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Evaluation of Oxidative DNA Damage and Its Relation with Anthropometric Indices in Healthy Adolescents
Farzaneh Bagherzadeh,
Mehrangiz Ebrahimi-Mameghani,
Mohammad Asghari Jafarabadi,
Zahra Aslani,
Sare Edalati
Issue:
Volume 4, Issue 2-1, March 2015
Pages:
21-25
Received:
20 December 2014
Accepted:
25 January 2015
Published:
2 March 2015
Abstract: Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Iran. In this study, evaluation of OS from urinary biomarker in healthy adolescents and its relevance to anthropometric index were investigated. Forty- hundred students aged 13 and 19 years old participated in this study. 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) as marker of oxidative DNA damage was measured in adolescents and also its relation with age, sex and body mass index was studied. Subjects were sampled by multistage cluster sampling. The average ratio of 8-OHdG to creatinine was 4.7±4.1.No significant difference of 8-OHdG was observed between boys and girls in this study.
Abstract: Reactive oxygen species (ROS) and oxidative stress (OS) have important role in prevention, initiation and progression of chronic diseases from early childhood, but OS status in healthy young subjects and appropriate methods for its measurement have been remained unclear. Evaluation of urinary biomarker set for OS has not been well documented in Ira...
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A Sesame Seeds-Based Breakfast Could Attenuate Sub-Clinical Inflammation in Type 2 Diabetic Patients: A Randomized Controlled Trial
Zahra Bahadoran,
Parvin Mirmiran,
Somayeh Hosseinpour-Niazi,
Fereidoun Azizi
Issue:
Volume 4, Issue 2-1, March 2015
Pages:
1-5
Received:
8 September 2014
Accepted:
15 September 2014
Published:
20 September 2014
Abstract: Background and aim: The aim of this study was to investigate the effects of Tahini, a traditional functional food made from ground un-hulled sesame seeds, on glucose homeostasis parameters and serum high-sensitive reactive protein (hs-CRP) in diabetic patients. Methods: This randomized clinical trial included 41 patients with type 2 diabetes, who were randomly assigned to one of two groups: Group A (Tahini 30 g/d, n=21) and group B (control, n=20). After an initial 2-week washout period, patients in group A, replaced a part of their usual breakfast with 2 tbsp (~28 g) Tahini, while group B patients continued the usual breakfast meal for 6 weeks. Insulin and hs-CRP levels were measured, and insulin sensitivity index and homeostasis model assessment of insulin resistance index (HOMA-IR) at were calculated baseline and 6 weeks intervention. Results: After 6-weeks, there was a significant 21.1% decrease in serum hs-CRP levels in group A. Slight but non-significant decrease in fasting serum glucose, serum insulin, insulin sensitivity index and HOMA-IR was observed during Tahini supplementation. Conclusion: Replacing a part of regular diet with Tahini as a functional food could attenuate sub-clinical inflammation in type 2 diabetic patients.
Abstract: Background and aim: The aim of this study was to investigate the effects of Tahini, a traditional functional food made from ground un-hulled sesame seeds, on glucose homeostasis parameters and serum high-sensitive reactive protein (hs-CRP) in diabetic patients. Methods: This randomized clinical trial included 41 patients with type 2 diabetes, who w...
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Potential Properties of Legumes as Important Functional Foods for Management of Type 2 Diabetes: A Short Review
Zahra Bahadoran,
Parvin Mirmiran
Issue:
Volume 4, Issue 2-1, March 2015
Pages:
6-9
Received:
13 September 2014
Accepted:
17 September 2014
Published:
20 September 2014
Abstract: The concept of functional foods in health promotion and disease management has been developed during the past two decades. Beyond the basic nutritional functions, functional foods have several potential biological properties and have hence been given much attention. Leguminous seeds (peas, beans, lentils, peanuts), rich sources of bioactive proteins and peptides, functional fiber, indigestible carbohydrates and phytochemicals, have been recently introduced them as unique functional foods. Studies showed that higher consumption of legumes could attenuate postprandial glycemia and insulinemia, increase insulin sensitivity, regulate lipid and lipoprotein metabolism, and diminish oxidative stress. The potential efficacies of leguminous seeds and their bioactive components have made them as excellent choice for supplementary treatment in type 2 diabetes.
Abstract: The concept of functional foods in health promotion and disease management has been developed during the past two decades. Beyond the basic nutritional functions, functional foods have several potential biological properties and have hence been given much attention. Leguminous seeds (peas, beans, lentils, peanuts), rich sources of bioactive protein...
