Antihyperglycemic Activity and Phytochemical Screening of Khaya Senegalensis (Meliaceae) in Wistar Rats
Adeoti Mansour Franck,
Gogahy Konan,
Monteomo Gnate François,
Camara-Cisse Massara,
Djaman Allico Joseph,
Dosso Mireille
Issue:
Volume 4, Issue 5, October 2016
Pages:
53-57
Received:
19 August 2016
Accepted:
9 September 2016
Published:
14 October 2016
Abstract: The aim of this study was to identify the chemical group, evaluate an acute toxicity study and analyze the effect of aqueous extract Khaya senegalensis (Meliaceae), on experimentally induced hyperglycemic condition in rats. The phytochemical study of the aqueous extract of Khaya senegalensis revealed the presence of active secondary metabolic compounds such as flavonoids, polyphenols, catechol tannins, quinones, saponins, sterols and terpenes. The stem bark of Khaya senegalensis was used for acute toxicity study by gavage in Swiss mice. The aqueous extract of Khaya senegalensis (AEKS) at the dose of 35±5 mg/kg administrated by gavage showed that all the mice treated were living after 24 hours. The lethal dose obtained by intraperitoneal administration with graded doses to the mice was 1778 mg/kg. This extract could be non-toxic. The study of AEKS activity on blood glucose in rats showed a significant (p <0.01) the concentration of glucose in the serum of the treated rats with the AEKS (96.2 ± 30 mg/dl) and Glibenclamide (92.4±10 mg/dL), compared to glucose concentrations in the serum of hyperglycemic rats (197.1 ± 50 mg/dl). Thus, the study showed hypoglycemic activity of aqueous extract of Khaya senegalensis. In conclusion, the administration of AEKS causes hypoglycemic activity in rats given oral glucose load. Hypoglycemia this is due to the presence of active chemical groups in the extract of this plant, such as flavonoids, catechin tannins, polyphenols, quinones, sterols and terpenes. These results confirm the therapeutic indication in traditional medicine Khaya senegalensis in the treatment of diabetic disease.
Abstract: The aim of this study was to identify the chemical group, evaluate an acute toxicity study and analyze the effect of aqueous extract Khaya senegalensis (Meliaceae), on experimentally induced hyperglycemic condition in rats. The phytochemical study of the aqueous extract of Khaya senegalensis revealed the presence of active secondary metabolic compo...
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Oxidative Degradation of Atropine Drug by Permanganate Ion in Perchloric and Sulfuric Acid Solutions: A Comparative Kinetic Study
Ahmed Fawzy,
Ishaq A. Zaafarany,
Fahd A. Tirkistani,
Basim H. Asghar
Issue:
Volume 4, Issue 5, October 2016
Pages:
58-65
Received:
28 August 2016
Accepted:
5 September 2016
Published:
18 October 2016
Abstract: The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] and [H+] were found to be less than unity. The effect of acid concentration suggests that the reactions were acid-catalyzed. Variation of either ionic strength or dielectric constant of the medium had no effect significantly on the oxidation rates. The reactions mechanism adequately describing the kinetic results was proposed. In both acids, the main oxidation products of atropine were identified by spectral and chemical analyses as tropine and phenylmalonic acid. Under comparable experimental conditions, the oxidation rate of atropine in sulfuric acid was approximately three times higher than that in perchloric acid. The reactions constants involved in the different steps of the reactions mechanism have been evaluated. With admiration to the rate-limiting step of these reactions, the activation parameters have been evaluated and discussed.
Abstract: The kinetics of oxidations of atropine (ATR) by permanganate ion in both perchloric and sulfuric acid solutions was studied using spectrophotometric technique at a constant ionic strength of 1.2 moldm-3 and at 25°C. In both acids, the reactions showed a first order dependence with respect to [permanganate], whereas the orders with respect to [ATR] ...
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