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Heat Shock Protein 90 Alpha Genes Are Up-regulated by Acute Exercise
Ehiaghe Friday Alfred,
Digban Kester,
Ehiaghe Imuetiyan Joy
Issue:
Volume 5, Issue 4, August 2017
Pages:
57-60
Received:
22 March 2017
Accepted:
15 April 2017
Published:
5 July 2017
Abstract: This study was designed to further determine the expression pattern and role of heat shock protein 90 alpha genes in pre and post acute exercise amongst young male undergraduates in Nnewi, Nigeria. Twenty five (25) healthy young male undergraduate students with an average age of 24.3± 3 years and body mass index of 22.7± 1.8(Kg/m2) participated fully in the study. The subjects took part in an endurance race using the Bruce treadmill protocol for sub-maximal exercise for a maximum of 21 minutes. Blood samples were collected from the participants before commencement of the study, at 1 hour, 4 hours and 24 hours post exercise. Heat shock protein 90 alpha genes expression patterns were detected using reverse transcriptase polymerase chain reaction method. The expression pattern of heat shock protein 90 alpha genes was up-regulated at 1 hours post exercise and sustained till 24 hours post exercise at 200bp in all the exercised subjects when compared with the pre-exercise stage. Post exercise stress activates the release of heat shock protein 90 alpha genes which are needed to restore cellular homeostasis.
Abstract: This study was designed to further determine the expression pattern and role of heat shock protein 90 alpha genes in pre and post acute exercise amongst young male undergraduates in Nnewi, Nigeria. Twenty five (25) healthy young male undergraduate students with an average age of 24.3± 3 years and body mass index of 22.7± 1.8(Kg/m2) participated ful...
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Evaluation of Hepatoprotective Activities Aqueous and Hydroethanolic Extracts from the Leaves of Erythrococca anomala in Rats
Miezan Bile Aka Patrice,
Kouakou Sylvain Landry,
Droucoula Guillaume Cyril,
Kouakou-Syransy Giselle,
Koffi Akissi Jeanne,
Yapi Houphouet Felix
Issue:
Volume 5, Issue 4, August 2017
Pages:
61-66
Received:
18 May 2017
Accepted:
31 May 2017
Published:
13 July 2017
Abstract: Widely used in Ivory Coast and sub-Saharan Africa in traditional medicine as anti-inflammatory, antioxidant, laxative and purgative, Erythrococca anomala (Euphorbiaceae), is an annual plant. In this work, the aim was to evaluate the Hepatoprotective activity of the aqueous and hydroethanolic extracts of the leaves. Carbon Tetrachloride (CCl4) was used to induce hepatotoxicity in rats. This hepatotoxic effect causes a significant increase in the levels of liver enzymes and serum proteins. Hepatoprotective activity was assessed by assaying liver enzymes such as serum transaminases (alanine aminotransferase and aspartate aminotransferase) and proteins by spectrophotometric and electrophoretic techniques. When administered orally as a preventive and curative dose of 100 and 200 mg / kg body weight, the extracts significantly reduce significantly as silymarin, the reference hepatoprotective substance at 100 mg / kg bw, hepatotoxicity induced by Carbon tetrachloride (CCL4) at a dose of 5 mg / kg bw after a significant reduction in liver enzyme levels, globulins and a significant increase in albumin. The possible mechanism of this hepatoprotective activity of the extracts may be due to the action of the antioxidants such as the flavonoids, the phenols present in the extracts.
Abstract: Widely used in Ivory Coast and sub-Saharan Africa in traditional medicine as anti-inflammatory, antioxidant, laxative and purgative, Erythrococca anomala (Euphorbiaceae), is an annual plant. In this work, the aim was to evaluate the Hepatoprotective activity of the aqueous and hydroethanolic extracts of the leaves. Carbon Tetrachloride (CCl4) was u...
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Effects of Rosin Sizing Agent on the Fixation of Boron in Styrax tonkinensis Wood
Thi Thanh Hien Nguyen,
Shujun Li
Issue:
Volume 5, Issue 4, August 2017
Pages:
67-72
Received:
5 May 2017
Accepted:
5 June 2017
Published:
13 July 2017
Abstract: The aim of this study was to evaluate the effect of rosin upon fixing boron in Styrax tonkinensis (Piere) wood treated with mixtures of 3% boric acid and 1% rosin sizing agent. After treatment, wood samples were also analyzed by scanning electron microscope observation and energy-dispersive X-ray spectroscopy (SEM-EDX). The results showed that all boron-rosin formulations impregnated Styrax tonkinensis wood evenly penetrated into the wood blocks. Boron-rosin treatment decreased by 16% the amount of boron leaching from treated wood samples compared with those from the samples treated with boric acid alone. The SEM-EDX analysis proved that the boron element was still in the cell lumens of leached wood blocks. Results indicated that rosin emulsion sizing agent can have an effect on the fixation of boron in wood. This signifies that using of rosin as fixing agents may contribute to lead to wood treated with boron based preservatives being more widely used.
Abstract: The aim of this study was to evaluate the effect of rosin upon fixing boron in Styrax tonkinensis (Piere) wood treated with mixtures of 3% boric acid and 1% rosin sizing agent. After treatment, wood samples were also analyzed by scanning electron microscope observation and energy-dispersive X-ray spectroscopy (SEM-EDX). The results showed that all ...
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Hydrophylic Polyurethaneurea Containing the Copolymer of N-vinylpyrrolidone, Vinyl Acetate and Vinyl Alcohol for Possible Biomedical Use
Tetiana Rudenchyk,
Rita Rozhnova,
Nataliia Galatenko
Issue:
Volume 5, Issue 4, August 2017
Pages:
73-78
Received:
30 May 2017
Accepted:
26 June 2017
Published:
31 July 2017
Abstract: The series of polyurethaneurea (PUU) containing in its structure the fragments of the copolymer of N-vinylpyrrolidone, vinyl acetate and vinyl alcohol (VP-VA) with the 1.6-hexamethylenediamine (HMDA) macrochain extender and the series of PUU with the 4.4'-diaminodiphenylmethane (DADPh) macrochain extender having different ratio of HMDA and DADPh to VP-VA (30:70; 40:60; 50:50; 60:40; 70:30) were synthesized. It has been established that PUU containing in its structure the DADPh macrochain extender is characterized by higher values of the tensile strength and relative elongation at break, glass-transition temperature and the change of the specific heat capacity and hydrophilicity compared to PUU containing in its structure the HMDA macrochain extender. It was found that the increase in amount of VP-VA copolymers in PUU structure increases hydrophilicity by 19-41% for PUU with HMDA and by 16-62% for PUU with DADPh and will contribute to a prolonged release of biologically active substances from the polymer matrix. The results obtained allowed us to determine that the PUU with VP-VA copolymer fragments in the structure synthesized with the ratio of HMDA and DADPh to VP-VA 70:30 is characterized by sufficient physical-mechanical properties (σ = 3.1 MPa, ε = 47% and σ = 5.2 MPa, ε = 90%, accordingly), hydrophilicity (21.0% and 19.4%, accordingly) and can be used as a polymer matrix for medicine biologically active composite materials.
Abstract: The series of polyurethaneurea (PUU) containing in its structure the fragments of the copolymer of N-vinylpyrrolidone, vinyl acetate and vinyl alcohol (VP-VA) with the 1.6-hexamethylenediamine (HMDA) macrochain extender and the series of PUU with the 4.4'-diaminodiphenylmethane (DADPh) macrochain extender having different ratio of HMDA and DADPh to...
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