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Effect of Lentil Sprouts on Glycemic Control in Overweight and Obese Patients with Type 2 Diabetes
Zahra Aslani,
Beitollahe Alipour,
Zahra Bahadoran,
Farzane Bagherzadeh,
Parvin Mirmiran
Issue:
Volume 4, Issue 2-1, March 2015
Pages:
10-14
Received:
30 October 2014
Accepted:
4 November 2014
Published:
14 November 2014
Abstract: Health benefits of Lentil sprout (LS) have not yet been well documented. In this study, effects of LS consumption on glycemic parameters and anthropometric measurements in overweight and obese patients with type 2 diabetes were investigated. Thirty-nine type 2 diabetic patients were randomly divided into two groups; LS group and controls. Patients in LS group received 60 g lentil sprouts daily, and the patients in control group continued regular diet. Anthropometric measurements, the levels of fasting blood glucose (FBS), hemoglobin A1C (HbA1c), serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were assessed at baseline and after 8-weeks. After 8 weeks, serum levels of HbA1c and HOMA-IR were lower in the LS group compared to control group (P<0.05). The QUICKI also was higher in the LS group compared to controls (0.34 vs. 0.32, P<0.05). The results suggested that LS consumption could have favorable effects on glycemic control in overweight and obese patients with type 2 diabetes.
Abstract: Health benefits of Lentil sprout (LS) have not yet been well documented. In this study, effects of LS consumption on glycemic parameters and anthropometric measurements in overweight and obese patients with type 2 diabetes were investigated. Thirty-nine type 2 diabetic patients were randomly divided into two groups; LS group and controls. Patients ...
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Lentil’s (Lens Culinaris L.) Functional Properties in Prevention and Treatment of Non-Communicable Chronic Diseases: A Review
Zahra Aslani,
Beitollahe Alipour,
Parvin Mirmiran,
Zahra Bahadoran
Issue:
Volume 4, Issue 2-1, March 2015
Pages:
15-20
Received:
9 December 2014
Accepted:
23 December 2014
Published:
31 December 2014
Abstract: Background: using functional food in diet planning and diet therapy is one of the newest approaches in prevention and treatment of non-communicable chronic diseases. Lentil has many bioactive and functional compounds and we have reviewed the influence of lentil in prevention and treatment of chronic diseases in this review study. Materials and methods: In order to do search about mentioned objective key words including Lentils (Lens culinarisL.), functional foods, bioactive peptides, nutritional value, health polyphenol in combination with glycemic index (GI), insulin resistance, diabetes, cancer and hypertension, the sources in PubMed database were examined in the years between1986-2013. Key words such as lentils (Lens culinarisL.), functional foods, bioactive peptides, nutritional value, diabetes, cancer and hypertension were studied with access to Persian sources of Scientific Information Database (SID). Cell studies, animal models, clinical studies and review articles were used with favorable quality. Results: Lentils are rich sources of fibers, resistant starches, prebiotic compounds, phytochemicals, proteins and bioactive peptides, phenolic acids and antioxidants. Lentil has the highest total antioxidant capacity among other foods including apples, dates, raspberries, cherries, figs, oranges, garlic, cabbage and peanuts. High content of fibers and other phytochemicals are found in lentils that could improve glycemic response in diabetic patients, lipid and lipoprotein metabolism and weight management. Lentils may have favorable effects in prevention of diabetes, cancer and cardiovascular diseases (CVDs) prevalence. Conclusion: Increased dietary intake of lentils is considered as an important key in prevention and treatment of chronic diseases, especially type 2 diabetes, cardiovascular and cancer diseases.
Abstract: Background: using functional food in diet planning and diet therapy is one of the newest approaches in prevention and treatment of non-communicable chronic diseases. Lentil has many bioactive and functional compounds and we have reviewed the influence of lentil in prevention and treatment of chronic diseases in this review study. Materials and meth...
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Screening of Potential Sources of Tannin and Its Therapeutic Application
Mamta Kumari,
Shashi Jain
Issue:
Volume 4, Issue 2-1, March 2015
Pages:
26-29
Received:
18 November 2014
Accepted:
4 December 2014
Published:
21 March 2015
Abstract: Tannins are a unique category of plant phytochemicals especially in terms of their vast potential health-benefiting properties. Researchers have described the capacity of tannins to enhance glucose uptake and inhibit adipogenesis, thus being potential drugs for the treatment of non-insulin dependent diabetes mellitus. Thus, the present research was conducted to find out tannin content of food products. The percentage of tannin in various analyzed sources ranged from 0.0 to 108.53%; highest in kathaa and lowest in ker and mango bark. The percentage of tannins present in the plants, however, varies. Numerous studies have confirmed that the naturally occurring polyphenols are key factor for the beneficial effects of the herbal medicines. Isolation and identification of active constituents from plants, preparation of standardized dose & dosage regimen can play a significant role in improving the hypoglycaemic action.
Abstract: Tannins are a unique category of plant phytochemicals especially in terms of their vast potential health-benefiting properties. Researchers have described the capacity of tannins to enhance glucose uptake and inhibit adipogenesis, thus being potential drugs for the treatment of non-insulin dependent diabetes mellitus. Thus, the present research was...
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