Analysis of Regulatory of Interrelated Activity of Hepatocyte and Hepatitis B Viruses
Mohiniso Baxromovna Hidirova,
Abrorjon Maxamatsoliyevich Turgunov
Issue:
Volume 6, Issue 1, March 2018
Pages:
1-7
Received:
25 October 2017
Accepted:
16 November 2017
Published:
16 January 2018
Abstract: In this article, we will present the results of the stability analysis of the equilibrium point of the mathematical model of the regulatory of the interrelated activity of the hepatocyte and hepatitis B viruses. The analysis of this model used the conditions of the Hayes criterion. In this study, the general condition of the Hayes criterion is obtained. If the general condition of the Hayes criterion is satisfied, then the equilibrium point is stable. If the general condition of the Hayes criterion is not fulfilled, then the equilibrium point is not stable, and hence thiscan describe modes "limit cycle", "chaos" and "black hole" mathematical models of the interrelated activity of the liver cell and hepatitis B viruses. The results of the computational experiment on the quantitative analysis of the regulatory of liver cell and HBV are presented.
Abstract: In this article, we will present the results of the stability analysis of the equilibrium point of the mathematical model of the regulatory of the interrelated activity of the hepatocyte and hepatitis B viruses. The analysis of this model used the conditions of the Hayes criterion. In this study, the general condition of the Hayes criterion is obta...
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Evaluation of Physicochemical Characteristics of Groundwater from Selected Areas in Unguwa Uku, Kano Metropolitan, Northwestern Nigeria
Sadiq Abdurrahman Abubakar Shawai,
Rabi’u Musa Kutama,
Bilkisu Bello Abubakar,
Jafaru Muazu
Issue:
Volume 6, Issue 1, March 2018
Pages:
8-12
Received:
26 October 2017
Accepted:
25 November 2017
Published:
19 January 2018
Abstract: Present investigation was carried out on groundwater in Unguwa Uku for water quality parameters during October, 2016. Parameters such as total hardness (TH), alkalinity, electrical conductivity (EC), turbidity, pH, temperature, chloride, calcium, free CO2, suspended solids (SS), total suspended solids (TSS), total dissolve solids (TDS), colour, and odour were analyzed from five locations. The analysis were carried out using standard analytical methods. The analysis of data reveals that, the value of free CO2 ranges from 9- 104 mg/L, 36.05- 72.10 mg/L for Calcium, 2-13 NTU for turbidity, 583.59-2065.03mg/L for total hardness 7.1-8.3 for pH, 21.7-23.4°C for temperature, 202-970 mg/L for TDS, 250-305 mg/L for alkalinity, 405-1939µS/cm for conductivities, 5TCU for colour, 111.70-659.51mg/L for suspended solids, 669.03-1255.51mg/L for total suspended solids, 106.57-296.10mg/L for chloride. The results obtained revealed that, the values of alkalinity, TDS, TSS, SS, pH, temperature, colour, odour, free CO2, and concentrations of Calcium of the water samples analyzed are within the acceptable limits set by World Health Organization (WHO) and Nigerian Standards for Drinking Water Quality (NSDWQ) for the drinking water. The values of electrical conductivity and total hardness are above the maximum permissible limits and may have adverse effects on the human health of the study area. However, not all the values of turbidity and chloride in the samples are within the acceptable limits of WHO and NSDWQ in the drinking water. This paper also recommended that, government and non-governmental agencies should make reasonable effort to control, regulate and educate the people in the study area for proper disposal of domestic effluents.
Abstract: Present investigation was carried out on groundwater in Unguwa Uku for water quality parameters during October, 2016. Parameters such as total hardness (TH), alkalinity, electrical conductivity (EC), turbidity, pH, temperature, chloride, calcium, free CO2, suspended solids (SS), total suspended solids (TSS), total dissolve solids (TDS), colour, and...
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Improved Endurance Gain in BALB / C Mice by a Nanotechnology Medical Device
Silvia Altobello,
Antonio Filippone,
Luigi Grillo,
De Martino Angelo,
Beninati Simone,
Alessandro Pumpo
Issue:
Volume 6, Issue 1, March 2018
Pages:
13-19
Received:
1 February 2018
Accepted:
24 February 2018
Published:
22 March 2018
Abstract: The main finding of the present study was the improved endurance gain in BALB / C mice, following the application of a patch (T-NES®-HIT Tech.), enriched with an active central pad, based on micronized silver. In order to transfer very thin Extremely Low Frequency (ELF) magnetoelectric signals, the pad contains a nanotechnological material (silver micronized by plasma vaporization) that is appropriately activated with optical, magnetic, electrical, and acoustic signals. It has been reported previously that the ELF magnetic field, induces an action on cellular glycocalics, fundamental for cellular communication and recognition, and a direct activation of protons and ionic fluxes. The treated animals underwent exercises with Rotarod and several parameters were evaluated and compared with untreated control mice. The following parameters were measured: steady state generic training, long slow distance, high intensity "endurance" and steady state split session training. The ELF magnetic field of T-NES®-HIT Tech. micronized silver patch device, applied to BALB / C mice, markedly improved their endurance gain performance as evidenced by the increase of their aerobic capacity, maximum heart rate and maximum aerobic speed.
Abstract: The main finding of the present study was the improved endurance gain in BALB / C mice, following the application of a patch (T-NES®-HIT Tech.), enriched with an active central pad, based on micronized silver. In order to transfer very thin Extremely Low Frequency (ELF) magnetoelectric signals, the pad contains a nanotechnological material (silver ...
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Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro
Chunlei Zhang,
Jinghua Li
Issue:
Volume 6, Issue 1, March 2018
Pages:
20-25
Received:
20 March 2018
Accepted:
2 April 2018
Published:
8 May 2018
Abstract: Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that the mechanical strength had maximum value and the tensile modulus was up to 0.79 MPa when the molecular weight of CS was 650,000 and the mass ratio of CS/glycerol was 1:1.4. The aggregate distribution of the Mat was located in the bottom surface of the film and was asymmetrical by SEM observation. Via release behavior tests in vitro, the drug-loading film showed high drug-loading capacity and long slowing-release properties. The release time of the drug-loading film increased along with the increase of CS molecular weight. When the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan, the release times of the drug-loading film was increased to 108 h. Thus, we conclude that the matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation method is simple and avoid using a large number of organic solvents. The novel drug-loading film can obviously prolong release of drugs.
Abstract: Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that t...
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