abstract: Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-low permeability respectively. This issue of solubility has been a major challenge over the years especially for water-insoluble drugs. Powdered solution technology involves the formulation of drugs by conversion of liquid drugs, drug suspension or drug solution in non-volatile solvents, to form non-adherent, free flowing and compressible powder mixtures by blending the solution with appropriate carriers and coating materials. A liquid layer is formed on the particle surface which is instantly adsorbed by the coating material. This leads to the formation of a dry, free flowing and compressible powder. Coating material is required to cover the surface and maintain the powder flowability. A powder of known quantity can only retain limited amount of liquid medication while maintaining acceptable flowability and compressibility. A mathematical model has been introduced for liquisolid system that desires to have an acceptable flowable and compressible properties. Two fundamental properties characterize this model. They are the flowable liquid retention potential and the compressible liquid retention potential.
Abstract: Liquisolid technique also known as powdered solution technology is a novel concept used in the dissolution rate of poorly water insoluble drugs. According to Biopharmaceutical Classification System (BCS), drugs are classified based on their solubility and permeability. Class II and IV drugs have low solubility-high permeability, and low-solubility-...
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Tuber Yield Loss Assessment of Potato (Solanum tuberosum) Due to Late Blight (Phytophthora infestans) Disease in Central Highland Parts of Ethiopia
Asela Kesho,
Yitagesu Tadesse
Issue:
Volume 4, Issue 2, June 2023
Pages:
25-28
Received:
17 July 2023
Accepted:
2 August 2023
Published:
22 August 2023
Abstract: Late blight (Phytophthora infenstans) disease is one of the most devastating potato diseases world-widely which causes significant loss in production. It is known to hurt the highest losses from disease attacks. Among potato diseases bacterial wilt and late blight are one of the most economically important. In Ethiopia yield loss study on potato late blight was very old and scanty. This study was designed to update yield loss data for potato late blight disease. In this study, 3 treatments were used with a completely randomized block design (RCBD) with 3 replications including the control. The results of AUDPC and tuber yield shows significant differences (P<0.05) among treatments. Compared to the unsprayed plot fungicides significantly controlled the disease at both early and late stages. The lowest (175.0) AUDPC was recorded on fungicide Gachena 525 WG sprayed treatment followed by Mancozeb 80% WP (190.0). The control treatment (water sprayed) had the highest AUDPC (1450.0). The highest (29.3 t/ha) mean tuber yield was obtained from the fungicide Gachena 525 WG followed by the standard fungicide (Mancozeb 80% WP) which gave (27.2 t/ha) whereas the control treatment gave 4.9 t/ha. The fungicide subjected to the test (Gachena 525 WG) deserves to be considered as an alternate fungicide to the widely used fungicide Mancozeb 80% WP in the country. The highest (83.28%) yield loss occurred in the unsprayed plots of the Jalene variety as compared to the best-protected plots sprayed with Gachena 525 WG fungicide. Generally, disease and yield parameters indicate that among the fungicides spray; Gachena 525 WG was the most effective followed by Mancozeb 80% WP sprayed plots as compared to the unsprayed plots.
Abstract: Late blight (Phytophthora infenstans) disease is one of the most devastating potato diseases world-widely which causes significant loss in production. It is known to hurt the highest losses from disease attacks. Among potato diseases bacterial wilt and late blight are one of the most economically important. In Ethiopia yield loss study on potato la...
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